WO2000045856A3 - Novel methods of imaging and treatment with targeted compositions - Google Patents
Novel methods of imaging and treatment with targeted compositions Download PDFInfo
- Publication number
- WO2000045856A3 WO2000045856A3 PCT/US2000/002620 US0002620W WO0045856A3 WO 2000045856 A3 WO2000045856 A3 WO 2000045856A3 US 0002620 W US0002620 W US 0002620W WO 0045856 A3 WO0045856 A3 WO 0045856A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- patient
- vesicles
- ultrasound
- targeted
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 238000002604 ultrasonography Methods 0.000 abstract 4
- 208000007536 Thrombosis Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 108010022425 Platelet Glycoprotein GPIIb-IIIa Complex Proteins 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/228—Host-guest complexes, clathrates, chelates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU35866/00A AU777304B2 (en) | 1999-02-03 | 2000-02-02 | Novel methods of imaging and treatment with targeted compositions |
CA002362200A CA2362200A1 (en) | 1999-02-03 | 2000-02-02 | Novel methods of imaging and treatment with targeted compositions |
EP00914480A EP1146911A2 (en) | 1999-02-03 | 2000-02-02 | Novel methods of imaging and treatment with targeted compositions |
AU2005200059A AU2005200059A1 (en) | 1999-02-03 | 2005-01-07 | Novel methods of imaging and treatment with targeted compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/243,640 | 1999-02-03 | ||
US09/243,640 US6521211B1 (en) | 1995-06-07 | 1999-02-03 | Methods of imaging and treatment with targeted compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000045856A2 WO2000045856A2 (en) | 2000-08-10 |
WO2000045856A3 true WO2000045856A3 (en) | 2001-02-15 |
Family
ID=22919542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/002620 WO2000045856A2 (en) | 1999-02-03 | 2000-02-02 | Novel methods of imaging and treatment with targeted compositions |
Country Status (5)
Country | Link |
---|---|
US (2) | US6521211B1 (en) |
EP (1) | EP1146911A2 (en) |
AU (2) | AU777304B2 (en) |
CA (1) | CA2362200A1 (en) |
WO (1) | WO2000045856A2 (en) |
Cited By (4)
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---|---|---|---|---|
US8835556B2 (en) | 2002-12-31 | 2014-09-16 | Nektar Therapeutics | Hydrolytically stable maleimide-terminated polymers |
US9295737B2 (en) | 2002-03-01 | 2016-03-29 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US9408926B2 (en) | 2002-03-01 | 2016-08-09 | Bracco Suisse S.A. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US9446155B2 (en) | 2002-03-01 | 2016-09-20 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
Families Citing this family (210)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
US6139819A (en) * | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6521211B1 (en) * | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US6033645A (en) * | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US7452551B1 (en) * | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
US20050019266A1 (en) * | 1997-05-06 | 2005-01-27 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
US6416740B1 (en) * | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
US7637948B2 (en) | 1997-10-10 | 2009-12-29 | Senorx, Inc. | Tissue marking implant |
US6726650B2 (en) * | 1997-12-04 | 2004-04-27 | Bracco Research S.A. | Automatic liquid injection system and method |
US20010003580A1 (en) * | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US8498693B2 (en) | 1999-02-02 | 2013-07-30 | Senorx, Inc. | Intracorporeal marker and marker delivery device |
US20090030309A1 (en) | 2007-07-26 | 2009-01-29 | Senorx, Inc. | Deployment of polysaccharide markers |
US6725083B1 (en) | 1999-02-02 | 2004-04-20 | Senorx, Inc. | Tissue site markers for in VIVO imaging |
US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
US7651505B2 (en) | 2002-06-17 | 2010-01-26 | Senorx, Inc. | Plugged tip delivery for marker placement |
US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
US7983734B2 (en) * | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
US7049140B1 (en) * | 1999-04-29 | 2006-05-23 | Vanderbilt University | X-ray guided drug delivery |
US6575991B1 (en) | 1999-06-17 | 2003-06-10 | Inrad, Inc. | Apparatus for the percutaneous marking of a lesion |
AU5905400A (en) * | 1999-07-14 | 2001-02-05 | Board Of Regents, The University Of Texas System | Methods and compositions for delivery and retention of active agents to lymph nodes |
AU6635900A (en) * | 1999-08-13 | 2001-03-13 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents and for lymphatic system |
US7220401B2 (en) * | 1999-09-24 | 2007-05-22 | Barnes-Jewish Hospital | Blood clot-targeted nanoparticles |
US8263739B2 (en) * | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
EP1289565B1 (en) | 2000-06-02 | 2015-04-22 | Bracco Suisse SA | Compounds for targeting endothelial cells |
US7335169B2 (en) * | 2000-08-24 | 2008-02-26 | Timi 3 Systems, Inc. | Systems and methods for delivering ultrasound energy at an output power level that remains essentially constant despite variations in transducer impedance |
US20030069526A1 (en) * | 2000-08-24 | 2003-04-10 | Timi 3 Systems, Inc. | Applicators that house and support ultrasound transducers for transcutaneous delivery of ultrasound energy |
US20020082529A1 (en) * | 2000-08-24 | 2002-06-27 | Timi 3 Systems, Inc. | Systems and methods for applying pulsed ultrasonic energy |
US20040073115A1 (en) * | 2000-08-24 | 2004-04-15 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasound energy to increase tissue perfusion and/or vasodilation without substantial deep heating of tissue |
US20020072691A1 (en) * | 2000-08-24 | 2002-06-13 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasonic energy to the thoracic cavity |
WO2002015768A2 (en) * | 2000-08-24 | 2002-02-28 | Timi 3 Systems, Inc. | Systems and method for applying ultrasonic energy |
US7241270B2 (en) * | 2000-08-24 | 2007-07-10 | Timi 3 Systems Inc. | Systems and methods for monitoring and enabling use of a medical instrument |
US20020049395A1 (en) * | 2000-08-24 | 2002-04-25 | Timi 3 | Systems for applying ultrasound energy to the thoracic cavity |
US7220232B2 (en) * | 2000-08-24 | 2007-05-22 | Timi 3 Systems, Inc. | Method for delivering ultrasonic energy |
EP2319449B1 (en) | 2000-11-20 | 2016-03-09 | Senorx, Inc. | Tissue site markers for in vivo imaging |
US20040191246A1 (en) * | 2003-02-26 | 2004-09-30 | Connelly Patrick R. | Process for in vivo treatment of specific biological targets in bodily fluid |
US7846096B2 (en) | 2001-05-29 | 2010-12-07 | Ethicon Endo-Surgery, Inc. | Method for monitoring of medical treatment using pulse-echo ultrasound |
US20030092988A1 (en) | 2001-05-29 | 2003-05-15 | Makin Inder Raj S. | Staging medical treatment using ultrasound |
AU2002314855B2 (en) * | 2001-05-30 | 2007-08-09 | Board Of Trustees Of The Leland Stanford, Jr., University | Delivery system for nucleic acids |
US20030044354A1 (en) * | 2001-08-16 | 2003-03-06 | Carpenter Alan P. | Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release |
