WO2000054823A1 - System and method for collecting platelets and other blood components - Google Patents
System and method for collecting platelets and other blood components Download PDFInfo
- Publication number
- WO2000054823A1 WO2000054823A1 PCT/US2000/006561 US0006561W WO0054823A1 WO 2000054823 A1 WO2000054823 A1 WO 2000054823A1 US 0006561 W US0006561 W US 0006561W WO 0054823 A1 WO0054823 A1 WO 0054823A1
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- WO
- WIPO (PCT)
- Prior art keywords
- rotor
- component
- plasma
- platelets
- centrifuge
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362265—Details of valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362262—Details of incorporated reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362263—Details of incorporated filters
- A61M1/362264—Details of incorporated filters the filter being a blood filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362266—Means for adding solutions or substances to the blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3389—Continuous level detection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
Definitions
- This invention generally relates to systems and methods for processing blood and other biological fluids.
- Fig. 1 shows a typical disposable bag set used in the prior art to collect platelets from whole blood.
- the set includes a needle 10 or cannula, which is inserted into a vein of a donor.
- the needle 10 is connected to the tube 11, which in turn is connected to collection bag 12, so as to allow whole blood to flow from the donor through the needle 10 and the tube 11 into collection bag 12.
- the collection bag 12 contains anticoagulant.
- the needle 10 is removed from the donor, and tube 11 is cut and heat sealed.
- the remainder of the bag set is then brought to a centrifuge, which spins the bag set so that the blood in collection bag 12 separates into platelet-rich plasma and red blood cells.
- the centrifuge is not located at the point where the blood donation takes place.
- the bag set is removed from the centrifuge.
- the platelet-rich plasma is urged from collection bag 12 through tube 13 into platelet-storage bag 14.
- the tube 13 leading to the platelet- and plasma-storage bags 14, 15 is then cut and heat sealed.
- Storage-solution bag 16 holds RBC-storage solution.
- the RBC- storage solution is urged from the storage-solution bag 16 into the collection bag 12.
- the tube 41 connecting the collection and storage-solution bags 12, 16 is then cut and heat sealed.
- the first portion may be hung, so that gravity causes the RBC component to pass from the collection bag 12 through the filter 17 to RBC-storage bag 18.
- the filter 17 removes white blood cells (WBCs) from the red blood cells. After the red blood cells (and storage solution) pass into the RBC-storage bag 18, tube 19 is cut and heat sealed.
- WBCs white blood cells
- the second portion is centrifuged at a high rotational speed in order to separate the platelets from the plasma.
- some of the plasma is urged from the platelet- storage bag 14 into the plasma-storage bag 15.
- 50 mis of plasma are left with the platelets in the platelet-storage bag 14.
- the tube connecting these two bags is cut and heat sealed.
- the platelet-storage bag 14 holds platelets in about 50ml of plasma
- the plasma-storage bag 15 holds platelet-poor plasma
- the RBC- storage bag 18 of course, holds red blood cells.
- This prior-art process of collecting and separating blood components involves many steps and frequent human intervention.
- the arrangement of the prior-art bag set does not permit the process to be easily automated.
- the present invention is directed to systems and methods for collecting, from whole blood, platelets suspended in plasma.
- centrifuging the blood at a high enough rotational speed the platelets are separated from the plasma and the red blood cells.
- some of the plasma is removed while the centrifuge is being spun to keep the platelets separated from the plasma.
- the speed of rotation is altered so as to cause the platelets to mix with the remaining plasma.
- the platelets can then be collected with the remaining plasma.
- a system that may be used for carrying out the invention includes a centrifuge rotor, a flow-control arrangement and a spinner.
- the flow-control arrangement introduces whole blood into the centrifuge rotor and removes blood components from the centrifuge rotor.
- a controller causes the spinner to rotate at two different speeds: The rotor is spun at a first speed so as to separate the blood into a first component, a second component and a third component.
- the first component is primarily plasma.
- the second component is located, while the rotor is being spun, outside of the first component and is primarily red blood cells.
- the third component is located, while the rotor is being spun, between the first and second components and includes platelets.
- the controller causes the rotor's speed of rotation to be altered so as to cause the third component to mix with the first component.
- the controller also causes the flow- control arrangement to remove from the rotor a portion of the plasma containing platelets.
- the controller causes the flow-control arrangement to remove some of the first component (the plasma) before the third component (comprising the platelets) is mixed with the first component.
