WO2000041768A8 - Patient portable device for photodynamic therapy - Google Patents

Patient portable device for photodynamic therapy

Info

Publication number
WO2000041768A8
WO2000041768A8 PCT/US2000/000805 US0000805W WO0041768A8 WO 2000041768 A8 WO2000041768 A8 WO 2000041768A8 US 0000805 W US0000805 W US 0000805W WO 0041768 A8 WO0041768 A8 WO 0041768A8
Authority
WO
WIPO (PCT)
Prior art keywords
optical fiber
patient
light source
light
distal portion
Prior art date
Application number
PCT/US2000/000805
Other languages
French (fr)
Other versions
WO2000041768A1 (en
Inventor
James Chen
Brian Wilkerson
Dave Brown
Darrin Huston
Mike Mcquade
Original Assignee
Light Sciences Ltd
James Chen
Brian Wilkerson
Dave Brown
Darrin Huston
Mike Mcquade
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Light Sciences Ltd, James Chen, Brian Wilkerson, Dave Brown, Darrin Huston, Mike Mcquade filed Critical Light Sciences Ltd
Priority to AU27252/00A priority Critical patent/AU2725200A/en
Priority to DE60038436T priority patent/DE60038436T2/en
Priority to JP2000593376A priority patent/JP4358447B2/en
Priority to CA2356478A priority patent/CA2356478C/en
Priority to EP00905599A priority patent/EP1144049B1/en
Publication of WO2000041768A1 publication Critical patent/WO2000041768A1/en
Publication of WO2000041768A8 publication Critical patent/WO2000041768A8/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2005Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser with beam delivery through an interstitially insertable device, e.g. needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B2018/2255Optical elements at the distal end of probe tips
    • A61B2018/2261Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0635Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645Applicators worn by the patient

Abstract

A patient portable photodynamic therapy device securable to a patient includes a lightweight rechargeable battery and a light source, such as an LED or a cold cathode fluorescent (CCF) tube powered thereby. The light source is coupled in light channeling relation to a proximal portion of a biocompatible optical fiber, which includes a distal portion with an optional diffuser that uniformly distributes light as it exits the distal portion. The light channeling between the light source and an optical fiber may be accomplished through any number of lens, including a totally internally reflective (TIR) lens. The distal end of the optical fiber is optionally provided with an anchoring balloon that can be inflated after the optical fiber is properly positioned at a treatment site within a patient's body. The balloon securely lodges the distal portion within the tissue at the treatment site, and is deflated to facilitate the removal of the optical fiber once the treatment is complete.
PCT/US2000/000805 1999-01-15 2000-01-14 Patient portable device for photodynamic therapy WO2000041768A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU27252/00A AU2725200A (en) 1999-01-15 2000-01-14 Patient portable device for photodynamic therapy
DE60038436T DE60038436T2 (en) 1999-01-15 2000-01-14 PATIENT PORTABLE DEVICE FOR PHOTODYNAMIC THERAPY
JP2000593376A JP4358447B2 (en) 1999-01-15 2000-01-14 Portable device for patients with photodynamic therapy
CA2356478A CA2356478C (en) 1999-01-15 2000-01-14 Patient portable device for photodynamic therapy
EP00905599A EP1144049B1 (en) 1999-01-15 2000-01-14 Patient portable device for photodynamic therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/232,129 US6454789B1 (en) 1999-01-15 1999-01-15 Patient portable device for photodynamic therapy
US09/232,129 1999-01-15

Publications (2)

Publication Number Publication Date
WO2000041768A1 WO2000041768A1 (en) 2000-07-20
WO2000041768A8 true WO2000041768A8 (en) 2001-04-05

Family

ID=22871981

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000805 WO2000041768A1 (en) 1999-01-15 2000-01-14 Patient portable device for photodynamic therapy

Country Status (9)

Country Link
US (2) US6454789B1 (en)
EP (1) EP1144049B1 (en)
JP (1) JP4358447B2 (en)
AT (1) ATE390172T1 (en)
AU (1) AU2725200A (en)
CA (1) CA2356478C (en)
DE (1) DE60038436T2 (en)
ES (1) ES2302687T3 (en)
WO (1) WO2000041768A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572643B2 (en) 1998-01-20 2017-02-21 Kerr Corporation Apparatus and method for curing materials with radiation

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2329756A (en) 1997-09-25 1999-03-31 Univ Bristol Assemblies of light emitting diodes
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
EP1131099A2 (en) 1999-01-15 2001-09-12 Light Sciences Corporation Noninvasive vascular therapy
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US7166719B2 (en) 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US20050073839A1 (en) * 2003-09-18 2005-04-07 The Litebook Company Ltd Light therapy device
CA2317319A1 (en) 2000-03-14 2001-09-14 The Litebook Company Ltd Light therapy device
SE0003673D0 (en) * 2000-10-10 2000-10-10 Medeikonos Ab Radiation device for photodynamic therapy
US20020087206A1 (en) * 2000-12-28 2002-07-04 Henry Hirschberg Implantable intracranial photo applicator for long term fractionated photodynamic and radiation therapy in the brain and method of using the same
US7101384B2 (en) * 2001-03-08 2006-09-05 Tru-Light Corporation Light processing of selected body components
US20050004632A1 (en) * 2001-03-08 2005-01-06 Mellen-Thomas Benedict Universal light processing for a human body
US7316769B2 (en) * 2001-03-19 2008-01-08 Cornell Research Foundation, Inc. Length-dependent recoil separation of long molecules
US7303578B2 (en) 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
US20030130624A1 (en) * 2002-01-07 2003-07-10 Kowalik Francis C. Medical infusion system with integrated power supply and pump therefor
KR101047246B1 (en) 2002-07-25 2011-07-06 조나단 에스. 담 Method and apparatus for using curing LED
US7182597B2 (en) 2002-08-08 2007-02-27 Kerr Corporation Curing light instrument
WO2004038759A2 (en) 2002-08-23 2004-05-06 Dahm Jonathan S Method and apparatus for using light emitting diodes
US20040093056A1 (en) 2002-10-26 2004-05-13 Johnson Lianw M. Medical appliance delivery apparatus and method of use
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
CN2885311Y (en) * 2006-01-18 2007-04-04 郑成福 Via urethra prostate therapeutic equipment using photodynamic therapy
US20080269846A1 (en) * 2003-03-14 2008-10-30 Light Sciences Oncology, Inc. Device for treatment of blood vessels using light
US10376711B2 (en) 2003-03-14 2019-08-13 Light Sciences Oncology Inc. Light generating guide wire for intravascular use
US7637934B2 (en) * 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
US7604660B2 (en) 2003-05-01 2009-10-20 Merit Medical Systems, Inc. Bifurcated medical appliance delivery apparatus and method
US10252079B2 (en) * 2003-06-06 2019-04-09 Koninklijke Philips N.V. Hand-held light therapy apparatus
US6974224B2 (en) * 2003-07-30 2005-12-13 Tru-Light Corporation Modularized light processing of body components
US20060095102A1 (en) * 2003-09-17 2006-05-04 Thomas Perez Method and apparatus for sublingual application of light to blood
US7052167B2 (en) * 2004-02-25 2006-05-30 Vanderschuit Carl R Therapeutic devices and methods for applying therapy
US8257416B2 (en) * 2004-02-25 2012-09-04 Vanderschuit Carl R Therapeutic devices and methods for applying therapy
US7862594B2 (en) * 2004-02-27 2011-01-04 Custom Spine, Inc. Polyaxial pedicle screw assembly
MXPA06014522A (en) * 2004-06-15 2007-03-23 Henkel Corp High power led electro-optic assembly.
US20060004281A1 (en) * 2004-06-30 2006-01-05 Michael Saracen Vest-based respiration monitoring system
WO2006049703A1 (en) * 2004-10-28 2006-05-11 Henkel Corporation Led assembly with led-reflector interconnect
US20060095100A1 (en) * 2004-10-29 2006-05-04 Kian Shin Lee Method and apparatus for regulating light administered at a patient treatment site
US8109981B2 (en) * 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
US20060173514A1 (en) * 2005-02-02 2006-08-03 Advanced Photodynamic Technologies, Inc. Wound treatment device for photodynamic therapy and method of using same
US20070248930A1 (en) * 2005-02-17 2007-10-25 Biolux Research Ltd. Light therapy apparatus and methods
US20060200212A1 (en) * 2005-02-17 2006-09-07 Brawn Peter R Light therapy device for treatment of bone disorders and biostimulation of bone and soft tissue
US20060206171A1 (en) * 2005-03-14 2006-09-14 Michael Gertner Devices, methods and kits for radiation treatment via a target body surface
US20060229689A1 (en) * 2005-04-08 2006-10-12 Led Technologies, Llc LED therapy device
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
US8113830B2 (en) 2005-05-27 2012-02-14 Kerr Corporation Curing light instrument
US8364412B2 (en) * 2005-07-21 2013-01-29 The Invention Science Fund I, Llc Selective resonance of chemical structures
US8386183B2 (en) * 2005-07-21 2013-02-26 The Invention Science Fund I, Llc Selective resonant reconfiguration of chemical structures
US8346484B2 (en) 2005-07-21 2013-01-01 The Invention Science Fund I, Llc Selective resonance of chemical structures
US9211332B2 (en) 2005-07-21 2015-12-15 The Invention Science Fund I, Llc Selective resonance of bodily agents
US9427465B2 (en) 2005-07-21 2016-08-30 Deep Science, Llc Selective resonance of chemical structures
US8386186B2 (en) * 2005-07-21 2013-02-26 The Invention Science Fund I, Llc Selective resonance of chemical structures
US8112233B2 (en) * 2005-07-21 2012-02-07 The Invention Science Fund I, Llc Selective resonance of chemical structures
US20070021924A1 (en) * 2005-07-21 2007-01-25 Ishikawa Muriel Y Selective resonance of chemical structures
US8195403B2 (en) * 2005-07-21 2012-06-05 The Invention Science Fund I, Llc Selective resonance of bodily agents
US20070208395A1 (en) * 2005-10-05 2007-09-06 Leclerc Norbert H Phototherapy Device and Method of Providing Phototherapy to a Body Surface
US20070219600A1 (en) * 2006-03-17 2007-09-20 Michael Gertner Devices and methods for targeted nasal phototherapy
HRP20060149B1 (en) 2006-04-19 2008-11-30 Institut "Ruđer Bošković" Intelligent sequential illuminator photodynamic therapy
WO2007130465A2 (en) * 2006-05-02 2007-11-15 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US8057464B2 (en) 2006-05-03 2011-11-15 Light Sciences Oncology, Inc. Light transmission system for photoreactive therapy
US8047686B2 (en) 2006-09-01 2011-11-01 Dahm Jonathan S Multiple light-emitting element heat pipe assembly
US8480662B2 (en) * 2007-08-22 2013-07-09 Cardiac Pacemakers, Inc. Systems and devices for photoablation
US20090088822A1 (en) * 2007-09-27 2009-04-02 Led Healing Light, Llc Therapeutic pulse laser methods and apparatus
CA2891990C (en) 2008-05-20 2022-07-26 Ralph Sebastian Dacosta Device and method for fluorescence-based imaging and monitoring
US20100118139A1 (en) * 2008-07-19 2010-05-13 Yuming Huang Portable Device to Detect the Spin of Table Tennis Ball
US7993640B2 (en) 2008-08-06 2011-08-09 Light Sciences Oncology, Inc. Enhancement of light activated therapy by immune augmentation using anti-CTLA-4 antibody
USRE49724E1 (en) * 2008-09-29 2023-11-14 Tom Kerber Device for photodynamical therapy of cancer
EP2229979A1 (en) 2009-03-18 2010-09-22 Norbert Hilty Irradiation-cooling combination for use in photodynamic therapy
US9072572B2 (en) 2009-04-02 2015-07-07 Kerr Corporation Dental light device
US9066777B2 (en) 2009-04-02 2015-06-30 Kerr Corporation Curing light device
US20110008372A1 (en) * 2009-07-08 2011-01-13 Light Sciences Oncology, Inc. Enhancement of light activated drug therapy through combination with other therapeutic agents
CN103003368B (en) 2010-03-17 2016-09-21 纳诺洛吉卡股份公司 Folic acid fluorescent material, the multi-fluorescence porous combination thing of material and the potential application thereof strengthened
US9242118B2 (en) 2010-12-08 2016-01-26 Biolux Research Ltd. Methods useful for remodeling maxillofacial bone using light therapy and a functional appliance
US9034023B2 (en) * 2011-01-24 2015-05-19 Biolitec Pharma Marketing Ltd Dynamic colorectal PDT application
JP5970475B2 (en) * 2011-01-27 2016-08-17 日東電工株式会社 Phototherapy device and method containing optionally substituted terphenyl and quaterphenyl compounds
US9687669B2 (en) 2011-11-09 2017-06-27 John Stephan Wearable light therapy apparatus
US10195379B2 (en) * 2012-03-06 2019-02-05 Koninklijke Philips N.V. Patient interface having illuminated portion
CN102715981B (en) * 2012-06-29 2014-08-20 深圳普门科技有限公司 Annular light spot obtaining device for light therapy equipment, glaucoma treatment device and method for controlling annular light spots in annular light spot obtaining device
US20150360048A1 (en) 2013-02-07 2015-12-17 Rocomp Global, Llc Electromagnetic radiation targeting devices, assemblies, systems and methods
CN105682603A (en) 2013-10-22 2016-06-15 碧奥鲁克斯研究有限公司 Intra-oral light-therapy apparatuses and methods for their use
US9949889B2 (en) 2013-11-11 2018-04-24 Joylux, Inc. At-home light-emitting diode and massage device for vaginal rejuvenation
JP6608382B2 (en) 2014-02-26 2019-11-20 ルマ セラピューティクス,インク. Ultraviolet light treatment apparatus and method
DK3171765T3 (en) 2014-07-24 2021-11-01 Univ Health Network COLLECTION AND ANALYSIS OF DATA FOR DIAGNOSTIC PURPOSES
WO2016035082A1 (en) * 2014-09-04 2016-03-10 Dr. Eyal Bressler Ltd. Assembly for photodynamic therapy
US10179085B2 (en) 2015-10-02 2019-01-15 Joylux, Inc. Light-emitting diode and massage device for delivering focused light for vaginal rejuvenation
CN109310527A (en) 2016-02-09 2019-02-05 鲁玛治疗公司 For treating psoriasic method, composition and equipment by light therapy
KR20170128934A (en) * 2016-05-16 2017-11-24 한국과학기술연구원 Optical Control System for Lower Urinary Tract Dysfunctions
US20190083809A1 (en) 2016-07-27 2019-03-21 Z2020, Llc Componentry and devices for light therapy delivery and methods related thereto
CA3031991A1 (en) 2016-07-27 2018-02-01 Z2020 Llc Componentry and devices for light therapy delivery and methods related thereto
US11638833B2 (en) 2017-08-02 2023-05-02 Multi Radiance Medical Reducing light polution in photobiomodulation therapy of a patients eye
US10744341B2 (en) 2017-08-02 2020-08-18 Multi Radiance Medical System and method for directing light into a patients eye
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
CN210004181U (en) 2018-04-26 2020-01-31 米沃奇电动工具公司 Portable lamp
USD906559S1 (en) 2018-04-26 2020-12-29 Milwaukee Electric Tool Corporation Light
US11529153B2 (en) 2020-08-21 2022-12-20 University Of Washington Vaccine generation
WO2022040258A1 (en) 2020-08-21 2022-02-24 University Of Washington Disinfection method and apparatus
US11425905B2 (en) 2020-09-02 2022-08-30 University Of Washington Antimicrobial preventive netting
WO2022103775A1 (en) 2020-11-12 2022-05-19 Singletto Inc. Microbial disinfection for personal protection equipment
USD959683S1 (en) 2021-04-30 2022-08-02 Shenzhen Yihong Lighting Co., Ltd. Red light therapy belt
US11878183B1 (en) 2021-06-14 2024-01-23 Jaals, Llc Laser therapy device and method of conducting laser therapy

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL78723C (en) 1949-07-23
BE506677A (en) 1950-10-31
NL199484A (en) 1954-08-20
JPS5384998A (en) 1976-12-29 1978-07-26 Takashi Yamamoto Cancer controlling method
US4337759A (en) 1979-10-10 1982-07-06 John M. Popovich Radiant energy concentration by optical total internal reflection
JPS57185220A (en) 1981-05-07 1982-11-15 Yakult Honsha Co Ltd Carcinostatic agent containing chlorophyll derivative as active component
US4649151A (en) 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4675338A (en) 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4693885A (en) 1984-07-18 1987-09-15 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4753958A (en) 1985-02-07 1988-06-28 University Of Cal Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins
US4693556A (en) 1985-06-04 1987-09-15 Laser Therapeutics, Inc. Apparatus for producing a spherical pattern of light and method of manufacture
ATE84036T1 (en) 1985-10-23 1993-01-15 Nihon Mediphysics Co Ltd PORPHYRIN DERIVATIVES, THEIR PRODUCTION AND USE.
US5811248A (en) 1986-03-31 1998-09-22 Charter Ventures Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
US5494793A (en) 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
US5283255A (en) 1987-01-20 1994-02-01 The University Of British Columbia Wavelength-specific cytotoxic agents
US5171749A (en) 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
US4746840A (en) * 1987-04-06 1988-05-24 Lim Kenneth S Fluorescent reflector lamp assembly
US5919217A (en) * 1987-12-08 1999-07-06 Medic-Light, Inc. Portable phototherapy unit
US4823244A (en) * 1988-01-29 1989-04-18 Niagara Medical Innovations Inc. Light source assembly
US5026367A (en) * 1988-03-18 1991-06-25 Cardiovascular Laser Systems, Inc. Laser angioplasty catheter and a method for use thereof
US5002962A (en) 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US4998930A (en) 1988-08-03 1991-03-12 Phototherapeutic Systems Intracavity laser phototherapy method
US5055446A (en) 1988-10-21 1991-10-08 University Of Cincinnati Method to improve survival of patients during sepsis by diet composition
JP2882814B2 (en) * 1989-08-24 1999-04-12 株式会社エス・エル・ティ・ジャパン Laser irradiation equipment
US5543514A (en) 1989-12-21 1996-08-06 Board Of Regents, The University Of Texas System Water-soluble sapphyrins
US5594136A (en) 1989-12-21 1997-01-14 Pharmacyclics, Inc. Texaphyrin solid supports and devices
JPH10511005A (en) 1990-01-08 1998-10-27 ヘルス リサーチ インコーポレイテッド Submersible lens fiber optic assembly
SE465953B (en) * 1990-04-09 1991-11-25 Morgan Gustafsson DEVICE FOR TREATMENT OF UNDESECTED EXTERNAL ACCOMMODATIONS
US5484778C1 (en) 1990-07-17 2001-05-08 Univ Cleveland Hospitals Phthalocynine photosensitizers for photodynamic therapy and methods for their use
US5169395A (en) * 1991-04-26 1992-12-08 Pdt Cardiovascular, Inc. Laser delivery system
US5769844A (en) 1991-06-26 1998-06-23 Ghaffari; Shahriar Conventional light-pumped high power system for medical applications
US5263925A (en) * 1991-07-22 1993-11-23 Gilmore Jr Thomas F Photopheresis blood treatment
IL100545A (en) 1991-12-29 1995-03-15 Dimotech Ltd Apparatus for photodynamic therapy treatment
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5660827A (en) 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
CA2452130A1 (en) 1992-03-05 1993-09-16 Francis J. Burrows Methods and compositions for targeting the vasculature of solid tumors
US5474765A (en) 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5676453A (en) 1992-04-16 1997-10-14 Tir Technologies, Inc. Collimating TIR lens devices employing fluorescent light sources
US5613769A (en) 1992-04-16 1997-03-25 Tir Technologies, Inc. Tir lens apparatus having non-circular configuration about an optical axis
US5655832A (en) 1992-04-16 1997-08-12 Tir Technologies, Inc. Multiple wavelength light processor
US5404869A (en) 1992-04-16 1995-04-11 Tir Technologies, Inc. Faceted totally internally reflecting lens with individually curved faces on facets
US5806955A (en) 1992-04-16 1998-09-15 Tir Technologies, Inc. TIR lens for waveguide injection
US5807881A (en) 1992-05-27 1998-09-15 Quadra Logic Technologies, Inc. Method for selectively reducing activated leukocyte cell population
US5608060A (en) 1992-06-09 1997-03-04 Neorx Corporation Biotinidase-resistant biotin-DOTA conjugates
ES2160600T3 (en) 1992-09-21 2001-11-16 Quadra Logic Tech Inc TRANSCUTANEOUS ACTIVATION IN VIVO OF PHOTOSENSIBLE AGENTS IN THE BLOOD.
GB2272278B (en) * 1992-10-23 1997-04-09 Cancer Res Campaign Tech Light source
US5700243A (en) 1992-10-30 1997-12-23 Pdt Systems, Inc. Balloon perfusion catheter
AU679016B2 (en) 1992-11-20 1997-06-19 University Of British Columbia, The Method of activating photosensitive agents
US5491765A (en) * 1992-12-08 1996-02-13 Olympus Optical Co., Ltd. Light source devices for endoscopes
US5482698A (en) 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
US5445608A (en) * 1993-08-16 1995-08-29 James C. Chen Method and apparatus for providing light-activated therapy
US5420768A (en) 1993-09-13 1995-05-30 Kennedy; John Portable led photocuring device
US5514669A (en) * 1993-09-29 1996-05-07 Medical College Of Ohio Use of photodynamic therapy to treat prostatic tissue
US5454794A (en) * 1993-10-15 1995-10-03 Pdt Systems, Inc. Steerable light diffusing catheter
US5913834A (en) * 1993-11-04 1999-06-22 Francais; Caramia System for imparting sensory effects across a mother's abdomen to a fetus and monitoring effects on the fetus
IL108918A (en) * 1994-03-10 1997-04-15 Medic Lightech Ltd Apparatus for efficient photodynamic treatment
US5798349A (en) 1994-03-14 1998-08-25 The General Hospital Corporation Use of green porphyrins to treat neovasculature in the eye
US5851225A (en) 1994-03-18 1998-12-22 Spectra Science Corporation Photoemitting catheters and other structures suitable for use in photo-dynamic therapy and other applications
US5616140A (en) * 1994-03-21 1997-04-01 Prescott; Marvin Method and apparatus for therapeutic laser treatment
US5989245A (en) * 1994-03-21 1999-11-23 Prescott; Marvin A. Method and apparatus for therapeutic laser treatment
US5474528A (en) 1994-03-21 1995-12-12 Dusa Pharmaceuticals, Inc. Combination controller and patch for the photodynamic therapy of dermal lesion
US5456661A (en) * 1994-03-31 1995-10-10 Pdt Cardiovascular Catheter with thermally stable balloon
US5519534A (en) 1994-05-25 1996-05-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane
US5685308A (en) 1994-08-05 1997-11-11 Acuson Corporation Method and apparatus for receive beamformer system
US5698866A (en) 1994-09-19 1997-12-16 Pdt Systems, Inc. Uniform illuminator for phototherapy
DE69519384T2 (en) 1994-09-29 2001-05-23 British Telecomm Optical fiber with quantum dots
US5591855A (en) 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
WO1996014206A1 (en) 1994-11-08 1996-05-17 Spectra Science Corporation Semiconductor nanocrystal display materials and display apparatus employing same
US5746494A (en) * 1994-11-22 1998-05-05 Asahi Kogaku Kogyo Kabushiki Kaisha Illuminating apparatus of endoscope
US5745882A (en) 1995-01-09 1998-04-28 Us West Marketing Resources Group, Inc. Electronic classified advertising interface method and instructions with continuous search notification
US5882328A (en) 1995-01-13 1999-03-16 Qlt Phototherapeutics, Inc. Method to prevent transplant rejection
US5643334A (en) 1995-02-07 1997-07-01 Esc Medical Systems Ltd. Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment
NL9500495A (en) 1995-03-13 1996-10-01 Cordis Europ Balloon catheter with a single lumen and assembly of such a catheter and a light guide.
US5576013A (en) 1995-03-21 1996-11-19 Eastern Virginia Medical School Treating vascular and neoplastic tissues
US5686113A (en) 1995-03-21 1997-11-11 Temple University Of The Commonwealth System Of Higher Education Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses
FR2732094A1 (en) * 1995-03-22 1996-09-27 Philips Eclairage LIGHT GENERATOR FOR OPTICAL FIBERS
US5735817A (en) * 1995-05-19 1998-04-07 Shantha; T. R. Apparatus for transsphenoidal stimulation of the pituitary gland and adjoining brain structures
US5571152A (en) 1995-05-26 1996-11-05 Light Sciences Limited Partnership Microminiature illuminator for administering photodynamic therapy
US5703896A (en) 1995-06-07 1997-12-30 The Regents Of The University Of Colorado Silicon quantum dot laser
JPH0947518A (en) * 1995-06-26 1997-02-18 Lederle Japan Ltd Optical fiber laser probe for photodynamic therapy
EP0862432A4 (en) 1995-09-06 2003-03-19 Univ New York State Res Found Two-photon upconverting dyes and applications
US5776175A (en) * 1995-09-29 1998-07-07 Esc Medical Systems Ltd. Method and apparatus for treatment of cancer using pulsed electromagnetic radiation
DE29517716U1 (en) * 1995-11-08 1996-01-25 Waldmann Gmbh & Co Herbert Device for photodynamic radiation
US5952329A (en) * 1996-01-23 1999-09-14 The General Hospital Corporation Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors
US5835648A (en) * 1996-03-07 1998-11-10 Miravant Systems, Inc. Surface illuminator for photodynamic therapy
US5800478A (en) 1996-03-07 1998-09-01 Light Sciences Limited Partnership Flexible microcircuits for internal light therapy
US5770730A (en) 1996-03-08 1998-06-23 Health Research, Inc. Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
NZ331977A (en) 1996-03-26 2000-07-28 Pharmacyclics Inc Texaphyrin in photodynamic therapy of pigment-related lesions
US6135620A (en) * 1996-04-10 2000-10-24 Re-Energy, Inc. CCFL illuminated device
US5797868A (en) * 1996-07-25 1998-08-25 Cordis Corporation Photodynamic therapy balloon catheter
US5709653A (en) 1996-07-25 1998-01-20 Cordis Corporation Photodynamic therapy balloon catheter with microporous membrane
US5814008A (en) 1996-07-29 1998-09-29 Light Sciences Limited Partnership Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy
WO1998006456A1 (en) 1996-08-08 1998-02-19 Light Sciences Limited Partnership Method and apparatus to treat gingival and periodontal disease
US5904147A (en) * 1996-08-16 1999-05-18 University Of Massachusetts Intravascular catheter and method of controlling hemorrhage during minimally invasive surgery
US5715837A (en) 1996-08-29 1998-02-10 Light Sciences Limited Partnership Transcutaneous electromagnetic energy transfer
US5849027A (en) 1996-09-04 1998-12-15 Mbg Technologies, Inc. Photodynamic therapy method and apparatus
US5702432A (en) 1996-10-03 1997-12-30 Light Sciences Limited Partnership Intracorporeal light treatment of blood
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US5741316A (en) 1996-12-02 1998-04-21 Light Sciences Limited Partnership Electromagnetic coil configurations for power transmission through tissue
US6080160A (en) 1996-12-04 2000-06-27 Light Sciences Limited Partnership Use of shape memory alloy for internally fixing light emitting device at treatment site
US6021347A (en) * 1996-12-05 2000-02-01 Herbst; Ewa Electrochemical treatment of malignant tumors
US5997569A (en) 1997-01-29 1999-12-07 Light Sciences Limited Partnership Flexible and adjustable grid for medical therapy
US5876427A (en) 1997-01-29 1999-03-02 Light Sciences Limited Partnership Compact flexible circuit configuration
US5782896A (en) 1997-01-29 1998-07-21 Light Sciences Limited Partnership Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe
US5746495A (en) * 1997-02-05 1998-05-05 Klamm; Thomas L. Portable work light with optical fiber adapter
US5824657A (en) 1997-03-18 1998-10-20 Cubist Pharmaceuticals, Inc. Aminoacyl sulfamides for the treatment of hyperproliferative disorders
US5817048A (en) 1997-03-20 1998-10-06 Brown University Research Foundation Ultrasonic alternative to laser-based photodynamic therapy
US5827186A (en) 1997-04-11 1998-10-27 Light Sciences Limited Partnership Method and PDT probe for minimizing CT and MRI image artifacts