US7306925B2 (en) * | 2001-11-09 | 2007-12-11 | Vanderbilt University | Phage antibodies to radiation-inducible neoantigens |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
DE10163130B4 (en) * | 2001-12-20 | 2009-05-14 | Cyto Tools Gmbh | Apoptotic peptides and pharmaceutical compositions comprising them |
MXPA04007188A (en) | 2002-01-24 | 2005-10-18 | Barnes Jewish Hospital | Integrin targeted imaging agents. |
US7407778B2 (en) * | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
AU2003219922B2 (en) * | 2002-02-27 | 2009-09-10 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
US7261876B2 (en) * | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
US20060002940A1 (en) * | 2002-03-15 | 2006-01-05 | Jennifer Stevenson | Method of immunotherapy |
US6836528B2 (en) * | 2002-07-23 | 2004-12-28 | Ge Medical Systems Global Technology Company, Llc | Methods and apparatus for detecting structural, perfusion, and functional abnormalities |
US7229423B2 (en) * | 2003-02-05 | 2007-06-12 | Timi 3 System, Inc | Systems and methods for applying audible acoustic energy to increase tissue perfusion and/or vasodilation |
AU2009210402A1 (en) * | 2002-07-24 | 2009-09-10 | Timi 3 Systems, Inc. | Systems and methods for monitoring and enabling use of a medical instrument |
US7838296B2 (en) * | 2002-08-28 | 2010-11-23 | Separation Technology, Inc. | Methods and apparatus for ultrasonic determination of red blood cell indices |
US7052463B2 (en) * | 2002-09-25 | 2006-05-30 | Koninklijke Philips Electronics, N.V. | Method and apparatus for cooling a contacting surface of an ultrasound probe |
PT2363114E (en) * | 2002-10-29 | 2015-07-02 | Insmed Inc | Sustained release of antiinfectives |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
US20060036158A1 (en) | 2003-11-17 | 2006-02-16 | Inrad, Inc. | Self-contained, self-piercing, side-expelling marking apparatus |
CA2509153C (en) * | 2002-12-31 | 2013-04-16 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
US20080208084A1 (en) * | 2003-02-05 | 2008-08-28 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasound energy to increase tissue perfusion and/or vasodilation without substantial deep heating of tissue |
US8663650B2 (en) * | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
US20040242845A1 (en) * | 2003-02-21 | 2004-12-02 | Nicolau Yves Claude | Methods and compositions comprising supramolecular antigenic constructs and antibodies elicited against them |
CA2517939C (en) * | 2003-03-03 | 2015-11-24 | Dyax Corp. | Peptides that specifically bind hgf receptor (cmet) and uses thereof |
US20050118102A1 (en) * | 2003-04-28 | 2005-06-02 | Intematix Corporation | Spin resonance heating and/or imaging in medical applications |
US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
CN1795198B (en) * | 2003-05-29 | 2011-08-17 | 杰伊·W·佩特格尤 | Glycerophosphocholine and its derivatives for medical imaging of neuropsychiatric disorders |
EP1638504A4 (en) * | 2003-06-13 | 2011-07-20 | Cerevast Therapeutics Inc | Non-invasive intravascular thrombolyisis using modified ultrasound techniques |
US7807171B2 (en) * | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
US20080026995A1 (en) * | 2003-07-25 | 2008-01-31 | Ac Immune Sa | Therapeutic vaccine targeted against p-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
US7358226B2 (en) * | 2003-08-27 | 2008-04-15 | The Regents Of The University Of California | Ultrasonic concentration of drug delivery capsules |
US20050273002A1 (en) | 2004-06-04 | 2005-12-08 | Goosen Ryan L | Multi-mode imaging marker |
CN101137326B (en) * | 2003-12-01 | 2010-10-20 | 医疗物理有限公司 | Adrenergic imaging agent and its uses and related kit |
US20050124897A1 (en) * | 2003-12-03 | 2005-06-09 | Scimed Life Systems, Inc. | Apparatus and methods for delivering acoustic energy to body tissue |
US20060058708A1 (en) * | 2003-12-24 | 2006-03-16 | Gill Heart | Method and apparatus for ultrasonically increasing the transportation of therapeutic substances through tissue |
DE102004008594B4 (en) * | 2004-02-21 | 2015-03-19 | Neoperl Gmbh | Sanitary outlet device |
US7247141B2 (en) * | 2004-03-08 | 2007-07-24 | Ethicon Endo-Surgery, Inc. | Intra-cavitary ultrasound medical system and method |
WO2005087221A1 (en) * | 2004-03-15 | 2005-09-22 | Christine Allen | Biodegradable biocompatible implant and method of manufacturing same |
US20050228286A1 (en) * | 2004-04-07 | 2005-10-13 | Messerly Jeffrey D | Medical system having a rotatable ultrasound source and a piercing tip |
US20050234438A1 (en) * | 2004-04-15 | 2005-10-20 | Mast T D | Ultrasound medical treatment system and method |
US20050240124A1 (en) * | 2004-04-15 | 2005-10-27 | Mast T D | Ultrasound medical treatment system and method |
US7494467B2 (en) * | 2004-04-16 | 2009-02-24 | Ethicon Endo-Surgery, Inc. | Medical system having multiple ultrasound transducers or an ultrasound transducer and an RF electrode |
JP4559770B2 (en) * | 2004-04-20 | 2010-10-13 | 株式会社東芝 | Ultrasonic diagnostic apparatus and ultrasonic diagnostic method |
US20050256405A1 (en) * | 2004-05-17 | 2005-11-17 | Makin Inder Raj S | Ultrasound-based procedure for uterine medical treatment |
US7883468B2 (en) * | 2004-05-18 | 2011-02-08 | Ethicon Endo-Surgery, Inc. | Medical system having an ultrasound source and an acoustic coupling medium |
US7951095B2 (en) | 2004-05-20 | 2011-05-31 | Ethicon Endo-Surgery, Inc. | Ultrasound medical system |
US20050261588A1 (en) * | 2004-05-21 | 2005-11-24 | Makin Inder Raj S | Ultrasound medical system |
US7695436B2 (en) | 2004-05-21 | 2010-04-13 | Ethicon Endo-Surgery, Inc. | Transmit apodization of an ultrasound transducer array |
US7806839B2 (en) * | 2004-06-14 | 2010-10-05 | Ethicon Endo-Surgery, Inc. | System and method for ultrasound therapy using grating lobes |
EP1778104A1 (en) * | 2004-07-29 | 2007-05-02 | X-Sten, Corp. | Spinal ligament modification devices |
WO2007008220A2 (en) * | 2004-08-05 | 2007-01-18 | Baylor Research Institute | Gene or drug delivery system |
WO2006022786A1 (en) * | 2004-08-20 | 2006-03-02 | David Mullen | Tissue marking devices and systems |
WO2006028993A2 (en) * | 2004-09-02 | 2006-03-16 | Vanderbilt University | Assessment of cancer susceptibility to molecular targeted therapy by use of recombinant peptides |
US20080009561A1 (en) * | 2004-09-03 | 2008-01-10 | Imarx Therapeutics, Inc. | Apparatus And Method To Prepare A Microsphere-Forming Composition |
JP4829796B2 (en) * | 2004-10-22 | 2011-12-07 | 株式会社日立メディコ | Ultrasound contrast agent |
US20070059775A1 (en) * | 2005-03-29 | 2007-03-15 | The Trustees Of Columbia University In The City Of New York | Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques |
EP1714642A1 (en) * | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
US10357328B2 (en) | 2005-04-20 | 2019-07-23 | Bard Peripheral Vascular, Inc. and Bard Shannon Limited | Marking device with retractable cannula |
WO2006116021A2 (en) * | 2005-04-22 | 2006-11-02 | Intematix Corporation | Mri technique based on electron spin resonance and endohedral contrast agent |
US8435558B1 (en) | 2005-06-28 | 2013-05-07 | University Of South Florida | Ultrasound enhancement of drug release across non-ionic surfactant membranes |
