WO2000040203A3 - Polymeric delivery agents and delivery agent compounds - Google Patents

Polymeric delivery agents and delivery agent compounds Download PDF

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Publication number
WO2000040203A3
WO2000040203A3 PCT/US2000/000476 US0000476W WO0040203A3 WO 2000040203 A3 WO2000040203 A3 WO 2000040203A3 US 0000476 W US0000476 W US 0000476W WO 0040203 A3 WO0040203 A3 WO 0040203A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
agent compounds
agents
polymeric
delivery agent
Prior art date
Application number
PCT/US2000/000476
Other languages
French (fr)
Other versions
WO2000040203A2 (en
Inventor
Sam J Milstein
Eugene N Barantsevitch
Nai Fang Wang
Jun Liao
John E Smart
Richard D Conticello
Raphael M Ottenbrite
Original Assignee
Emisphere Tech Inc
Univ Virginia Commonwealth
Sam J Milstein
Eugene N Barantsevitch
Nai Fang Wang
Jun Liao
John E Smart
Richard D Conticello
Raphael M Ottenbrite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0008590-1A priority Critical patent/BR0008590A/en
Priority to EP00914419A priority patent/EP1146860A4/en
Priority to IL14396200A priority patent/IL143962A0/en
Priority to AU35813/00A priority patent/AU3581300A/en
Priority to JP2000591961A priority patent/JP2002534363A/en
Priority to US09/889,005 priority patent/US6627228B1/en
Application filed by Emisphere Tech Inc, Univ Virginia Commonwealth, Sam J Milstein, Eugene N Barantsevitch, Nai Fang Wang, Jun Liao, John E Smart, Richard D Conticello, Raphael M Ottenbrite filed Critical Emisphere Tech Inc
Priority to NZ512581A priority patent/NZ512581A/en
Priority to CA002358463A priority patent/CA2358463A1/en
Publication of WO2000040203A2 publication Critical patent/WO2000040203A2/en
Publication of WO2000040203A3 publication Critical patent/WO2000040203A3/en
Priority to US10/447,608 priority patent/US7208483B2/en
Priority to US11/669,649 priority patent/US7727558B2/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH] (Somatotropin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/30Introducing nitrogen atoms or nitrogen-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use

Abstract

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
PCT/US2000/000476 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agent compounds WO2000040203A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP00914419A EP1146860A4 (en) 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agent compounds
IL14396200A IL143962A0 (en) 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agent compounds
AU35813/00A AU3581300A (en) 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agent compounds
JP2000591961A JP2002534363A (en) 1999-01-08 2000-01-07 Polymeric delivery agent and delivery agent compound
US09/889,005 US6627228B1 (en) 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agents compounds
BR0008590-1A BR0008590A (en) 1999-01-08 2000-01-07 Polymeric delivery agent, composition, unit dosage form, method for administering a biologically active agent to an animal requiring the agent, method for preparing a composition; it's composed
NZ512581A NZ512581A (en) 1999-01-08 2000-01-07 Polymeric delivery agents comprising a polymer conjugated to a modified amino acid and derivatives thereof
CA002358463A CA2358463A1 (en) 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agent compounds
US10/447,608 US7208483B2 (en) 1999-01-08 2003-05-28 Polymeric delivery agents and delivery agent compounds
US11/669,649 US7727558B2 (en) 1999-01-08 2007-01-31 Polymeric delivery agents and delivery agent compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11527399P 1999-01-08 1999-01-08
US60/115,273 1999-01-08

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US09889005 A-371-Of-International 2000-01-07
US09/889,005 A-371-Of-International US6627228B1 (en) 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agents compounds
US10/447,608 Continuation US7208483B2 (en) 1999-01-08 2003-05-28 Polymeric delivery agents and delivery agent compounds
US10/447,608 Division US7208483B2 (en) 1999-01-08 2003-05-28 Polymeric delivery agents and delivery agent compounds

Publications (2)

Publication Number Publication Date
WO2000040203A2 WO2000040203A2 (en) 2000-07-13
WO2000040203A3 true WO2000040203A3 (en) 2000-12-14

Family

ID=22360305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/000476 WO2000040203A2 (en) 1999-01-08 2000-01-07 Polymeric delivery agents and delivery agent compounds

Country Status (11)

Country Link
US (3) US6627228B1 (en)
EP (1) EP1146860A4 (en)
JP (1) JP2002534363A (en)
CN (1) CN1338924A (en)
AU (1) AU3581300A (en)
BR (1) BR0008590A (en)
CA (1) CA2358463A1 (en)
IL (1) IL143962A0 (en)
NZ (1) NZ512581A (en)
WO (1) WO2000040203A2 (en)
ZA (1) ZA200105213B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
US9364502B2 (en) 2006-06-28 2016-06-14 Emisphere Technologies, Inc. Gallium nitrate formulations

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6344213B1 (en) 1996-03-29 2002-02-05 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6221367B1 (en) * 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US6916489B2 (en) * 1992-06-15 2005-07-12 Emisphere Technologies, Inc. Active agent transport systems
US6610329B2 (en) 1993-04-22 2003-08-26 Emisphere Technologies Inc. Compositions for the delivery of antigens
US7285526B2 (en) * 1995-07-14 2007-10-23 Meiogen Biotechnology Corporation Interferon antagonists useful for the treatment of interferon related diseases
IL140930A0 (en) * 1998-08-07 2002-02-10 Emisphere Tech Inc Compounds and compositions for delivering active agents
US6991798B1 (en) 1998-08-07 2006-01-31 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
JP2002542304A (en) * 1999-04-28 2002-12-10 ベクトレイムド インコーポレイテッド Enzymatically activated polymerized drug conjugate
DE60044827D1 (en) 1999-09-10 2010-09-23 Procter & Gamble POLYOXYALKYLENE CONJUGATES AS ENZYMINHIBITORS
US6723788B1 (en) 1999-09-10 2004-04-20 The Procter & Gamble Company Enzyme inhibitors
DE60038183T2 (en) * 1999-12-16 2009-02-19 Emisphere Technologies, Inc. COMPOUNDS AND COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
US7151191B2 (en) * 2000-01-13 2006-12-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
MXPA02012855A (en) * 2000-06-29 2004-04-20 Emisphere Tech Inc Compounds and compositions for delivering active agents.
NZ524138A (en) 2000-09-06 2004-12-24 Emisphere Tech Inc Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents
MXPA03007857A (en) 2001-03-01 2004-05-24 Emisphere Tech Inc Compounds and compositions for delivering active agents.
CN101045166A (en) 2001-05-21 2007-10-03 耐科塔医药公司 Pulmonary administration of chemically modified insulin
RU2004116692A (en) * 2001-11-02 2005-03-20 Секисуй Кемикал Ко., Лтд. (Jp) CYTOKINE INDUCING SUBSTANCE AND DEVICE FOR CYTOKINE INDUCTION
EP2272501B1 (en) 2002-01-09 2013-03-20 Emisphere Technologies, Inc. Polymorphs of sodium 4-((4-chloro-2-hydroxybenzoyl) amino) butanoate
US20050148497A1 (en) 2002-02-20 2005-07-07 Khan Mohammed A. Method for administering glp-1 molecules
JP2005524657A (en) * 2002-02-27 2005-08-18 ファーメイン, エルティーディー. Compositions for delivering therapeutic agents and other substances, and methods of making and using said compositions
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
TWI293882B (en) * 2003-03-24 2008-03-01 Sankyo Co Polymeric modifiers and pharmaceutical compositions
CN100384894C (en) * 2003-03-24 2008-04-30 三共株式会社 Higher molecular modifier and medicinal composition
CA2525399A1 (en) * 2003-05-12 2004-11-25 Affymax, Inc. Novel spacer moiety for poly(ethylene glycol)-modified peptide-based co mpounds
MXPA06001353A (en) 2003-08-08 2006-05-04 Abgenix Inc Antibodies directed to parathyroid hormone (pth) and uses thereof.
US7318925B2 (en) 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
JP4754487B2 (en) 2003-08-20 2011-08-24 エミスフィアー テクノロジーズ インコーポレイテッド Compounds, methods and formulations for oral delivery of glucagon-like peptide (GLP) -1 compounds or melanocortin 4 receptor (MC4) agonist peptides
DE602004004156T2 (en) 2003-08-20 2007-10-11 Eli Lilly And Co., Indianapolis COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL ADMINISTRATION OF A GLUCAGON LIKE PEPTIDE (GLP) -1 COMPOUNDS OR A MEPANOLORTIN-4-RECEPTOR (MC4) AS AGONIST PEPTIDES
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
JP2005209106A (en) * 2004-01-26 2005-08-04 Nec Corp Portable communication terminal, received e-mail management method, program and recording medium
JP2007532684A (en) 2004-04-16 2007-11-15 エミスフェアー・テクノロジーズ・インク 8- (2-Hydroxyphenoxy) octyldiethanolamine and its salts for delivery of active agents
BRPI0510226A (en) 2004-05-06 2007-10-23 Emisphere Tech Inc solid pharmaceutical composition, solid dosage form, method for administering heparin to an animal, method for treating or preventing thrombosis in an animal, method for preparing a wet heparin solid dosage form
WO2005117854A2 (en) 2004-05-14 2005-12-15 Emisphere Technologies, Inc. Aryl ketone compounds and compositions for delivering active agents
AU2005244904B2 (en) 2004-05-14 2011-10-13 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
RU2406504C2 (en) 2004-05-19 2010-12-20 Эмисфире Текнолоджис, Инк. Methods for preparing acyclovir formulation
JP4885856B2 (en) * 2004-05-19 2012-02-29 エミスフェアー・テクノロジーズ・インク Topical cromolyn formulation
US7906137B2 (en) * 2004-05-21 2011-03-15 Mediplex Corporation, Korea Delivery agents for enhancing mucosal absorption of therapeutic agents
US7384990B2 (en) * 2004-06-17 2008-06-10 Hewlett-Packard Development Company, L.P. Latex particulates with active ester functional groups
MX2007008082A (en) 2004-12-29 2007-09-05 Emisphere Tech Inc Pharmaceutical formulations of gallium salts.
US8110547B2 (en) 2005-01-12 2012-02-07 Emisphere Technologies, Inc. Compositions for buccal delivery of parathyroid hormone
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
WO2007011958A2 (en) 2005-07-15 2007-01-25 Emisphere Technologies, Inc. Intraoral dosage forms of glucagon
AU2006280953B2 (en) 2005-08-19 2013-01-24 Emisphere Technologies, Inc. Cyclopropyl compounds and compositions for delivering active agents
WO2007076371A2 (en) 2005-12-19 2007-07-05 Pharmain Corporation Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
ES2538254T3 (en) 2006-04-18 2015-06-18 Emisphere Technologies, Inc. Dialkyl Ether Administration Agents
US8771712B2 (en) 2006-05-09 2014-07-08 Emisphere Technologies, Inc. Topical administration of acyclovir
CN105439877B (en) * 2006-07-26 2019-07-23 于崇曦 The prodrug of positively charged water-soluble Diflunisal and related compound
WO2008014430A1 (en) 2006-07-27 2008-01-31 Emisphere Technologies, Inc. Arylsulfanyl compounds and compositions for delivering active agents
WO2008022242A2 (en) 2006-08-18 2008-02-21 Emisphere Technologies, Inc. Synthesis of propyl phenoxy ethers and use as delivery agents
JP5577094B2 (en) * 2006-08-31 2014-08-20 エミスフェアー・テクノロジーズ・インク Compounds and compositions for delivering active agents
WO2008112368A2 (en) 2007-02-08 2008-09-18 Emisphere Technologies, Inc. Phenylalkylcarboxylic acid delivery agents
EP2129218B1 (en) 2007-02-16 2016-10-19 Emisphere Technologies, Inc. Compounds having a cyclic moiety and compositions for delivering active agents
EP2136624A4 (en) 2007-03-21 2011-11-30 Emisphere Tech Inc Allylqxy and alkyloxy benzoic acid delivery agents
KR20120059645A (en) 2007-04-24 2012-06-08 닛뽕소다 가부시키가이샤 Process for producing substituted methylamine compound and triazine derⅳatⅳe
CN103641776A (en) * 2007-04-24 2014-03-19 日本曹达株式会社 Manufacturing method of N-methylene substituted methylamine polymer and triazine derivative
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
US20090176892A1 (en) * 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
US20100021538A1 (en) * 2008-02-29 2010-01-28 Youngro Byun Pharmaceutical compositions containing heparin derivatives
ITRM20080551A1 (en) * 2008-10-15 2010-04-16 Univ Catania AMPHIFYL DERIVATIVES OF POLYOSSIETHYLENE GLYCOL (PEG), PREPARATION PROCEDURE AND THEIR USE IN THE PREPARATION OF PHARMACEUTICAL SYSTEMS.
EP2461803B1 (en) 2009-08-03 2018-10-17 Emisphere Technologies, Inc. Fast-acting naproxen composition with reduced gastrointestinal effects
EP3808339A1 (en) 2012-05-03 2021-04-21 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
KR102310775B1 (en) 2012-05-03 2021-10-07 칼라 파마슈티컬스, 인크. Pharmaceutical nanoparticles showing improved mucosal transport
KR101839864B1 (en) 2012-09-21 2018-03-20 인텐시티 쎄라퓨틱스, 인코포레이티드 Method of treating cancer
WO2014127214A1 (en) 2013-02-15 2014-08-21 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
ES2831625T3 (en) 2013-02-20 2021-06-09 Kala Pharmaceuticals Inc Therapeutic compounds and their uses
