WO2000053230A3 - Surface modification of lamellar particles - Google Patents

Surface modification of lamellar particles Download PDF

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Publication number
WO2000053230A3
WO2000053230A3 PCT/GB2000/000755 GB0000755W WO0053230A3 WO 2000053230 A3 WO2000053230 A3 WO 2000053230A3 GB 0000755 W GB0000755 W GB 0000755W WO 0053230 A3 WO0053230 A3 WO 0053230A3
Authority
WO
WIPO (PCT)
Prior art keywords
surface modification
lamellar particles
particles
lamellar
biodegradable
Prior art date
Application number
PCT/GB2000/000755
Other languages
French (fr)
Other versions
WO2000053230A2 (en
Inventor
Stanley Stewart Davis
Andrew Wells
Original Assignee
West Pharm Serv Drug Res Ltd
Stanley Stewart Davis
Andrew Wells
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharm Serv Drug Res Ltd, Stanley Stewart Davis, Andrew Wells filed Critical West Pharm Serv Drug Res Ltd
Priority to AU29251/00A priority Critical patent/AU2925100A/en
Priority to NZ513696A priority patent/NZ513696A/en
Priority to EP00907774A priority patent/EP1159011A2/en
Priority to JP2000603719A priority patent/JP2002538223A/en
Priority to CA002364444A priority patent/CA2364444A1/en
Publication of WO2000053230A2 publication Critical patent/WO2000053230A2/en
Publication of WO2000053230A3 publication Critical patent/WO2000053230A3/en
Priority to NO20014033A priority patent/NO20014033L/en
Priority to US09/948,319 priority patent/US6635254B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Lamellar particles comprising a biodegradable and biocompatible polymer and carrying a cationic charge on their surface. Methods for preparing these particles and compositions containing them.
PCT/GB2000/000755 1999-03-06 2000-03-03 Surface modification of lamellar particles WO2000053230A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU29251/00A AU2925100A (en) 1999-03-06 2000-03-03 Surface modification of lamellar particles
NZ513696A NZ513696A (en) 1999-03-06 2000-03-03 Surface modification of lamellar particles
EP00907774A EP1159011A2 (en) 1999-03-06 2000-03-03 Surface modification of lamellar particles
JP2000603719A JP2002538223A (en) 1999-03-06 2000-03-03 Surface improvement of layered particles
CA002364444A CA2364444A1 (en) 1999-03-06 2000-03-03 Surface modification of lamellar particles
NO20014033A NO20014033L (en) 1999-03-06 2001-08-20 Surface modification of laminated particles
US09/948,319 US6635254B2 (en) 1999-03-06 2001-09-06 Surface modification of lamellar particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9905136.9A GB9905136D0 (en) 1999-03-06 1999-03-06 Surface modification of lamellar particles
GB9905136.9 1999-03-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/948,319 Continuation US6635254B2 (en) 1999-03-06 2001-09-06 Surface modification of lamellar particles

Publications (2)

Publication Number Publication Date
WO2000053230A2 WO2000053230A2 (en) 2000-09-14
WO2000053230A3 true WO2000053230A3 (en) 2001-08-02

Family

ID=10849075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/000755 WO2000053230A2 (en) 1999-03-06 2000-03-03 Surface modification of lamellar particles

Country Status (10)

Country Link
US (1) US6635254B2 (en)
EP (1) EP1159011A2 (en)
JP (1) JP2002538223A (en)
AU (1) AU2925100A (en)
CA (1) CA2364444A1 (en)
GB (1) GB9905136D0 (en)
NO (1) NO20014033L (en)
NZ (1) NZ513696A (en)
WO (1) WO2000053230A2 (en)
ZA (1) ZA200106902B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
CN1780555A (en) * 2003-05-01 2006-05-31 韦斯特制药服务药物输送和临床研究中心有限公司 Nasal administration of the LH-RH analog leuprolide
US20060263350A1 (en) * 2003-09-26 2006-11-23 Fairfield Clinical Trials Llc Combination antihistamine medication
FR2870741B1 (en) * 2004-05-25 2008-03-14 Coletica Sa HYDRATED LAMELLAR OR LIPOSOME PHASE CONTAINING A FATTY MONOAMINE OR A CATIONIC POLYMER PROMOTING INTERCELLULAR PENETRATION AND A COSMETIC OR PHARMACEUTICAL COMPOSITION CONTAINING THE SAME.
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
WO2008105773A2 (en) 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
CA2652280C (en) * 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
WO2008019142A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
EP2144600A4 (en) * 2007-04-04 2011-03-16 Massachusetts Inst Technology Poly (amino acid) targeting moieties
WO2008124634A1 (en) * 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
ES2627233T3 (en) 2007-10-12 2017-07-27 Massachusetts Institute Of Technology Vaccine Nanotechnology
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) * 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995035097A1 (en) * 1994-06-18 1995-12-28 University Of Nottingham Polymer microparticles for drug delivery
WO1997002810A2 (en) * 1995-07-13 1997-01-30 Danbiosyst Uk Limited Polymeric lamellar substrate particles for drug delivery
WO1999006026A1 (en) * 1997-07-30 1999-02-11 Biovector Therapeutics (S.A.) Stable particulate complexes with neutral or negative global charge of lamellar structure

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5431620A (en) 1994-07-07 1995-07-11 Beckman Instruments, Inc. Method and system for adjusting centrifuge operation parameters based upon windage
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
KR960016882A (en) * 1994-11-01 1996-06-17 강재헌 Sustained-release biodegradable preparations for the treatment of periodontitis
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995035097A1 (en) * 1994-06-18 1995-12-28 University Of Nottingham Polymer microparticles for drug delivery
WO1997002810A2 (en) * 1995-07-13 1997-01-30 Danbiosyst Uk Limited Polymeric lamellar substrate particles for drug delivery
WO1999006026A1 (en) * 1997-07-30 1999-02-11 Biovector Therapeutics (S.A.) Stable particulate complexes with neutral or negative global charge of lamellar structure

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KHAIRULLAH, N. MOHAMED ET AL: "Preparation of polymeric lamellar substrate particles of specific size ranges as potential new adjuvants", XP002149280, retrieved from STN *
JABBAL-GILL, INDERJIT ET AL: "Potential of polymeric lamellar substrate particles (PLSP) as adjuvants for vaccines", VACCINE (2000), 18(3-4), 238-250, XP002149281 *
PITARD, BRUNO ET AL: "Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer", PROC. NATL. ACAD. SCI. U. S. A. (1997), 94(26), 14412-14417, XP002149282 *
PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER. (2000), 27TH, 323-324 *

Also Published As

Publication number Publication date
US20020068091A1 (en) 2002-06-06
AU2925100A (en) 2000-09-28
JP2002538223A (en) 2002-11-12
GB9905136D0 (en) 1999-04-28
NZ513696A (en) 2003-03-28
ZA200106902B (en) 2003-11-21
US6635254B2 (en) 2003-10-21
NO20014033D0 (en) 2001-08-20
WO2000053230A2 (en) 2000-09-14
CA2364444A1 (en) 2000-09-14
EP1159011A2 (en) 2001-12-05
NO20014033L (en) 2001-10-10

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