WO2000058729A3 - Micromechanical antibody sensor - Google Patents

Micromechanical antibody sensor Download PDF

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Publication number
WO2000058729A3
WO2000058729A3 PCT/US2000/008256 US0008256W WO0058729A3 WO 2000058729 A3 WO2000058729 A3 WO 2000058729A3 US 0008256 W US0008256 W US 0008256W WO 0058729 A3 WO0058729 A3 WO 0058729A3
Authority
WO
WIPO (PCT)
Prior art keywords
approximately
micromechanical
deflections
coating
spring element
Prior art date
Application number
PCT/US2000/008256
Other languages
French (fr)
Other versions
WO2000058729B1 (en
WO2000058729A2 (en
Inventor
Thomas G Thundat
K Bruce Jacobson
Mitchel J Doktycz
Stephen J Kennel
Robert J Warmack
Original Assignee
Lockheed Martin Energy Res Cor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lockheed Martin Energy Res Cor filed Critical Lockheed Martin Energy Res Cor
Priority to EP00918480A priority Critical patent/EP1185865B1/en
Priority to AU39281/00A priority patent/AU3928100A/en
Priority to DE60033653T priority patent/DE60033653T2/en
Publication of WO2000058729A2 publication Critical patent/WO2000058729A2/en
Publication of WO2000058729A3 publication Critical patent/WO2000058729A3/en
Publication of WO2000058729B1 publication Critical patent/WO2000058729B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

A sensor apparatus is provided using a microcantilevered spring element having a coating of a detector molecule such as an antibody or antigen. A sample containing a target molecule or substrate is provided to the coating. The spring element bends in response to the stress induced by the binding which occurs between the detector and target molecules. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 νm long, approximately 1 to 50 νm wide, and approximately 0.3 to 3.0 νm thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers.
PCT/US2000/008256 1999-03-30 2000-03-29 Micromechanical antibody sensor WO2000058729A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00918480A EP1185865B1 (en) 1999-03-30 2000-03-29 Detection method using a micromechanical antibody sensor
AU39281/00A AU3928100A (en) 1999-03-30 2000-03-29 Micromechanical antibody sensor
DE60033653T DE60033653T2 (en) 1999-03-30 2000-03-29 DETECTION METHOD USING A MICROMECHANICAL ANTIBODY SENSOR

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/281,032 US6289717B1 (en) 1999-03-30 1999-03-30 Micromechanical antibody sensor
US09/281,032 1999-03-30

Publications (3)

Publication Number Publication Date
WO2000058729A2 WO2000058729A2 (en) 2000-10-05
WO2000058729A3 true WO2000058729A3 (en) 2001-05-17
WO2000058729B1 WO2000058729B1 (en) 2001-10-18

Family

ID=23075680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/008256 WO2000058729A2 (en) 1999-03-30 2000-03-29 Micromechanical antibody sensor

Country Status (6)

