WO2000073421A3 - Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells - Google Patents

Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells Download PDF

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Publication number
WO2000073421A3
WO2000073421A3 PCT/US2000/040052 US0040052W WO0073421A3 WO 2000073421 A3 WO2000073421 A3 WO 2000073421A3 US 0040052 W US0040052 W US 0040052W WO 0073421 A3 WO0073421 A3 WO 0073421A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
epithelial cells
human amniotic
cryopreservation
amniotic epithelial
Prior art date
Application number
PCT/US2000/040052
Other languages
French (fr)
Other versions
WO2000073421A2 (en
Inventor
Valerie W Hu
Allan L Goldstein
Gordon Wigginton
Peter D Prestidge
Jonathan M Sackier
Original Assignee
Lifebank Services L L C
Valerie W Hu
Allan L Goldstein
Gordon Wigginton
Peter D Prestidge
Jonathan M Sackier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifebank Services L L C, Valerie W Hu, Allan L Goldstein, Gordon Wigginton, Peter D Prestidge, Jonathan M Sackier filed Critical Lifebank Services L L C
Priority to AU48609/00A priority Critical patent/AU4860900A/en
Publication of WO2000073421A2 publication Critical patent/WO2000073421A2/en
Publication of WO2000073421A3 publication Critical patent/WO2000073421A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Abstract

The present invention is directed to human amniotic epithelial cells derived from placenta at delivery, and the methods for isolating, culturing, and cryopreserving them for future therapeutic uses. Additionally, the present invention is directed to methods for inducing differentiation of these multipotentials cells, for assaying the cell types derived, and for manipulating the cells by gene transfection and other means for therapeutic applications, icluding but not limited to enzyme replacement and gene therapy, tissue regeneration and replacement, as well as burn and wound dressings.
PCT/US2000/040052 1999-06-02 2000-06-01 Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells WO2000073421A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU48609/00A AU4860900A (en) 1999-06-02 2000-06-01 Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13774099P 1999-06-02 1999-06-02
US60/137,740 1999-06-02

Publications (2)

Publication Number Publication Date
WO2000073421A2 WO2000073421A2 (en) 2000-12-07
WO2000073421A3 true WO2000073421A3 (en) 2001-04-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/040052 WO2000073421A2 (en) 1999-06-02 2000-06-01 Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells

Country Status (2)

Country Link
AU (1) AU4860900A (en)
WO (1) WO2000073421A2 (en)

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US8057789B2 (en) 2002-02-13 2011-11-15 Anthrogenesis Corporation Placental stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US8318483B2 (en) 2003-06-27 2012-11-27 Advanced Technologies And Regenerative Medicine, Llc Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US8460650B2 (en) 2007-02-12 2013-06-11 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
US8617535B2 (en) 2002-11-26 2013-12-31 Anthrogenesis Corporation Cytotherapeutics, cytotherapeutic units and methods for treatments using them
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US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
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US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
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US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9254302B2 (en) 2010-04-07 2016-02-09 Anthrogenesis Corporation Angiogenesis using placental stem cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9598669B2 (en) 2005-12-29 2017-03-21 Anthrogenesis Corporation Composition for collecting placental stem cells and methods of using the composition

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