WO2000063701A3 - Microarrays of polypeptides - Google Patents
Microarrays of polypeptides Download PDFInfo
- Publication number
- WO2000063701A3 WO2000063701A3 PCT/US2000/010171 US0010171W WO0063701A3 WO 2000063701 A3 WO2000063701 A3 WO 2000063701A3 US 0010171 W US0010171 W US 0010171W WO 0063701 A3 WO0063701 A3 WO 0063701A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptides
- microarrays
- ligands
- quantitation
- antigens
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00617—Delimitation of the attachment areas by chemical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002366123A CA2366123A1 (en) | 1999-04-15 | 2000-04-14 | Microarrays of polypeptides |
EP00923395A EP1169649A2 (en) | 1999-04-15 | 2000-04-14 | Microarrays of polypeptides |
JP2000612755A JP2002542487A (en) | 1999-04-15 | 2000-04-14 | Polypeptide microarray |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12944999P | 1999-04-15 | 1999-04-15 | |
US60/129,449 | 1999-04-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2000063701A2 WO2000063701A2 (en) | 2000-10-26 |
WO2000063701A3 true WO2000063701A3 (en) | 2001-03-08 |
WO2000063701A9 WO2000063701A9 (en) | 2002-06-27 |
Family
ID=22440002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/010171 WO2000063701A2 (en) | 1999-04-15 | 2000-04-14 | Microarrays of polypeptides |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1169649A2 (en) |
JP (1) | JP2002542487A (en) |
CA (1) | CA2366123A1 (en) |
WO (1) | WO2000063701A2 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6893877B2 (en) * | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
AU2001292959A1 (en) | 2000-09-22 | 2002-04-02 | Clontech Laboratories, Inc. | Highly sensitive proteomic analysis methods and kits and systems for practicing the same |
US7615340B2 (en) | 2000-10-03 | 2009-11-10 | Minerva Biotechnologies Corporation | Electronic detection of interaction and detection of interaction based on the interruption of flow |
AU2002219971A1 (en) * | 2000-11-01 | 2002-05-15 | Minerva Biotechnologies Corporation | Detection of binding species with colloidal and non-colloidal structures |
WO2002084283A2 (en) * | 2001-04-10 | 2002-10-24 | Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts | Method for determining analyte molecules in a sample |
JP3893030B2 (en) * | 2001-04-18 | 2007-03-14 | 独立行政法人科学技術振興機構 | Bacterial endotoxin adsorbent and screening method thereof |
US20050009204A1 (en) * | 2003-07-11 | 2005-01-13 | Ye Fang | Multiplexed binding assays for receptor arrays |
GB0113358D0 (en) * | 2001-06-01 | 2001-07-25 | Scient Generics Ltd | Enhanced target capture |
US7902121B2 (en) | 2001-07-02 | 2011-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | MHC-antigen arrays for detection and characterization of immune responses |
JP2005514617A (en) * | 2001-07-02 | 2005-05-19 | ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ | Microarray for cell phenotyping and manipulation |
US20050014147A1 (en) * | 2001-08-21 | 2005-01-20 | Hessner Martin J | Method and apparatus for three label microarrays |
JP2003149242A (en) * | 2001-11-09 | 2003-05-21 | Gifu Univ | Method of detecting antibody and antigen micro-array |
WO2003062831A1 (en) * | 2002-01-24 | 2003-07-31 | The Regents Of The University Of California | Method for determining differences in molecular interactions and for screening a combinatorial library |
AU2003226975A1 (en) * | 2002-02-12 | 2003-09-04 | Biotesys Gmbh | Analysis of a protein expression pattern |
FR2840409B1 (en) * | 2002-05-28 | 2004-08-27 | Dev Des Antigenes Combinatoire | DEVICE FOR PRESENTING PEPTIDES OR PROTEINS, ITS PREPARATION METHOD AND USES THEREOF |
JP2005528102A (en) * | 2002-06-03 | 2005-09-22 | パムジーン ビー.ブイ. | Methods for cell-based high-throughput assays using versatile survival microarrays |
US20040142379A1 (en) * | 2003-01-16 | 2004-07-22 | Carlsberg Research Laboratory | Affinity fishing for ligands and proteins receptors |
