WO2000076642A3 - Mixing apparatus and method of mixing during conducting an assay - Google Patents

Mixing apparatus and method of mixing during conducting an assay Download PDF

Info

Publication number
WO2000076642A3
WO2000076642A3 PCT/GB2000/002259 GB0002259W WO0076642A3 WO 2000076642 A3 WO2000076642 A3 WO 2000076642A3 GB 0002259 W GB0002259 W GB 0002259W WO 0076642 A3 WO0076642 A3 WO 0076642A3
Authority
WO
WIPO (PCT)
Prior art keywords
mixing
assay
inlet
during conducting
port
Prior art date
Application number
PCT/GB2000/002259
Other languages
French (fr)
Other versions
WO2000076642A2 (en
Inventor
David Andrewes
John Anthony O'dell
Anthony Stevenson
John Curtis
Adrian Richard Gray
John Philip Vessey
Felix Fernando
Mark Creswell
David Alan Percival
John Worthington Attridge
Original Assignee
Provalis Diagnostics Ltd
David Andrewes
Dell John Anthony O
Anthony Stevenson
John Curtis
Adrian Richard Gray
John Philip Vessey
Felix Fernando
Mark Creswell
David Alan Percival
John Worthington Attridge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provalis Diagnostics Ltd, David Andrewes, Dell John Anthony O, Anthony Stevenson, John Curtis, Adrian Richard Gray, John Philip Vessey, Felix Fernando, Mark Creswell, David Alan Percival, John Worthington Attridge filed Critical Provalis Diagnostics Ltd
Priority to EP00937102A priority Critical patent/EP1185357A2/en
Priority to IL14700800A priority patent/IL147008A0/en
Priority to AU52391/00A priority patent/AU5239100A/en
Priority to JP2001502960A priority patent/JP2003501250A/en
Priority to NZ516057A priority patent/NZ516057A/en
Priority to CA002374590A priority patent/CA2374590A1/en
Priority to BR0011444-8A priority patent/BR0011444A/en
Priority to KR1020017015892A priority patent/KR20020016828A/en
Priority to MXPA01012565A priority patent/MXPA01012565A/en
Publication of WO2000076642A2 publication Critical patent/WO2000076642A2/en
Publication of WO2000076642A3 publication Critical patent/WO2000076642A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/726—Devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/049—Valves integrated in closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0491—Position sensing, encoding; closed-loop control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/022—Casings
    • G01N2201/0221—Portable; cableless; compact; hand-held

Abstract

Apparatus, instrument, device and a method of mixing for conducting an assay. Apparatus (31) comprising a first and second inlet and an inlet port accommodating a filter and/or binder retaining means, the inlet port moveable relative to first and second inlets such that the port (9) can be brought into liquid communication with each inlet, and a sample chamber (3, 5) comprising a paddle (100) wich undergeos a reciprocating motion.
PCT/GB2000/002259 1999-06-10 2000-06-09 Mixing apparatus and method of mixing during conducting an assay WO2000076642A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP00937102A EP1185357A2 (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing during conducting an assay
IL14700800A IL147008A0 (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing
AU52391/00A AU5239100A (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing
JP2001502960A JP2003501250A (en) 1999-06-10 2000-06-09 Mixing device and mixing method
NZ516057A NZ516057A (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing
CA002374590A CA2374590A1 (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing during conducting an assay
BR0011444-8A BR0011444A (en) 1999-06-10 2000-06-09 Mixing apparatus and mixing process
KR1020017015892A KR20020016828A (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing
MXPA01012565A MXPA01012565A (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9913560.0A GB9913560D0 (en) 1999-06-10 1999-06-10 Mixing apparatus and method of mixing
GB9913560.0 1999-06-10

Publications (2)

Publication Number Publication Date
WO2000076642A2 WO2000076642A2 (en) 2000-12-21
WO2000076642A3 true WO2000076642A3 (en) 2001-07-05

Family

ID=10855133

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002259 WO2000076642A2 (en) 1999-06-10 2000-06-09 Mixing apparatus and method of mixing during conducting an assay

Country Status (13)

Country Link
EP (1) EP1185357A2 (en)
JP (1) JP2003501250A (en)
KR (1) KR20020016828A (en)
CN (1) CN1384769A (en)
AU (1) AU5239100A (en)
BR (1) BR0011444A (en)
CA (1) CA2374590A1 (en)
GB (1) GB9913560D0 (en)
IL (1) IL147008A0 (en)
MX (1) MXPA01012565A (en)
NZ (1) NZ516057A (en)
RU (1) RU2001133017A (en)
WO (1) WO2000076642A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1760672B (en) * 2004-10-12 2010-05-12 因韦尔尼斯医药瑞士股份有限公司 Device for detecting sample and method for detecting sample
CN101498717B (en) * 2005-04-30 2013-08-28 美艾利尔瑞士公司 Sample collecting device used for collecting solid or semi-solid sample
KR100798471B1 (en) * 2007-10-08 2008-01-28 주식회사 인포피아 Reaction cassette for measuring glycated hemoglobin and measuring method thereof
EP3189861A1 (en) * 2008-11-28 2017-07-12 Terumo Kabushiki Kaisha Blood bag system and cassette
CN103217321A (en) * 2012-05-17 2013-07-24 常州市环境监测中心 Drum type rotation instrument
WO2015017413A1 (en) * 2013-07-29 2015-02-05 Mbio Diagnostics, Inc. Assay cartridge processing systems and methods and associated assay cartridges
AT520184B1 (en) * 2017-09-18 2019-02-15 Zeta Biopharma Gmbh Stirring head with identification device
CN210982482U (en) * 2018-04-24 2020-07-10 深圳市帝迈生物技术有限公司 Automatic mixing device of blood sample and blood cell analytical equipment
CN108705670B (en) * 2018-05-03 2020-04-10 芜湖凯德机械制造有限公司 Dispensing device for mixing ingredients
CN108613932B (en) * 2018-07-18 2023-08-22 无锡迅杰光远科技有限公司 Novel side-illuminated sample mixing device
CN110907380B (en) * 2019-12-25 2022-11-22 安徽清大云博环保科技有限公司 Method for measuring trace silicate in water