US7981442B2 (en) * | 2005-06-28 | 2011-07-19 | University Of South Florida | Ultrasound enhancement of drug release across non-ionic surfactant membranes |
US20070016184A1 (en) * | 2005-07-14 | 2007-01-18 | Ethicon Endo-Surgery, Inc. | Medical-treatment electrode assembly and method for medical treatment |
EP1912575B1 (en) | 2005-07-29 | 2011-01-19 | Vertos Medical, Inc. | Percutaneous tissue excision devices |
US20070055263A1 (en) * | 2005-07-29 | 2007-03-08 | X-Sten Corp. | Tools for Percutaneous Spinal Ligament Decompression and Device for Supporting Same |
US20070110674A1 (en) * | 2005-07-29 | 2007-05-17 | Yuhong Xu | Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems |
US10219815B2 (en) * | 2005-09-22 | 2019-03-05 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
US20070083120A1 (en) * | 2005-09-22 | 2007-04-12 | Cain Charles A | Pulsed cavitational ultrasound therapy |
US8057408B2 (en) | 2005-09-22 | 2011-11-15 | The Regents Of The University Of Michigan | Pulsed cavitational ultrasound therapy |
US8052658B2 (en) | 2005-10-07 | 2011-11-08 | Bard Peripheral Vascular, Inc. | Drug-eluting tissue marker |
US20090220431A1 (en) * | 2005-12-02 | 2009-09-03 | Jin-Woo Cheon | Magnetic resonance imaging contrast agents containing water-soluble nanoparticles of manganese oxide or manganese metal oxide |
EP3067047B1 (en) | 2005-12-08 | 2022-04-20 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
WO2007071028A1 (en) * | 2005-12-23 | 2007-06-28 | St. Mary's University | Compounds, complexes and uses thereof |
US20070196282A1 (en) * | 2006-02-21 | 2007-08-23 | Siemens Medical Solutions Usa, Inc. | Medical diagnostic ultrasound with temperature-dependent contrast agents |
US20090214439A1 (en) * | 2006-03-15 | 2009-08-27 | Trustees Of Tufts College | Fluorinated Carbohydrates and Their Use in Tumor Visualization, Tissue Engineering, and Cancer Chemotherapy |
US7942830B2 (en) | 2006-05-09 | 2011-05-17 | Vertos Medical, Inc. | Ipsilateral approach to minimally invasive ligament decompression procedure |
US10087082B2 (en) * | 2006-06-06 | 2018-10-02 | Florida State University Research Foundation, Inc. | Stabilized silica colloid |
US20080294039A1 (en) * | 2006-08-04 | 2008-11-27 | Senorx, Inc. | Assembly with hemostatic and radiographically detectable pellets |
EP2079385B1 (en) | 2006-10-23 | 2013-11-20 | C.R.Bard, Inc. | Breast marker |
EP2109409B1 (en) | 2006-12-12 | 2018-09-05 | C.R.Bard, Inc. | Multiple imaging mode tissue marker |
US8401622B2 (en) | 2006-12-18 | 2013-03-19 | C. R. Bard, Inc. | Biopsy marker with in situ-generated imaging properties |
WO2008100906A2 (en) * | 2007-02-12 | 2008-08-21 | Vertos Medical, Inc. | Tissue excision devices and methods |
JP5162923B2 (en) | 2007-02-27 | 2013-03-13 | 株式会社日立製作所 | Ultrasonic imaging device |
WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US20080311045A1 (en) * | 2007-06-06 | 2008-12-18 | Biovaluation & Analysis, Inc. | Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo |
US7960336B2 (en) * | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
CN101918841B (en) * | 2007-09-11 | 2013-09-11 | 科德生物工程有限公司 | Peptide-lipid constructs and their use in diagnostic and therapeutic applications |
WO2009035347A1 (en) | 2007-09-11 | 2009-03-19 | Cristina-Simona Weinberg | Peptide-lipid constructs and their use in diagnostic and therapeutic applications |
US20090118709A1 (en) * | 2007-11-06 | 2009-05-07 | Vertos Medical, Inc. A Delaware Corporation | Tissue Excision Tool, Kits and Methods of Using the Same |
WO2009094554A2 (en) * | 2008-01-25 | 2009-07-30 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
WO2009099767A2 (en) | 2008-01-31 | 2009-08-13 | C.R. Bard, Inc. | Biopsy tissue marker |
US9327061B2 (en) | 2008-09-23 | 2016-05-03 | Senorx, Inc. | Porous bioabsorbable implant |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US8968210B2 (en) * | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
USD619253S1 (en) | 2008-10-23 | 2010-07-06 | Vertos Medical, Inc. | Tissue modification device |
USD611146S1 (en) | 2008-10-23 | 2010-03-02 | Vertos Medical, Inc. | Tissue modification device |
USD610259S1 (en) | 2008-10-23 | 2010-02-16 | Vertos Medical, Inc. | Tissue modification device |
USD621939S1 (en) | 2008-10-23 | 2010-08-17 | Vertos Medical, Inc. | Tissue modification device |
USD619252S1 (en) | 2008-10-23 | 2010-07-06 | Vertos Medical, Inc. | Tissue modification device |
US8670818B2 (en) | 2008-12-30 | 2014-03-11 | C. R. Bard, Inc. | Marker delivery device for tissue marker placement |
AU2010284313B2 (en) | 2009-08-17 | 2016-01-28 | Histosonics, Inc. | Disposable acoustic coupling medium container |
EP2470267B1 (en) | 2009-08-26 | 2015-11-11 | The Regents Of The University Of Michigan | Micromanipulator control arm for therapeutic and imaging ultrasound transducers |
CA2770706C (en) | 2009-08-26 | 2017-06-20 | Charles A. Cain | Devices and methods for using controlled bubble cloud cavitation in fractionating urinary stones |
US8207651B2 (en) | 2009-09-16 | 2012-06-26 | Tyco Healthcare Group Lp | Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point |
EP2480127A4 (en) * | 2009-09-22 | 2015-06-24 | Targeson Inc | Optical imaging contrast agents and uses therof |
US8539813B2 (en) | 2009-09-22 | 2013-09-24 | The Regents Of The University Of Michigan | Gel phantoms for testing cavitational ultrasound (histotripsy) transducers |
ITPI20100095A1 (en) * | 2010-07-28 | 2012-01-29 | Giuseppe Sabino | A MEANS OF AN ANTIGEN-SPECIFIC ECOGRAPHIC CONTRAST, A PROCEDURE FOR ITS PREPARATION AND ITS USES. |
WO2012020124A1 (en) | 2010-08-12 | 2012-02-16 | Ac Immune S.A. | Vaccine engineering |
AR083561A1 (en) | 2010-10-26 | 2013-03-06 | Ac Immune Sa | PREPARATION OF AN ANTIGENIC CONSTRUCTION |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
WO2013019730A1 (en) | 2011-07-29 | 2013-02-07 | The Washington University | Antibodies to tip-1 and grp78 |
US9144694B2 (en) | 2011-08-10 | 2015-09-29 | The Regents Of The University Of Michigan | Lesion generation through bone using histotripsy therapy without aberration correction |
US8723640B2 (en) | 2011-08-16 | 2014-05-13 | Elwha Llc | Distillation of status data relating to regimen compliance responsive to the presence and absence of wireless signals relating to one or more threshold frequencies |
US20130072854A1 (en) * | 2011-09-19 | 2013-03-21 | General Electric Company | Microbubble complexes and methods of use |
US9049783B2 (en) | 2012-04-13 | 2015-06-02 | Histosonics, Inc. | Systems and methods for obtaining large creepage isolation on printed circuit boards |
EP2844343B1 (en) | 2012-04-30 | 2018-11-21 | The Regents Of The University Of Michigan | Ultrasound transducer manufacturing using rapid-prototyping method |
KR102277921B1 (en) | 2012-05-21 | 2021-07-14 | 인스메드 인코포레이티드 | Systems for treating pulmonary infections |
US20130331738A1 (en) * | 2012-06-11 | 2013-12-12 | Board Of Trustees University Of Arkansas | Compositions and methods for potentiating sonothrombolysis |
