WO2000042002A1 - Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors - Google Patents
Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors Download PDFInfo
- Publication number
- WO2000042002A1 WO2000042002A1 PCT/US1999/030417 US9930417W WO0042002A1 WO 2000042002 A1 WO2000042002 A1 WO 2000042002A1 US 9930417 W US9930417 W US 9930417W WO 0042002 A1 WO0042002 A1 WO 0042002A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- iodo
- phenylamino
- methyl
- benzenesulfonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000593570A JP2002534497A (en) | 1999-01-13 | 1999-12-21 | Sulfohydroxamic acids and sulfohydroxamates and their use as MEK inhibitors |
EP99968151A EP1144372B1 (en) | 1999-01-13 | 1999-12-21 | Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors |
DE69928697T DE69928697T2 (en) | 1999-01-13 | 1999-12-21 | Sulphohydroxamic acid and sulphohydroxamates and their use as inhibitors of MEK inhibition |
US09/889,101 US6455582B1 (en) | 1999-01-13 | 1999-12-21 | Sulohydroxamic acids and sulohyroxamates and their use as MEK inhibitors |
AT99968151T ATE311363T1 (en) | 1999-01-13 | 1999-12-21 | SULFOHYDROXAMIC ACID AND SULFOHYDROXAMATE AND THEIR USE AS MEK INHIBITORS |
CA002349467A CA2349467A1 (en) | 1999-01-13 | 1999-12-21 | Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors |
BR9916894-4A BR9916894A (en) | 1999-01-13 | 1999-12-21 | sulfohydroxamic acids and sulfohydroxamates and their use as mek inhibitors |
AU24828/00A AU2482800A (en) | 1999-01-13 | 1999-12-21 | Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11565299P | 1999-01-13 | 1999-01-13 | |
US60/115,652 | 1999-01-13 | ||
US12241799P | 1999-03-02 | 1999-03-02 | |
US60/122,417 | 1999-03-02 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/889,101 A-371-Of-International US6455582B1 (en) | 1999-01-13 | 1999-12-21 | Sulohydroxamic acids and sulohyroxamates and their use as MEK inhibitors |
US10/244,915 Division US6835749B2 (en) | 1999-01-13 | 2002-09-13 | Sulfohydroxamic acids and sulfohydroxamates and their use as MEK inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000042002A1 true WO2000042002A1 (en) | 2000-07-20 |
Family
ID=26813429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/030417 WO2000042002A1 (en) | 1999-01-13 | 1999-12-21 | Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors |
Country Status (10)
Country | Link |
---|---|
US (2) | US6455582B1 (en) |
EP (1) | EP1144372B1 (en) |
JP (1) | JP2002534497A (en) |
AT (1) | ATE311363T1 (en) |
AU (1) | AU2482800A (en) |
BR (1) | BR9916894A (en) |
CA (1) | CA2349467A1 (en) |
DE (1) | DE69928697T2 (en) |
ES (1) | ES2251851T3 (en) |
WO (1) | WO2000042002A1 (en) |
Cited By (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001005393A2 (en) * | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
WO2001068619A1 (en) * | 2000-03-15 | 2001-09-20 | Warner-Lambert Company | 5-amide substituted diarylamines as mex inhibitors |
WO2002076496A1 (en) * | 2001-03-22 | 2002-10-03 | Van Andel Institute | Anthrax lethal factor inhibits tumor growth and angiogenesis |
US7001905B2 (en) | 2000-03-15 | 2006-02-21 | Warner-Lambert Company | Substituted diarylamines as MEK inhibitors |
US7060856B2 (en) | 2003-10-21 | 2006-06-13 | Warner-Lambert Company | Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
WO2007049820A1 (en) | 2005-10-28 | 2007-05-03 | Takeda Pharmaceutical Company Limited | Heterocyclic amide compound and use thereof |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
WO2007132867A1 (en) | 2006-05-15 | 2007-11-22 | Takeda Pharmaceutical Company Limited | Prophylactic and therapeutic agent for cancer |
US7425637B2 (en) | 2002-03-13 | 2008-09-16 | Array Biopharma Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7485643B2 (en) | 2003-11-19 | 2009-02-03 | Array Biopharma Inc. | Bicyclic inhibitors of MEK and methods of use thereof |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
US7612035B2 (en) | 2000-09-01 | 2009-11-03 | Van Andel Research Institute | Inhibition of mitogen-activated protein kinase (MAPK) pathway: a selective therapeutic strategy against melanoma |
WO2010051933A2 (en) | 2008-11-10 | 2010-05-14 | Bayer Schering Pharma Aktiengesellschaft | Substituted sulphonamido phenoxybenzamides |
WO2010068738A1 (en) | 2008-12-10 | 2010-06-17 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