Country Link
US (1) US6289717B1 (en)
EP (1) EP1185865B1 (en)
AT (1) ATE355523T1 (en)
AU (1) AU3928100A (en)
DE (1) DE60033653T2 (en)
WO (1) WO2000058729A2 (en)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9819319D0 (en) * 1998-09-05 1998-10-28 Aea Technology Plc Assay of chemical binding
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
JP2003507723A (en) * 1999-08-19 2003-02-25 ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア Apparatus and method for visually recognizing minute force by pallet of cantilever array block
KR100517243B1 (en) * 1999-11-03 2005-09-28 인터내셔널 비지네스 머신즈 코포레이션 Cantilever sensors and transducers
US6523392B2 (en) * 2000-01-25 2003-02-25 Arizona Board Of Regents Microcantilever sensor
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
JP2005504260A (en) * 2000-08-09 2005-02-10 カリフォルニア インスティテュート オブ テクノロジー Active NEMS array for biochemical analysis
US7375321B2 (en) 2000-08-09 2008-05-20 California Institute Of Technology Dynamics bionems sensors and arrays of bionems sensor immersed in fluids
ATE402760T1 (en) * 2000-08-15 2008-08-15 Bioforce Nanosciences Inc DEVICE FOR FORMING NANOMOLECULAR NETWORKS
JP3357914B2 (en) * 2000-08-30 2002-12-16 独立行政法人産業技術総合研究所 Method for detecting low molecular compounds in solution
EP1322951A2 (en) * 2000-09-20 2003-07-02 Molecular Reflections Microfabricated ultrasound array for use as resonant sensors
EP1202046A1 (en) * 2000-10-25 2002-05-02 Abb Research Ltd. Method and apparatus for determining biological species
WO2003008941A2 (en) * 2001-07-17 2003-01-30 Bioforce Nanosciences, Inc. Combined molecular blinding detection through force microscopy and mass spectrometry
US20030062193A1 (en) * 2001-09-07 2003-04-03 Jacob Thaysen Flexible structure with integrated sensor/actuator
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
AU2002350427A1 (en) * 2001-11-19 2003-06-10 Cantion A/S Sensor system with a reference surface mimicking the detection surface but with low ligand binding capacity
US6671631B2 (en) 2002-01-04 2003-12-30 General Electric Company Systems and methods for analyzing viscoelastic properties of combinatorial libraries of materials
EP1467948A1 (en) * 2002-01-24 2004-10-20 Cantion A/S A sensor
AU2003206679A1 (en) * 2002-02-08 2003-09-02 Cantion A/S Scion.Dtu A sensor comprising mechanical amplification of surface stress sensitive cantilever
DE10209245B4 (en) * 2002-03-04 2005-12-22 Concentris Gmbh Device and method for the detection of microorganisms
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
US7395693B2 (en) * 2004-12-02 2008-07-08 The Arizona Board of Regents, a body corporate of the state of Arizona acting for Northern Arizona University Embedded piezoelectric microcantilever sensors
US6823717B2 (en) * 2002-06-03 2004-11-30 Timothy L. Porter Hybrid microcantilever sensors
WO2003104784A1 (en) * 2002-06-07 2003-12-18 Cantion A/S A cantilever sensor with a current shield and a method for its production
US8524488B2 (en) * 2002-09-10 2013-09-03 The Regents Of The University Of California Methods and devices for determining a cell characteristic, and applications employing the same
DE60309903T2 (en) 2002-09-24 2007-10-18 Intel Corporation, Santa Clara DETECTION OF MOLECULAR BINDING BY MONITORING OF FEEDBACK CHECK CONTROLLED STEERING DEFLECTIONS