US10881310B2 (en) | 2012-08-25 | 2021-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Motion artifact mitigation methods and devices for pulse photoplethysmography |
EP2903688A4 (en) | 2012-10-05 | 2016-06-15 | Univ Michigan | Bubble-induced color doppler feedback during histotripsy |
AU2013352259B2 (en) | 2012-11-29 | 2018-06-14 | Insmed Incorporated | Stabilized vancomycin formulations |
US20160022816A1 (en) * | 2013-03-14 | 2016-01-28 | Empire Technology Developement LLC | Identification of surgical smoke |
US9255907B2 (en) | 2013-03-14 | 2016-02-09 | Empire Technology Development Llc | Identification of surgical smoke |
US10035009B2 (en) | 2013-04-15 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for treating pancreatic cancer |
WO2015003154A1 (en) | 2013-07-03 | 2015-01-08 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
JP6600304B2 (en) | 2013-07-03 | 2019-10-30 | ヒストソニックス,インコーポレーテッド | Optimized histotripsy excitation sequence for bubble cloud formation using shock scattering |
US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
USD716451S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD715942S1 (en) | 2013-09-24 | 2014-10-21 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716450S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD715442S1 (en) | 2013-09-24 | 2014-10-14 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
WO2015070050A1 (en) | 2013-11-08 | 2015-05-14 | Baylor Research Institute | Nuclear loclization of glp-1 stimulates myocardial regeneration and reverses heart failure |
KR20150062802A (en) * | 2013-11-29 | 2015-06-08 | 삼성전자주식회사 | Double-layerec liposome comprising a inner liposome comprising hydrophobic active ingredient, and use thereof |
ES2820226T3 (en) | 2014-05-15 | 2021-04-20 | Insmed Inc | Methods for treating nontuberculous mycobacterial lung infections |
WO2016014939A1 (en) | 2014-07-24 | 2016-01-28 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
WO2016054079A1 (en) | 2014-09-29 | 2016-04-07 | Zyomed Corp. | Systems and methods for blood glucose and other analyte detection and measurement using collision computing |
NZ733010A (en) | 2014-12-31 | 2023-01-27 | Lantheus Medical Imaging Inc | Lipid-encapsulated gas microsphere compositions and related methods |
US20160338874A1 (en) * | 2015-05-19 | 2016-11-24 | Zoll Circulation, Inc. | System and method for assessing tissue after hypothermia |
WO2016210133A1 (en) | 2015-06-24 | 2016-12-29 | The Regents Of The Universtiy Of Michigan | Histotripsy therapy systems and methods for the treatment of brain tissue |
US9554738B1 (en) | 2016-03-30 | 2017-01-31 | Zyomed Corp. | Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing |
EP3436049B1 (en) | 2016-03-31 | 2022-01-12 | Baylor Research Institute | Angiopoietin-like protein 8 (angptl8) |
US20190117800A1 (en) * | 2016-04-19 | 2019-04-25 | Microvascuar Therapeutics Llc | Systems and methods for filling vials with gases |
WO2017192910A2 (en) | 2016-05-04 | 2017-11-09 | Lantheus Medical Imaging, Inc. | Methods and devices for preparation of ultrasound contrast agents |
US10493172B2 (en) | 2016-06-02 | 2019-12-03 | California Institute Of Technology | Gas-filled structures and related compositions, methods and systems to image a target site |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
US11118210B2 (en) | 2016-07-28 | 2021-09-14 | California Institute Of Technology | Genetically engineered gas vesicle gene clusters, genetic circuits, vectors, prokaryotic cells, compositions, methods and systems for contrast-enhanced imaging |
US10955496B2 (en) | 2016-07-28 | 2021-03-23 | California Institute Of Technology | Gas-filled structures and related compositions, methods and systems for magnetic resonance imaging |
WO2018148595A1 (en) | 2017-02-10 | 2018-08-16 | Washington University | Antibodies to tip1 and methods of use thereof |
US20190009110A1 (en) * | 2017-07-06 | 2019-01-10 | Slender Medical Ltd. | Ultrasound energy applicator |
JP7460534B2 (en) | 2018-03-30 | 2024-04-02 | インスメッド インコーポレイテッド | Continuous manufacturing method for liposome medicines |
AU2019389001A1 (en) | 2018-11-28 | 2021-06-10 | Histosonics, Inc. | Histotripsy systems and methods |
WO2020146379A1 (en) | 2019-01-07 | 2020-07-16 | California Institute Of Technology | Gas vesicle expression systems, gas vesicle constructs and related genetic circuits, vectors, mammalian cells, hosts, compositions, methods and systems |
US11786218B2 (en) | 2019-01-07 | 2023-10-17 | California Institute Of Technology | Burst ultrasound reconstruction with signal templates and related methods and systems |
US11446523B2 (en) | 2019-03-28 | 2022-09-20 | California Institute Of Technology | Compositions, methods and systems for gas vesicle based cavitation |
WO2021041934A1 (en) * | 2019-08-28 | 2021-03-04 | California Institute Of Technology | Protease sensitive gvpc and related gas vesicle gene clusters, expression systems, constructs, vectors, genetic circuits, cells, compositions, methods and systems for contrast-enhanced imaging |
US11813485B2 (en) | 2020-01-28 | 2023-11-14 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040285A1 (en) * | 1995-06-07 | 1996-12-19 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
EP0901793A1 (en) * | 1997-09-15 | 1999-03-17 | Imarx Pharmaceutical Corp. | Thermal preactivation of gaseous precursor filled compositions |
WO1999013919A1 (en) * | 1997-09-17 | 1999-03-25 | Imarx Pharmaceutical Corp. | Novel targeted contrast agents for diagnostic and therapeutic use |
Family Cites Families (270)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3015128A (en) | 1960-08-18 | 1962-01-02 | Southwest Res Inst | Encapsulating apparatus |
NL302030A (en) | 1962-12-21 | 1900-01-01 | ||
US3291843A (en) | 1963-10-08 | 1966-12-13 | Du Pont | Fluorinated vinyl ethers and their preparation |
BE661981A (en) | 1964-04-03 | |||
US3594326A (en) | 1964-12-03 | 1971-07-20 | Ncr Co | Method of making microscopic capsules |
US3968203A (en) | 1965-10-01 | 1976-07-06 | Jerome G. Spitzer | Aerosol astringent composition |
US3401475A (en) | 1966-07-18 | 1968-09-17 | Dow Chemical Co | Label and labelled container |
US3488714A (en) | 1966-09-19 | 1970-01-06 | Dow Chemical Co | Formed laminate structure and method of preparation |
US3615972A (en) | 1967-04-28 | 1971-10-26 | Dow Chemical Co | Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same |
US3532500A (en) | 1967-07-25 | 1970-10-06 | Eastman Kodak Co | Light sensitive vesicular composition comprising an azido-s-triazine compound |
US3557294A (en) | 1967-10-12 | 1971-01-19 | Allied Chem | Fluorinated ethers as inhalation convulsants |
US3479811A (en) | 1967-11-29 | 1969-11-25 | Dow Chemical Co | Yarn and method of making the same |
US3732172A (en) | 1968-02-28 | 1973-05-08 | Ncr Co | Process for making minute capsules and prefabricated system useful therein |
US3650831A (en) | 1969-03-10 | 1972-03-21 | Armour Dial Inc | Method of cleaning surfaces |
US4027007A (en) | 1970-12-09 | 1977-05-31 | Colgate-Palmolive Company | Antiperspirants formulated with borax |
US3873564A (en) | 1971-03-03 | 1975-03-25 | Synvar Ass | 2-Imidazolinyl-3-oxide-1-oxypropionic acid |
