WO2000059471A1 - Propofol formulation with enhanced microbial characteristics - Google Patents
Propofol formulation with enhanced microbial characteristics Download PDFInfo
- Publication number
- WO2000059471A1 WO2000059471A1 PCT/US2000/008378 US0008378W WO0059471A1 WO 2000059471 A1 WO2000059471 A1 WO 2000059471A1 US 0008378 W US0008378 W US 0008378W WO 0059471 A1 WO0059471 A1 WO 0059471A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- emulsion
- water
- propofol
- oil
- soybean oil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0009541-9A BR0009541A (en) | 1999-04-05 | 2000-03-29 | Emulsion, pharmaceutical composition, and method for preparing an oil-in-water emulsion pharmaceutical composition |
EP00919842A EP1165045A1 (en) | 1999-04-05 | 2000-03-29 | Propofol formulation with enhanced microbial characteristics |
MXPA01010064A MXPA01010064A (en) | 1999-04-05 | 2000-03-29 | Propofol formulation with enhanced microbial characteristics. |
CA002366793A CA2366793C (en) | 1999-04-05 | 2000-03-29 | Propofol formulation with enhanced microbial characteristics |
KR1020017012652A KR100741604B1 (en) | 1999-04-05 | 2000-03-29 | Propofol Formulation With Enhanced Microbial Characteristics |
JP2000609035A JP2002541086A (en) | 1999-04-05 | 2000-03-29 | Propofol formulations with enhanced microbial characteristics |
AU40463/00A AU774259B2 (en) | 1999-04-05 | 2000-03-29 | Propofol formulation with enhanced microbial characteristics |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/286,159 US6100302A (en) | 1999-04-05 | 1999-04-05 | Propofol formulation with enhanced microbial characteristics |
US09/286,159 | 1999-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000059471A1 true WO2000059471A1 (en) | 2000-10-12 |
Family
ID=23097354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/008378 WO2000059471A1 (en) | 1999-04-05 | 2000-03-29 | Propofol formulation with enhanced microbial characteristics |
Country Status (9)
Country | Link |
---|---|
US (1) | US6100302A (en) |
EP (1) | EP1165045A1 (en) |
JP (1) | JP2002541086A (en) |
KR (2) | KR100861820B1 (en) |
AU (1) | AU774259B2 (en) |
BR (1) | BR0009541A (en) |
CA (1) | CA2366793C (en) |
MX (1) | MXPA01010064A (en) |
WO (1) | WO2000059471A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1292282A2 (en) * | 2000-06-16 | 2003-03-19 | RTP Pharma Inc. | Improved injectable dispersions of propofol |
WO2003105817A1 (en) * | 2002-05-02 | 2003-12-24 | Fdl, Inc. | Novel parenteral composition comprising propofol |
KR100459025B1 (en) * | 2002-05-02 | 2004-12-03 | (주) 에프디엘 | Novel composition comprising propofol for the use of injection |
US8759404B2 (en) | 2005-08-05 | 2014-06-24 | Bharat Serums & Vaccines Ltd. | Intravenous propofol emulsion compositions having preservative efficacy |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6749868B1 (en) | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US6399087B1 (en) * | 2000-12-20 | 2002-06-04 | Amphastar Pharmaceuticals, Inc. | Propofol formulation with enhanced microbial inhibition |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
CA2461349C (en) | 2001-09-26 | 2011-11-29 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
AU2002334675A1 (en) | 2001-09-26 | 2003-04-07 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
CA2479665C (en) * | 2002-03-20 | 2011-08-30 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
EP1539122B1 (en) * | 2002-07-29 | 2014-01-29 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
US7550155B2 (en) * | 2002-07-29 | 2009-06-23 | Transform Pharmaceuticals Inc. | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses |
CA2503956A1 (en) * | 2002-10-29 | 2004-05-13 | Transform Pharmaceuticals, Inc. | Propofol with cysteine |
DK1585548T3 (en) | 2002-12-09 | 2018-09-03 | Abraxis Bioscience Llc | COMPOSITIONS AND PROCEDURES FOR THE DELIVERY OF PHARMACOLOGICAL AGENTS |
US20040225022A1 (en) * | 2003-05-09 | 2004-11-11 | Desai Neil P. | Propofol formulation containing reduced oil and surfactants |
US8476010B2 (en) | 2003-07-10 | 2013-07-02 | App Pharmaceuticals Llc | Propofol formulations with non-reactive container closures |