- the system also preferably includes a plasma-volume determination sensor in communication with the controller; the plasma-volume determination sensor determines the volume of the first component in the rotor. The controller may thus remove a portion of the first component based on the determined volume of the first component.
- FIG. 1 shows a disposable set that may be used in a prior-art system for collecting platelets from whole blood.
- FIG. 2 shows a cross-sectional view of a variable- volume rotor mounted in a chuck that spins the rotor and causes the rotor's volume to change.
- FIG. 3 shows a disposable set using a variable-volume rotor, such as the one in FIG. 2.
- FIG. 4 shows a control unit holding the disposable of FIG. 3.
- FIG. 2 shows a cross-section of a rotor 21 mounted in a chuck 80, which is located in the control unit and which holds the rotor 21.
- This rotor 21 may be any one of a variety of designs, but preferably the rotor has a variable total volume, such as the rotors shown and described in U.S. Patent No. 5,733,253 (which is incorporated herein by reference).
- the rotor shown in FIG. 2 is similar to the rotor shown in Figs. 1-4 of U.S. Patent No. 5,733,253, but it will be appreciated that other designs, such as other designs shown in U.S. Patent No.
- the interior of the chuck 80 includes one or more apertures 84 to permit the gas to come into fluid communication with the diaphragm 70.
- the rotor 21 may also include a interior wall 75 with perforations 71.
- the boundary wall 72 and the interior wall 75 form a passage 73, through which blood and blood components may flow to and from the rotor's non-rotating portion 74 and the tubing 33 attached to the rest of the disposable set.
- a rotary seal 76 provides a seal between the rotating and non-rotating portions of the rotor 21.
- channels may be located on the interior surface of the boundary wall 72 to provide fluid communication between the rotor's non-rotating portion 74 and the outer radius of the rotor's interior (as shown in Figures 41 and 42 of above-referenced U.S. Patent No. 5,733,253).
- FIG. 2 shows the rotor 21 at its maximum volume, with the diaphragm 70 stretched as far as the chuck 80 permits it to be stretched.
- the rotor 21 is spun sufficiently fast by the chuck 80 and the motor 81 to cause the blood to be separated into red blood cells 93, platelets 92 and plasma 91. Since, of these three blood components, the RBC component 93 of the blood has the greatest specific gravity, the RBC component is the furthest from the rotor's axis of rotation.
- the plasma component 91 has the lightest specific gravity, and therefore the plasma component is the closest to the axis of rotation.
- the platelet component 92 having an intermediate specific gravity, forms a thin layer between the plasma and RBC components.
- the plasma 91 is collected (i.e., urged through fixed portion 74 to tube 33) by continuing to spin the rotor 21 and using the pump 83 to increase the pressure against the diaphragm 70, and/or by slowing the revolutions of the rotor 21.
- the rotor 21 should preferably continue to be spun quickly and smoothly enough to keep the platelets 92 in a separate layer.
- the platelets 92 may be mixed with the remaining plasma by sharply changing the speed of rotation of the rotor 21. It has been found that, by sharply changing the rotor's speed of rotation, the platelets will mix with the neighboring plasma. Because the red blood cells have a much heavier specific gravity, the red blood cells tend to remain in their separate layer. Of course, the rotor's speed must not be altered so radically and quickly as to cause the red blood cells as well to mix with the other components. Alternatively, the speed of rotation may be slowed sufficiently— although not necessarily sharply—so that the platelets mix with the plasma but the red blood cells remain separate.
- the pump 83 may be created by the pump 83 to push the diaphragm 70 further outward and force the platelets, now suspended in plasma, out of the rotor into tube 33.
- the red blood cells may then be collected.
- Each of the components, platelets suspended in plasma, platelet- poor plasma, and the red blood cells should be directed to a separate container. Alternatively, one or both of the platelet-poor plasma and the red blood cells may be returned to the donor.
- FIG. 3 shows a disposable set that may be used in the platelet-collection process just described.
- the disposable set includes the rotor 21, a plasma- storage container 24, a platelet-storage container 99, a RBC-storage container 28, a filter 17 for removing white blood cells from the red blood cells, a cannula 10 (or other means for permitting whole blood to enter the disposable set), and tubing 33 connecting these components.
- the plasma-storage container 24 may contain anticoagulant, which may be introduced into the whole blood as it is being drawn through the needle 10 to the rotor 21.
- the platelet-storage container 99 may contain platelet-storage solution, and the RBC-storage container 28 may contain RBC preservative.