US4108806A (en) | 1971-12-06 | 1978-08-22 | The Dow Chemical Company | Thermoplastic expandable microsphere process and product |
US4179546A (en) | 1972-08-28 | 1979-12-18 | The Dow Chemical Company | Method for expanding microspheres and expandable composition |
US3960583A (en) | 1974-05-02 | 1976-06-01 | Philadelphia Quartz Company | Method of preparing modified hollow, largely spherical particles by spray drying |
CH588887A5 (en) | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
US3945956A (en) | 1975-06-23 | 1976-03-23 | The Dow Chemical Company | Polymerization of styrene acrylonitrile expandable microspheres |
US4138383A (en) | 1975-11-24 | 1979-02-06 | California Institute Of Technology | Preparation of small bio-compatible microspheres |
GB1523965A (en) | 1976-03-19 | 1978-09-06 | Ici Ltd | Pharmaceutical compositions containing steroids |
US4162282A (en) | 1976-04-22 | 1979-07-24 | Coulter Electronics, Inc. | Method for producing uniform particles |
GB1599881A (en) | 1977-02-02 | 1981-10-07 | Millington A R | Preparation for diagnostic radiology |
US4265551A (en) | 1977-07-13 | 1981-05-05 | U.S. Philips Corporation | Drive for transporting and reversing an ink ribbon, and for withdrawing the printing head in printing devices |
CH621479A5 (en) | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute | |
CH624011A5 (en) | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
US4192859A (en) | 1978-09-29 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Contrast media containing liposomes as carriers |
US4310506A (en) | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
US4276885A (en) | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4265251A (en) | 1979-06-28 | 1981-05-05 | Rasor Associates, Inc. | Method of determining pressure within liquid containing vessel |
US4303736A (en) | 1979-07-20 | 1981-12-01 | Leonard Torobin | Hollow plastic microspheres |
US4310505A (en) | 1979-11-08 | 1982-01-12 | California Institute Of Technology | Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances |
US4342826A (en) | 1980-02-04 | 1982-08-03 | Collaborative Research, Inc. | Immunoassay products and methods |
US4421562A (en) | 1980-04-13 | 1983-12-20 | Pq Corporation | Manufacturing process for hollow microspheres |
US4344929A (en) | 1980-04-25 | 1982-08-17 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US4315514A (en) | 1980-05-08 | 1982-02-16 | William Drewes | Method and apparatus for selective cell destruction |
US4331654A (en) | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US4681119A (en) | 1980-11-17 | 1987-07-21 | Schering Aktiengesellschaft | Method of production and use of microbubble precursors |
US4442843A (en) | 1980-11-17 | 1984-04-17 | Schering, Ag | Microbubble precursors and methods for their production and use |
US4657756A (en) | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
CA1170569A (en) | 1980-11-17 | 1984-07-10 | Julia S. Rasor | Microbubble precursors and methods for their production and use |
US4420442A (en) | 1981-04-13 | 1983-12-13 | Pq Corporation | Manufacturing process for hollow microspheres |
US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
EP0068961A3 (en) | 1981-06-26 | 1983-02-02 | Thomson-Csf | Apparatus for the local heating of biological tissue |
US4534899A (en) | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
US4426330A (en) | 1981-07-20 | 1984-01-17 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
US4569836A (en) | 1981-08-27 | 1986-02-11 | Gordon Robert T | Cancer treatment by intracellular hyperthermia |
DE3141641A1 (en) | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION |
BR8107560A (en) | 1981-11-19 | 1983-07-05 | Luiz Romariz Duarte | ULTRASONIC STIMULATION OF BONE FRACTURE CONSOLIDATION |
US4540629A (en) | 1982-04-08 | 1985-09-10 | Pq Corporation | Hollow microspheres with organosilicon-silicate walls |
DE3225848A1 (en) | 1982-07-07 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | PREPARATION OF CORTICOIDS FOR TOPICAL APPLICATION |
JPS58501576A (en) | 1982-09-22 | 1983-09-22 | エム.ビイ−.フイラ−ズ プテイ.リミテツド | Material, hollow bilayer silicate microspheres |
FR2534487B1 (en) | 1982-10-15 | 1988-06-10 | Dior Christian Parfums | METHOD FOR THE HOMOGENEIZATION OF HYDRATED LIPIDAL LAMELLAR PHASE DISPERSIONS, AND SUSPENSIONS OBTAINED THEREBY |
EP0111386B1 (en) | 1982-10-26 | 1987-11-19 | University Of Aberdeen | Ultrasound hyperthermia unit |
US4603044A (en) | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
US4731239A (en) | 1983-01-10 | 1988-03-15 | Gordon Robert T | Method for enhancing NMR imaging; and diagnostic use |
US4572203A (en) | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
US4718433A (en) | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
US4775522A (en) | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
US4981692A (en) | 1983-03-24 | 1991-01-01 | The Liposome Company, Inc. | Therapeutic treatment by intramammary infusion |
US5141738A (en) | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
US4485193A (en) | 1983-05-10 | 1984-11-27 | The Dow Chemical Company | Expandable synthetic resinous thermoplastic particles, method for the preparation thereof and the application therefor |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US4900540A (en) | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
JPS6019033A (en) * | 1983-07-12 | 1985-01-31 | Matsumoto Yushi Seiyaku Kk | Hollow micro-balloon and preparation thereof |
US4615879A (en) | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
FR2563725B1 (en) | 1984-05-03 | 1988-07-15 | Dory Jacques | APPARATUS FOR EXAMINING AND LOCATING ULTRASONIC TUMORS WITH A LOCALIZED HYPERTHERMAL TREATMENT DEVICE |
DE3585967D1 (en) | 1984-03-08 | 1992-06-11 | Phares Pharma Holland | LIPOSOME FORMING COMPOSITION. |
GB8407557D0 (en) | 1984-03-23 | 1984-05-02 | Hayward J A | Polymeric lipsomes |
FR2562421B1 (en) | 1984-04-09 | 1989-02-17 | Sandoz Sa | IMPROVEMENTS ON INTERLEUKIN THERAPY |
US4728575A (en) | 1984-04-27 | 1988-03-01 | Vestar, Inc. | Contrast agents for NMR imaging |
US5008109A (en) | 1984-05-25 | 1991-04-16 | Vestar, Inc. | Vesicle stabilization |
US5008050A (en) | 1984-06-20 | 1991-04-16 | The Liposome Company, Inc. | Extrusion technique for producing unilamellar vesicles |
US4620546A (en) | 1984-06-30 | 1986-11-04 | Kabushiki Kaisha Toshiba | Ultrasound hyperthermia apparatus |
SE8403905D0 (en) | 1984-07-30 | 1984-07-30 | Draco Ab | LIPOSOMES AND STEROID ESTERS |
US4767610A (en) | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
US4789501A (en) | 1984-11-19 | 1988-12-06 | The Curators Of The University Of Missouri | Glass microspheres |
US4921706A (en) | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
US4830858A (en) | 1985-02-11 | 1989-05-16 | E. R. Squibb & Sons, Inc. | Spray-drying method for preparing liposomes and products produced thereby |
US4689986A (en) | 1985-03-13 | 1987-09-01 | The University Of Michigan | Variable frequency gas-bubble-manipulating apparatus and method |
US5186922A (en) | 1985-03-15 | 1993-02-16 | See/Shell Biotechnology, Inc. | Use of biodegradable microspheres labeled with imaging energy constrast materials |
