WO2000071242A1 - Synthesizer apparatus - Google Patents

Synthesizer apparatus Download PDF

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Publication number
WO2000071242A1
WO2000071242A1 PCT/FI2000/000468 FI0000468W WO0071242A1 WO 2000071242 A1 WO2000071242 A1 WO 2000071242A1 FI 0000468 W FI0000468 W FI 0000468W WO 0071242 A1 WO0071242 A1 WO 0071242A1
Authority
WO
WIPO (PCT)
Prior art keywords
synthesizer
devices
module
synthesizer apparatus
synthesis
Prior art date
Application number
PCT/FI2000/000468
Other languages
French (fr)
Inventor
Antti P. Manninen
Original Assignee
Pam Solutions Ltd Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pam Solutions Ltd Oy filed Critical Pam Solutions Ltd Oy
Priority to AU47602/00A priority Critical patent/AU4760200A/en
Publication of WO2000071242A1 publication Critical patent/WO2000071242A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00018—Construction aspects
    • B01J2219/0002—Plants assembled from modules joined together
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Definitions

  • the present invention relates to a synthesizer apparatus, and more specifically to a multi-purpose, module-based synthesizer apparatus for performing a variety of chemical syntheses.
  • the present invention is intended to create a solution for carrying out the aforesaid variety of tasks flexibly and in a highly adaptable manner. This is achieved by means of an apparatus, the characteristic features of which are stated in the accompanying Claims.
  • the apparatus automates chemical synthesis.
  • a particular new feature of the apparatus is that the same basic unit can be applied to various chemical syntheses and that individual devices can be linked to form a network of different synthesizers, to accelerate the development of syntheses and processes, and also, if required, to permit the production of larger amounts of substances, by using several devices simultaneously.
  • Figure 1 shows the structure of one synthesizer according to the invention
  • Figure 2 shows an apparatus comprising one synthesizer module and the computer required by it.
  • Figure 3 shows an apparatus entity comprising several synthesizer modules and a control computer.
  • Figure 4 shows an alternative, in which the synthesizers are distributed between several users, with one, two, or three apparatuses for each user.
  • the apparatus includes at least one procedure-specific detachable and exchangeable component, which is called an additional module.
  • the common basic module part contains components performing common functions, such as;
  • - reagent tray from which some of the reagents are taken, in which reagents can be diluted prior to addition, and to which the end products can be transferred, if necessary, - injector units and pumps, for the addition of liquid substances,
  • the reactor and its auxiliary devices are exchangeable and are attached to detachable front panels. Device changes are needed if very different syntheses are carried out.
  • the invention can be applied to many different situations.
  • An apparatus according to the invention can be used, for instance, to form a synthesizer network of individual modules.
  • Effective and versatile research equipment is typically rather difficult to operate and usually requires an operator who is familiar with one or more apparatuses.
  • large apparatuses are almost entirely useless, if some component breaks down or if it takes a long time to service or find a repair technician. Naturally, this reduces both the effective operating time of the apparatus and the results achieved with it.
  • Figure 1 shows one model for a synthesizer module.
  • the fixed part 1 contains electronics 3, operating devices 4, and a reagent tray 5.
  • the exchangeable part 2 contains the reactor 6 itself and its auxiliary devices 7.
  • the present invention also has the advantage that purchasers can first acquire a single device for a relatively small sum of money and check that it operates in practice. This situation is shown in Figure 2, in which there is only a single synthesizer module 8 with its control computer 9. After this, the number of devices required by the research can be safely added, resulting in the network solution according to Figure 3 as described above, if this is necessary.
  • a single synthesizer developing a fault can be detached from the network for servicing, while the others continue to operate as before.
  • a network of devices is very suitable for synthesis development, as the parameters (temperature, speed of addition of substances, mixing speed, etc.) are independent in each device.
  • all the synthesizers in the network can be set to carry out the same synthesis.
  • Another extremely important feature of the invention is that, in a research group, a smaller apparatus entity can be given to an individual researcher, to carry out a sub-project. Similarly, in operator training, a new operator can use a single device, while the other devices are used for active research use.
  • Figure 4 shows clearly the division of an apparatus entity into units with one, two, and three synthesizers.