US7270952B2 (en) 2002-09-24 2007-09-18 Intel Corporation Detecting molecular binding by monitoring feedback controlled cantilever deflections
WO2004038762A2 (en) * 2002-10-21 2004-05-06 Alegis Microsystems Nanomotion sensing system and method
US7344678B2 (en) * 2002-11-15 2008-03-18 The Regents Of The University Of California Composite sensor membrane
WO2004046689A2 (en) * 2002-11-15 2004-06-03 The Regents Of The University Of California System and method for multiplexed biomolecular analysis
CA2512181A1 (en) * 2003-01-02 2004-07-22 Bioforce Nanosciences, Inc. Method and apparatus for molecular analysis in small sample volumes
EP1588168B1 (en) * 2003-01-26 2009-07-08 Eberhard-Karls-Universität Tübingen Universitätsklinikum Method for separating and detecting at least one analyte in biological matrices
US7521257B2 (en) * 2003-02-11 2009-04-21 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno Chemical sensor with oscillating cantilevered probe and mechanical stop
US7260980B2 (en) 2003-03-11 2007-08-28 Adams Jesse D Liquid cell and passivated probe for atomic force microscopy and chemical sensing
EP1644473B1 (en) * 2003-06-03 2014-01-15 Cantimer Incorporated Phase change sensor
US6763705B1 (en) 2003-06-16 2004-07-20 Ut-Battelle, Llc High throughput microcantilever detector
WO2005031300A2 (en) * 2003-06-27 2005-04-07 Purdue Research Foundation Device for detecting biological and chemical particles
BRPI0413294B1 (en) 2003-08-06 2019-01-02 Bridger Tech Inc device, method and system
TWI256473B (en) * 2003-08-27 2006-06-11 Ind Tech Res Inst Biosensor and method for bone mineral density measurement
DE10342331A1 (en) * 2003-09-11 2005-05-04 Surface Imaging Systems S I S Method for measuring bending of beam in gas detector comprises directing light from optical fiber on to it and measuring signal produced by interference by reflected light, beam having coating which reacts with component in gas
US20060257286A1 (en) * 2003-10-17 2006-11-16 Adams Jesse D Self-sensing array of microcantilevers for chemical detection
WO2005043126A2 (en) * 2003-10-27 2005-05-12 Drexel University Piezoelectric cantilever sensors
US6978656B2 (en) * 2003-10-31 2005-12-27 Hewlett-Packard Development Company, L.P. Transducer-based sensor system and method
KR100580631B1 (en) * 2003-11-22 2006-05-16 삼성전자주식회사 A substrate having an oxide layer, method for detecting a target substance using the same and optical sensor containing the same
US20090246889A1 (en) * 2003-11-22 2009-10-01 Samsung Electronics Co., Ltd. Substrate having oxide layer, method for detecting target material using the substrate, and optical sensor including the substrate
WO2005052557A1 (en) * 2003-11-28 2005-06-09 Lumiscence A/S An examination system for examination of a specimen; sub-units and units therefore, a sensor and a microscope
US7531002B2 (en) * 2004-04-16 2009-05-12 Depuy Spine, Inc. Intervertebral disc with monitoring and adjusting capabilities
US20050255448A1 (en) * 2004-05-13 2005-11-17 Arun Majumdar System for amplifying optical detection of cantilever deflection
US7497133B2 (en) 2004-05-24 2009-03-03 Drexel University All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement
US20050262943A1 (en) * 2004-05-27 2005-12-01 Glenn Claydon Apparatus, methods, and systems to detect an analyte based on changes in a resonant frequency of a spring element