- the RBC preservative may be urged from the RBC-storage container 28 into the rotor 21, where the RBC preservative is mixed with the red blood cells remaining in the rotor 21.
- the red blood cells and the preservative may then be urged from the rotor 21 through the filter 17 into the RBC-storage container 28, in the manner described in concurrently filed application, serial no. / , for a "System and Method for Separating
- FIG. 4 shows the disposable set of FIG. 3 mounted in a control unit 20.
- the control unit 20 includes a flow-control arrangement for controlling and /or causing flow between the needle 10, the rotor 21 and the storage containers 24, 99, 28.
- the flow-control arrangement may include valves 22, 23, 98, 27, which control the flow through the various branches of the tubing. Alternatively, a single valving cassette may be used to control the flow through the various branches of the tubing.
- fluid By varying the pressure against the rotor's diaphragm (item 70 in FIG. 9), and by varying the speed that the rotor is spun 21, fluid may be urged into or out of the rotor from and to the needle 10 or the storage containers 24, 99, 28.
- control unit may be provided with independent pumping mechanisms (such as a peristaltic pump) that act on the tubing (or on a valving cassette) to force fluid through the tubing in the desired direction.
- independent pumping mechanisms such as a peristaltic pump
- the control unit may be provided with an arrangement for determining the volume of the red blood cells.
- One means of determining the volume of the red blood cells is to provide an array 97 of optical sensors (shown in FIG. 2) in the chuck 80 to determine the radius of the inner boundary of the red blood cells 93 when the blood has been centrifuged into different components. (If the boundary wall 72 is translucent, the array may be mounted above the rotor 21 instead of below it.)
- the control unit 20 may then calculate the volume of the red blood cells based on the location of this boundary when the rotor is filled with, say, one unit of blood. Using this volume information, the control unit may determine approximately the weight of the red blood cells in the rotor, based on the specific gravity of red blood cells.
- the control unit may determine the weight of all the blood components in the rotor when the rotor is filled. By subtracting the weight of the red blood cells from the total weight of all the blood components in the rotor, the control unit may determine approximately the weight of the plasma in the rotor, and how much of it should be removed in order to leave approximately 50 mis of plasma in the rotor.
- the control unit can stop removing plasma when the correct amount of plasma has been removed.
- the platelet-poor plasma is preferably directed to the plasma-storage container 24.
- the speed of the rotor may then be changed rapidly, in order to cause the platelets 92 to become mixed in the approximately 50 mis of the plasma remaining.
- the platelet /plasma combination is then urged from the rotor and sent to the platelet-storage container 99.
- Another optical sensor 96, mounted on the outlet tube 33 senses when the red blood cells start emerging from the rotor. (See FIG. 4.) When the red blood cells are detected, flow to the platelet-collection container 99 is stopped, and the red blood cells may be directed through filter 17 to a RBC-collection container 28.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU33979/00A AU3397900A (en) | 1999-03-17 | 2000-03-14 | System and method for collecting platelets and other blood components |
DE60029313T DE60029313T2 (en) | 1999-03-17 | 2000-03-14 | ARRANGEMENT FOR REMOVING BLOOD PLATES AND OTHER BLOOD COMPONENTS |
JP2000604895A JP4183915B2 (en) | 1999-03-17 | 2000-03-14 | Apparatus and method for collecting platelets and other blood components |
EP00912217A EP1161269B1 (en) | 1999-03-17 | 2000-03-14 | System for collecting platelets and other blood components |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/271,601 | 1999-03-17 | ||
US09/271,601 US6296602B1 (en) | 1999-03-17 | 1999-03-17 | Method for collecting platelets and other blood components from whole blood |
Publications (1)
Publication Number | Publication Date |
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WO2000054823A1 true WO2000054823A1 (en) | 2000-09-21 |
Family
ID=23036275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/006561 WO2000054823A1 (en) | 1999-03-17 | 2000-03-14 | System and method for collecting platelets and other blood components |
