WO2000053108A1 - Arrangement for transferring an ovum from a follicle - Google Patents
Arrangement for transferring an ovum from a follicle Download PDFInfo
- Publication number
- WO2000053108A1 WO2000053108A1 PCT/NL2000/000164 NL0000164W WO0053108A1 WO 2000053108 A1 WO2000053108 A1 WO 2000053108A1 NL 0000164 W NL0000164 W NL 0000164W WO 0053108 A1 WO0053108 A1 WO 0053108A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inner tube
- ovum
- lumen
- outer tube
- flushing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2217/00—General characteristics of surgical instruments
- A61B2217/002—Auxiliary appliance
- A61B2217/005—Auxiliary appliance with suction drainage system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2217/00—General characteristics of surgical instruments
- A61B2217/002—Auxiliary appliance
- A61B2217/007—Auxiliary appliance with irrigation system
Definitions
- the present invention relates to an arrangement for transferring an ovum from a follicle with a combined aspiration and flushing technique and in accordance with the introductory part of claim 1.
- the two tubes that is to say, the inner tube and the outer tube, are made of stainless steel .
- the inner tube has an outside diameter that accurately fits in the inside diameter of the outer tube and is coaxially located inside the outer tube.
- the inner tube is provided with an inward deformation running in longitudinal direction of the tube, seen in cross-sectional view of the tube, not exceeding 120°. The consequence of this local inward deformation is that the wall of the inner tube, seen in cross-sectional view of the tube, has an inwardly directed convex portion that connects to the remaining portion of the wall of the inner tube via rounded concave portions.
- the inner tube is to fit accurately within the outer tube, which necessitates accurate tolerances, both as regards the inside diameter of the outer tube and the outside diameter of the inner tube .
- Adhering to accurate tolerances always has a disadvantageous effect on the cost price.
- Another disadvantage is that the ovum pick-up lumen does not have a round cross section since the wall of the inner tube has a local inward deformation.
- the point of the needle is made, for example by means of grinding, material is to be removed both from the outer tube and from the inner tube.
- the grinding is to be carried out with the flushing lumen in a certain orientation in order to guarantee that with the finished product the flushing lumen is in the right position relative to the point of the double lumen needle .
- the arrangement according to the invention has a number of characteristic advantages.
- the inner tube does not accurately fit in the outer tube, so that no accurate tolerances are necessary either for the outer tube or for the inner tube.
- the inner tube is made of a flexible material, so that the dimensions of the ovum pick-up lumen when an ovum passes can at least slightly adapt to the dimensions of the ovum.
- the flushing lumen is bounded by the inside wall of the inner tube, while the ovum lumen is bounded by the space between the outside wall of the inner tube and the inner wall of the outside tube. This implies that the flushing fluid used is in contact with metal only along the path from the distal end of the needle body to the outlet at the end remote from the distal needle end. This is deemed favourable.
- Metals are soluble in water only to a very small extent, it is true, but, nevertheless, an ovum should as much as possible be avoided contacting metals or fluids that have been in contact with metals. According to the state of the art, plastics can be manufactured having a composition that may be deemed utterly man- friendly.
- Claim 3 relates to a practical embodiment of the invention.
- the inner tube has such outside shape that the latter can be contiguous to the inside wall of the outer tube and thus over this part of the circumference has an outside diameter that is at least substantially equal to the inside diameter of the outer wall.
- the remaining, second part of the outside wall of the inner tube can elastically be deformed in the direction of the first portion. It will then be favourable when, during the passage of an ovum, the second part of the inner tube is deformed as far as possible in the direction of the first part.
- the flushing lumen should not be closed off completely when in that case too it is deemed desirable to have supply of flushing fluid.
- Claim 4 relates to an embodiment of the arrangement according to the invention in which the inner tube is connected at least at the distal end by gluing it to the inside wall of the outer tube.
- this embodiment can be designed so that during the grinding process of the point to the needle body at the distal end of the needle the inner tube need not be taken into account at all and the material of the inner tube need not be ground either.
- the embodiment according to claim 5 is of importance. This embodiment is possible due to the flexibility of the inner tube as a result of which it is possible to feed-in the inner tube in a bend through an opening in the outer tube.
- Figure 1 shows a general side view of an arrangement according to the invention with a double lumen needle, a connector and tubings connected to the connector for supplying flushing fluid and discharging the ovum to the exterior;
- Figure 2 shows a side view in cross section on an enlarged scale of a part of the needle body of the arrangement of Fig. 1 near the distal needle end;
- Figure 3 shows a plan view of the needle end which is shown in Fig. 2 ;
- Figure 4 shows a cross sectional view along the line IV- IV in Fig. 2;
- Figure 5 shows once again a cross sectional view of
- Figure 6 shows a cross-sectional view of the double lumen needle according to the arrows VI -VI in Fig. 5; and Figure 7 shows a side view in cross section on an enlarged scale of the connector of the arrangement of Fig. 1 and of the parts of the arrangement which are connected to the connector .
- Fig. 1 comprises a double lumen needle having an elongate needle body 1.
- Figs. 2, 3 and 5 there is a sharp point 5 at the distal needle end 3 to be inserted into the follicle, because the distal end is locally tapered.
- an ovum pick-up lumen 7 present inside the needle body 1 for removing an ovum 9 from a follicle, see Fig. 5, as well as a flushing lumen 11 for inserting a flushing fluid into the follicle.
- the needle body comprises an outer tube with an inner tube 15 therein, which extends over at least part of the length of the outer tube 13.
- the needle body 1 is connected to a connector 19 near the end 17 remote from the distal end 3, see Figs. 1 and 1 .
- the connector 19 has a connector body 21 which is connected at a first end 23 to the needle end 17 of the needle body 1, which end 17 is remote from the distal needle end.
- the connector 19 has an inlet 27 for discharging the ovum 9 to the exterior.
- the connector 19 is connected to an ovum discharge tubing 29 of a suitable plastic material.
- the ovum discharge tubing 29 is included in a stopper 31 of a suitable elastic material, such as silicon rubber, the ovum discharge tubing 29 being passed through as far as a slightly flange-like end 33.
- the stopper 31 can be sealed in the neck of a glass receptacle 35.
- a tube 37 is extended through the stopper 31 to the exterior, the end of which tube has a coupling 39 for a connection to a vacuum source.
- the outlet 27, see again Fig. 7, is connected to the ovum pick-up lumen 7 via conduit means which are formed by a part of the ovum discharge tubing 29 and a part of the outer tube 13 of the needle body 1.
- conduit means which are formed by a part of the ovum discharge tubing 29 and a part of the outer tube 13 of the needle body 1.
- the ovum discharge tubing 29 at the free end 41 is slid fluid tight over the outside wall of the outer tube 13 of the needle body 1.
- a strengthening sleeve 43 of an elastic plastic material which is slightly less flexible than the material of the ovum discharge tubing 29 is installed around the ovum discharge tubing near the second end 25 of the connector.
- the channel means between the outlet 27 and the needle body end 17 located opposite the distal end, which channel determines a first fluid pathway for the aspiration of an ovum 9 is thus formed by the parts of the outer tube 13 of the needle body that run inside the connector body 21 and the ovum discharge tubing 29 connected to it in a clamping and fluid tight fashion.
- an ovum 9 can thus be aspirated from a follicle and transferred to the receptacle 35 via the ovum lumen 7 through the fluid pathway present in the connector 19 and through the ovum discharge tubing 29.
- a flushing inlet 45 for supplying a flushing medium.
- a flushing medium supply tubing 47 is present whose end has a coupling 49 for connection to a source of flushing medium.
- a connector tube 51 to which the tubing 47 is connected in a clamping and fluid tight fashion.
- a sleeve 53 resembling the sleeve 43 is present to strengthen the connection from the supply tubing 47 to the connector body 21.
- the flushing inlet 45 is in fluid communication to the flushing lumen 11 in a manner to be discussed in more detail for determining a second fluid pathway for flushing a follicle . As will be apparent from the Figures 2 to 7, both fluid pathways inside the connector 19 and also inside the needle body 1 are completely separated.
- the inner tube 15 in cross section has dimensions that are considerably smaller than the inside diameter of the outer tube 13 , the inner tube 15 being made of a flexible plastic material selected for minimum presence of materials that might be harmful to the ovum 9.
- the flushing medium 11 is bounded by the inside wall of the inner tube 15.
- the ovum lumen 7 is bounded by the space between the outside wall of the inner tube 15 and the inside wall of the outer tube 13.
- the central axis 55 of the inner tube 15 is located eccentrically relative to the central axis 57 of the outer tube 13. This is especially distinct in Fig. 2.
- the outside wall of the inner tube 15 is located along a first part 15A of its circumference against the inside wall of the outer tube 13.
- the remaining second part 15B of the outside wall of the inner tube 15 is deformable under the influence of an external or internal pressure respectively, caused by the pressure exerted by an ovum 9 that passes while being aspirated by the ovum lumen 7 and the pressure of the flushing medium respectively, between a first position which is shown in Figs.
- the inner tube 15 in the embodiment shown in cross section has more or less the shape of a double convex lens .
- the outer tube 13 of the needle body 1 is provided with a taper 59 tapering to a sharp point 5. Therefore, only the outer tube needs to be ground.
- the inner tube 15 is cut off straight at the distal end 61, at least in the embodiment shown. At that point and, if so required, also over a further part of the length, the inner tube is bonded to the inside wall of the outer tube 13 by means of gluing.
- the outer tube 13 has an opening 63 through the wall. Through this opening 63 the flexible inner tube 15 within the connector body 21 is led out.
- the inner tube 15 ends at the end 65 remote from the distal end 61 at a location outside the outer tube 13 and within the connector body 21, and within the tube 51 mentioned before.
- the tube has an end 67 with a cross section that is adapted to the cross section of the flexible tube 15.
- suitable means such as glue, the inner tube 15 is attached in fluid tight fashion to the end 67 of the tube 51. In this way there is a fluid pathway from the coupling 49 through the supply tubing 47, the tube 51 and the inner tube 15 for supplying the flushing medium 11 for flushing a follicle.
- the inner tube 15 may have a different shape and be installed internally within the outer tube 13 in a different manner.
- the distal end of the inner tube may have a different shape than that shown in Fig. 3.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/936,006 US6607503B1 (en) | 1999-03-10 | 2000-03-10 | Arrangement for transferring an ovum from a follicle |
JP2000603599A JP4491703B2 (en) | 1999-03-10 | 2000-03-10 | Egg collection device from follicle |
EP00911486A EP1158913B1 (en) | 1999-03-10 | 2000-03-10 | Arrangement for transferring an ovum from a follicle |
DE60022632T DE60022632T2 (en) | 1999-03-10 | 2000-03-10 | ARRANGEMENT FOR TRANSFERRING AN EGG OF A FOLLICLE |
AU33352/00A AU754782B2 (en) | 1999-03-10 | 2000-03-10 | Arrangement for transferring an ovum from a follicle |
AT00911486T ATE304323T1 (en) | 1999-03-10 | 2000-03-10 | ARRANGEMENT FOR TRANSFERRING AN EGG FROM A FOLLICLE |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1011522A NL1011522C2 (en) | 1999-03-10 | 1999-03-10 | Device for transferring an ovum from a follicle. |
NL1011522 | 1999-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000053108A1 true WO2000053108A1 (en) | 2000-09-14 |
Family
ID=19768813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2000/000164 WO2000053108A1 (en) | 1999-03-10 | 2000-03-10 | Arrangement for transferring an ovum from a follicle |
Country Status (8)
Country | Link |
---|---|
US (1) | US6607503B1 (en) |
EP (1) | EP1158913B1 (en) |
JP (1) | JP4491703B2 (en) |
AT (1) | ATE304323T1 (en) |
AU (1) | AU754782B2 (en) |
DE (1) | DE60022632T2 (en) |
NL (1) | NL1011522C2 (en) |
WO (1) | WO2000053108A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1393686A1 (en) * | 2002-08-30 | 2004-03-03 | Smiths Group plc | Oocyte and embryo handling apparatus regulating the temperature within a tube |
GB2394179A (en) * | 2001-10-25 | 2004-04-21 | Smiths Group Plc | Dual lumen oocyte recovery needle |
WO2004089229A1 (en) * | 2003-04-01 | 2004-10-21 | William A. Cook Australia Pty. Ltd. | Aspiration and flushing needle |
WO2004100807A1 (en) * | 2003-05-19 | 2004-11-25 | Jiahui Xia | A micro-holding pipette with an oblique opening |
US20100081989A1 (en) * | 2007-04-24 | 2010-04-01 | Gynotec | Arrangement for Transferring An Ovum From A Follicle |
WO2021232122A1 (en) * | 2020-05-20 | 2021-11-25 | Wta - Watanabe Tecnologia Aplicada Eireli | Protected follicular aspiration device |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US8876750B2 (en) * | 2004-09-27 | 2014-11-04 | Art, Limited | Coaxial tubing system for phacoemulsification handpieces |
EP2124778B1 (en) * | 2007-02-21 | 2019-09-25 | Benvenue Medical, Inc. | Devices for treating the spine |
AT504989B1 (en) * | 2007-03-09 | 2008-12-15 | Hans-Peter Dr Steiner | PUNCTION DEVICE FOR REMOVING AN ORGANIC SAMPLE, AND GUIDE ADAPTER FOR ATTACHING A PUNCTION DEVICE TO AN ULTRASONIC HEAD |
GB0719037D0 (en) * | 2007-09-28 | 2007-11-07 | Vitrolife Sweden Ab | Sampling needle |
AT505749B1 (en) | 2008-03-17 | 2009-04-15 | Hans-Peter Dr Steiner | COIL UNIT FOR A PUNCTION DEVICE |
WO2010054660A1 (en) * | 2008-11-11 | 2010-05-20 | Herlev Hospital | Double cannula system for anaesthetic needle |
DE202010006116U1 (en) * | 2010-04-17 | 2010-08-05 | Interatio-Meditec Medizintechnik Vertriebs-Gmbh | Rinsing system for cleaning surgical wounds |
WO2014115304A1 (en) * | 2013-01-25 | 2014-07-31 | 株式会社北里メディカル | Needle for collecting living cell |
CN105496524A (en) * | 2014-09-24 | 2016-04-20 | 陈薪 | Double-cavity ova harvesting device with semi-automatic follicle flushing function |
KR101602576B1 (en) | 2014-10-21 | 2016-03-16 | (주)메디엔비즈 | Ovum pick up apparatus and aspiration needle for ovum pick up |
WO2018028780A1 (en) * | 2016-08-10 | 2018-02-15 | Saga Surgical Ab | A biopsy needle arrangement |
CN108143471A (en) * | 2018-02-09 | 2018-06-12 | 牛焕付 | A kind of suitable one-handed performance takes ovum system |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0131166A1 (en) * | 1983-06-14 | 1985-01-16 | Fertility And Genetics Research, Inc. | Non-surgical apparatus for human embryo transfer |
WO1986006968A1 (en) * | 1985-05-24 | 1986-12-04 | John Lui Yovich | Follicle aspiration/flushing needles |
DE3522782A1 (en) * | 1985-06-26 | 1987-01-15 | Peter Brehm Chir Mechanik Werk | Double-lumen follicle-biopsy cannula |
AU565996B3 (en) | 1987-01-30 | 1987-10-29 | William A Cook Australia Pty Ltd | Combined aspiration and flushing connector |
US5160319A (en) * | 1991-10-23 | 1992-11-03 | Baxter International Inc. | Dual-lumen oocyte aspiration needle |
Family Cites Families (8)
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US3610226A (en) * | 1968-02-27 | 1971-10-05 | Anthony M Albisser | A double lumen cannula for blood sampling |
DE2703087C2 (en) * | 1977-01-26 | 1984-11-29 | Günter van Dr.med. 4000 Düsseldorf Endert | Double lumen catheter |
US4319580A (en) * | 1979-08-28 | 1982-03-16 | The Board Of Regents Of The University Of Washington | Method for detecting air emboli in the blood in an intracorporeal blood vessel |
JPS6010740B2 (en) * | 1981-05-07 | 1985-03-19 | 宏司 井上 | Endotracheal tube for unilateral lung ventilation |
US4986279A (en) * | 1989-03-01 | 1991-01-22 | National-Standard Company | Localization needle assembly with reinforced needle assembly |
EP0586056B1 (en) * | 1992-07-07 | 1998-04-15 | William A. Cook Australia Pty. Ltd. | Medical coupling devices |
US6196989B1 (en) * | 1998-06-04 | 2001-03-06 | Alcon Laboratories, Inc. | Tip for liquefracture handpiece |
US6024693A (en) * | 1998-10-16 | 2000-02-15 | Datascope Investment Corp. | Intra-aortic balloon catheter |
-
1999
- 1999-03-10 NL NL1011522A patent/NL1011522C2/en not_active IP Right Cessation
-
2000
- 2000-03-10 JP JP2000603599A patent/JP4491703B2/en not_active Expired - Lifetime
- 2000-03-10 AT AT00911486T patent/ATE304323T1/en not_active IP Right Cessation
- 2000-03-10 EP EP00911486A patent/EP1158913B1/en not_active Expired - Lifetime
- 2000-03-10 DE DE60022632T patent/DE60022632T2/en not_active Expired - Fee Related
- 2000-03-10 WO PCT/NL2000/000164 patent/WO2000053108A1/en active IP Right Grant
- 2000-03-10 AU AU33352/00A patent/AU754782B2/en not_active Ceased
- 2000-03-10 US US09/936,006 patent/US6607503B1/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0131166A1 (en) * | 1983-06-14 | 1985-01-16 | Fertility And Genetics Research, Inc. | Non-surgical apparatus for human embryo transfer |
WO1986006968A1 (en) * | 1985-05-24 | 1986-12-04 | John Lui Yovich | Follicle aspiration/flushing needles |
DE3522782A1 (en) * | 1985-06-26 | 1987-01-15 | Peter Brehm Chir Mechanik Werk | Double-lumen follicle-biopsy cannula |
AU565996B3 (en) | 1987-01-30 | 1987-10-29 | William A Cook Australia Pty Ltd | Combined aspiration and flushing connector |
US5160319A (en) * | 1991-10-23 | 1992-11-03 | Baxter International Inc. | Dual-lumen oocyte aspiration needle |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6979339B2 (en) | 2001-10-25 | 2005-12-27 | Smiths Group Plc | Medico-surgical instruments |
GB2394179A (en) * | 2001-10-25 | 2004-04-21 | Smiths Group Plc | Dual lumen oocyte recovery needle |
GB2394179B (en) * | 2001-10-25 | 2004-11-10 | Smiths Group Plc | Medico-surgical instruments |
US6875168B2 (en) | 2002-08-30 | 2005-04-05 | Smiths Group Plc | Oocyte and embryo handling apparatus |
EP1393686A1 (en) * | 2002-08-30 | 2004-03-03 | Smiths Group plc | Oocyte and embryo handling apparatus regulating the temperature within a tube |
AU2003236463B2 (en) * | 2002-08-30 | 2007-10-18 | Smiths Group Plc | Oocyte and embryo handling apparatus |
WO2004089229A1 (en) * | 2003-04-01 | 2004-10-21 | William A. Cook Australia Pty. Ltd. | Aspiration and flushing needle |
WO2004100807A1 (en) * | 2003-05-19 | 2004-11-25 | Jiahui Xia | A micro-holding pipette with an oblique opening |
CN100366226C (en) * | 2003-05-19 | 2008-02-06 | 夏家辉 | Holding open inclined plane type microscopic ovum holding tube |
US20100081989A1 (en) * | 2007-04-24 | 2010-04-01 | Gynotec | Arrangement for Transferring An Ovum From A Follicle |
AU2008241686B2 (en) * | 2007-04-24 | 2013-10-17 | Gynotec | Arrangement for transferring an ovum from a follicle |
US8696615B2 (en) | 2007-04-24 | 2014-04-15 | Gynotec | Arrangement for transferring an ovum from a follicle |
WO2021232122A1 (en) * | 2020-05-20 | 2021-11-25 | Wta - Watanabe Tecnologia Aplicada Eireli | Protected follicular aspiration device |
Also Published As
Publication number | Publication date |
---|---|
AU3335200A (en) | 2000-09-28 |
EP1158913A1 (en) | 2001-12-05 |
EP1158913B1 (en) | 2005-09-14 |
DE60022632T2 (en) | 2006-07-06 |
NL1011522C2 (en) | 2000-09-12 |
JP4491703B2 (en) | 2010-06-30 |
US6607503B1 (en) | 2003-08-19 |
AU754782B2 (en) | 2002-11-28 |
JP2002537935A (en) | 2002-11-12 |
ATE304323T1 (en) | 2005-09-15 |
DE60022632D1 (en) | 2005-10-20 |
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