US4663161A (en) | 1985-04-22 | 1987-05-05 | Mannino Raphael J | Liposome methods and compositions |
JPS63500175A (en) | 1985-05-22 | 1988-01-21 | リポソ−ム テクノロジ−,インコ−ポレイテツド | Liposome inhalation method and inhalation system |
EP0216730B1 (en) | 1985-08-12 | 1991-01-23 | Battelle Memorial Institute | Porous spherical glass filtrating beads and method for the manufacturing thereof |
US4684479A (en) | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
US4938947A (en) | 1985-11-01 | 1990-07-03 | Centre National De La Recherche Scientifique (Cnrs) | Aerosol composition for in vivo imaging |
US4865836A (en) | 1986-01-14 | 1989-09-12 | Fluoromed Pharmaceutical, Inc. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US4927623A (en) | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
US4987154A (en) | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
US5080885A (en) * | 1986-01-14 | 1992-01-14 | Alliance Pharmaceutical Corp. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
DE3785054T2 (en) | 1986-01-24 | 1993-07-08 | Childrens Hosp Medical Center | STABLE EMULSIONS OF STRONGLY FLUORED ORGANIC COMPOUNDS. |
US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
US4834964A (en) | 1986-03-07 | 1989-05-30 | M.R.I., Inc. | Use of charged nitroxides as NMR image enhancing agents for CSF |
JPH0751496B2 (en) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | Manufacturing method of liposome |
DE3614657A1 (en) | 1986-04-30 | 1987-11-05 | Dornier Medizintechnik | LIPID VESICLES CONTAINING PHARMAKA, METHOD FOR THE PRODUCTION AND INTRODUCTION THEREOF IN THE BODY OF A LIVING BEING AND RELEASE OF THE PHARMACA CONTAINING IN THE LIPID VESICLES |
IL79559A0 (en) | 1986-07-29 | 1986-10-31 | Univ Ramot | Contrast agents for nmr medical imaging |
FR2602774B1 (en) | 1986-07-29 | 1990-10-19 | Atta | NOVEL POLYHYDROXYLATED AND PERFLUOROALKYLATED AMPHIPHILIC MOLECULES HAVING SURFACTANT PROPERTIES |
US4728578A (en) | 1986-08-13 | 1988-03-01 | The Lubrizol Corporation | Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers |
US4776991A (en) | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
US4781871A (en) | 1986-09-18 | 1988-11-01 | Liposome Technology, Inc. | High-concentration liposome processing method |
US4769241A (en) | 1986-09-23 | 1988-09-06 | Alpha Therapeutic Corporation | Apparatus and process for oxygenation of liquid state dissolved oxygen-carrying formulation |
ZW11287A1 (en) | 1986-11-04 | 1989-01-25 | Aeci Ltd | Process for the production of an explosive |
DE3637926C1 (en) | 1986-11-05 | 1987-11-26 | Schering Ag | Ultrasonic manometry in a liquid using microbubbles |
US5049388A (en) | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
US4863717A (en) | 1986-11-10 | 1989-09-05 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging |
US4933121A (en) | 1986-12-10 | 1990-06-12 | Ciba Corning Diagnostics Corp. | Process for forming liposomes |
DK175531B1 (en) | 1986-12-15 | 2004-11-22 | Nexstar Pharmaceuticals Inc | Delivery vehicle with amphiphil-associated active ingredient |
US5283255A (en) | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
CA1321048C (en) | 1987-03-05 | 1993-08-10 | Robert W. J. Lencki | Microspheres and method of producing same |
US5000960A (en) | 1987-03-13 | 1991-03-19 | Micro-Pak, Inc. | Protein coupling to lipid vesicles |
US5219538A (en) | 1987-03-13 | 1993-06-15 | Micro-Pak, Inc. | Gas and oxygen carrying lipid vesicles |
US4866096A (en) | 1987-03-20 | 1989-09-12 | Air Products And Chemicals, Inc. | Stable fluorochemical aqueous emulsions |
US4895876A (en) * | 1987-03-20 | 1990-01-23 | Air Products And Chemicals, Inc. | Concentrated stable fluorochemical aqueous emulsions containing triglycerides |
CH672733A5 (en) | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
ES2026257T3 (en) | 1987-06-23 | 1992-04-16 | Hafslund Nycomed Innovation Ab | IMPROVEMENTS INTRODUCED IN THE PRESENTATION OF IMAGES BY NUCLEAR MAGNETIC RESONANCE. |
US5354549A (en) | 1987-07-24 | 1994-10-11 | Nycomed Imaging As | Iodinated esters |
DE3741201A1 (en) | 1987-12-02 | 1989-06-15 | Schering Ag | ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT |
IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
US4844882A (en) | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
US5425366A (en) | 1988-02-05 | 1995-06-20 | Schering Aktiengesellschaft | Ultrasonic contrast agents for color Doppler imaging |
DE58908194D1 (en) | 1988-02-05 | 1994-09-22 | Schering Ag | ULTRASONIC CONTRAST AGENTS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS DIAGNOSTICS AND THERAPEUTICS. |
US4898734A (en) | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
DE3812816A1 (en) | 1988-04-16 | 1989-11-02 | Lawaczeck Ruediger Dipl Phys P | METHOD FOR SOLUBILIZING LIPOSOMES AND / OR BIOLOGICAL MEMBRANES AND THE USE THEREOF |
US5171755A (en) | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
US4893624A (en) | 1988-06-21 | 1990-01-16 | Massachusetts Institute Of Technology | Diffuse focus ultrasound hyperthermia system |
DE3824354A1 (en) | 1988-07-19 | 1990-01-25 | Basf Ag | METHOD FOR THE PRODUCTION OF CELL-CONTAINING PLASTICS BY THE POLYISOCYANATE-POLYADDITION PROCESS BY MEANS OF STORAGE-STABLE, FUEL-CONTAINING EMULSIONS AND THESE EMULSIONS |
US4996041A (en) | 1988-08-19 | 1991-02-26 | Toshiyuki Arai | Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system |
US4993415A (en) | 1988-08-19 | 1991-02-19 | Alliance Pharmaceutical Corp. | Magnetic resonance imaging with perfluorocarbon hydrides |
DE3828905A1 (en) | 1988-08-23 | 1990-03-15 | Schering Ag | MEDIALLY COMPOSED OF CAVITATE OR CLATHRATE MAKING HOST / GUEST COMPLEX AS A CONTRAST |
US5045304A (en) | 1988-08-31 | 1991-09-03 | Wayne State University | Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same |
DE3829999A1 (en) | 1988-09-01 | 1990-03-15 | Schering Ag | ULTRASONIC METHOD AND CIRCUITS THEREOF |
US5410516A (en) | 1988-09-01 | 1995-04-25 | Schering Aktiengesellschaft | Ultrasonic processes and circuits for performing them |
US4957656A (en) | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
US5066789A (en) | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
FR2637182B1 (en) | 1988-10-03 | 1992-11-06 | Lvmh Rech | COMPOSITIONS BASED ON HYDRATED LIPID LAMID PHASES OR LIPOSOMES CONTAINING AN ECDYSTEROID, PREFERABLY ECDYSTERONE, OR A DERIVATIVE THEREOF; AND COSMETIC, PHARMACEUTICAL, ESPECIALLY DERMATOLOGICAL, SERICULTURE OR PHYTOSANITARY COMPOSITIONS INCORPORATING THE SAME |
US5169836A (en) | 1988-11-10 | 1992-12-08 | Trustees Of The University Of Penna. | Inhibitors of platelet binding |
EP0382451A3 (en) | 1989-02-07 | 1991-05-29 | Merck & Co. Inc. | Viper venom polypeptides and variants |
US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
US5395609A (en) | 1989-06-19 | 1995-03-07 | Antisoma Limited | Synthetic peptides for use in tumor detection |
WO1990015807A1 (en) | 1989-06-22 | 1990-12-27 | Applications Et Transferts De Technologies Avancées | Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties |
FR2649335B1 (en) | 1989-07-05 | 1991-09-20 | Texinfine Sa | METHOD AND DEVICE FOR THE DIRECT PRODUCTION OF LIPOSOMES |
