WO2000067678A2 - Intraocular lens with accommodative properties - Google Patents
Intraocular lens with accommodative properties Download PDFInfo
- Publication number
- WO2000067678A2 WO2000067678A2 PCT/IB2000/000881 IB0000881W WO0067678A2 WO 2000067678 A2 WO2000067678 A2 WO 2000067678A2 IB 0000881 W IB0000881 W IB 0000881W WO 0067678 A2 WO0067678 A2 WO 0067678A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- intraocular lens
- iris
- lens
- anterior
- eye
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
- A61F2/1605—Anterior chamber lenses for use in addition to the natural lenses of the eyes, e.g. iris fixated, iris floating
Definitions
- This invention relates to intraocular lenses for implantation in the human eye, in particular intraocular lenses having in vivo accommodative properties to assist or replace part of the focusing capabilities of the eye.
- presbyopia the natural capability of the human lens to change its shape and therefore refractive power, is gradually lost with age. All of the cited prior art artificial lenses however cannot change shape to adjust refractive power on a continuous basis and consequently may suffer from multiple image formation or blur because of the different active optical areas of the lens that are needed to focus at different distances.
- lenses have been constructed that respond to anatomical variations of the ciliary body.
- Several means have been employed. Examples are US patent 5,843,188 to McDonald et al., US patent 4,892,543 to Turley, US patent 5,489,302 to Skottun, and US patent 4,932,966 to Christie et al.
- these lenses seem to have very little or no accomodative effect. This is probably due to the simultaneous contraction of the iris which pushes the lens posteriorly, thereby neutralizing the forward movements of the lens caused by a contraction of the ciliary muscle.
- None of the aforementioned lenses can accommodate or change shape, based on a change in diameter of the pupil during the process of accommodative focusing of the eye.
- the primary purpose of the new lens design and method of implantation is therefore to make use of all the natural mechanisms involved in the accommodative reflex: the change in pupil diameter of the eye and the changes in state of contraction of the ciliary muscle, in order to assist in focusing of nearby objects.
- the new intraocular lens consists of two parts.
- the posterior part or haptic part is to be inserted behind the iris and in front of the natural lens or artificial implant.
- the overall length and structure of this part is variable and should fit as close as possible into the ciliary sulcus for two reasons.
- An anterior or optical part made of flexible material, is placed before the iris. Its diameter is variable but should be large enough to cover the pupillary margins to some degree under various conditions of natural dilation. This is important for optical reasons as well as mechanical reasons, to avoid luxation of the optical part behind the iris.
- the anterior and posterior part of the lens are separated by a compressible circular groove in which the iris will settle.
- the diameter of this groove is important and must be slightly larger than the pupillary diameter measured under normal photopic daylight conditions and for distance vision. Since the pupil becomes smaller in near vision, the iris will exert a slight pressure at the level of the groove of the lens which will cause a progressive and evenly distributed flexing of the anterior part of the intraocular lens, as the diameter of the compressible circular groove slightly decreases. This flexing will induce an increase in refractive power which basically corresponds to a variable part of the amount necessary for focusing nearby objects.
- the use of the change in pupil diameter versus other methods, mentioned in the prior art, is advantageous for several reasons.
- the post-operative status and functioning of the implant is easily observed using the biomicroscope.
- this new lens design will avoid the disadvantages of the anterior chamber angle fixation phakic lenses. Because no parts of the new lens will touch the anterior chamber angle, secondary glaucoma and pain will not occur.
- this new lens is located at a safe distance from the coraeal endothelium and has no chance to luxate anteriorly because of its attachment to the posterior part of the lens, there is no risk for endothelial touch and subsequent endothelial cell loss. Because this new lens respects the shape and the centration or decentration of the pupillary border, no pupillary deformation will occur.
- this new lens design will avoid the disadvantages of the iris fixated anterior chamber phakic lenses. Because this new lens design has no fixed iris fixation but a groove which accommodates the iris in a flexible way, no iris perforation nor pupillary deformation can occur. Because this new lens is covering completely the pupillary margins, no complaints of halos due to decentration are to be expected. Because of its large distance from the corneal endothelium, no corneal touch is possible.