US7029855B1 (en) * | 2003-01-28 | 2006-04-18 | Proteomyx Inc. | Radioactive multiplexing analytical methods for biomarkers discovery |
US20040209262A1 (en) * | 2003-04-21 | 2004-10-21 | Bass Jay K. | Biopolymeric arrays comprising test probes for two or more different species and methods for using the same |
EP1689882B1 (en) * | 2003-10-07 | 2014-11-26 | TRAN, Nathaniel Tue | Radioactive multiplexing analytical methods |
AU2007273055B2 (en) | 2006-07-14 | 2014-05-01 | The Regents Of The University Of California | Cancer biomarkers and methods of use thereof |
WO2009075773A2 (en) | 2007-12-07 | 2009-06-18 | Goldstein Steven A | Identification of toxin ligands |
EP3508854A1 (en) | 2010-04-27 | 2019-07-10 | The Regents of The University of California | Cancer biomarkers and methods of use thereof |
US11543411B2 (en) | 2014-12-05 | 2023-01-03 | Prelude Corporation | DCIS recurrence and invasive breast cancer |
EP3591401A1 (en) | 2018-07-06 | 2020-01-08 | Euroimmun Medizinische Labordiagnostika AG | Method for the automated detection of antibodies in a liquid biological sample using an antigen chip |
EP3591406A1 (en) | 2018-07-06 | 2020-01-08 | Euroimmun Medizinische Labordiagnostika AG | Device and method for antibody detection |
AU2019339508A1 (en) | 2018-09-14 | 2021-04-15 | Prelude Corporation | Method of selection for treatment of subjects at risk of invasive breast cancer |
CN112557644B (en) * | 2020-12-21 | 2024-03-22 | 珠海碳云智能科技有限公司 | Screening method for polypeptide for detecting target antibody and application of screened polypeptide |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
WO1997042507A1 (en) * | 1996-05-02 | 1997-11-13 | Isis Innovation Limited | Peptide array and method |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000012575A1 (en) * | 1998-08-28 | 2000-03-09 | Jerini Bio Tools Gmbh | Method for producing polymeric solid phase supporting materials |
FR2789401B1 (en) * | 1999-02-08 | 2003-04-04 | Cis Bio Int | METHOD FOR MANUFACTURING LIGAND DIES ADDRESSED ON A MEDIUM |
-
2000
- 2000-04-14 JP JP2000612755A patent/JP2002542487A/en not_active Withdrawn
- 2000-04-14 EP EP00923395A patent/EP1169649A2/en not_active Withdrawn
- 2000-04-14 CA CA002366123A patent/CA2366123A1/en not_active Abandoned
- 2000-04-14 WO PCT/US2000/010171 patent/WO2000063701A2/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
WO1997042507A1 (en) * | 1996-05-02 | 1997-11-13 | Isis Innovation Limited | Peptide array and method |
Non-Patent Citations (6)
Title |
---|
CHRISTOPHER P. HOLMES ET AL.: "THE USE OF LIGHT-DIRECTED COMBINATORIAL PEPTIDE SYNTHESIS IN EPITOPE MAPPING", BIOPOLYMERS (PEPTIDE SCIENCE), vol. 37, no. 3, 1995, NEW YORK, US, pages 199 - 211, XP000654595, ISSN: 0006-3525 * |
JEFFREY W. JACOBS & STEPHEN P.A. FODOR: "COMBINATORIAL CHEMISTRY - APPLICATIONS OF LIGHT DIRECTED CHEMICAL SYNTHESIS", TIBTECH, vol. 12, no. 1, 1994, CAMBRIDGE, UK, pages 19 - 26, XP000652268 * |
RONALD FRANK: "SPOT-SYNTHESIS: AN EASY TECHNIQUE FOR THE POSITIONALLY ADDRESSABLE, PARALLEL CHEMICAL SYNTHESIS ON A MEMBRANE SUPPORT", TETRAHEDRON, vol. 48, no. 42, 16 October 1992 (1992-10-16), UK, pages 9217 - 9232, XP000353580, ISSN: 0040-4020 * |
S. M. RUBER ET AL.: "LIGHT-DIRECTED COMBINATORIAL PEPTIDE SYNTHESIS", 1992, PROCEEDINGS OF THE 12TH AMERICAN PEPTIDE SYMPOSIUM, 16-21 JUNE 1991, CAMBRIDGE, MA, USA, LEIDEN, NL, XP000371924, 185690 * |
See also references of EP1169649A2 * |
STEPHEN P.A. FODOR ET AL.: "LIGHT-DIRECTED, SPATIALLY ADDRESSABLE PARALLEL CHEMICAL SYNTHESIS", SCIENCE, vol. 251, no. 4995, 15 February 1991 (1991-02-15), US, pages 767 - 773, XP000486899, ISSN: 0036-8075 * |
Also Published As
Publication number | Publication date |
---|---|
JP2002542487A (en) | 2002-12-10 |
WO2000063701A2 (en) | 2000-10-26 |
CA2366123A1 (en) | 2000-10-26 |
WO2000063701A9 (en) | 2002-06-27 |
EP1169649A2 (en) | 2002-01-09 |
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