WO2000043354A3 - Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4 - Google Patents

Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4 Download PDF

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Publication number
WO2000043354A3
WO2000043354A3 PCT/US2000/001604 US0001604W WO0043354A3 WO 2000043354 A3 WO2000043354 A3 WO 2000043354A3 US 0001604 W US0001604 W US 0001604W WO 0043354 A3 WO0043354 A3 WO 0043354A3
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WIPO (PCT)
Prior art keywords
compounds
vla
leukocyte adhesion
adhesion mediated
inhibit leukocyte
Prior art date
Application number
PCT/US2000/001604
Other languages
French (fr)
Other versions
WO2000043354A2 (en
Inventor
Francine S Grant
Bradley S Johnson
Michael A Pleiss
Eugene D Thorsett
Original Assignee
Elan Pharm Inc
Francine S Grant
Bradley S Johnson
Michael A Pleiss
Eugene D Thorsett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Elan Pharm Inc, Francine S Grant, Bradley S Johnson, Michael A Pleiss, Eugene D Thorsett filed Critical Elan Pharm Inc
Priority to EP00911619A priority Critical patent/EP1144364B1/en
Priority to DE60021251T priority patent/DE60021251D1/en
Priority to JP2000594772A priority patent/JP2002535304A/en
Priority to AT00911619T priority patent/ATE299490T1/en
Priority to CA002357781A priority patent/CA2357781A1/en
Priority to AU33488/00A priority patent/AU3348800A/en
Publication of WO2000043354A2 publication Critical patent/WO2000043354A2/en
Publication of WO2000043354A3 publication Critical patent/WO2000043354A3/en
Priority to HK02106864.8A priority patent/HK1045495A1/en

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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Abstract

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
PCT/US2000/001604 1999-01-22 2000-01-21 Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4 WO2000043354A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP00911619A EP1144364B1 (en) 1999-01-22 2000-01-21 Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4
DE60021251T DE60021251D1 (en) 1999-01-22 2000-01-21 MULTICYCLIC COMPOUNDS FOR INHIBITING THE LEAGOZYTE ADHESION MEDIATED BY VLA-4
JP2000594772A JP2002535304A (en) 1999-01-22 2000-01-21 Polycyclic compounds inhibiting leukocyte adhesion mediated by VAL-4
AT00911619T ATE299490T1 (en) 1999-01-22 2000-01-21 MULTICYCLIC COMPOUNDS FOR INHIBITING VLA-4-MEDIATED LEUKOCYTE ADHESION
CA002357781A CA2357781A1 (en) 1999-01-22 2000-01-21 Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4
AU33488/00A AU3348800A (en) 1999-01-22 2000-01-21 Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4
HK02106864.8A HK1045495A1 (en) 1999-01-22 2002-09-20 Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4

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US11673599P 1999-01-22 1999-01-22
US60/116,735 1999-01-22
US11774399P 1999-01-29 1999-01-29
US60/117,743 1999-01-29

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WO2000043354A3 true WO2000043354A3 (en) 2000-11-23

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AR035838A1 (en) 2004-07-21
AU3348800A (en) 2000-08-07
ATE299490T1 (en) 2005-07-15
CN1344247A (en) 2002-04-10
JP2002535304A (en) 2002-10-22
HK1045495A1 (en) 2002-11-29
WO2000043354A2 (en) 2000-07-27
CN1231212C (en) 2005-12-14
US20060074110A1 (en) 2006-04-06
CA2357781A1 (en) 2000-07-27
EP1144364B1 (en) 2005-07-13
EP1144364A2 (en) 2001-10-17

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