- this new lens design will avoid the disadvantages of posterior chamber phakic lenses that solely rely on stabilization by the ciliary body. Because the lens has primarily an iris suspension and streamlined design, lenticular touch and irritation of the ciliary body will be minimized.
- Figure 1A is an anatomical sectioning through the anterior segment of the eye, illustrating the prior art positioning of a conventional iris supported intraocular lens.
- Figure IB is an anatomical sectioning through the anterior segment of the eye, illustrating the positioning of a prior art conventional angle supported intraocular lens.
- Figure 1C is an anatomical sectioning through the anterior segment of the eye, illustrating the prior art positioning of a conventional sulcular supported intraocular lens.
- Figure 1 D is an anatomical sectioning through the anterior segment of the eye, illustrating theprior art positioning of a conventional iris suspended intraocular lens.
- Figure IE is an anatomical sectioning through the anterior segment of the eye, illustrating the positioning of the new intraocular lens.
- the posterior part of the lens is inserted behind the iris and before the natural lens.
- the anterior part of the lens is located before the iris.
- the iris is located within the circular groove.
- Figure 2A is a side view of the intraocular lens, showing the groove which accommodates the pupil margins of the iris, the anterior optical part of the intraocular lens which is placed before the iris and the posterior haptic part of the intraocular lens which is placed behind the iris and before the natural lens.
- Figure 2B is a view from above of the intraocular lens, illustrating the anterior optical part which is smaller than the posterior haptic part and is centered on the posterior part.
- Figure 2C is a different embodiment of the intraocular lens, illustrating a decentered anterior optical part. This type of intraocular lens is meant to be used in case of a nasally decentered pupillary area.
- Figure 3A is a side view of the intraocular lens when the sphincter muscle of the pupil is in a resting natural position in the groove, corresponding to far distance focusing under daylight conditions.
- Figure 3B is a side view of the intraocular lens when the sphincter of the pupil is in a contracted state.
- the anterior part of the intraocular lens is pushed slightly foreward and flexes, as illustrated by the different arrows.
- Figures 1A, IB, 1C and IE illustrate the differences in positioning of the new lens in the eye versus the cited prior art.
- the anterior optical part is placed before the iris
- the pupil margin that contains the sphincter muscle of the iris is inserted in the circular and compressible groove
- the posterior haptic part is placed behind the iris and before the natural lens in the sulcus delineated by the ciliary body and iris.
- Firm contact with the sulcus margin is not necessary and not desired.
- this new lens design permits a less rigid, but more stable centration within the pupil and offers the advantages previously mentioned.
- the preferred embodiment of the optical part 10 of the intraocular lens is circular and its anterior surface is convex, although other configurations and shapes may be employed.
- the optical part 10 of the intraocular lens may be constructed of any of the currently used deformable substances such as silicone polymeric materials, acrylic polymeric materials, hydrogel forming polymeric materials and mixtures of these materials or alike.
- the lens materials used can be coated with chemicals for various purposes, as described in prior art.
- the diameter of the optical part can be variable but preferably should not be less than the average diameter of the pupil as measured under dark background conditions.
- the preferred embodiment of the haptic part 12 is as thin as possible. It follows the general contours of the anterior surface of a human lens and is oval in shape with an overall length which is variable and adjusted to match the surgical «white to white corneal diameter». This is done to obtain the aforementioned optimal stabilization of the lens by the sulcus 22 of the eye.
- the oval shape is purely illustrative and any other configuration may be used, as long as a stable positioning of the intraocular lens is provided.
- the posterior surface of the haptical part preferably has an anterior vaulting 14 facing the natural lens to promote the circulation of intraocular fluids and to prevent a permanent adherence.
- the haptic part 12 is preferably made of one piece together with the optical part 10 of the intraocular lens.
- the haptic part 12 may be constructed from any of the commonly employed materials as previously described, as well as from rigid material such as polymethyl-metacrylate derivatives.
