WO2000062918A3 - Microreactor module - Google Patents

Microreactor module Download PDF

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Publication number
WO2000062918A3
WO2000062918A3 PCT/DE2000/001213 DE0001213W WO0062918A3 WO 2000062918 A3 WO2000062918 A3 WO 2000062918A3 DE 0001213 W DE0001213 W DE 0001213W WO 0062918 A3 WO0062918 A3 WO 0062918A3
Authority
WO
WIPO (PCT)
Prior art keywords
microreactor
module
fluid channels
microreactor module
modules
Prior art date
Application number
PCT/DE2000/001213
Other languages
German (de)
French (fr)
Other versions
WO2000062918A2 (en
Inventor
Wolfgang Ehrfeld
Holger Loewe
Frank Michel
Astrid Lohf
Christian Hofmann
Original Assignee
Inst Mikrotechnik Mainz Gmbh
Wolfgang Ehrfeld
Holger Loewe
Frank Michel
Astrid Lohf
Christian Hofmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Mikrotechnik Mainz Gmbh, Wolfgang Ehrfeld, Holger Loewe, Frank Michel, Astrid Lohf, Christian Hofmann filed Critical Inst Mikrotechnik Mainz Gmbh
Publication of WO2000062918A2 publication Critical patent/WO2000062918A2/en
Publication of WO2000062918A3 publication Critical patent/WO2000062918A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/565—Seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00909—Separation using filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure

Abstract

The invention relates to a microreactor module (100) comprising reactor elements such as fluid channels, reaction chambers, heating devices, mixing devices and such like. To be able to configure a microsystem from a plurality of identical and different types of microreactor modules (100) the microreactor module is provided with connecting elements (120, 122) which when two microreactor modules (100) are joined connect with a form fit in such a way that fluid channels leading from one module to the next are linked such that they are sealed off to the exterior.
PCT/DE2000/001213 1999-04-16 2000-04-14 Microreactor module WO2000062918A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999117330 DE19917330B4 (en) 1999-04-16 1999-04-16 Microreactor module
DE19917330.3 1999-04-16

Publications (2)

Publication Number Publication Date
WO2000062918A2 WO2000062918A2 (en) 2000-10-26
WO2000062918A3 true WO2000062918A3 (en) 2001-02-01

Family

ID=7904860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/001213 WO2000062918A2 (en) 1999-04-16 2000-04-14 Microreactor module

Country Status (2)

Country Link
DE (1) DE19917330B4 (en)
WO (1) WO2000062918A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8381798B2 (en) 2007-03-29 2013-02-26 Fujifilm Corporation Micro fluid device having piping to control fluid temperature

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DE10036633B4 (en) * 2000-07-27 2005-03-10 Hte Ag The High Throughput Exp Arrangement in a modular design and method for the parallel testing of a plurality of components of a material library
DE10155010A1 (en) 2001-11-06 2003-05-15 Cpc Cellular Process Chemistry Microreactor system
DE10216714A1 (en) * 2002-04-10 2004-01-15 INSTITUT FüR ANGEWANDTE CHEMIE BERLIN-ADLERSHOF E.V. Modular connection point for facilities of microreaction technology
US7244961B2 (en) 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
JP2004069498A (en) * 2002-08-06 2004-03-04 Canon Inc Liquid conveying device and method
ITMI20021939A1 (en) * 2002-09-12 2004-03-13 Nuvera Fuel Cells Europ Srl MEMBRANE ELECTROCHEMICAL GENERATOR WITH IMPROVED ASSEMBLY AND MAINTENANCE
JP4804718B2 (en) 2003-04-28 2011-11-02 富士フイルム株式会社 Fluid mixing device and fluid mixing system
JP2006526492A (en) * 2003-05-09 2006-11-24 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング Micro processing control components
DE10322486A1 (en) * 2003-05-17 2004-12-02 Degussa Ag Device for carrying out chemical synthesis processes with independent modularization with regard to the quantitative capacity and the number of possible process steps
DE10335068A1 (en) * 2003-07-31 2005-03-03 Dahlbeck, Rolf, Dr.-Ing. Micro-reactor module, for forming micro-reactor system, comprises projections with sealing surfaces connected by tensioning device
DE10352128A1 (en) * 2003-11-04 2005-06-09 Dylla, Anett, Dipl.-Ing. Multifunctional power grid and devices for this
DE602005020249D1 (en) * 2004-02-02 2010-05-12 Silicon Valley Scient Inc INTEGRATED SYSTEM WITH MODULAR MICROFLUIDIC COMPONENTS
US7795359B2 (en) 2005-03-04 2010-09-14 Novartis Ag Continuous process for production of polymeric materials
DE102005015433A1 (en) 2005-04-05 2006-10-12 Forschungszentrum Karlsruhe Gmbh Mixer system, reactor and reactor system
CA2705355C (en) * 2007-11-13 2013-02-26 F. Hoffmann-La Roche Ag Modular sensor cassette
DE102008047902A1 (en) 2008-09-19 2010-03-25 Albert-Ludwigs-Universität Freiburg Kit for constructing reactor, comprises stackable elements, which are designed, so that they liquid-tightly release against each other finally to the reactor with integrated channels, reactor chamber with adaptable volumes and access links
GB2475835A (en) * 2009-11-27 2011-06-08 Magna Parva Ltd Sample Processing System
US10124333B2 (en) * 2014-06-10 2018-11-13 Reolab Inc. Discrete elements for 3D microfluidics
ES2822089T3 (en) 2016-10-07 2021-04-29 Boehringer Ingelheim Vetmedica Gmbh Analysis device and method for examining a sample
CN107626271B (en) * 2017-11-07 2023-06-16 菲立化学工程(遂昌)有限公司 Microchannel reactor
KR102375602B1 (en) 2018-07-28 2022-03-18 한국과학기술원 Modular micro-fluidic chip and micro-fluidic flow system having thereof
EP3778026A4 (en) * 2018-07-28 2022-01-19 Korea Advanced Institute Of Science And Technology Modular fluid chip and fluid flow system comprising same
EP3861355A1 (en) * 2018-10-01 2021-08-11 Boehringer Ingelheim Vetmedica GmbH Analyzer for testing a sample
JP2023504815A (en) * 2019-12-03 2023-02-07 ザ ユニバーシティー オブ アデレード Cell culture microdevice
DE102022102894A1 (en) 2022-02-08 2023-08-10 Institut für Energie- und Umwelttechnik e.V. (IUTA) Microfluidic system and method of making such

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8381798B2 (en) 2007-03-29 2013-02-26 Fujifilm Corporation Micro fluid device having piping to control fluid temperature

Also Published As

Publication number Publication date
WO2000062918A2 (en) 2000-10-26
DE19917330B4 (en) 2004-08-26
DE19917330A1 (en) 2000-10-19

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