Country Status (6)
Country | Link |
---|---|
US (2) | US6296602B1 (en) |
EP (1) | EP1161269B1 (en) |
JP (2) | JP4183915B2 (en) |
AU (1) | AU3397900A (en) |
DE (1) | DE60029313T2 (en) |
WO (1) | WO2000054823A1 (en) |
Cited By (14)
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EP1566191A2 (en) * | 2004-02-20 | 2005-08-24 | Gambro, Inc., | Apparatus and method for separating a volume of composite liquid into at least two components |
JP2005536293A (en) * | 2002-08-23 | 2005-12-02 | ガンブロ インコーポレーテッド | Method and apparatus for blood component separation |
EP1736186A1 (en) * | 2005-06-22 | 2006-12-27 | Gambro, Inc., | Apparatus and method for separating at least two discrete volumes of composite liquid into at least two components |
WO2008049537A1 (en) | 2006-10-23 | 2008-05-02 | Apg Medical Ltd. | Use of magnetic cs capsules and/or micro-capsules for the treatment of aneurysms |
EP1925328A3 (en) * | 2005-06-22 | 2008-09-17 | Gambro BCT, Inc. | Set of bags for the separation of a composite liquid in a centrifuge |
US7648639B2 (en) | 2003-08-25 | 2010-01-19 | CaridianBCT, Inc | Method for separating a volume of composite liquid into at least two components |
US8016736B2 (en) | 2006-10-20 | 2011-09-13 | Caridianbct Biotechnologies, Llc | Methods for washing a red blood cell component and for removing prions therefrom |
US8840535B2 (en) | 2010-05-27 | 2014-09-23 | Terumo Bct, Inc. | Multi-unit blood processor with temperature sensing |
US8944983B2 (en) | 2010-06-17 | 2015-02-03 | Terumo Bct, Inc. | Multi-unit blood processor with isolated valves for radio frequency sealing |
KR101515698B1 (en) | 2013-04-11 | 2015-05-04 | 노정자 | Apparatus for separating centrifugally platelet rich plasma and method for separating centrifugally the same |
US9028388B2 (en) | 2010-06-07 | 2015-05-12 | Terumo Bct, Inc. | Multi-unit blood processor with volume prediction |
US9327296B2 (en) | 2012-01-27 | 2016-05-03 | Fenwal, Inc. | Fluid separation chambers for fluid processing systems |
US9733805B2 (en) | 2012-06-26 | 2017-08-15 | Terumo Bct, Inc. | Generating procedures for entering data prior to separating a liquid into components |
US10207044B2 (en) | 2015-07-29 | 2019-02-19 | Fenwal, Inc. | Five-port blood separation chamber and methods of using the same |
Families Citing this family (123)
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US5733253A (en) * | 1994-10-13 | 1998-03-31 | Transfusion Technologies Corporation | Fluid separation system |
DE69827019T2 (en) * | 1997-05-20 | 2006-02-02 | Zymequest, Inc., Beverly | DEVICE AND METHOD FOR PROCESSING BIOLOGICAL CELLS |
US6852074B1 (en) * | 1997-05-20 | 2005-02-08 | Zymequest, Inc. | Biological processing apparatus for expressing fluid material |
US6296602B1 (en) | 1999-03-17 | 2001-10-02 | Transfusion Technologies Corporation | Method for collecting platelets and other blood components from whole blood |
US6652475B1 (en) * | 1999-07-07 | 2003-11-25 | Mission Medical, Inc. | Automated blood component separation system |
US6524231B1 (en) * | 1999-09-03 | 2003-02-25 | Baxter International Inc. | Blood separation chamber with constricted interior channel and recessed passage |
EP1363739B1 (en) | 2000-11-02 | 2011-12-21 | CaridianBCT, Inc. | Fluid separation devices, systems and methods |
US6790371B2 (en) * | 2001-04-09 | 2004-09-14 | Medtronic, Inc. | System and method for automated separation of blood components |
US6702744B2 (en) * | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
JP4058614B2 (en) * | 2001-08-09 | 2008-03-12 | 株式会社Jimro | Bone marrow needle |
US8608661B1 (en) | 2001-11-30 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Method for intravascular delivery of a treatment agent beyond a blood vessel wall |
US7211037B2 (en) | 2002-03-04 | 2007-05-01 | Therakos, Inc. | Apparatus for the continuous separation of biological fluids into components and method of using same |
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Also Published As
Publication number | Publication date |
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AU3397900A (en) | 2000-10-04 |
JP4901798B2 (en) | 2012-03-21 |
DE60029313D1 (en) | 2006-08-24 |
EP1161269B1 (en) | 2006-07-12 |
US6558307B2 (en) | 2003-05-06 |
US20010051569A1 (en) | 2001-12-13 |
EP1161269A1 (en) | 2001-12-12 |
JP4183915B2 (en) | 2008-11-19 |
JP2002538898A (en) | 2002-11-19 |
DE60029313T2 (en) | 2007-07-05 |
US6296602B1 (en) | 2001-10-02 |
JP2008220969A (en) | 2008-09-25 |
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