WO2000065024A3 - Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules - Google Patents

Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules Download PDF

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Publication number
WO2000065024A3
WO2000065024A3 PCT/US2000/010500 US0010500W WO0065024A3 WO 2000065024 A3 WO2000065024 A3 WO 2000065024A3 US 0010500 W US0010500 W US 0010500W WO 0065024 A3 WO0065024 A3 WO 0065024A3
Authority
WO
WIPO (PCT)
Prior art keywords
encapsulation
hydrophobic molecules
polymeric micelles
delivery
hyperbranched polymeric
Prior art date
Application number
PCT/US2000/010500
Other languages
French (fr)
Other versions
WO2000065024A2 (en
Inventor
Kathryn E Uhrich
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/298,729 external-priority patent/US6365146B1/en
Application filed by Univ Rutgers filed Critical Univ Rutgers
Priority to CA002370952A priority Critical patent/CA2370952A1/en
Priority to MXPA01010752A priority patent/MXPA01010752A/en
Priority to AU43621/00A priority patent/AU782787B2/en
Priority to EP00923508A priority patent/EP1176983A4/en
Publication of WO2000065024A2 publication Critical patent/WO2000065024A2/en
Publication of WO2000065024A3 publication Critical patent/WO2000065024A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/005—Hyperbranched macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C5/00—Photographic processes or agents therefor; Regeneration of such processing agents
    • G03C5/26—Processes using silver-salt-containing photosensitive materials or agents therefor
    • G03C5/29—Development processes or agents therefor
    • G03C5/305—Additives other than developers
    • G03C5/3056—Macromolecular additives

Abstract

Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.
PCT/US2000/010500 1999-04-23 2000-04-18 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules WO2000065024A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002370952A CA2370952A1 (en) 1999-04-23 2000-04-18 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
MXPA01010752A MXPA01010752A (en) 1999-04-23 2000-04-18 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules.
AU43621/00A AU782787B2 (en) 1999-04-23 2000-04-18 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
EP00923508A EP1176983A4 (en) 1999-04-23 2000-04-18 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/298,729 1999-04-23
US09/298,729 US6365146B1 (en) 1999-04-23 1999-04-23 Polymer encapsulation of hydrophobic materials
US09/422,295 1999-10-21
US09/422,295 US6328988B1 (en) 1999-04-23 1999-10-21 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules

Publications (2)

Publication Number Publication Date
WO2000065024A2 WO2000065024A2 (en) 2000-11-02
WO2000065024A3 true WO2000065024A3 (en) 2001-02-08

Family

ID=26970845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/010500 WO2000065024A2 (en) 1999-04-23 2000-04-18 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules

Country Status (6)

Country Link
US (4) US6328988B1 (en)
EP (1) EP1176983A4 (en)
AU (1) AU782787B2 (en)
CA (1) CA2370952A1 (en)
MX (1) MXPA01010752A (en)
WO (1) WO2000065024A2 (en)

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Also Published As

Publication number Publication date
EP1176983A4 (en) 2005-12-28
US20020035217A1 (en) 2002-03-21
US20050089504A1 (en) 2005-04-28
CA2370952A1 (en) 2000-11-02
AU782787B2 (en) 2005-08-25
US20030170202A1 (en) 2003-09-11
WO2000065024A2 (en) 2000-11-02
US6497895B2 (en) 2002-12-24
MXPA01010752A (en) 2002-08-20
AU4362100A (en) 2000-11-10
US6328988B1 (en) 2001-12-11
EP1176983A2 (en) 2002-02-06

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