US5957960A (en) 1997-05-05 1999-09-28 Light Sciences Limited Partnership Internal two photon excitation device for delivery of PDT to diffuse abnormal cells
JP2002508753A (en) 1997-05-20 2002-03-19 エール ユニバーシティ Drug dependent treatment using opiate antagonists and serotonin compounds
US6100893A (en) * 1997-05-23 2000-08-08 Light Sciences Limited Partnership Constructing solid models using implicit functions defining connectivity relationships among layers of an object to be modeled
US5757557A (en) 1997-06-09 1998-05-26 Tir Technologies, Inc. Beam-forming lens with internal cavity that prevents front losses
US5921244A (en) 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
SE9702272L (en) 1997-06-13 1998-12-14 Ericsson Telefon Ab L M Device in a radio unit
US5766222A (en) 1997-07-07 1998-06-16 Petit; Michael G. Nipple illuminator for photodynamic therapy
US6048359A (en) * 1997-08-25 2000-04-11 Advanced Photodynamic Technologies, Inc. Spatial orientation and light sources and method of using same for medical diagnosis and photodynamic therapy
US6138681A (en) 1997-10-13 2000-10-31 Light Sciences Limited Partnership Alignment of external medical device relative to implanted medical device
US5865840A (en) 1997-10-22 1999-02-02 Light Sciences Limited Partnership Enhancement of light activation effect by immune augmentation
US6071944A (en) * 1997-11-12 2000-06-06 Bowling Green State University Method of treatment of pigmented cancer cells utilizing photodynamic therapy
US6331744B1 (en) 1998-02-10 2001-12-18 Light Sciences Corporation Contactless energy transfer apparatus
US6281611B1 (en) * 1998-02-10 2001-08-28 Light Sciences Corporation Use of moving element to produce heat
US5945762A (en) 1998-02-10 1999-08-31 Light Sciences Limited Partnership Movable magnet transmitter for inducing electrical current in an implanted coil
US5997842A (en) 1998-04-13 1999-12-07 Light Sciences Limited Partnership Radionuclide excited phosphorescent material for administering PDT
AU3969099A (en) 1998-05-13 1999-11-29 Light Sciences Limited Partnership Controlled activation of targeted radionuclides
US6416531B2 (en) 1998-06-24 2002-07-09 Light Sciences Corporation Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy
US6096066A (en) 1998-09-11 2000-08-01 Light Sciences Limited Partnership Conformal patch for administering light therapy to subcutaneous tumors
US6429936B1 (en) * 1998-11-06 2002-08-06 C&L Instruments Synchronous multiwavelength fluorescence system
US20010049502A1 (en) 1998-11-25 2001-12-06 Light Sciences Corporation Guide sheath for repeated placement of a device
US6344050B1 (en) * 1998-12-21 2002-02-05 Light Sciences Corporation Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue
JP2002534483A (en) 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション Therapeutic compositions for metabolic bone disorders or bone metastases
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
EP1131099A2 (en) 1999-01-15 2001-09-12 Light Sciences Corporation Noninvasive vascular therapy
US6273904B1 (en) 1999-03-02 2001-08-14 Light Sciences Corporation Polymer battery for internal light device
US6210425B1 (en) 1999-07-08 2001-04-03 Light Sciences Corporation Combined imaging and PDT delivery system
US6238426B1 (en) 1999-07-19 2001-05-29 Light Sciences Corporation Real-time monitoring of photodynamic therapy over an extended time
US20030114434A1 (en) 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US6319273B1 (en) 1999-12-16 2001-11-20 Light Sciences Corporation Illuminating device for treating eye disease
US6534040B2 (en) 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
EP1267935A2 (en) 2000-01-12 2003-01-02 Light Sciences Corporation Novel treatment for eye disease
US6520669B1 (en) * 2000-06-19 2003-02-18 Light Sciences Corporation Flexible substrate mounted solid-state light sources for exterior vehicular lighting
US6580228B1 (en) * 2000-08-22 2003-06-17 Light Sciences Corporation Flexible substrate mounted solid-state light sources for use in line current lamp sockets