US7217428B2 (en) * 2004-05-28 2007-05-15 Technology Innovations Llc Drug delivery apparatus utilizing cantilever
JP2006039260A (en) * 2004-07-28 2006-02-09 Sii Nanotechnology Inc Method for removing particle of photomask by using atomic force microscope
US7673517B2 (en) 2005-11-10 2010-03-09 The United States Of America As Represented By The Secretary Of The Navy System and method for optical interrogation of micro-mechanical sensors using microcavity interferometry
KR100583233B1 (en) * 2004-09-16 2006-05-26 한국과학기술연구원 Method and system for detecting bio-element
US20060059984A1 (en) * 2004-09-23 2006-03-23 Doktycz Mitchel J Coupled spring system for measuring molecular forces
DE102004046685B3 (en) * 2004-09-24 2006-06-29 Concentris Gmbh Measuring cell and method for liquid analysis
GB2437753B8 (en) 2004-10-01 2009-05-20 Nevada System Of Higher Education Cantilevered probe detector with piezoelectric element
JP2006153831A (en) * 2004-10-27 2006-06-15 Mitsubishi Chemicals Corp Cantilever sensor, sensor system, and method for detecting substance to be detected in specimen liquid
DE102004053261A1 (en) * 2004-11-04 2006-05-11 Robert Bosch Gmbh Micromechanical sensor for chemical analysis
EP1825560A4 (en) * 2004-11-20 2010-09-15 Kenneth E Salsman Device for emission of high frequency signals
US7280078B2 (en) * 2004-11-20 2007-10-09 Scenterra, Inc. Sensor for detecting high frequency signals
ATE384950T1 (en) * 2004-12-22 2008-02-15 Fiat Ricerche MINIATURIZED SENSOR FOR DETECTING PROPERTIES OF A LIQUID, ESPECIALLY A LUBRICANT OIL
EP2818187A3 (en) 2005-02-18 2015-04-15 Zimmer, Inc. Smart joint implant sensors
JP4514639B2 (en) * 2005-03-31 2010-07-28 国立大学法人群馬大学 Cantilever type sensor
EP1913393A4 (en) * 2005-06-16 2010-03-03 Univ California Large scale parallel immuno-based allergy test and device for evanescent field excitation of fluorescence
US7313945B2 (en) * 2005-10-31 2008-01-01 Hewlett-Packard Development Company, L.P. Cantilevers for sensing fluid properties
US7429125B2 (en) * 2005-11-09 2008-09-30 Hewlett-Packard Development Company, L.P. System and method for cantilever based calorimetric analysis
US20070127164A1 (en) * 2005-11-21 2007-06-07 Physical Logic Ag Nanoscale Sensor
US8171795B1 (en) * 2006-01-23 2012-05-08 Drexel University Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air
CN101371132B (en) * 2006-01-23 2013-05-01 德雷塞尔大学 Self-exciting, self-sensing piezoelectric cantilever sensor
US7691130B2 (en) * 2006-01-27 2010-04-06 Warsaw Orthopedic, Inc. Spinal implants including a sensor and methods of use
US20080011058A1 (en) * 2006-03-20 2008-01-17 The Regents Of The University Of California Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels
US7709264B2 (en) * 2006-09-21 2010-05-04 Philip Morris Usa Inc. Handheld microcantilever-based sensor for detecting tobacco-specific nitrosamines
US8481335B2 (en) * 2006-11-27 2013-07-09 Drexel University Specificity and sensitivity enhancement in cantilever sensing
US7992431B2 (en) * 2006-11-28 2011-08-09 Drexel University Piezoelectric microcantilevers and uses in atomic force microscopy
WO2008067386A2 (en) 2006-11-28 2008-06-05 Drexel University Piezoelectric microcantilever sensors for biosensing
US20080160638A1 (en) * 2006-12-27 2008-07-03 David Lederman Functionalized Microcantilever Sensor and Associated Method For Detection of Targeted Analytes
