WO2000040203A3 - Polymeric delivery agents and delivery agent compounds - Google Patents
Polymeric delivery agents and delivery agent compounds Download PDFInfo
- Publication number
- WO2000040203A3 WO2000040203A3 PCT/US2000/000476 US0000476W WO0040203A3 WO 2000040203 A3 WO2000040203 A3 WO 2000040203A3 US 0000476 W US0000476 W US 0000476W WO 0040203 A3 WO0040203 A3 WO 0040203A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- delivery
- agent compounds
- agents
- polymeric
- delivery agent
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00914419A EP1146860A4 (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents and delivery agent compounds |
IL14396200A IL143962A0 (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents and delivery agent compounds |
AU35813/00A AU3581300A (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents and delivery agent compounds |
JP2000591961A JP2002534363A (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agent and delivery agent compound |
US09/889,005 US6627228B1 (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents and delivery agents compounds |
BR0008590-1A BR0008590A (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agent, composition, unit dosage form, method for administering a biologically active agent to an animal requiring the agent, method for preparing a composition; it's composed |
NZ512581A NZ512581A (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents comprising a polymer conjugated to a modified amino acid and derivatives thereof |
CA002358463A CA2358463A1 (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents and delivery agent compounds |
US10/447,608 US7208483B2 (en) | 1999-01-08 | 2003-05-28 | Polymeric delivery agents and delivery agent compounds |
US11/669,649 US7727558B2 (en) | 1999-01-08 | 2007-01-31 | Polymeric delivery agents and delivery agent compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11527399P | 1999-01-08 | 1999-01-08 | |
US60/115,273 | 1999-01-08 |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09889005 A-371-Of-International | 2000-01-07 | ||
US09/889,005 A-371-Of-International US6627228B1 (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents and delivery agents compounds |
US10/447,608 Continuation US7208483B2 (en) | 1999-01-08 | 2003-05-28 | Polymeric delivery agents and delivery agent compounds |
US10/447,608 Division US7208483B2 (en) | 1999-01-08 | 2003-05-28 | Polymeric delivery agents and delivery agent compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000040203A2 WO2000040203A2 (en) | 2000-07-13 |
WO2000040203A3 true WO2000040203A3 (en) | 2000-12-14 |
Family
ID=22360305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/000476 WO2000040203A2 (en) | 1999-01-08 | 2000-01-07 | Polymeric delivery agents and delivery agent compounds |
Country Status (11)
Country | Link |
---|---|
US (3) | US6627228B1 (en) |
EP (1) | EP1146860A4 (en) |
JP (1) | JP2002534363A (en) |
CN (1) | CN1338924A (en) |
AU (1) | AU3581300A (en) |
BR (1) | BR0008590A (en) |
CA (1) | CA2358463A1 (en) |
IL (1) | IL143962A0 (en) |
NZ (1) | NZ512581A (en) |
WO (1) | WO2000040203A2 (en) |
ZA (1) | ZA200105213B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
US9364502B2 (en) | 2006-06-28 | 2016-06-14 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6344213B1 (en) | 1996-03-29 | 2002-02-05 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6221367B1 (en) * | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
US6916489B2 (en) * | 1992-06-15 | 2005-07-12 | Emisphere Technologies, Inc. | Active agent transport systems |
US6610329B2 (en) | 1993-04-22 | 2003-08-26 | Emisphere Technologies Inc. | Compositions for the delivery of antigens |