US5019370A (en) | 1989-07-10 | 1991-05-28 | University Of Kentucky Research Foundation | Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging |
US5194266A (en) | 1989-08-08 | 1993-03-16 | Liposome Technology, Inc. | Amphotericin B/cholesterol sulfate composition and method |
US5562608A (en) | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
NZ235563A (en) | 1989-10-13 | 1993-04-28 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical composition |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5620689A (en) | 1989-10-20 | 1997-04-15 | Sequus Pharmaceuuticals, Inc. | Liposomes for treatment of B-cell and T-cell disorders |
US5352435A (en) | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5209720A (en) | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
US5123414A (en) | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5334381A (en) | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5305757A (en) | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5149319A (en) | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
US5656211A (en) * | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5230882A (en) | 1989-12-22 | 1993-07-27 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5776429A (en) * | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5228446A (en) | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5088499A (en) | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5705187A (en) * | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
DE4004430A1 (en) | 1990-02-09 | 1991-08-14 | Schering Ag | CONSTRUCTED POLYALDEHYDE CONSTITUENTS |
IN172208B (en) | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
US5672585A (en) | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5358702A (en) | 1990-04-10 | 1994-10-25 | Unger Evan C | Methoxylated gel particle contrast media for improved diagnostic imaging |
US5078994A (en) | 1990-04-12 | 1992-01-07 | Eastman Kodak Company | Microgel drug delivery system |
JPH03297475A (en) | 1990-04-16 | 1991-12-27 | Ken Ishihara | Controlling method for emission of medicine by means of resonance sound wave |
US5137928A (en) | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
US5190982A (en) | 1990-04-26 | 1993-03-02 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
US5205287A (en) | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
US5196348A (en) | 1990-06-11 | 1993-03-23 | Air Products And Chemicals, Inc. | Perfluoro-crown ethers in fluorine magnetic resonance spectroscopy of biopsied tissue |
US5315997A (en) | 1990-06-19 | 1994-05-31 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging using diamagnetic contrast |
US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
IL95743A (en) | 1990-09-19 | 1993-02-21 | Univ Ramot | Method of measuring blood flow |
AU635449B2 (en) | 1990-10-05 | 1993-03-18 | Bracco International B.V. | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
US5487390A (en) | 1990-10-05 | 1996-01-30 | Massachusetts Institute Of Technology | Gas-filled polymeric microbubbles for ultrasound imaging |
US5196309A (en) | 1990-11-15 | 1993-03-23 | The Scripps Research Institute | Characterization of platelet aggregation disorders |
AU657111B2 (en) | 1990-12-20 | 1995-03-02 | Dana-Farber Cancer Institute | Control of gene expression by ionizing radiation |
US5107842A (en) | 1991-02-22 | 1992-04-28 | Molecular Biosystems, Inc. | Method of ultrasound imaging of the gastrointestinal tract |
DE69215722T3 (en) | 1991-03-22 | 2001-03-08 | Katsuro Tachibana | Amplifiers for ultrasound therapy of diseases and liquid pharmaceutical compositions containing them |
GB9106686D0 (en) | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106673D0 (en) | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5496535A (en) | 1991-04-12 | 1996-03-05 | Alliance Pharmaceutical Corp. | Fluorocarbon contrast media for use with MRI and radiographic imaging |
US5147631A (en) | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
JPH06507904A (en) | 1991-05-23 | 1994-09-08 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | Oil-soluble compounds for magnetic resonance imaging |
US5558857A (en) | 1991-06-03 | 1996-09-24 | Nycomed Imaging As | Contrast agents |
JP2868335B2 (en) | 1991-06-13 | 1999-03-10 | 富士通株式会社 | Switching system and disconnection notification method in switching system |
GB9116610D0 (en) | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
DE69230885T3 (en) | 1991-09-17 | 2008-01-24 | Ge Healthcare As | GASOUS ULTRASONIC CONTRASTING AGENTS |
MX9205298A (en) | 1991-09-17 | 1993-05-01 | Steven Carl Quay | GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA |
US5409688A (en) | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
US5362477A (en) | 1991-10-25 | 1994-11-08 | Mallinckrodt Medical, Inc. | 19F magnetic resonance imaging agents which include a nitroxide moiety |
US5196183A (en) | 1991-12-04 | 1993-03-23 | Sterling Winthrop Inc. | Contrast agents for ultrasound imaging |
GB9200387D0 (en) | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
GB9200388D0 (en) | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
WO1993015722A1 (en) | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
JP3325300B2 (en) | 1992-02-28 | 2002-09-17 | 株式会社東芝 | Ultrasound therapy equipment |
DK0627940T3 (en) * | 1992-03-05 | 2003-09-01 | Univ Texas | Use of immunoconjugates for diagnosis and / or therapy of vascularized tumors |
US5247935A (en) | 1992-03-19 | 1993-09-28 | General Electric Company | Magnetic resonance guided focussed ultrasound surgery |
WO1993020802A1 (en) | 1992-04-09 | 1993-10-28 | Northwestern University | Acoustically reflective liposomes and methods to make and use the same |
US5225531A (en) | 1992-04-09 | 1993-07-06 | Washington University | Hexapeptide Lys Gly Ala Gly Asp Val |
US5858399A (en) | 1992-04-09 | 1999-01-12 | Northwestern University | Acoustically reflective liposomes and methods to make and use the same |
US5339814A (en) | 1992-04-14 | 1994-08-23 | Lasker Sigmund E | Process for visualizing tissue metabolism using oxygen-17 |
US5846516A (en) | 1992-06-03 | 1998-12-08 | Alliance Pharmaceutial Corp. | Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications |
DE4221256C2 (en) | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenic composition for topical use |
JPH06192291A (en) | 1992-09-07 | 1994-07-12 | Nippon Steel Corp | Novel peptide and platelet aggregation-inhibiting agent and blood anticoagulant using the same |
US5552155A (en) | 1992-12-04 | 1996-09-03 | The Liposome Company, Inc. | Fusogenic lipsomes and methods for making and using same |
US5558855A (en) | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
CZ191695A3 (en) | 1993-01-25 | 1996-05-15 | Sonus Pharma Inc | Biologically compatible contrast agent, process of its preparation and representation method by ultrasound |
FR2700952B1 (en) | 1993-01-29 | 1995-03-17 | Oreal | New cosmetic or dermopharmaceutical compositions in the form of aqueous gels modified by the addition of expanded microspheres. |
BR9405798A (en) | 1993-02-22 | 1995-12-12 | Vivorx Pharmaceuticals Inc | Methods for in vivo release of biological material and useful compositions thereof |
