WO2000075363A3 - Enzymatic measurement of mycophenolic acid - Google Patents

Enzymatic measurement of mycophenolic acid Download PDF

Info

Publication number
WO2000075363A3
WO2000075363A3 PCT/US2000/012872 US0012872W WO0075363A3 WO 2000075363 A3 WO2000075363 A3 WO 2000075363A3 US 0012872 W US0012872 W US 0012872W WO 0075363 A3 WO0075363 A3 WO 0075363A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycophenolic acid
enzymatic measurement
measurement
present
biological samples
Prior art date
Application number
PCT/US2000/012872
Other languages
French (fr)
Other versions
WO2000075363A2 (en
Inventor
Allan R Dorn
Original Assignee
Roche Diagnostics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Corp filed Critical Roche Diagnostics Corp
Priority to DE60029413T priority Critical patent/DE60029413T2/en
Priority to JP2001501643A priority patent/JP3854864B2/en
Priority to EP00935908A priority patent/EP1112373B1/en
Priority to CA002339821A priority patent/CA2339821C/en
Publication of WO2000075363A2 publication Critical patent/WO2000075363A2/en
Publication of WO2000075363A3 publication Critical patent/WO2000075363A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Abstract

The present invention provides a method for the enzymatic measurement of mycophenolic acid and other IMPDH inhibitors in biological samples. The present invention also provides assay reagents and packaged kits useful for performing enzymatic measurement of mycophenolic acid and other IMPDH inhibitors in biological samples.
PCT/US2000/012872 1999-06-09 2000-05-11 Enzymatic measurement of mycophenolic acid WO2000075363A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60029413T DE60029413T2 (en) 1999-06-09 2000-05-11 ENZYMATIC MEASUREMENT OF MYCOPHENOLIC ACID
JP2001501643A JP3854864B2 (en) 1999-06-09 2000-05-11 Enzymatic method for measuring mycophenolic acid
EP00935908A EP1112373B1 (en) 1999-06-09 2000-05-11 Enzymatic measurement of mycophenolic acid
CA002339821A CA2339821C (en) 1999-06-09 2000-05-11 Enzymatic measurement of mycophenolic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/328,741 US6107052A (en) 1999-06-09 1999-06-09 Enzymatic measurement of mycophenolic acid
US09/328,741 1999-06-09

Publications (2)

Publication Number Publication Date
WO2000075363A2 WO2000075363A2 (en) 2000-12-14
WO2000075363A3 true WO2000075363A3 (en) 2001-04-12

Family

ID=23282234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012872 WO2000075363A2 (en) 1999-06-09 2000-05-11 Enzymatic measurement of mycophenolic acid

Country Status (8)

Country Link
US (1) US6107052A (en)
EP (1) EP1112373B1 (en)
JP (1) JP3854864B2 (en)
AT (1) ATE333510T1 (en)
CA (1) CA2339821C (en)
DE (1) DE60029413T2 (en)
ES (1) ES2267541T3 (en)
WO (1) WO2000075363A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524808B1 (en) * 1999-06-25 2003-02-25 Roche Diagnostics Corporation Enzyme inhibition immunoassay
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
EP1207394B1 (en) * 2000-11-14 2009-12-30 Roche Diagnostics GmbH Immunoassay for HIV protease inhibitors
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US20050203612A1 (en) * 2000-12-22 2005-09-15 Avantec Vascular Corporation Devices delivering therapeutic agents and methods regarding the same
US20030050692A1 (en) * 2000-12-22 2003-03-13 Avantec Vascular Corporation Delivery of therapeutic capable agents
US7083642B2 (en) * 2000-12-22 2006-08-01 Avantec Vascular Corporation Delivery of therapeutic capable agents
US7077859B2 (en) * 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
AU2002322719A1 (en) * 2001-07-26 2003-02-17 Avantec Vascular Corporation Delivery of therapeutic capable agents
WO2005051229A2 (en) * 2003-11-24 2005-06-09 Avantec Vascular Corporation Devices delivering therapeutic agents and methods regarding the same
US7276362B2 (en) 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
EP1740564A2 (en) * 2004-04-26 2007-01-10 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Process for preparation of mycophenolic acid and ester derivatives thereof
KR20080069571A (en) * 2006-06-29 2008-07-28 테바 파마슈티컬 인더스트리즈 리미티드 Regulation of acid metabolite production
MX2008015797A (en) * 2007-04-11 2009-03-06 Teva Gyogyszergyar Zartkoeruen Method for reducing impurity level in mycophenolic acid fermentation.
CN113396226A (en) * 2019-01-31 2021-09-14 豪夫迈·罗氏有限公司 Stabilization of NADPH or NADH in ammonia detection assays

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002004A1 (en) * 1994-07-07 1996-01-25 Behringwerke Ag Immunoassay for mycophenolic acid
WO1997040028A1 (en) * 1996-04-23 1997-10-30 Vertex Pharmaceuticals Incorporated Urea derivatives as inhibitors of impdh enzyme

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US5665583A (en) * 1988-08-12 1997-09-09 Arch Dev Corp Methods and materials relating to IMPDH and GMP production
US5283257A (en) * 1992-07-10 1994-02-01 The Board Of Trustees Of The Leland Stanford Junior University Method of treating hyperproliferative vascular disease
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6153398A (en) * 1997-12-24 2000-11-28 The University Of Chicago Method to identify specific inhibitors of IMP dehydrogenase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002004A1 (en) * 1994-07-07 1996-01-25 Behringwerke Ag Immunoassay for mycophenolic acid
WO1997040028A1 (en) * 1996-04-23 1997-10-30 Vertex Pharmaceuticals Incorporated Urea derivatives as inhibitors of impdh enzyme

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COONEY D.A ET AL.: "Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity", ADVANCES IN ENZYME REGULATION, vol. 21, 1983, pages 271 - 303, XP000943965 *
JONES C E ET AL: "High-performance liquid chromatography determination of mycophenolic acid and its glucuronide metabolite in human plasma", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS,NL,ELSEVIER SCIENCE PUBLISHERS, vol. 708, no. 1-2, 24 April 1998 (1998-04-24), pages 229 - 234, XP004121232, ISSN: 0378-4347 *
KERR K.M. ET AL.: "The roles of conserved residues in IMP dehydrogenase and identification of a transition state analog", BIOCHEMISTRY, vol. 36, no. 43, 1997, US, pages 13365 - 13373, XP000943833 *

Also Published As

Publication number Publication date
ES2267541T3 (en) 2007-03-16
EP1112373A2 (en) 2001-07-04
ATE333510T1 (en) 2006-08-15
WO2000075363A2 (en) 2000-12-14
CA2339821C (en) 2009-01-27
DE60029413D1 (en) 2006-08-31
JP3854864B2 (en) 2006-12-06
US6107052A (en) 2000-08-22
DE60029413T2 (en) 2007-02-22
JP2003523730A (en) 2003-08-12
CA2339821A1 (en) 2000-12-14
EP1112373B1 (en) 2006-07-19

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