US7285526B2 (en) * | 1995-07-14 | 2007-10-23 | Meiogen Biotechnology Corporation | Interferon antagonists useful for the treatment of interferon related diseases |
IL140930A0 (en) * | 1998-08-07 | 2002-02-10 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
JP2002542304A (en) * | 1999-04-28 | 2002-12-10 | ベクトレイムド インコーポレイテッド | Enzymatically activated polymerized drug conjugate |
DE60044827D1 (en) | 1999-09-10 | 2010-09-23 | Procter & Gamble | POLYOXYALKYLENE CONJUGATES AS ENZYMINHIBITORS |
US6723788B1 (en) | 1999-09-10 | 2004-04-20 | The Procter & Gamble Company | Enzyme inhibitors |
DE60038183T2 (en) * | 1999-12-16 | 2009-02-19 | Emisphere Technologies, Inc. | COMPOUNDS AND COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS |
US7151191B2 (en) * | 2000-01-13 | 2006-12-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
MXPA02012855A (en) * | 2000-06-29 | 2004-04-20 | Emisphere Tech Inc | Compounds and compositions for delivering active agents. |
NZ524138A (en) | 2000-09-06 | 2004-12-24 | Emisphere Tech Inc | Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents |
MXPA03007857A (en) | 2001-03-01 | 2004-05-24 | Emisphere Tech Inc | Compounds and compositions for delivering active agents. |
CN101045166A (en) | 2001-05-21 | 2007-10-03 | 耐科塔医药公司 | Pulmonary administration of chemically modified insulin |
RU2004116692A (en) * | 2001-11-02 | 2005-03-20 | Секисуй Кемикал Ко., Лтд. (Jp) | CYTOKINE INDUCING SUBSTANCE AND DEVICE FOR CYTOKINE INDUCTION |
EP2272501B1 (en) | 2002-01-09 | 2013-03-20 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-((4-chloro-2-hydroxybenzoyl) amino) butanoate |
US20050148497A1 (en) | 2002-02-20 | 2005-07-07 | Khan Mohammed A. | Method for administering glp-1 molecules |
JP2005524657A (en) * | 2002-02-27 | 2005-08-18 | ファーメイン, エルティーディー. | Compositions for delivering therapeutic agents and other substances, and methods of making and using said compositions |
US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
US7635463B2 (en) * | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
TWI293882B (en) * | 2003-03-24 | 2008-03-01 | Sankyo Co | Polymeric modifiers and pharmaceutical compositions |
CN100384894C (en) * | 2003-03-24 | 2008-04-30 | 三共株式会社 | Higher molecular modifier and medicinal composition |
CA2525399A1 (en) * | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Novel spacer moiety for poly(ethylene glycol)-modified peptide-based co mpounds |
MXPA06001353A (en) | 2003-08-08 | 2006-05-04 | Abgenix Inc | Antibodies directed to parathyroid hormone (pth) and uses thereof. |
US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
JP4754487B2 (en) | 2003-08-20 | 2011-08-24 | エミスフィアー テクノロジーズ インコーポレイテッド | Compounds, methods and formulations for oral delivery of glucagon-like peptide (GLP) -1 compounds or melanocortin 4 receptor (MC4) agonist peptides |
DE602004004156T2 (en) | 2003-08-20 | 2007-10-11 | Eli Lilly And Co., Indianapolis | COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL ADMINISTRATION OF A GLUCAGON LIKE PEPTIDE (GLP) -1 COMPOUNDS OR A MEPANOLORTIN-4-RECEPTOR (MC4) AS AGONIST PEPTIDES |
US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
JP2005209106A (en) * | 2004-01-26 | 2005-08-04 | Nec Corp | Portable communication terminal, received e-mail management method, program and recording medium |
JP2007532684A (en) | 2004-04-16 | 2007-11-15 | エミスフェアー・テクノロジーズ・インク | 8- (2-Hydroxyphenoxy) octyldiethanolamine and its salts for delivery of active agents |
BRPI0510226A (en) | 2004-05-06 | 2007-10-23 | Emisphere Tech Inc | solid pharmaceutical composition, solid dosage form, method for administering heparin to an animal, method for treating or preventing thrombosis in an animal, method for preparing a wet heparin solid dosage form |