US5362478A (en) | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
AU6365894A (en) | 1993-03-16 | 1994-10-11 | Alliance Pharmaceutical Corporation | Fluorocarbon compositions containing a visible or fluorescent label |
US5567415A (en) | 1993-05-12 | 1996-10-22 | The Board Of Regents Of The University Of Nebraska | Ultrasound contrast agents and methods for their manufacture and use |
US5701899A (en) | 1993-05-12 | 1997-12-30 | The Board Of Regents Of The University Of Nebraska | Perfluorobutane ultrasound contrast agent and methods for its manufacture and use |
US5716597A (en) | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
US5855865A (en) | 1993-07-02 | 1999-01-05 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
HUT74827A (en) | 1993-07-02 | 1997-02-28 | Molecular Biosystems Inc | Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents |
US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
EP0711179B2 (en) | 1993-07-30 | 2010-09-01 | IMCOR Pharmaceutical Co. | Stabilized microbubble compositions for ultrasound |
DE59409568D1 (en) | 1993-09-09 | 2000-11-30 | Schering Ag | ACTIVE SUBSTANCES AND GAS CONTAINING MICROPARTICLES |
US5433204A (en) | 1993-11-16 | 1995-07-18 | Camilla Olson | Method of assessing placentation |
ZA952485B (en) | 1994-03-28 | 1995-12-15 | Nycomed Imaging As | Liposomes |
US5466467A (en) | 1994-03-30 | 1995-11-14 | The United States Of America As Represented By The Secretary Of The Navy | Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes |
US5545396A (en) | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
WO1995029705A1 (en) | 1994-05-03 | 1995-11-09 | Molecular Biosystems, Inc. | Composition for ultrasonically quantitating myocardial perfusion |
US5571797A (en) | 1994-05-11 | 1996-11-05 | Arch Development Corporation | Method of inducing gene expression by ionizing radiation |
US5502094A (en) | 1994-05-20 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use |
US5736121A (en) | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
US6159445A (en) | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
US5562893A (en) | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
US5509896A (en) | 1994-09-09 | 1996-04-23 | Coraje, Inc. | Enhancement of thrombolysis with external ultrasound |
US5540909A (en) | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US5569448A (en) | 1995-01-24 | 1996-10-29 | Nano Systems L.L.C. | Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
EP0727225A3 (en) | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasound imaging |
US5556372A (en) | 1995-02-15 | 1996-09-17 | Exogen, Inc. | Apparatus for ultrasonic bone treatment |
US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
US5560364A (en) | 1995-05-12 | 1996-10-01 | The Board Of Regents Of The University Of Nebraska | Suspended ultra-sound induced microbubble cavitation imaging |
US5558092A (en) | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US6033645A (en) * | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
US6521211B1 (en) * | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US5606973A (en) | 1995-06-07 | 1997-03-04 | Molecular Biosystems, Inc. | Liquid core microdroplets for ultrasound imaging |
US5897851A (en) | 1995-06-07 | 1999-04-27 | Sonus Pharmaceuticals, Inc. | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging |
US5733024A (en) * | 1995-09-13 | 1998-03-31 | Silicon Valley Group, Inc. | Modular system |
US5648098A (en) | 1995-10-17 | 1997-07-15 | The Board Of Regents Of The University Of Nebraska | Thrombolytic agents and methods of treatment for thrombosis |
US5840023A (en) | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
US5976501A (en) | 1996-06-07 | 1999-11-02 | Molecular Biosystems, Inc. | Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion |
US5849727A (en) | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
TW320761B (en) * | 1996-10-03 | 1997-11-21 | Mos Electronics Taiwan Inc | Manufacturing method of high density DRAM with cylindrical stack capacitor |
US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
US6261537B1 (en) | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
US6537246B1 (en) * | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6398772B1 (en) * | 1999-03-26 | 2002-06-04 | Coraje, Inc. | Method and apparatus for emergency treatment of patients experiencing a thrombotic vascular occlusion |
-
1999
- 1999-02-03 US US09/243,640 patent/US6521211B1/en not_active Expired - Fee Related
-
2000
- 2000-02-02 AU AU35866/00A patent/AU777304B2/en not_active Ceased
- 2000-02-02 EP EP00914480A patent/EP1146911A2/en not_active Withdrawn
- 2000-02-02 CA CA002362200A patent/CA2362200A1/en not_active Abandoned
- 2000-02-02 WO PCT/US2000/002620 patent/WO2000045856A2/en active IP Right Grant
-
2003
- 2003-01-13 US US10/341,167 patent/US7329402B2/en not_active Expired - Fee Related
-
2005
- 2005-01-07 AU AU2005200059A patent/AU2005200059A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040285A1 (en) * | 1995-06-07 | 1996-12-19 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
EP0901793A1 (en) * | 1997-09-15 | 1999-03-17 | Imarx Pharmaceutical Corp. | Thermal preactivation of gaseous precursor filled compositions |
WO1999013919A1 (en) * | 1997-09-17 | 1999-03-25 | Imarx Pharmaceutical Corp. | Novel targeted contrast agents for diagnostic and therapeutic use |
Non-Patent Citations (4)
Title |
---|
HAUTANEN A ET AL: "Effects of modifications of the RGD sequence and its context on recognition by the fibronectin receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, JAN 25 1989, VOL. 264, NO. 3, PAGE(S) 1437-1442, XP002150374 * |
TAKEUCHI M ET AL: "Enhanced visualization of intravascular thrombus with the use of a thrombus targeting ultrasound contrast agent (MRX408): Evidence from in vivo experimental echocardiographic studies.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 31, no. 2 SUPPL. A, February 1998 (1998-02-01), & 47th Annual Scientific Session of the American College of Cardiology;Atlanta, Georgia, USA; March 29-April 1, 1998, pages 57A, abstract 803-6, XP000952675, ISSN: 0735-1097 * |
UNGER EVAN C ET AL: "In vitro studies of a new thrombus-specific ultrasound contrast agent.", AMERICAN JOURNAL OF CARDIOLOGY, vol. 81, no. 12 SUPPL. A, 12 June 1998 (1998-06-12), & Symposium: Ninth International Congress on Echocardiography: Clinical Cardiology, 1997, pages 58G - 61G, XP002087505, ISSN: 0002-9149 * |
WU YUNQIU ET AL: "Preliminary report: Binding and lysing of blood clots using MRX-408.", INVESTIGATIVE RADIOLOGY, vol. 33, no. 12, December 1998 (1998-12-01), pages 880 - 885, XP000952676, ISSN: 0020-9996 * |
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CA2362200A1 (en) | 2000-08-10 |
WO2000045856A2 (en) | 2000-08-10 |
AU2005200059A1 (en) | 2005-02-03 |
US6521211B1 (en) | 2003-02-18 |
US7329402B2 (en) | 2008-02-12 |
AU3586600A (en) | 2000-08-25 |
US20030157025A1 (en) | 2003-08-21 |
AU777304B2 (en) | 2004-10-07 |
EP1146911A2 (en) | 2001-10-24 |
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