WO2008086246A1 (en) * 2007-01-05 2008-07-17 Innovative American Technology, Inc. Advanced calorimetric spectroscopy for commercial applications
AU2008223285A1 (en) * 2007-02-01 2008-09-12 Drexel University A hand-held phase-shift detector for sensor applications
US8168120B1 (en) 2007-03-06 2012-05-01 The Research Foundation Of State University Of New York Reliable switch that is triggered by the detection of a specific gas or substance
US8191403B2 (en) * 2007-03-27 2012-06-05 Richmond Chemical Corporation Petroleum viscosity measurement and communication system and method
US8241569B2 (en) 2007-11-23 2012-08-14 Drexel University Lead-free piezoelectric ceramic films and a method for making thereof
US8551407B2 (en) * 2007-11-29 2013-10-08 Michigan Technological University Bacteriorhodopsin-based sensors
US8741663B2 (en) 2008-03-11 2014-06-03 Drexel University Enhanced detection sensitivity with piezoelectric sensors
EP2281192A4 (en) * 2008-05-16 2014-02-05 Univ Drexel System and method for evaluating tissue
US8459123B2 (en) * 2008-06-19 2013-06-11 The United States Of America, As Represented By The Secretary Of The Navy Micromechanical chemical sensors with multiple chemoselective resonant elements and frequency division multiplexed readout
WO2010055959A1 (en) * 2008-11-11 2010-05-20 Korea Institute Of Science And Technology System for detecting biomolecule wi th high sensitivity using micro-cant i lever
DE202010017793U1 (en) * 2009-03-20 2012-08-31 Attana Ab Analytical method and sensor
US20110086368A1 (en) * 2009-10-08 2011-04-14 Drexel University Method for immune response detection
US8722427B2 (en) * 2009-10-08 2014-05-13 Drexel University Determination of dissociation constants using piezoelectric microcantilevers
US20120220486A1 (en) * 2009-11-01 2012-08-30 Caerus Molecular Diagnostics Incorporated Methods and apparatus for binding assays
KR101118474B1 (en) * 2009-12-15 2012-03-13 한국전기연구원 Apparatus for detecting bio contents using optical coherence
WO2011162847A2 (en) 2010-03-31 2011-12-29 Cornell University Stress-based sensor, method and applications
US9222867B2 (en) 2011-01-05 2015-12-29 Brian L. Norling Resonant micromachined biochemical sensor
TR201901893T4 (en) 2011-10-14 2019-03-21 Ecole Polytechnique Fed Lausanne Epfl Nano scale motion detector.
US8740209B2 (en) * 2012-02-22 2014-06-03 Expresslo Llc Method and apparatus for ex-situ lift-out specimen preparation
US9370321B2 (en) 2012-06-25 2016-06-21 Empire Technology Development Llc Ultrasound based antigen binding detection
KR101583470B1 (en) 2014-03-05 2016-01-12 한국과학기술연구원 A cantilever sensor with slit and biosensor having the same
EP2955507A1 (en) 2014-06-12 2015-12-16 Danmarks Tekniske Universitet A substrate, an apparatus and a method of determining the presence of a molecule
CN105486243B (en) * 2015-12-24 2018-05-11 成都上甲光电科技有限公司 Bridge flexiblity monitor system based on visual light imaging technology
US10191036B1 (en) 2018-03-22 2019-01-29 NUB4U, Inc. System for detecting and removing biological analytes in fluids
DE102020107918B4 (en) * 2020-03-23 2021-11-18 Digital Diagnostics AG DETECTION OF VIRUSES
CN114371124B (en) * 2022-01-14 2024-01-12 安徽理工大学 Drop adhesive force detecting system based on micro-cantilever beam