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572643B2 (en) 1998-01-20 2017-02-21 Kerr Corporation Apparatus and method for curing materials with radiation

Also Published As

Publication number Publication date
DE60038436T2 (en) 2009-04-23
EP1144049B1 (en) 2008-03-26
US20020198576A1 (en) 2002-12-26
ATE390172T1 (en) 2008-04-15
DE60038436D1 (en) 2008-05-08
JP4358447B2 (en) 2009-11-04
EP1144049A1 (en) 2001-10-17
CA2356478C (en) 2010-04-06
US6986782B2 (en) 2006-01-17
US6454789B1 (en) 2002-09-24
JP2002534235A (en) 2002-10-15
AU2725200A (en) 2000-08-01
CA2356478A1 (en) 2000-07-20
ES2302687T3 (en) 2008-08-01
WO2000041768A1 (en) 2000-07-20

Similar Documents

Publication Publication Date Title
WO2000041768A8 (en) Patient portable device for photodynamic therapy
US7267673B2 (en) System for treatment of acne skin condition using a narrow band light source
KR890001272B1 (en) Inserting device for illuminating light using cure
WO2006130401A3 (en) Method and apparatus for providing light to blood
CA2211243A1 (en) Photodynamic therapy balloon catheter
US4842356A (en) Light ray radiation device for use in medical treatment of the nose and throat passages
CN107249502A (en) From illuminated cheek retractor
NZ332862A (en) Balloon catheter for photoactive therapy with extended irradiation window
WO2004052238A3 (en) Phototherapy bandage
DE69434525D1 (en) Apparatus for photodynamic therapy
WO2004032755A3 (en) Treatment of spinal metastases
EP1124613A4 (en) Photodynamic therapy method and apparatus
NZ332863A (en) Balloon Catheter for photodynamic therapy
WO2002053218A3 (en) An implantable photo applicator for long term fractionated photodynamic and radiation therapy and method of using the same
TW200621325A (en) Light therapeutic device
WO2002003876A3 (en) Improved light guide for coupling light output from a light source to the skin
US20070073362A1 (en) Device for administering a treatment in a body cavity of a human
ATE492314T1 (en) INSTRUMENT FOR BONE TREATMENT
CN116251302A (en) Photodynamic therapeutic instrument probe for treating cervical cancer front lesion and photodynamic therapeutic instrument
UA40721A (en) therapeutic douche

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 29/2000 UNDER (81) ADD "AE, TZ"

WWE Wipo information: entry into national phase

Ref document number: 27252/00

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2356478

Country of ref document: CA

Ref country code: CA

Ref document number: 2356478

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 593376

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000905599

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000905599

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642