WO2005117854A2 (en) | 2004-05-14 | 2005-12-15 | Emisphere Technologies, Inc. | Aryl ketone compounds and compositions for delivering active agents |
AU2005244904B2 (en) | 2004-05-14 | 2011-10-13 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
RU2406504C2 (en) | 2004-05-19 | 2010-12-20 | Эмисфире Текнолоджис, Инк. | Methods for preparing acyclovir formulation |
JP4885856B2 (en) * | 2004-05-19 | 2012-02-29 | エミスフェアー・テクノロジーズ・インク | Topical cromolyn formulation |
US7906137B2 (en) * | 2004-05-21 | 2011-03-15 | Mediplex Corporation, Korea | Delivery agents for enhancing mucosal absorption of therapeutic agents |
US7384990B2 (en) * | 2004-06-17 | 2008-06-10 | Hewlett-Packard Development Company, L.P. | Latex particulates with active ester functional groups |
MX2007008082A (en) | 2004-12-29 | 2007-09-05 | Emisphere Tech Inc | Pharmaceutical formulations of gallium salts. |
US8110547B2 (en) | 2005-01-12 | 2012-02-07 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
US20060257355A1 (en) * | 2005-05-10 | 2006-11-16 | Abiomed, Inc. | Impregnated polymer compositions and devices using them |
WO2007011958A2 (en) | 2005-07-15 | 2007-01-25 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
AU2006280953B2 (en) | 2005-08-19 | 2013-01-24 | Emisphere Technologies, Inc. | Cyclopropyl compounds and compositions for delivering active agents |
WO2007076371A2 (en) | 2005-12-19 | 2007-07-05 | Pharmain Corporation | Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same |
ES2538254T3 (en) | 2006-04-18 | 2015-06-18 | Emisphere Technologies, Inc. | Dialkyl Ether Administration Agents |
US8771712B2 (en) | 2006-05-09 | 2014-07-08 | Emisphere Technologies, Inc. | Topical administration of acyclovir |
CN105439877B (en) * | 2006-07-26 | 2019-07-23 | 于崇曦 | The prodrug of positively charged water-soluble Diflunisal and related compound |
WO2008014430A1 (en) | 2006-07-27 | 2008-01-31 | Emisphere Technologies, Inc. | Arylsulfanyl compounds and compositions for delivering active agents |
WO2008022242A2 (en) | 2006-08-18 | 2008-02-21 | Emisphere Technologies, Inc. | Synthesis of propyl phenoxy ethers and use as delivery agents |
JP5577094B2 (en) * | 2006-08-31 | 2014-08-20 | エミスフェアー・テクノロジーズ・インク | Compounds and compositions for delivering active agents |
WO2008112368A2 (en) | 2007-02-08 | 2008-09-18 | Emisphere Technologies, Inc. | Phenylalkylcarboxylic acid delivery agents |
EP2129218B1 (en) | 2007-02-16 | 2016-10-19 | Emisphere Technologies, Inc. | Compounds having a cyclic moiety and compositions for delivering active agents |
EP2136624A4 (en) | 2007-03-21 | 2011-11-30 | Emisphere Tech Inc | Allylqxy and alkyloxy benzoic acid delivery agents |
KR20120059645A (en) | 2007-04-24 | 2012-06-08 | 닛뽕소다 가부시키가이샤 | Process for producing substituted methylamine compound and triazine derⅳatⅳe |
CN103641776A (en) * | 2007-04-24 | 2014-03-19 | 日本曹达株式会社 | Manufacturing method of N-methylene substituted methylamine polymer and triazine derivative |
US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
US8563527B2 (en) | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
US20090176892A1 (en) * | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
US20100021538A1 (en) * | 2008-02-29 | 2010-01-28 | Youngro Byun | Pharmaceutical compositions containing heparin derivatives |
ITRM20080551A1 (en) * | 2008-10-15 | 2010-04-16 | Univ Catania | AMPHIFYL DERIVATIVES OF POLYOSSIETHYLENE GLYCOL (PEG), PREPARATION PROCEDURE AND THEIR USE IN THE PREPARATION OF PHARMACEUTICAL SYSTEMS. |
EP2461803B1 (en) | 2009-08-03 | 2018-10-17 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
EP3808339A1 (en) | 2012-05-03 | 2021-04-21 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
KR102310775B1 (en) | 2012-05-03 | 2021-10-07 | 칼라 파마슈티컬스, 인크. | Pharmaceutical nanoparticles showing improved mucosal transport |
KR101839864B1 (en) | 2012-09-21 | 2018-03-20 | 인텐시티 쎄라퓨틱스, 인코포레이티드 | Method of treating cancer |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
ES2831625T3 (en) | 2013-02-20 | 2021-06-09 | Kala Pharmaceuticals Inc | Therapeutic compounds and their uses |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
CN106061261B (en) | 2013-11-01 | 2018-04-24 | 卡拉制药公司 | Crystal form of therapeutic compounds and application thereof |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US9962363B2 (en) | 2014-02-10 | 2018-05-08 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
SI3104854T1 (en) | 2014-02-10 | 2020-09-30 | Respivant Sciences Gmbh | Mast cell stabilizers for lung disease treatment |
US20200040126A1 (en) * | 2015-06-17 | 2020-02-06 | Dow Global Technologies Llc | Method for controlled release of antimicrobial compounds |
EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
JP2019528320A (en) | 2016-08-31 | 2019-10-10 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh | Cromolyn composition for the treatment of chronic cough due to idiopathic pulmonary fibrosis |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
WO2018048750A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
WO2018048746A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
WO2018067341A1 (en) | 2016-10-07 | 2018-04-12 | Patara Pharma, LLC | Cromolyn compositions for treatment of pulmonary fibrosis |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5541155A (en) * | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
US5811127A (en) * | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
Family Cites Families (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3436604A (en) * | 1966-04-25 | 1969-04-01 | Texas Instruments Inc | Complex integrated circuit array and method for fabricating same |
ES369853A1 (en) | 1969-07-24 | 1971-07-16 | Bama S A Lab | Procedure for the obtaining of derivatives of the epsilon-amino-caproico acid. (Machine-translation by Google Translate, not legally binding) |
US3727064A (en) * | 1971-03-17 | 1973-04-10 | Monsanto Co | Opto-isolator devices and method for the fabrication thereof |
US3746934A (en) * | 1971-05-06 | 1973-07-17 | Siemens Ag | Stack arrangement of semiconductor chips |
DE2517229A1 (en) | 1975-04-18 | 1976-10-28 | Boehringer Mannheim Gmbh | PHENYLALKYLCARBONIC ACID DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
CA1077842A (en) | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
US4031113A (en) * | 1976-03-29 | 1977-06-21 | Morton-Norwich Products, Inc. | 5-[5-(4-Chlorophenyl)-2-furanyl]dihydro-2(3H)-furanone |
US4103318A (en) * | 1977-05-06 | 1978-07-25 | Ford Motor Company | Electronic multichip module |
NZ196349A (en) | 1980-03-07 | 1984-08-24 | Interx Research Corp | Enhancement of absorption rate of orally administered polar bioactive agents |
US4398235A (en) * | 1980-09-11 | 1983-08-09 | General Motors Corporation | Vertical integrated circuit package integration |
US4437235A (en) * | 1980-12-29 | 1984-03-20 | Honeywell Information Systems Inc. | Integrated circuit package |
JPS58140026A (en) | 1982-01-14 | 1983-08-19 | Toyo Jozo Co Ltd | Pharmaceutical having improved absorbability |
CA1188987A (en) | 1981-03-06 | 1985-06-18 | Masataka Morishita | Preparation having excellent absorption property |
US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
US4692433A (en) | 1983-10-12 | 1987-09-08 | The Regents Of The University Of California | Method and composition for regulating serum calcium levels of mammals |
US4757066A (en) | 1984-10-15 | 1988-07-12 | Sankyo Company Limited | Composition containing a penem or carbapenem antibiotic and the use of the same |