Abstract

The invention relates to a synthesizer apparatus, which includes a computer (9) or similar for controlling chemical syntheses and an actual reactor (8) for creating and performing the desired chemical reaction. The synthesizer (8) is divided into a fixed basic unit or module (1), which contains devices (3, 4, 5) for carrying out the basic operations and a separate, exchangeable additional unit or module (2), which contains devices (6, 7) for performing the operations that depend on the particular reaction to be carried out.

Description

Synthesizer Apparatus
The present invention relates to a synthesizer apparatus, and more specifically to a multi-purpose, module-based synthesizer apparatus for performing a variety of chemical syntheses.
There is a long history of carrying out syntheses, first by using primitive equipment and later for many years by using manually operated laboratory equipment. Nowadays, however, numerous semi or fully automatic apparatuses have come onto the market, which rapidly and reliably perform the syntheses for which they are intended.
Laboratory work involves very many different operations. The differences are due in part to the number of the compounds to be synthesized, but also in part their different characters. Often, the apparatuses have also different purposes, such as teaching and training, or work aimed at synthesizing a specific compound.
The present invention is intended to create a solution for carrying out the aforesaid variety of tasks flexibly and in a highly adaptable manner. This is achieved by means of an apparatus, the characteristic features of which are stated in the accompanying Claims.
In brief, the apparatus according to this invention automates chemical synthesis. A particular new feature of the apparatus is that the same basic unit can be applied to various chemical syntheses and that individual devices can be linked to form a network of different synthesizers, to accelerate the development of syntheses and processes, and also, if required, to permit the production of larger amounts of substances, by using several devices simultaneously.
In the following, the invention is also explained by reference to the accompanying drawings, which show some embodiments of a synthesizer according to the invention.
Thus: Figure 1 shows the structure of one synthesizer according to the invention;
Figure 2 shows an apparatus comprising one synthesizer module and the computer required by it.
Figure 3 shows an apparatus entity comprising several synthesizer modules and a control computer.
Figure 4 shows an alternative, in which the synthesizers are distributed between several users, with one, two, or three apparatuses for each user.
In the following, the invention is explained in detail by reference to applicable parts of the aforesaid drawings. The components of the synthesizer can be roughly divided into two groups, the basic module and the additional modules.
The basic module of the synthesizer
As known, all synthesizer apparatuses have common characteristics, such as the regulation of the reactor temperature, the addition of substances to the reactor, and the removal of various reagents from the reactor. In the present invention, these common characteristics are collected in the fixed part of the apparatus, which is here characterized with the term basic module. In addition to this, the apparatus includes at least one procedure-specific detachable and exchangeable component, which is called an additional module.
The common basic module part contains components performing common functions, such as;
- electronics,
- possibility to add accessories, - internal, controlled heating and cooling, based on known methods (resistance heating, thermo-electric cooling/heating, etc.),
- reagent tray, from which some of the reagents are taken, in which reagents can be diluted prior to addition, and to which the end products can be transferred, if necessary, - injector units and pumps, for the addition of liquid substances,
- liquid-transfer lines,
- possibility to use various measurement sensors (e.g., pH, etc.),
- a computer connection, and
- recipe-based software for operating one or more devices.
The reactor and its auxiliary devices are exchangeable and are attached to detachable front panels. Device changes are needed if very different syntheses are carried out.
The following are examples of synthesis-specific front panels:
1) Synthesis on top of a fixed phase (combinatorial synthesis).
In this case, a traditional magnetic mixer cannot be used, as it would grind the fixed carrier too finely. Therefore, in this version, an inverting mixer is used and the reactions are usually carried out at room temperature or under pressure at a raised temperature, without using coolers.
2) Traditional solution-phase synthesis. In traditional syntheses, magnetic mixing is the easiest and most suitable form of mixing. In this case, a vertical cooler and/or distillation cooler is also often used, so that the cooling circulation comes from the apparatus's own cooling system. A solids-addition device is also attached to this front panel, with addition being carried out either using a screw device or on a batch basis with single doses or in some other suitable manner.
3) Searching for reaction conditions and phase separations.
If the same reactions are repeated, for example, when optimizing conditions, it is necessary to use a reactor with a combined bottom-valve/mixer unit, permitting the automatic emptying of the reaction vessel. A reactor of this kind is also needed, if phase separation takes place after washing. As stated above, the invention can be applied to many different situations. An apparatus according to the invention can be used, for instance, to form a synthesizer network of individual modules.
Effective and versatile research equipment is typically rather difficult to operate and usually requires an operator who is familiar with one or more apparatuses. In addition, large apparatuses are almost entirely useless, if some component breaks down or if it takes a long time to service or find a repair technician. Naturally, this reduces both the effective operating time of the apparatus and the results achieved with it.
One simplified basic configuration of an apparatus according to the invention is shown in Figure 1 , which shows one model for a synthesizer module. The fixed part 1 contains electronics 3, operating devices 4, and a reagent tray 5. The exchangeable part 2 contains the reactor 6 itself and its auxiliary devices 7.
According to this invention, it is equally simple to use a single device or a network of several devices. When a new device is connected to a network, all that is necessary is to open its own operating window, which is identical to those of the other devices. Being in a network, as in Figure 3, all the synthesizer devices 8 operate as individual units, only being controlled through the same computer 9.
The present invention also has the advantage that purchasers can first acquire a single device for a relatively small sum of money and check that it operates in practice. This situation is shown in Figure 2, in which there is only a single synthesizer module 8 with its control computer 9. After this, the number of devices required by the research can be safely added, resulting in the network solution according to Figure 3 as described above, if this is necessary.
In a network of more than one device, a single synthesizer developing a fault can be detached from the network for servicing, while the others continue to operate as before. Thus, there is only a break in operation in a single synthesizer, minimizing losses of time and money. A network of devices is very suitable for synthesis development, as the parameters (temperature, speed of addition of substances, mixing speed, etc.) are independent in each device. On the other hand, if larger quantities of some substance are required, all the synthesizers in the network can be set to carry out the same synthesis.
Another extremely important feature of the invention is that, in a research group, a smaller apparatus entity can be given to an individual researcher, to carry out a sub-project. Similarly, in operator training, a new operator can use a single device, while the other devices are used for active research use.
Figure 4 shows clearly the division of an apparatus entity into units with one, two, and three synthesizers.