US8546453B2 (en) * | 2003-08-14 | 2013-10-01 | Rensheng Zhang | Propofol compositions and methods for reducing pain associated with propofol injection |
BRPI0515181A (en) * | 2004-09-13 | 2008-07-22 | Bharat Serums & Vaccines Ltd | sterile oil-in-water composition for intravenous administration, use of a monoglyceride and process for preparing a composition for intravenous administration |
JP2009504634A (en) * | 2005-08-12 | 2009-02-05 | ブハラット セルムズ アンド ヴァクシンズ リミテッド | Aqueous anesthetic composition comprising propofol |
US8034765B2 (en) * | 2005-08-31 | 2011-10-11 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
KR101420445B1 (en) | 2005-08-31 | 2014-07-16 | 아브락시스 바이오사이언스, 엘엘씨 | Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
JP2013001700A (en) * | 2011-06-21 | 2013-01-07 | Fujifilm Corp | Propofol-containing oil-in-water type emulsion composition |
JP5759804B2 (en) * | 2011-06-27 | 2015-08-05 | 富士フイルム株式会社 | Container preparation |
IN2014DN10322A (en) | 2012-05-16 | 2015-08-07 | Mewa Singh | |
CN104490780B (en) * | 2015-01-16 | 2017-04-19 | 河北一品制药有限公司 | Preparation method of propofol fat emulsion injection |
US11622937B2 (en) | 2015-08-20 | 2023-04-11 | Mewa Singh | Polyphenolic polymer to make water-insoluble molecules become water-soluble |
CN110478366A (en) * | 2019-08-23 | 2019-11-22 | 宜昌人福药业有限责任公司 | Topical compositions and its preparation method and application containing water-insoluble antalgesic |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000010531A1 (en) * | 1998-08-19 | 2000-03-02 | Rtp Pharma Inc. | Injectable aqueous dispersions of propofol |
WO2000024376A1 (en) * | 1998-10-23 | 2000-05-04 | Abbott Laboratories | Propofol composition |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
BR9506681A (en) * | 1994-02-04 | 1997-11-18 | Scotia Lipidteknik Ab | Oil-in-water emulsion and pharmaceutical composition |
GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
US5637625A (en) * | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
-
1999
- 1999-04-05 US US09/286,159 patent/US6100302A/en not_active Expired - Fee Related
-
2000
- 2000-03-29 JP JP2000609035A patent/JP2002541086A/en active Pending
- 2000-03-29 AU AU40463/00A patent/AU774259B2/en not_active Ceased
- 2000-03-29 CA CA002366793A patent/CA2366793C/en not_active Expired - Fee Related
- 2000-03-29 MX MXPA01010064A patent/MXPA01010064A/en active IP Right Grant
- 2000-03-29 BR BR0009541-9A patent/BR0009541A/en not_active Application Discontinuation
- 2000-03-29 KR KR1020077010526A patent/KR100861820B1/en not_active IP Right Cessation
- 2000-03-29 EP EP00919842A patent/EP1165045A1/en not_active Withdrawn
- 2000-03-29 KR KR1020017012652A patent/KR100741604B1/en not_active IP Right Cessation
- 2000-03-29 WO PCT/US2000/008378 patent/WO2000059471A1/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000010531A1 (en) * | 1998-08-19 | 2000-03-02 | Rtp Pharma Inc. | Injectable aqueous dispersions of propofol |
WO2000024376A1 (en) * | 1998-10-23 | 2000-05-04 | Abbott Laboratories | Propofol composition |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1292282A2 (en) * | 2000-06-16 | 2003-03-19 | RTP Pharma Inc. | Improved injectable dispersions of propofol |
EP2036540A3 (en) * | 2000-06-16 | 2009-12-16 | Jagotec AG | Improved injectable dispersions of propofol |
WO2003105817A1 (en) * | 2002-05-02 | 2003-12-24 | Fdl, Inc. | Novel parenteral composition comprising propofol |
KR100459025B1 (en) * | 2002-05-02 | 2004-12-03 | (주) 에프디엘 | Novel composition comprising propofol for the use of injection |
US8759404B2 (en) | 2005-08-05 | 2014-06-24 | Bharat Serums & Vaccines Ltd. | Intravenous propofol emulsion compositions having preservative efficacy |
Also Published As
Publication number | Publication date |
---|---|
MXPA01010064A (en) | 2002-06-21 |
KR20010112400A (en) | 2001-12-20 |
AU774259B2 (en) | 2004-06-24 |
KR100861820B1 (en) | 2008-10-07 |
KR20070058012A (en) | 2007-06-07 |
EP1165045A1 (en) | 2002-01-02 |
AU4046300A (en) | 2000-10-23 |
CA2366793A1 (en) | 2000-10-12 |
US6100302A (en) | 2000-08-08 |
KR100741604B1 (en) | 2007-07-20 |
CA2366793C (en) | 2009-06-02 |
BR0009541A (en) | 2002-01-02 |
JP2002541086A (en) | 2002-12-03 |
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