WO2000071171A3 - Sigma-1 ligands for determining carcinoma proliferative status - Google Patents

Sigma-1 ligands for determining carcinoma proliferative status Download PDF

Info

Publication number
WO2000071171A3
WO2000071171A3 PCT/US2000/013834 US0013834W WO0071171A3 WO 2000071171 A3 WO2000071171 A3 WO 2000071171A3 US 0013834 W US0013834 W US 0013834W WO 0071171 A3 WO0071171 A3 WO 0071171A3
Authority
WO
WIPO (PCT)
Prior art keywords
sigma
ligands
proliferative status
determining
determining carcinoma
Prior art date
Application number
PCT/US2000/013834
Other languages
French (fr)
Other versions
WO2000071171A2 (en
Inventor
Robert H Mach
Yunsheng Huang
Steven R Childers
Kenneth T Wheeler
Original Assignee
Univ Wake Forest
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wake Forest filed Critical Univ Wake Forest
Priority to AU50324/00A priority Critical patent/AU5032400A/en
Publication of WO2000071171A2 publication Critical patent/WO2000071171A2/en
Publication of WO2000071171A3 publication Critical patent/WO2000071171A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Abstract

The invention provides a method for determining the proliferative status of cancer cells that express sigma-1 receptors, as well as detectably labeled compounds and pharmaceutically compositions that are useful for carrying out such methods.
PCT/US2000/013834 1999-05-21 2000-05-19 Sigma-1 ligands for determining carcinoma proliferative status WO2000071171A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50324/00A AU5032400A (en) 1999-05-21 2000-05-19 Sigma-1 ligands useful for determining the proliferative status of cancer cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13527499P 1999-05-21 1999-05-21
US60/135,274 1999-05-21

Publications (2)

Publication Number Publication Date
WO2000071171A2 WO2000071171A2 (en) 2000-11-30
WO2000071171A3 true WO2000071171A3 (en) 2001-06-28

Family

ID=22467347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/013834 WO2000071171A2 (en) 1999-05-21 2000-05-19 Sigma-1 ligands for determining carcinoma proliferative status

Country Status (2)

Country Link
AU (1) AU5032400A (en)
WO (1) WO2000071171A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004022783D1 (en) 2003-03-06 2009-10-08 Glaxo Group Ltd Hetereocyclic urea derivatives for the treatment of pain.
JP2006519806A (en) 2003-03-07 2006-08-31 グラクソ　グループ　リミテッド Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain.
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
JP6836502B2 (en) * 2014-05-30 2021-03-03 スプハエラ ファーマ ピーヴィーティー リミテッド New compound as an anti-tuberculosis drug
AR102537A1 (en) * 2014-11-05 2017-03-08 Flexus Biosciences Inc IMMUNOMODULATING AGENTS

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2008439A6 (en) * 1988-03-30 1989-07-16 Espanola Prod Quimicos Piperidinyl alkan-amine deriv. prepn.
US5492918A (en) * 1993-06-08 1996-02-20 Bayer Aktiengesellschaft Use of substituted chromans, some of which are known, as medicaments, new active compounds and processes for their preparation
WO1996020928A1 (en) * 1995-01-03 1996-07-11 Australian Nuclear Science & Technology Organisation Piperidine-based sigma receptor ligands
US5630996A (en) * 1992-06-09 1997-05-20 Neorx Corporation Two-step pretargeting methods using improved biotin-active agent conjugates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2008439A6 (en) * 1988-03-30 1989-07-16 Espanola Prod Quimicos Piperidinyl alkan-amine deriv. prepn.
US5630996A (en) * 1992-06-09 1997-05-20 Neorx Corporation Two-step pretargeting methods using improved biotin-active agent conjugates
US5492918A (en) * 1993-06-08 1996-02-20 Bayer Aktiengesellschaft Use of substituted chromans, some of which are known, as medicaments, new active compounds and processes for their preparation
WO1996020928A1 (en) * 1995-01-03 1996-07-11 Australian Nuclear Science & Technology Organisation Piperidine-based sigma receptor ligands

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARLING ET. AL.: "1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one", J. MED. CHEM., vol. 42, no. 14, July 1999 (1999-07-01), pages 2707 - 15, XP002154247 *
CAYRE ET AL.: "Comparitive 99mTc-Sestamibi and 3H-Daunomycin uptake in human carcinoma cells: relation to the MDR phenotype and effects of reversing agents", J. NUCL. MED., vol. 40, no. 4, April 1999 (1999-04-01), pages 673 - 75, XP002154248 *
HUANG ET AL.: "Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptors", J. MED. CHEM., vol. 41, 1998, pages 2361 - 70, XP002154246 *
MEEGALLA ET AL.: "First example of a 99mTc Complex as a dopamine transporter imaging agent", J. AM. CHEM. SOC., vol. 117, 1995, pages 11037 - 11038, XP002154249 *

Also Published As

Publication number Publication date
WO2000071171A2 (en) 2000-11-30
AU5032400A (en) 2000-12-12

Similar Documents

Publication Publication Date Title
EP1226823A3 (en) Method of treating certain cancers using an estrogen agonist/antagonist
WO1999003822A8 (en) Bicyclic metabotropic glutamate receptor ligands
AU6790000A (en) Improved fill material for dual damascene processes
AU5993399A (en) Gps location for mobile phones using the internet
WO2004096144A3 (en) Compositions and methods for induction of opioid receptors
MXPA03007892A (en) Additive for dewaterable slurry.
HK1031399A1 (en) Process for synthesizing cox-2 inhibitors.
GC0000129A (en) Method for annular sealing.
NO20025016L (en) Corrosion-protected coaxial cable, method for making the same and corrosion-inhibiting composition
AU2003264068A1 (en) Compositions and methods for treating cancer using maytansinoid cd44 antibody immonoconjugates and chemotherapeutic agents
WO2003057163A3 (en) Methods for preparing immunoconjugates
ZA200007090B (en) Coated PCBN cutting tools.
WO2003048301A3 (en) Anti-hla-dr antibodies and the methods of using thereof
HK1045693A1 (en) Bicyclic compounds composition and method for stabilizing the same.
AU2003217417A1 (en) Method for automatically allocating address prefixes
AU2002348503A1 (en) Quinuclidine-substituted heteroaromatic compounds as ligands at nicotinic acetylcholine receptors
ZA993230B (en) R.B. Jun method for surface mining.
WO2005111076A8 (en) Nectin 4 (n4) as a marker for cancer prognosis
AU2002305117A1 (en) Improved apparatus, methods and compositions for biotechnical separations
AU2003297318A1 (en) Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476.
ZA200402472B (en) Method for preparing benzenesulfonyl compounds.
WO2002012224A3 (en) Bicyclic compounds as h3 receptor ligands
AU1514200A (en) Apparatus for directional drilling
ZA200309514B (en) Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives.
WO2000071171A3 (en) Sigma-1 ligands for determining carcinoma proliferative status

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP