WO2000048642A3 - Biocompatible material with a novel functionality - Google Patents

Biocompatible material with a novel functionality Download PDF

Info

Publication number
WO2000048642A3
WO2000048642A3 PCT/DK2000/000065 DK0000065W WO0048642A3 WO 2000048642 A3 WO2000048642 A3 WO 2000048642A3 DK 0000065 W DK0000065 W DK 0000065W WO 0048642 A3 WO0048642 A3 WO 0048642A3
Authority
WO
WIPO (PCT)
Prior art keywords
macromolecules
structural features
biocompatible
layer
creating
Prior art date
Application number
PCT/DK2000/000065
Other languages
French (fr)
Other versions
WO2000048642B1 (en
WO2000048642A2 (en
Inventor
Volkmar Thom
Gunnar Jonsson
Mathias Ulbricht
Katja Jankova
George Altankov
Original Assignee
Surfarc Aps
Volkmar Thom
Gunnar Jonsson
Mathias Ulbricht
Katja Jankova
George Altankov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surfarc Aps, Volkmar Thom, Gunnar Jonsson, Mathias Ulbricht, Katja Jankova, George Altankov filed Critical Surfarc Aps
Priority to AU25366/00A priority Critical patent/AU2536600A/en
Priority to EP00903567A priority patent/EP1152774A2/en
Priority to JP2000599431A priority patent/JP2002537025A/en
Publication of WO2000048642A2 publication Critical patent/WO2000048642A2/en
Publication of WO2000048642A3 publication Critical patent/WO2000048642A3/en
Publication of WO2000048642B1 publication Critical patent/WO2000048642B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention is in the area of biomaterials, i.e. materials that are used in contact with living tissue and biological fluids for prosthetical, therapeutical, storage and the like. In particular, the invention relates to a novel approach of creating biocompatible surfaces, said surfaces being capable of functionally interacting with biological material. Said biocompatible surfaces comprise at least two components, such as a hydrophobic substratum and a macromolecule of hydrophilic nature, that cooperatively form a novel biocompatible surface. The novel approach is based on contacting said hydrophobic substratum with a laterally patterned monomolecular layer of hydrophilic and flexible macromolecules that exhibit a pronounced excluded volume. The surface is, in respect to polarity and morphology, a molecularly heterogeneous surface. Structural features of said macromolecular monolayer (as e.g. the layer thickness or its lateral density) are determined by, i) the structural features of the layer forming macromolecules (as e.g. their MW or their molecular architecture) and, ii) the method of creating said monomolecular layer (as e.g. by physi- or chemisorbing, or by chemically binding said macromolecules). The structural features of the layer forming macromolecule(s) is in turn determined by synthesis.
PCT/DK2000/000065 1999-02-17 2000-02-17 Biocompatible material with a novel functionality WO2000048642A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU25366/00A AU2536600A (en) 1999-02-17 2000-02-17 Biocompatible material with a novel functionality
EP00903567A EP1152774A2 (en) 1999-02-17 2000-02-17 Biocompatible material with a novel functionality
JP2000599431A JP2002537025A (en) 1999-02-17 2000-02-17 Biocompatible materials with new functions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900210 1999-02-17
DKPA199900210 1999-02-17

Publications (3)

Publication Number Publication Date
WO2000048642A2 WO2000048642A2 (en) 2000-08-24
WO2000048642A3 true WO2000048642A3 (en) 2000-12-21
WO2000048642B1 WO2000048642B1 (en) 2001-02-22

Family

ID=8090979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2000/000065 WO2000048642A2 (en) 1999-02-17 2000-02-17 Biocompatible material with a novel functionality

Country Status (4)

Country Link
EP (1) EP1152774A2 (en)
JP (1) JP2002537025A (en)
AU (1) AU2536600A (en)
WO (1) WO2000048642A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050053642A1 (en) * 2000-08-23 2005-03-10 Mathias Ulbricht Biocompatible materials
GB0115204D0 (en) * 2001-06-21 2001-08-15 Zellwerk Gmbh Ceramic materials, method for their production and use thereof
WO2004015376A2 (en) * 2002-08-07 2004-02-19 National Institutes Of Health Measurement systems and methods
EP2080603A1 (en) 2008-01-18 2009-07-22 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Manufacturing film or sheet material having openings
JP6901252B2 (en) * 2015-10-21 2021-07-14 株式会社日本触媒 Adhesive cell culture substrate, cell culture container and cell culture method using this
WO2017220108A1 (en) 2016-06-20 2017-12-28 Csf-Dynamics A/S A shunt device and a method for shunting cerebrospinal fluid
FR3061524B1 (en) * 2017-01-03 2019-05-24 Vianney Rabhi SYNCHRONIZED ROLLER WITH FREE WHEELS

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128170A (en) * 1989-05-11 1992-07-07 Kanegafunchi Kagaku Kogyo Kabushiki Kaisha Method for manufacturing medical device having a highly biocompatible surface
US5330911A (en) * 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5512474A (en) * 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
US5593814A (en) * 1989-06-03 1997-01-14 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Control of cell arrangement
WO1997018904A1 (en) * 1995-11-17 1997-05-29 Massachusetts Institute Of Technology Poly(ethylene oxide) coated surfaces
WO1997046590A1 (en) * 1996-06-03 1997-12-11 Gore Enterprise Holdings, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
WO1998023306A1 (en) * 1996-11-25 1998-06-04 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
WO1998047948A1 (en) * 1997-04-18 1998-10-29 California Institute Of Technology Multifunctional polymeric tissue coatings

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2325467B (en) * 1997-05-21 2000-11-01 Dainippon Ink & Chemicals Process for producing material with hydrophilic surface

