WO2000058735A3 - High throughput screening apparatus and methods for arraying microparticles - Google Patents

High throughput screening apparatus and methods for arraying microparticles Download PDF

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Publication number
WO2000058735A3
WO2000058735A3 PCT/US2000/008314 US0008314W WO0058735A3 WO 2000058735 A3 WO2000058735 A3 WO 2000058735A3 US 0008314 W US0008314 W US 0008314W WO 0058735 A3 WO0058735 A3 WO 0058735A3
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
arraying
fluid
high throughput
throughput screening
Prior art date
Application number
PCT/US2000/008314
Other languages
French (fr)
Other versions
WO2000058735A2 (en
Inventor
Amit Kumar
Original Assignee
Optigon Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Optigon Technologies filed Critical Optigon Technologies
Priority to AU41805/00A priority Critical patent/AU4180500A/en
Publication of WO2000058735A2 publication Critical patent/WO2000058735A2/en
Publication of WO2000058735A3 publication Critical patent/WO2000058735A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus

Abstract

A device that directs the rapid arraying of a determinate number of microparticles, such as polymeric beads, from bulk suspension, and that is particularly suited for high throughput screening of combinatorial libraries synthesized on polymer microbeads, is presented. The device further dispenses, in highly parallel fashion, predefined small volumes of a fluid. In a preferred embodiment, the device has disposed upon its surface a rectangular array of microparticle retention elements, each comprising a fluid retention surface and a blind depression. Microparticles are arrayed and a fluid is dispensed by sequential wetting and dewetting of the active surface. Corresponding methods are presented.
PCT/US2000/008314 1999-03-31 2000-03-29 High throughput screening apparatus and methods for arraying microparticles WO2000058735A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41805/00A AU4180500A (en) 1999-03-31 2000-03-29 High throughput screening apparatus and methods for arraying microparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28383099A 1999-03-31 1999-03-31
US09/283,830 1999-03-31

Publications (2)

Publication Number Publication Date
WO2000058735A2 WO2000058735A2 (en) 2000-10-05
WO2000058735A3 true WO2000058735A3 (en) 2001-05-31

Family

ID=23087748

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/008314 WO2000058735A2 (en) 1999-03-31 2000-03-29 High throughput screening apparatus and methods for arraying microparticles

Country Status (2)

Country Link
AU (1) AU4180500A (en)
WO (1) WO2000058735A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1019446C2 (en) * 2001-11-28 2003-06-02 Ibis Technologies B V Support for use in assay of a particle in a sample, comprises a surface suitable for receiving a microbead and inspection by an optical technique, where the microbead is suitable for binding a specific type of particle
NL1019875C2 (en) * 2001-11-28 2003-06-02 Ibis Technologies B V Support for use in determining particles in a sample and method for manufacturing such a support, and method for determining particles in a sample.
US7651665B2 (en) 2004-09-07 2010-01-26 Hewlett-Packard Development Company, L.P. Microtray for handling biosubstances
JP4987885B2 (en) 2006-03-09 2012-07-25 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Apparatus for carrying out a reaction in a droplet and method of use thereof
US9874501B2 (en) 2006-11-24 2018-01-23 Curiox Biosystems Pte Ltd. Use of chemically patterned substrate for liquid handling, chemical and biological reactions
WO2008063135A1 (en) 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
US10725020B2 (en) 2007-11-14 2020-07-28 Curiox Biosystems Pte Ltd. High throughput miniaturized assay system and methods
WO2013114217A1 (en) 2012-02-05 2013-08-08 Curiox Biosystems Pte Ltd. Array plates and methods for making and using same
US8784752B2 (en) 2009-04-17 2014-07-22 Curiox Biosystems Pte Ltd Use of chemically patterned substrate for liquid handling, chemical and biological reactions
WO2012011877A2 (en) 2010-07-23 2012-01-26 Curiox Biosystems Pte Ltd Apparatus and method for multiple reactions in small volumes
BR112013010261A2 (en) 2010-10-29 2016-09-13 Buckman Lab Int Inc method for preparing paper or cardboard, papermaking system, paper product and paper product
US9557318B2 (en) 2013-07-09 2017-01-31 Curiox Biosystems Pte Ltd. Array plates for washing samples
US10545139B2 (en) 2015-06-16 2020-01-28 Curiox Biosystems Pte Ltd. Methods and devices for performing biological assays using magnetic components
KR102446247B1 (en) 2017-04-05 2022-09-21 큐리옥스 바이오시스템즈 피티이 엘티디. Methods, devices and apparatus for cleaning samples on array plates
US20220258164A1 (en) * 2021-02-18 2022-08-18 Battelle Memorial Institute Nanowell array device for high throughput sample analysis

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729949A (en) * 1982-05-10 1988-03-08 Bar-Ilan University System and methods for cell selection
US4952518A (en) * 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
EP0539888A1 (en) * 1991-10-30 1993-05-05 Shimadzu Corporation Selecting device for cells and the like
US5334837A (en) * 1991-10-05 1994-08-02 Horiba, Ltd. Micro analytical method, sampling plate used in same, method of detecting organic compound by use of said micro analytical method, apparatus for same and method of dividing for micro-liquid flow
WO1997040383A1 (en) * 1996-04-24 1997-10-30 Glaxo Group Limited Systems and methods for arraying beads
WO1998015355A2 (en) * 1996-10-10 1998-04-16 Corning Incorporated Tool and method for transfer of drops
US5788814A (en) * 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729949A (en) * 1982-05-10 1988-03-08 Bar-Ilan University System and methods for cell selection
US4952518A (en) * 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
US5334837A (en) * 1991-10-05 1994-08-02 Horiba, Ltd. Micro analytical method, sampling plate used in same, method of detecting organic compound by use of said micro analytical method, apparatus for same and method of dividing for micro-liquid flow
EP0539888A1 (en) * 1991-10-30 1993-05-05 Shimadzu Corporation Selecting device for cells and the like
US5788814A (en) * 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
WO1997040383A1 (en) * 1996-04-24 1997-10-30 Glaxo Group Limited Systems and methods for arraying beads
WO1998015355A2 (en) * 1996-10-10 1998-04-16 Corning Incorporated Tool and method for transfer of drops

Also Published As

Publication number Publication date
WO2000058735A2 (en) 2000-10-05
AU4180500A (en) 2000-10-16

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