WO2011047796A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Substituted halophenoxybenzamide derivatives |
WO2011047795A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Substituted benzosulphonamides |
WO2011047788A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Substituted benzosulphonamides |
US7956191B2 (en) | 2004-10-20 | 2011-06-07 | Merck Serono Sa | 3-arylamino pyridine derivatives |
US8003651B2 (en) | 2006-07-06 | 2011-08-23 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
EP2361905A1 (en) | 2005-05-18 | 2011-08-31 | Array Biopharma Inc. | Heterocyclic Inhibitors of MEK and methods of use thereof |
WO2011106298A1 (en) | 2010-02-25 | 2011-09-01 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8101611B2 (en) | 2003-11-19 | 2012-01-24 | Array Biopharma Inc. | Substituted pyridazines inhibitors of MEK |
WO2012055953A1 (en) | 2010-10-29 | 2012-05-03 | Bayer Pharma Aktiengesellschaft | Substituted phenoxypyridines |
WO2012160130A1 (en) | 2011-05-25 | 2012-11-29 | Universite Paris Descartes | Erk inhibitors for use in treating spinal muscular atrophy |
US8329701B2 (en) | 2006-07-06 | 2012-12-11 | Array Biopharma Inc. | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
US8377937B2 (en) | 2007-07-05 | 2013-02-19 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8404725B2 (en) | 2008-08-04 | 2013-03-26 | Merck Patent Gmbh | Phenylamino isonicotinamide compounds |
WO2013107283A1 (en) | 2012-01-17 | 2013-07-25 | Tianjin Binjiang Pharma, Inc. | Benzoheterocyclic compounds and use thereof |
WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
US8618097B2 (en) | 2007-07-05 | 2013-12-31 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8680114B2 (en) | 2003-11-21 | 2014-03-25 | Array Biopharma, Inc. | AKT protein kinase inhibitors |
US8835434B2 (en) | 2008-01-09 | 2014-09-16 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
US8853216B2 (en) | 2008-01-09 | 2014-10-07 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
WO2015038704A1 (en) | 2013-09-11 | 2015-03-19 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Compositions for preparing cardiomyocytes |
US9150549B2 (en) | 2011-04-01 | 2015-10-06 | Genentech, Inc. | Combinations of AKT inhibitor compounds and erlotinib, and methods of use |
US9303040B2 (en) | 2006-07-06 | 2016-04-05 | Array Biopharma Inc. | Substituted piperazines as AKT inhibitors |
WO2016057367A1 (en) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US9682082B2 (en) | 2011-04-01 | 2017-06-20 | Genentech, Inc. | Combinations of AKT and MEK inhibitor compounds, and methods of use |
WO2020188015A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2021009568A1 (en) * | 2019-07-17 | 2021-01-21 | 2692372 Ontario, Inc. | Benzenesulfonamide derivatives and uses thereof |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
US11078540B2 (en) | 2010-03-09 | 2021-08-03 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
EP3936121A1 (en) | 2015-03-31 | 2022-01-12 | The General Hospital Corporation | Self assembling molecules for targeted drug delivery |
WO2022106897A3 (en) * | 2020-11-20 | 2022-06-30 | 2692372 Ontario, Inc. | Methods and composition for kras modifications |
WO2023168203A1 (en) | 2022-03-04 | 2023-09-07 | Kinnate Biopharma Inc. | Inhibitors of mek kinase |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2482800A (en) * | 1999-01-13 | 2000-08-01 | Warner-Lambert Company | Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors |
EP1699477A2 (en) * | 2003-12-11 | 2006-09-13 | Theravance, Inc. | Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
AU2007227457B2 (en) * | 2006-03-17 | 2013-03-28 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
JP5116245B2 (en) * | 2006-03-24 | 2013-01-09 | 地方独立行政法人 東京都立産業技術研究センター | Calibration curve compound for use in automated analyzers |
US20190008859A1 (en) | 2015-08-21 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5525625A (en) * | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
WO1998037881A1 (en) * | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999001426A1 (en) | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors |
US6310060B1 (en) | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
NL1007364C2 (en) | 1997-10-27 | 1999-04-28 | M Van Den Brand Beheer En Bele | A method for supplying at least two fluids to a mixing chamber, as well as such a device. |