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CN106061261B (en) 2013-11-01 2018-04-24 卡拉制药公司 Crystal form of therapeutic compounds and application thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9962363B2 (en) 2014-02-10 2018-05-08 Patara Pharma, LLC Mast cell stabilizers treatment for systemic disorders
SI3104854T1 (en) 2014-02-10 2020-09-30 Respivant Sciences Gmbh Mast cell stabilizers for lung disease treatment
US20200040126A1 (en) * 2015-06-17 2020-02-06 Dow Global Technologies Llc Method for controlled release of antimicrobial compounds
EP3331522A1 (en) 2015-08-07 2018-06-13 Patara Pharma LLC Methods for the treatment of mast cell related disorders with mast cell stabilizers
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
JP2019528320A (en) 2016-08-31 2019-10-10 レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh Cromolyn composition for the treatment of chronic cough due to idiopathic pulmonary fibrosis
US10253036B2 (en) 2016-09-08 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018048750A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018048746A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018067341A1 (en) 2016-10-07 2018-04-12 Patara Pharma, LLC Cromolyn compositions for treatment of pulmonary fibrosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5811127A (en) * 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3436604A (en) * 1966-04-25 1969-04-01 Texas Instruments Inc Complex integrated circuit array and method for fabricating same
ES369853A1 (en) 1969-07-24 1971-07-16 Bama S A Lab Procedure for the obtaining of derivatives of the epsilon-amino-caproico acid. (Machine-translation by Google Translate, not legally binding)
US3727064A (en) * 1971-03-17 1973-04-10 Monsanto Co Opto-isolator devices and method for the fabrication thereof
US3746934A (en) * 1971-05-06 1973-07-17 Siemens Ag Stack arrangement of semiconductor chips
DE2517229A1 (en) 1975-04-18 1976-10-28 Boehringer Mannheim Gmbh PHENYLALKYLCARBONIC ACID DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
CA1077842A (en) 1975-10-09 1980-05-20 Minnesota Mining And Manufacturing Company Albumin medicament carrier system
US4031113A (en) * 1976-03-29 1977-06-21 Morton-Norwich Products, Inc. 5-[5-(4-Chlorophenyl)-2-furanyl]dihydro-2(3H)-furanone
US4103318A (en) * 1977-05-06 1978-07-25 Ford Motor Company Electronic multichip module
NZ196349A (en) 1980-03-07 1984-08-24 Interx Research Corp Enhancement of absorption rate of orally administered polar bioactive agents
US4398235A (en) * 1980-09-11 1983-08-09 General Motors Corporation Vertical integrated circuit package integration
US4437235A (en) * 1980-12-29 1984-03-20 Honeywell Information Systems Inc. Integrated circuit package
JPS58140026A (en) 1982-01-14 1983-08-19 Toyo Jozo Co Ltd Pharmaceutical having improved absorbability
CA1188987A (en) 1981-03-06 1985-06-18 Masataka Morishita Preparation having excellent absorption property
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
US4692433A (en) 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
US4757066A (en) 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
WO1986004208A1 (en) * 1984-12-28 1986-07-17 Micro Engineering Co., Ltd. Method of stacking printed circuit boards
DE3675321D1 (en) * 1985-08-16 1990-12-06 Dai Ichi Seiko Co Ltd SEMICONDUCTOR ARRANGEMENT WITH PACK OF PIN PLUG TYPE.
US4925673A (en) 1986-08-18 1990-05-15 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
USRE35862E (en) 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
US4821007A (en) * 1987-02-06 1989-04-11 Tektronix, Inc. Strip line circuit component and method of manufacture
US4862249A (en) * 1987-04-17 1989-08-29 Xoc Devices, Inc. Packaging system for stacking integrated circuits
MX12394A (en) 1987-07-23 1993-12-01 Ciba Geigy Ag PROCEDURE FOR OBTAINING POLYETHYLENE GLYCOL CARBAMATES.
US4895725A (en) 1987-08-24 1990-01-23 Clinical Technologies Associates, Inc. Microencapsulation of fish oil
IT1214254B (en) * 1987-09-23 1990-01-10 Sgs Microelettonica S P A SEMICONDUCTOR DEVICE IN PLASTIC OR CERAMIC CONTAINER WITH "CHIPS" FIXED ON BOTH SIDES OF THE CENTRAL ISLAND OF THE "FRAME".
US5016138A (en) * 1987-10-27 1991-05-14 Woodman John K Three dimensional integrated circuit package
US4983533A (en) * 1987-10-28 1991-01-08 Irvine Sensors Corporation High-density electronic modules - process and product
US5198888A (en) * 1987-12-28 1993-03-30 Hitachi, Ltd. Semiconductor stacked device
US4833568A (en) * 1988-01-29 1989-05-23 Berhold G Mark Three-dimensional circuit component assembly and method corresponding thereto
US4891789A (en) * 1988-03-03 1990-01-02 Bull Hn Information Systems, Inc. Surface mounted multilayer memory printed circuit board
FR2636238B1 (en) 1988-09-14 1994-01-21 Morelle Jean NEW ANTISUDORAL COMPOSITIONS
US4911643A (en) * 1988-10-11 1990-03-27 Beta Phase, Inc. High density and high signal integrity connector
US4983402A (en) 1989-02-24 1991-01-08 Clinical Technologies Associates, Inc. Orally administerable ANF
US4976968A (en) 1989-02-24 1990-12-11 Clinical Technologies Associates, Inc. Anhydrous delivery systems for pharmacological agents
US4953060A (en) * 1989-05-05 1990-08-28 Ncr Corporation Stackable integrated circuit chip package with improved heat removal
US5104820A (en) * 1989-07-07 1992-04-14 Irvine Sensors Corporation Method of fabricating electronic circuitry unit containing stacked IC layers having lead rerouting
US5012323A (en) * 1989-11-20 1991-04-30 Micron Technology, Inc. Double-die semiconductor package having a back-bonded die and a face-bonded die interconnected on a single leadframe
US5041015A (en) * 1990-03-30 1991-08-20 Cal Flex, Inc. Electrical jumper assembly
AU8519891A (en) * 1990-08-01 1992-03-02 Staktek Corporation Ultra high density integrated circuit packages, method and apparatus
US5446620A (en) * 1990-08-01 1995-08-29 Staktek Corporation Ultra high density integrated circuit packages
US5499160A (en) * 1990-08-01 1996-03-12 Staktek Corporation High density integrated circuit module with snap-on rail assemblies
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5451410A (en) 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
JPH04284661A (en) * 1991-03-13 1992-10-09 Toshiba Corp Semiconductor device
US5099393A (en) * 1991-03-25 1992-03-24 International Business Machines Corporation Electronic package for high density applications
US5138430A (en) * 1991-06-06 1992-08-11 International Business Machines Corporation High performance versatile thermally enhanced IC chip mounting
JPH0513666A (en) * 1991-06-29 1993-01-22 Sony Corp Complex semiconductor device
US5311401A (en) * 1991-07-09 1994-05-10 Hughes Aircraft Company Stacked chip assembly and manufacturing method therefor
US5448450A (en) * 1991-08-15 1995-09-05 Staktek Corporation Lead-on-chip integrated circuit apparatus
US5281852A (en) * 1991-12-10 1994-01-25 Normington Peter J C Semiconductor device including stacked die
US5338837A (en) 1991-12-13 1994-08-16 The Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making same
US5241454A (en) * 1992-01-22 1993-08-31 International Business Machines Corporation Mutlilayered flexible circuit package
US5222014A (en) * 1992-03-02 1993-06-22 Motorola, Inc. Three-dimensional multi-chip pad array carrier
US5352461A (en) 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
HU211995B (en) 1992-06-30 1996-01-29 Gyogyszerkutato Intezet Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them
US5402006A (en) * 1992-11-10 1995-03-28 Texas Instruments Incorporated Semiconductor device with enhanced adhesion between heat spreader and leads and plastic mold compound
US5313097A (en) * 1992-11-16 1994-05-17 International Business Machines, Corp. High density memory module
US5583020A (en) 1992-11-24 1996-12-10 Ribozyme Pharmaceuticals, Inc. Permeability enhancers for negatively charged polynucleotides
US6205654B1 (en) * 1992-12-11 2001-03-27 Staktek Group L.P. Method of manufacturing a surface mount package
US5484959A (en) * 1992-12-11 1996-01-16 Staktek Corporation High density lead-on-package fabrication method and apparatus
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5455740A (en) * 1994-03-07 1995-10-03 Staktek Corporation Bus communication system for stacked high density integrated circuit packages
US5541812A (en) * 1995-05-22 1996-07-30 Burns; Carmen D. Bus communication system for stacked high density integrated circuit packages having an intermediate lead frame
US5644161A (en) * 1993-03-29 1997-07-01 Staktek Corporation Ultra-high density warp-resistant memory module
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
AU6819294A (en) 1993-04-22 1994-11-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5523619A (en) * 1993-11-03 1996-06-04 International Business Machines Corporation High density memory structure
US5658558A (en) * 1994-10-03 1997-08-19 Rohm And Haas Company Hair styling compositions and method of enhancing the performance of hair fixative resins
US5592364A (en) * 1995-01-24 1997-01-07 Staktek Corporation High density integrated circuit module with complex electrical interconnect rails
US5514907A (en) * 1995-03-21 1996-05-07 Simple Technology Incorporated Apparatus for stacking semiconductor chips
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (en) 1995-03-31 1998-05-19 Emisphere Tech Inc Compound composition dosage unit form methods for administering a biologically active agent for preparing a composition for administering an active agent and for preparing a compound and pharmacological composition
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5612570A (en) * 1995-04-13 1997-03-18 Dense-Pac Microsystems, Inc. Chip stack and method of making same
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
DE19516272A1 (en) * 1995-05-08 1996-11-14 Hermann Leguin Primary element scanner for determining deflection of scanning pin or similar
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US6025642A (en) * 1995-08-17 2000-02-15 Staktek Corporation Ultra high density integrated circuit packages
AU7072596A (en) 1995-09-11 1997-04-01 Emisphere Technologies, Inc. Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones
US5646446A (en) * 1995-12-22 1997-07-08 Fairchild Space And Defense Corporation Three-dimensional flexible assembly of integrated circuits
US6225688B1 (en) * 1997-12-11 2001-05-01 Tessera, Inc. Stacked microelectronic assembly and method therefor
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5773647A (en) 1997-02-07 1998-06-30 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6051561A (en) 1997-02-07 2000-04-18 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5776888A (en) 1997-02-07 1998-07-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US6208521B1 (en) * 1997-05-19 2001-03-27 Nitto Denko Corporation Film carrier and laminate type mounting structure using same
US6028352A (en) * 1997-06-13 2000-02-22 Irvine Sensors Corporation IC stack utilizing secondary leadframes
US6014316A (en) * 1997-06-13 2000-01-11 Irvine Sensors Corporation IC stack utilizing BGA contacts
US5869353A (en) * 1997-11-17 1999-02-09 Dense-Pac Microsystems, Inc. Modular panel stacking process
JPH11173269A (en) 1997-12-05 1999-06-29 Zexel:Kk Reciprocating compressor
US5926369A (en) * 1998-01-22 1999-07-20 International Business Machines Corporation Vertically integrated multi-chip circuit package with heat-sink support
US6172874B1 (en) * 1998-04-06 2001-01-09 Silicon Graphics, Inc. System for stacking of integrated circuit packages
PT1075282E (en) 1998-04-28 2005-09-30 Applied Research Systems PEG-LHRH ANALOG CONJUGATES
DE19833713C1 (en) * 1998-07-27 2000-05-04 Siemens Ag Laminate or stacked package arrangement based on at least two integrated circuits
US6294198B1 (en) * 1999-08-24 2001-09-25 Purepac Pharmaceutical Co. Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same
US6262895B1 (en) * 2000-01-13 2001-07-17 John A. Forthun Stackable chip package with flex carrier

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811127A (en) * 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
US9364502B2 (en) 2006-06-28 2016-06-14 Emisphere Technologies, Inc. Gallium nitrate formulations

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