Claims

Claims
1. A synthesizer apparatus, which includes a computer (9) or similar for controlling chemical syntheses and an actual synthesis reactor (8) for creating and performing the desired chemical reaction, characterized in that the synthesizer (8) is divided into a fixed basic unit or module (1), which contains devices (3, 4, 5) for carrying out the basic operations, and a separate, exchangeable additional unit or module (2), which contains devices (6, 7) for performing the operations that depend on the particular reaction to be carried out.
2. A synthesizer apparatus according to Claim 1 , characterized in that the basic module (1) contains devices, for example, for regulating temperature, adding and diluting reagents, a computer connection, and readiness for the installation of auxiliary devices.
3. A synthesizer apparatus according to Claim 1 , characterized in that it includes software, particularly recipe-based software, for operating one or more devices.
4. A synthesizer apparatus according to Claim 1 , characterized in that the additional module (2) is in the form of an exchangeable reaction panel, which panel contains the different components required for the synthesis in question.
5. A synthesizer apparatus according to one of the above Claims, characterized in that there are one or more synthesizers (8) connected to the computer unit and that either one or more of these can be used to perform the same synthesis or each synthesis unit can be used to perform different tasks independently.
6. A synthesizer apparatus according to one of the above Claims, characterized in that the exchangeable additional module (2) contains the actual reactor (6) and its auxiliary devices (7), such as a mixer, a cooler, an emptying or other valve, or other necessary auxiliary devices.
PCT/FI2000/000468 1999-05-24 2000-05-24 Synthesizer apparatus WO2000071242A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU47602/00A AU4760200A (en) 1999-05-24 2000-05-24 Synthesizer apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991175 1999-05-24
FI991175A FI111342B (en) 1999-05-24 1999-05-24 A synthesizer

Publications (1)

Publication Number Publication Date
WO2000071242A1 true WO2000071242A1 (en) 2000-11-30

Family

ID=8554721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2000/000468 WO2000071242A1 (en) 1999-05-24 2000-05-24 Synthesizer apparatus

Country Status (3)

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AU (1) AU4760200A (en)
FI (1) FI111342B (en)
WO (1) WO2000071242A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362699A (en) * 1981-03-10 1982-12-07 Bio Research, Inc. Apparatus for high pressure peptide synthesis
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362699A (en) * 1981-03-10 1982-12-07 Bio Research, Inc. Apparatus for high pressure peptide synthesis
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers

Also Published As

Publication number Publication date
FI991175A (en) 2000-11-25
FI991175A0 (en) 1999-05-24
FI111342B (en) 2003-07-15
AU4760200A (en) 2000-12-12

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