WO1986004208A1 (en) * | 1984-12-28 | 1986-07-17 | Micro Engineering Co., Ltd. | Method of stacking printed circuit boards |
DE3675321D1 (en) * | 1985-08-16 | 1990-12-06 | Dai Ichi Seiko Co Ltd | SEMICONDUCTOR ARRANGEMENT WITH PACK OF PIN PLUG TYPE. |
US4925673A (en) | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
USRE35862E (en) | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
US4821007A (en) * | 1987-02-06 | 1989-04-11 | Tektronix, Inc. | Strip line circuit component and method of manufacture |
US4862249A (en) * | 1987-04-17 | 1989-08-29 | Xoc Devices, Inc. | Packaging system for stacking integrated circuits |
MX12394A (en) | 1987-07-23 | 1993-12-01 | Ciba Geigy Ag | PROCEDURE FOR OBTAINING POLYETHYLENE GLYCOL CARBAMATES. |
US4895725A (en) | 1987-08-24 | 1990-01-23 | Clinical Technologies Associates, Inc. | Microencapsulation of fish oil |
IT1214254B (en) * | 1987-09-23 | 1990-01-10 | Sgs Microelettonica S P A | SEMICONDUCTOR DEVICE IN PLASTIC OR CERAMIC CONTAINER WITH "CHIPS" FIXED ON BOTH SIDES OF THE CENTRAL ISLAND OF THE "FRAME". |
US5016138A (en) * | 1987-10-27 | 1991-05-14 | Woodman John K | Three dimensional integrated circuit package |
US4983533A (en) * | 1987-10-28 | 1991-01-08 | Irvine Sensors Corporation | High-density electronic modules - process and product |
US5198888A (en) * | 1987-12-28 | 1993-03-30 | Hitachi, Ltd. | Semiconductor stacked device |
US4833568A (en) * | 1988-01-29 | 1989-05-23 | Berhold G Mark | Three-dimensional circuit component assembly and method corresponding thereto |
US4891789A (en) * | 1988-03-03 | 1990-01-02 | Bull Hn Information Systems, Inc. | Surface mounted multilayer memory printed circuit board |
FR2636238B1 (en) | 1988-09-14 | 1994-01-21 | Morelle Jean | NEW ANTISUDORAL COMPOSITIONS |
US4911643A (en) * | 1988-10-11 | 1990-03-27 | Beta Phase, Inc. | High density and high signal integrity connector |
US4983402A (en) | 1989-02-24 | 1991-01-08 | Clinical Technologies Associates, Inc. | Orally administerable ANF |
US4976968A (en) | 1989-02-24 | 1990-12-11 | Clinical Technologies Associates, Inc. | Anhydrous delivery systems for pharmacological agents |
US4953060A (en) * | 1989-05-05 | 1990-08-28 | Ncr Corporation | Stackable integrated circuit chip package with improved heat removal |
US5104820A (en) * | 1989-07-07 | 1992-04-14 | Irvine Sensors Corporation | Method of fabricating electronic circuitry unit containing stacked IC layers having lead rerouting |
US5012323A (en) * | 1989-11-20 | 1991-04-30 | Micron Technology, Inc. | Double-die semiconductor package having a back-bonded die and a face-bonded die interconnected on a single leadframe |
US5041015A (en) * | 1990-03-30 | 1991-08-20 | Cal Flex, Inc. | Electrical jumper assembly |
AU8519891A (en) * | 1990-08-01 | 1992-03-02 | Staktek Corporation | Ultra high density integrated circuit packages, method and apparatus |
US5446620A (en) * | 1990-08-01 | 1995-08-29 | Staktek Corporation | Ultra high density integrated circuit packages |
US5499160A (en) * | 1990-08-01 | 1996-03-12 | Staktek Corporation | High density integrated circuit module with snap-on rail assemblies |
US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
US5693338A (en) | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US5451410A (en) | 1993-04-22 | 1995-09-19 | Emisphere Technologies, Inc. | Modified amino acids for encapsulating active agents |
US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
JPH04284661A (en) * | 1991-03-13 | 1992-10-09 | Toshiba Corp | Semiconductor device |
US5099393A (en) * | 1991-03-25 | 1992-03-24 | International Business Machines Corporation | Electronic package for high density applications |