- the circular and compressible groove 16 in the intraocular lens is delineated by the optical part 10 and the haptic part 12. It can be of variable width, depth and shape in order to capture the margins of the iris. A typical groove will taper from 1 mm.to 0.2 mm. Various diameters of the groove 16 are provided to correspond to various pupillary diameters. The preferred diameter to be used in a particular eye, will be slightly larger than the pupillary diameter measured under daylight conditions of illumination and for focusing at a distance.
- This diameter is choosen to maximize the chances that, upon constriction of the sphincter of the iris during the accomodation reflex, the anterior surface of the optical part becomes more convex. This change in shape provides part or all of the additional dioptric power necessary for near focusing.
- variable parameters of the lens Prior to surgery, the following variable parameters of the lens have to determined for each patient:
- the diameter of the posterior haptic part is based on the «white to white diameter» of the cornea.
- the diameter of the groove will be derived from the measurement of the pupillary diameter in normal daylight and distance vision, using a computer assisted pupillometer.
- the diameter of the anterior part of the lens will be based on the diameter of the pupil measured in the dark, using a computer assisted infra-red pupillometer.
- the refractive power of the intraocular lens will be determined according to well-known parameters such as the refractive index of the material used, curvature of the anterior surface of the optical part,, and biometric data from the eye receiving the intraocular lens.
- the surgery can be performed according to the following preferred procedure.
- the eye is opened with a corneal or limbal incision.
- the length of the opening will depend on the foldability of the intraocular lens.
- the anterior chamber is partially filled with viscoelastic material while the iris is gently dilated and separated from the natural lens during the same manoeuver.
- the intraocular lens is then introduced in the anterior chamber of the eye with the optional help of a folder.
- the posterior part of the lens is placed behind the iris and before the natural lens.
- the iris in inserted in the groove so that the anterior part of the lens is positioned before the iris.
- a drug that constricts the pupil can be injected in the anterior chamber of the eye at this stage of the powery.
- an iridectomy can be performed prior to surgery with the Q-switched Nd-YAG laser. This can also be done during surgery using specific micro-surgical instruments for this purpose. After removal of the viscoelastic material, the incision of the eye is closed.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT00940679T ATE235862T1 (en) | 1999-05-11 | 2000-05-09 | INTRAOCULAR LENS WITH ACCOMODATION PROPERTIES |
DE2000601961 DE60001961T2 (en) | 1999-05-11 | 2000-05-09 | INTRAOCULAR LENS WITH ACCOMMODATION PROPERTIES |
EP20000940679 EP1202684B1 (en) | 1999-05-11 | 2000-05-09 | Intraocular lens with accommodative properties |
HK02107319.7A HK1045803A1 (en) | 1999-05-11 | 2002-10-05 | Intraocular lens with accommodative properties |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/309,611 | 1999-05-11 | ||
US09/309,611 US6200342B1 (en) | 1999-05-11 | 1999-05-11 | Intraocular lens with accommodative properties |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000067678A2 true WO2000067678A2 (en) | 2000-11-16 |
WO2000067678A3 WO2000067678A3 (en) | 2001-03-08 |
Family
ID=23198924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2000/000881 WO2000067678A2 (en) | 1999-05-11 | 2000-05-09 | Intraocular lens with accommodative properties |
Country Status (6)
Country | Link |
---|---|
US (1) | US6200342B1 (en) |
EP (1) | EP1202684B1 (en) |
AT (1) | ATE235862T1 (en) |
DE (1) | DE60001961T2 (en) |
HK (1) | HK1045803A1 (en) |
WO (1) | WO2000067678A2 (en) |
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Also Published As
Publication number | Publication date |
---|---|
DE60001961D1 (en) | 2003-05-08 |
EP1202684B1 (en) | 2003-04-02 |
WO2000067678A3 (en) | 2001-03-08 |
DE60001961T2 (en) | 2004-03-04 |
EP1202684A2 (en) | 2002-05-08 |
HK1045803A1 (en) | 2002-12-13 |
US6200342B1 (en) | 2001-03-13 |
ATE235862T1 (en) | 2003-04-15 |
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