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356346A (en) * 1966-01-03 1967-12-05 Landsberger Kurt Test tube stirring support
US3853010A (en) * 1973-03-05 1974-12-10 Varian Associates Sample container support with coding means
GB2018147A (en) * 1978-04-06 1979-10-17 G Sojuz Z Mek I Khim Ochistke Method of and apparatus for mixing substances
US4254083A (en) * 1979-07-23 1981-03-03 Eastman Kodak Company Structural configuration for transport of a liquid drop through an ingress aperture
US4283141A (en) * 1978-02-13 1981-08-11 Pye (Electronic Products) Limited Sample cell and stirrer for spectrophotometry
EP0033543A1 (en) * 1980-02-04 1981-08-12 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Method for the determination of a special hemoglobin variant and use of this method in detecting diabetes
US4407961A (en) * 1981-03-16 1983-10-04 Sanders James L Ion-exchange system and method for isolation and determination of glycosylated hemoglobin in human blood
US4533641A (en) * 1982-07-21 1985-08-06 Harbor Branch Foundation, Inc. Automatic chemical analysis methods
US4541291A (en) * 1982-08-20 1985-09-17 U.S. Philips Corporation Automatic sampling arrangement
US4612291A (en) * 1984-09-04 1986-09-16 American Monitor Corporation Method and apparatus for mixing serum and reagents for chemical analysis
EP0339277A1 (en) * 1988-04-11 1989-11-02 Miles Inc. Reaction vessel for performing sequential analytical assays
US4914023A (en) * 1986-06-10 1990-04-03 Serono Diagnostics Partners Method of extending the linear range of an enzyme immunoassay by measuring off-peak absorbance
US4947695A (en) * 1988-12-24 1990-08-14 Willy Lohr Apparatus for controlling a star wheel for positioning specimen containers
US5272092A (en) * 1987-11-12 1993-12-21 Hitachi, Ltd. Method for analyzing a reaction solution
US5597532A (en) * 1994-10-20 1997-01-28 Connolly; James Apparatus for determining substances contained in a body fluid
WO1998043739A2 (en) * 1997-03-27 1998-10-08 Biosite Diagnostics Incorporated Diagnostic devices and apparatus for the controlled movement of reagents without membranes
WO1999028038A1 (en) * 1997-11-28 1999-06-10 Cortecs Diagnostics Limited Device and apparatus for conducting an assay

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356346A (en) * 1966-01-03 1967-12-05 Landsberger Kurt Test tube stirring support
US3853010A (en) * 1973-03-05 1974-12-10 Varian Associates Sample container support with coding means
US4283141A (en) * 1978-02-13 1981-08-11 Pye (Electronic Products) Limited Sample cell and stirrer for spectrophotometry
GB2018147A (en) * 1978-04-06 1979-10-17 G Sojuz Z Mek I Khim Ochistke Method of and apparatus for mixing substances
US4254083A (en) * 1979-07-23 1981-03-03 Eastman Kodak Company Structural configuration for transport of a liquid drop through an ingress aperture
EP0033543A1 (en) * 1980-02-04 1981-08-12 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Method for the determination of a special hemoglobin variant and use of this method in detecting diabetes
US4407961A (en) * 1981-03-16 1983-10-04 Sanders James L Ion-exchange system and method for isolation and determination of glycosylated hemoglobin in human blood
US4533641A (en) * 1982-07-21 1985-08-06 Harbor Branch Foundation, Inc. Automatic chemical analysis methods
US4541291A (en) * 1982-08-20 1985-09-17 U.S. Philips Corporation Automatic sampling arrangement
US4612291A (en) * 1984-09-04 1986-09-16 American Monitor Corporation Method and apparatus for mixing serum and reagents for chemical analysis
US4914023A (en) * 1986-06-10 1990-04-03 Serono Diagnostics Partners Method of extending the linear range of an enzyme immunoassay by measuring off-peak absorbance
US5272092A (en) * 1987-11-12 1993-12-21 Hitachi, Ltd. Method for analyzing a reaction solution
EP0339277A1 (en) * 1988-04-11 1989-11-02 Miles Inc. Reaction vessel for performing sequential analytical assays
US4947695A (en) * 1988-12-24 1990-08-14 Willy Lohr Apparatus for controlling a star wheel for positioning specimen containers
US5597532A (en) * 1994-10-20 1997-01-28 Connolly; James Apparatus for determining substances contained in a body fluid
WO1998043739A2 (en) * 1997-03-27 1998-10-08 Biosite Diagnostics Incorporated Diagnostic devices and apparatus for the controlled movement of reagents without membranes
WO1999028038A1 (en) * 1997-11-28 1999-06-10 Cortecs Diagnostics Limited Device and apparatus for conducting an assay

Also Published As

Publication number Publication date
GB9913560D0 (en) 1999-08-11
CN1384769A (en) 2002-12-11
IL147008A0 (en) 2002-08-14
EP1185357A2 (en) 2002-03-13
AU5239100A (en) 2001-01-02
CA2374590A1 (en) 2000-12-21
WO2000076642A2 (en) 2000-12-21
NZ516057A (en) 2003-08-29
KR20020016828A (en) 2002-03-06
MXPA01012565A (en) 2003-07-14
RU2001133017A (en) 2004-01-27
JP2003501250A (en) 2003-01-14
BR0011444A (en) 2002-03-19

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