US5138430A (en) * | 1991-06-06 | 1992-08-11 | International Business Machines Corporation | High performance versatile thermally enhanced IC chip mounting |
JPH0513666A (en) * | 1991-06-29 | 1993-01-22 | Sony Corp | Complex semiconductor device |
US5311401A (en) * | 1991-07-09 | 1994-05-10 | Hughes Aircraft Company | Stacked chip assembly and manufacturing method therefor |
US5448450A (en) * | 1991-08-15 | 1995-09-05 | Staktek Corporation | Lead-on-chip integrated circuit apparatus |
US5281852A (en) * | 1991-12-10 | 1994-01-25 | Normington Peter J C | Semiconductor device including stacked die |
US5338837A (en) | 1991-12-13 | 1994-08-16 | The Trustees Of Princeton University | Glycosylated steroid derivatives for transport across biological membranes and process for making same |
US5241454A (en) * | 1992-01-22 | 1993-08-31 | International Business Machines Corporation | Mutlilayered flexible circuit package |
US5222014A (en) * | 1992-03-02 | 1993-06-22 | Motorola, Inc. | Three-dimensional multi-chip pad array carrier |
US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
HU211995B (en) | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
US5402006A (en) * | 1992-11-10 | 1995-03-28 | Texas Instruments Incorporated | Semiconductor device with enhanced adhesion between heat spreader and leads and plastic mold compound |
US5313097A (en) * | 1992-11-16 | 1994-05-17 | International Business Machines, Corp. | High density memory module |
US5583020A (en) | 1992-11-24 | 1996-12-10 | Ribozyme Pharmaceuticals, Inc. | Permeability enhancers for negatively charged polynucleotides |
US6205654B1 (en) * | 1992-12-11 | 2001-03-27 | Staktek Group L.P. | Method of manufacturing a surface mount package |
US5484959A (en) * | 1992-12-11 | 1996-01-16 | Staktek Corporation | High density lead-on-package fabrication method and apparatus |
US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
US5455740A (en) * | 1994-03-07 | 1995-10-03 | Staktek Corporation | Bus communication system for stacked high density integrated circuit packages |
US5541812A (en) * | 1995-05-22 | 1996-07-30 | Burns; Carmen D. | Bus communication system for stacked high density integrated circuit packages having an intermediate lead frame |
US5644161A (en) * | 1993-03-29 | 1997-07-01 | Staktek Corporation | Ultra-high density warp-resistant memory module |
US5709861A (en) | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
AU6819294A (en) | 1993-04-22 | 1994-11-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5523619A (en) * | 1993-11-03 | 1996-06-04 | International Business Machines Corporation | High density memory structure |
US5658558A (en) * | 1994-10-03 | 1997-08-19 | Rohm And Haas Company | Hair styling compositions and method of enhancing the performance of hair fixative resins |
US5592364A (en) * | 1995-01-24 | 1997-01-07 | Staktek Corporation | High density integrated circuit module with complex electrical interconnect rails |
US5514907A (en) * | 1995-03-21 | 1996-05-07 | Simple Technology Incorporated | Apparatus for stacking semiconductor chips |
US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
BR9604880A (en) | 1995-03-31 | 1998-05-19 | Emisphere Tech Inc | Compound composition dosage unit form methods for administering a biologically active agent for preparing a composition for administering an active agent and for preparing a compound and pharmacological composition |
US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US6090958A (en) | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5612570A (en) * | 1995-04-13 | 1997-03-18 | Dense-Pac Microsystems, Inc. | Chip stack and method of making same |
US5820881A (en) | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
DE19516272A1 (en) * | 1995-05-08 | 1996-11-14 | Hermann Leguin | Primary element scanner for determining deflection of scanning pin or similar |