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016699A1 (en) * 1995-10-30 1997-05-09 Trustees Of Boston University Piezoelectric force sensing apparatus and methods for biopolymer sequencing
US5807758A (en) * 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
WO1998050773A2 (en) * 1997-05-08 1998-11-12 University Of Minnesota Microcantilever biosensor
US6016686A (en) * 1998-03-16 2000-01-25 Lockheed Martin Energy Research Corporation Micromechanical potentiometric sensors

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242096A (en) 1977-11-14 1980-12-30 Minnesota Mining And Manufacturing Company Immunoassay for antigens
US4236893A (en) 1979-04-09 1980-12-02 Minnesota Mining And Manufacturing Company Method for the assay of classes of antigen-specific antibodies
US4637987A (en) 1984-05-07 1987-01-20 Gould Inc. Gas monitoring device and method
US4596697A (en) 1984-09-04 1986-06-24 The United States Of America As Represented By The Secretary Of The Army Chemical sensor matrix
US4735906A (en) 1984-11-28 1988-04-05 Texas A&M University Sensor having piezoelectric crystal for microgravimetric immunoassays
US5595908A (en) 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
JPH063448B2 (en) 1987-03-31 1994-01-12 日本光電工業株式会社 Method and apparatus for detecting antigen-antibody reaction
US4847193A (en) 1987-06-18 1989-07-11 Gene-Trak Systems Signal amplification in an assay employing a piezoelectric oscillator
US4906840A (en) 1988-01-27 1990-03-06 The Board Of Trustees Of Leland Stanford Jr., University Integrated scanning tunneling microscope
US5501986A (en) 1988-04-06 1996-03-26 E. I. Du Pont De Nemours And Company Piezoelectric specific binding assay with mass amplified reagents
US4999284A (en) 1988-04-06 1991-03-12 E. I. Du Pont De Nemours And Company Enzymatically amplified piezoelectric specific binding assay
US4905701A (en) 1988-06-15 1990-03-06 National Research Development Corporation Apparatus and method for detecting small changes in attached mass of piezoelectric devices used as sensors
US5306644A (en) 1988-09-29 1994-04-26 Hewlett-Packard Company Mass sensor method for measuring analytes in a sample
US5283037A (en) 1988-09-29 1994-02-01 Hewlett-Packard Company Chemical sensor utilizing a surface transverse wave device
US5130257A (en) 1988-09-29 1992-07-14 Hewlett-Packard Company Chemical sensor utilizing a surface transverse wave device
US5221415A (en) 1989-01-17 1993-06-22 Board Of Trustees Of The Leland Stanford Junior University Method of forming microfabricated cantilever stylus with integrated pyramidal tip
US5135852A (en) 1989-07-25 1992-08-04 E. I. Du Pont De Nemours And Company Piezoelectric cell growth biosensing method using polymer-metabolic product complex interactions
CA2024548C (en) 1989-09-05 2002-05-28 David Issachar Analyte specific chemical sensor
EP0494896B1 (en) 1989-10-04 1994-07-06 E.I. Du Pont De Nemours And Company Assay method for biological target complexes on the surface of a biosensor
US5179028A (en) 1990-04-20 1993-01-12 Hughes Aircraft Company Antibody coated crystal chemical sensor
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5445971A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5552274A (en) 1992-09-07 1996-09-03 Terumo Kabushiki Kaisha Method for detecting target sequences by oscillation frequency
USRE35544E (en) 1992-10-08 1997-07-01 Millipore Corporation Apparatus for monitoring moisture in a gas stream
US5339675A (en) 1992-10-08 1994-08-23 Millipore Corporation Apparatus for monitoring impurities in a gas stream
DE4334834A1 (en) 1993-10-13 1995-04-20 Andrzej Dr Ing Grzegorzewski Biosensor for measuring changes in viscosity and / or density
WO1994028372A1 (en) 1993-05-25 1994-12-08 Rosemount Inc. Organic chemical sensor
US5323636A (en) 1993-06-11 1994-06-28 The United States Of America As Represented By The Secretary Of The Army Dual-channel flexural acoustic wave chemical sensor
EP0711410B1 (en) * 1993-07-06 1997-03-26 International Business Machines Corporation Calorimetric sensor
US5445008A (en) 1994-03-24 1995-08-29 Martin Marietta Energy Systems, Inc. Microbar sensor
US5705399A (en) 1994-05-20 1998-01-06 The Cooper Union For Advancement Of Science And Art Sensor and method for detecting predetermined chemical species in solution
US5719324A (en) 1995-06-16 1998-02-17 Lockheed Martin Energy Systems, Inc. Microcantilever sensor
GB9522101D0 (en) 1995-10-28 1996-07-17 Aigis Ltd Blast attenuation
US6096559A (en) * 1998-03-16 2000-08-01 Lockheed Martin Energy Research Corporation Micromechanical calorimetric sensor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807758A (en) * 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
WO1997016699A1 (en) * 1995-10-30 1997-05-09 Trustees Of Boston University Piezoelectric force sensing apparatus and methods for biopolymer sequencing
WO1998050773A2 (en) * 1997-05-08 1998-11-12 University Of Minnesota Microcantilever biosensor
US6016686A (en) * 1998-03-16 2000-01-25 Lockheed Martin Energy Research Corporation Micromechanical potentiometric sensors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAVID R. BASELT ET AL.: "A high-sensitivity micromachined biosensor", PROCEEDINGS OF THE IEEE, vol. 85, no. 4, April 1997 (1997-04-01), pages 672 - 680, XP002158151 *

Also Published As

Publication number Publication date
DE60033653D1 (en) 2007-04-12
ATE355523T1 (en) 2006-03-15
AU3928100A (en) 2000-10-16
WO2000058729B1 (en) 2001-10-18
DE60033653T2 (en) 2007-11-15
EP1185865B1 (en) 2007-02-28
US6289717B1 (en) 2001-09-18
EP1185865A2 (en) 2002-03-13
WO2000058729A2 (en) 2000-10-05

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