AU2482800A (en) * | 1999-01-13 | 2000-08-01 | Warner-Lambert Company | Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors |
-
1999
- 1999-12-21 AU AU24828/00A patent/AU2482800A/en not_active Abandoned
- 1999-12-21 AT AT99968151T patent/ATE311363T1/en not_active IP Right Cessation
- 1999-12-21 US US09/889,101 patent/US6455582B1/en not_active Expired - Fee Related
- 1999-12-21 CA CA002349467A patent/CA2349467A1/en not_active Abandoned
- 1999-12-21 JP JP2000593570A patent/JP2002534497A/en active Pending
- 1999-12-21 WO PCT/US1999/030417 patent/WO2000042002A1/en active IP Right Grant
- 1999-12-21 BR BR9916894-4A patent/BR9916894A/en not_active IP Right Cessation
- 1999-12-21 EP EP99968151A patent/EP1144372B1/en not_active Expired - Lifetime
- 1999-12-21 DE DE69928697T patent/DE69928697T2/en not_active Expired - Fee Related
- 1999-12-21 ES ES99968151T patent/ES2251851T3/en not_active Expired - Lifetime
-
2002
- 2002-09-13 US US10/244,915 patent/US6835749B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5525625A (en) * | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
WO1998037881A1 (en) * | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
Cited By (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001005393A2 (en) * | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
WO2001005393A3 (en) * | 1999-07-16 | 2001-05-10 | Warner Lambert Co | Method for treating chronic pain using mek inhibitors |
WO2001068619A1 (en) * | 2000-03-15 | 2001-09-20 | Warner-Lambert Company | 5-amide substituted diarylamines as mex inhibitors |
US7001905B2 (en) | 2000-03-15 | 2006-02-21 | Warner-Lambert Company | Substituted diarylamines as MEK inhibitors |
US7612035B2 (en) | 2000-09-01 | 2009-11-03 | Van Andel Research Institute | Inhibition of mitogen-activated protein kinase (MAPK) pathway: a selective therapeutic strategy against melanoma |
WO2002076496A1 (en) * | 2001-03-22 | 2002-10-03 | Van Andel Institute | Anthrax lethal factor inhibits tumor growth and angiogenesis |
AU2002255852B2 (en) * | 2001-03-22 | 2006-11-09 | Van Andel Research Institute | Anthrax lethal factor inhibits tumor growth and angiogenesis |
US7425637B2 (en) | 2002-03-13 | 2008-09-16 | Array Biopharma Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
EP2130537A1 (en) | 2002-03-13 | 2009-12-09 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as mek inhibitors |
US8513293B2 (en) | 2002-03-13 | 2013-08-20 | Array Biopharma Inc. | Methods of treating a hyperproliferative disorder or inhibiting cell growth in a mammal |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US8193231B2 (en) | 2002-03-13 | 2012-06-05 | Array Biopharma Inc. | Compositions comprising N3 alkylated benzimidazole derivatives as MEK inhibitors and methods of use thereof |
EP2275102A1 (en) | 2002-03-13 | 2011-01-19 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US8193230B2 (en) | 2002-03-13 | 2012-06-05 | Array Biopharma Inc. | Compositions comprising N3 alkylated benzimidazole derivatives as MEK inhibitors and methods of use thereof |
US7973170B2 (en) | 2002-03-13 | 2011-07-05 | Array Biopharma Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US8178693B2 (en) | 2002-03-13 | 2012-05-15 | Array Biopharma Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
EP3000810A1 (en) | 2002-03-13 | 2016-03-30 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivative as mek inhibitor |
EP2130536A1 (en) | 2002-03-13 | 2009-12-09 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as mek inhibitors |
US8003805B2 (en) | 2002-03-13 | 2011-08-23 | Array Biopharma Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US8193229B2 (en) | 2002-03-13 | 2012-06-05 | Array Biopharma Inc. | Method of treatment using N3 alkylated benzimidazole derivatives as MEK inhibitors |
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ES2251851T3 (en) | 2006-05-01 |
EP1144372B1 (en) | 2005-11-30 |
ATE311363T1 (en) | 2005-12-15 |
EP1144372A1 (en) | 2001-10-17 |
US20030045521A1 (en) | 2003-03-06 |
US6835749B2 (en) | 2004-12-28 |
DE69928697T2 (en) | 2006-06-22 |
BR9916894A (en) | 2001-11-20 |
AU2482800A (en) | 2000-08-01 |
CA2349467A1 (en) | 2000-07-20 |
JP2002534497A (en) | 2002-10-15 |
DE69928697D1 (en) | 2006-01-05 |
US6455582B1 (en) | 2002-09-24 |
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