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128170A (en) * 1989-05-11 1992-07-07 Kanegafunchi Kagaku Kogyo Kabushiki Kaisha Method for manufacturing medical device having a highly biocompatible surface
US5593814A (en) * 1989-06-03 1997-01-14 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Control of cell arrangement
US5330911A (en) * 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5512474A (en) * 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
WO1997018904A1 (en) * 1995-11-17 1997-05-29 Massachusetts Institute Of Technology Poly(ethylene oxide) coated surfaces
WO1997046590A1 (en) * 1996-06-03 1997-12-11 Gore Enterprise Holdings, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
WO1998023306A1 (en) * 1996-11-25 1998-06-04 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
WO1998047948A1 (en) * 1997-04-18 1998-10-29 California Institute Of Technology Multifunctional polymeric tissue coatings

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DESAI N P ET AL: "Biological responses to polyethylene oxide modified polyethylene terephthalate surfaces", J. OF BIOMEDICAL MATERIALS RESEARCH, vol. 25, 1991, pages 829 - 843, XP002928816 *
DESAI N P ET AL: "Solution technique to incorporate polyethylene oxide and other watersoluble polymers into surfaces of polymeric biomaterials", BIOMATERIALS, vol. 12, March 1991 (1991-03-01), pages 144 - 153, XP002928815 *
GING-HO HSIUE ET AL: "Platelet adhesion and cellular interaction with poly(ethylene oxide)immobilized onto silicone rubber membrane surfaces", J. BIOMATER. SCI. POLYMER EDI., vol. 7, no. 10, 1996, pages 839 - 855, XP002928819 *
LITAUSZKI L ET AL: "Surfaces modified with PEO by the Williamson reaction and their affinity for proteins", J. OF BIOMEDICAL MATERIALS RESEARCH, vol. 35, 1997, pages 1 - 8, XP002928818 *
MIQIN THANG ET AL: "Proteins and cells on PEG immobilized silicon surfaces", BIOMATERIALS, vol. 19, 1998, pages 953 - 960, XP002928814 *
PARK A ET AL: "Integration of surface modification and 3D fabrication techniques to prepare patterned poly(L-lactide) substrates allowing regionally selective cell adhesion", J. BIOMATER. SCI. POLYMER EDN., vol. 9, no. 2, 1998, pages 89 - 110, XP002114420 *
ROBERTS C ET AL: "Using Mixed Self-Assembled Monolayers Presenting RGD and (EG)30H Groups To Characterize Long-Term Attachment of Bovine Capillary Endothelial Cells to Surfaces", J. AM. CHEM. SOC., vol. 120, 1998, pages 6548 - 6555, XP002928821 *
See also references of EP1152774A2 *
SOFIA S J ET AL: "Poly(ethylene oxide) Grafted to Silicon Surfaces: Grafting Density and Protein Adsorption", MACROMOLECULES, vol. 31, 1998, pages 5059 - 5070, XP002928817 *

Also Published As

Publication number Publication date
EP1152774A2 (en) 2001-11-14
WO2000048642B1 (en) 2001-02-22
AU2536600A (en) 2000-09-04
JP2002537025A (en) 2002-11-05
WO2000048642A2 (en) 2000-08-24

Similar Documents

Publication Publication Date Title
WO2002015955A3 (en) Biocompatible materials
Bovone et al. Engineering hydrogel adhesion for biomedical applications via chemical design of the junction
Li et al. Marine mussel adhesion and bio-inspired wet adhesives
Dalsin et al. Bioinspired antifouling polymers
Yoshida et al. From advanced biomedical coatings to multi‐functionalized biomaterials
Chen et al. Surface hydration: Principles and applications toward low-fouling/nonfouling biomaterials
Sakiyama-Elbert et al. Functional biomaterials: design of novel biomaterials
Raynor et al. Controlling cell adhesion to titanium: functionalization of poly [oligo (ethylene glycol) methacrylate] brushes with cell‐adhesive peptides
Lutz Thermo‐switchable materials prepared using the OEGMA‐platform
Raynor et al. Polymer brushes and self-assembled monolayers: Versatile platforms to control cell adhesion to biomaterials
Elbert et al. Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering
Rodrigues et al. Nacre-inspired nanocomposites produced using layer-by-layer assembly: Design strategies and biomedical applications
KR20010033076A (en) Biocompatible polymer film
NO931809L (en) hemophilia
EP1771134A2 (en) A tunable nonfouling surface of oligoethylene glycol
Roeven et al. PLL–poly (HPMA) bottlebrush-based antifouling coatings: three grafting routes
WO2000048642A3 (en) Biocompatible material with a novel functionality
Bilotto et al. Adhesive properties of adsorbed layers of two recombinant mussel foot proteins with different levels of DOPA and tyrosine
Vale et al. Polymeric biomaterials inspired by marine mussel adhesive proteins
Pallotta et al. Nanotechnologies for medical devices: potentialities and risks
Kim et al. Thickness-tunable eggshell membrane hydrolysate nanocoating with enhanced cytocompatibility and neurite outgrowth
Guney et al. Surface modification of polymeric biomaterials
Choi et al. Carboxylic acid end-capped brushes on titanium via interface-mediated RAFT polymerization and cell–surface interactions
Wislez et al. How to Increase Adhesion Strength of Catechol Polymers to Wet Inorganic Surfaces
Ratner Surface modification of polymers for biomedical applications: chemical, biological, and surface analytical challenges

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: B1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: B1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

B Later publication of amended claims
ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 599431

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000903567

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000903567

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000903567

Country of ref document: EP