US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
US5667806A (en) | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
US5824345A (en) | 1995-06-07 | 1998-10-20 | Emisphere Technologies, Inc. | Fragrances and flavorants |
US6025642A (en) * | 1995-08-17 | 2000-02-15 | Staktek Corporation | Ultra high density integrated circuit packages |
AU7072596A (en) | 1995-09-11 | 1997-04-01 | Emisphere Technologies, Inc. | Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones |
US5646446A (en) * | 1995-12-22 | 1997-07-08 | Fairchild Space And Defense Corporation | Three-dimensional flexible assembly of integrated circuits |
US6225688B1 (en) * | 1997-12-11 | 2001-05-01 | Tessera, Inc. | Stacked microelectronic assembly and method therefor |
US5990166A (en) | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5939381A (en) | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5876710A (en) | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US5879681A (en) | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US6051561A (en) | 1997-02-07 | 2000-04-18 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US5776888A (en) | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6060513A (en) | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5863944A (en) | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5962710A (en) | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
US6208521B1 (en) * | 1997-05-19 | 2001-03-27 | Nitto Denko Corporation | Film carrier and laminate type mounting structure using same |
US6028352A (en) * | 1997-06-13 | 2000-02-22 | Irvine Sensors Corporation | IC stack utilizing secondary leadframes |
US6014316A (en) * | 1997-06-13 | 2000-01-11 | Irvine Sensors Corporation | IC stack utilizing BGA contacts |
US5869353A (en) * | 1997-11-17 | 1999-02-09 | Dense-Pac Microsystems, Inc. | Modular panel stacking process |
JPH11173269A (en) | 1997-12-05 | 1999-06-29 | Zexel:Kk | Reciprocating compressor |
US5926369A (en) * | 1998-01-22 | 1999-07-20 | International Business Machines Corporation | Vertically integrated multi-chip circuit package with heat-sink support |
US6172874B1 (en) * | 1998-04-06 | 2001-01-09 | Silicon Graphics, Inc. | System for stacking of integrated circuit packages |
PT1075282E (en) | 1998-04-28 | 2005-09-30 | Applied Research Systems | PEG-LHRH ANALOG CONJUGATES |
DE19833713C1 (en) * | 1998-07-27 | 2000-05-04 | Siemens Ag | Laminate or stacked package arrangement based on at least two integrated circuits |
US6294198B1 (en) * | 1999-08-24 | 2001-09-25 | Purepac Pharmaceutical Co. | Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same |
US6262895B1 (en) * | 2000-01-13 | 2001-07-17 | John A. Forthun | Stackable chip package with flex carrier |
-
2000
- 2000-01-07 US US09/889,005 patent/US6627228B1/en not_active Expired - Lifetime
- 2000-01-07 JP JP2000591961A patent/JP2002534363A/en not_active Withdrawn
- 2000-01-07 NZ NZ512581A patent/NZ512581A/en unknown
- 2000-01-07 CN CN00803535A patent/CN1338924A/en active Pending
- 2000-01-07 CA CA002358463A patent/CA2358463A1/en not_active Abandoned
- 2000-01-07 EP EP00914419A patent/EP1146860A4/en not_active Withdrawn
- 2000-01-07 AU AU35813/00A patent/AU3581300A/en not_active Abandoned
- 2000-01-07 IL IL14396200A patent/IL143962A0/en unknown
- 2000-01-07 WO PCT/US2000/000476 patent/WO2000040203A2/en not_active Application Discontinuation
- 2000-01-07 BR BR0008590-1A patent/BR0008590A/en not_active Application Discontinuation
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2001
- 2001-06-25 ZA ZA200105213A patent/ZA200105213B/en unknown
-
2003
- 2003-05-28 US US10/447,608 patent/US7208483B2/en not_active Expired - Fee Related
-
2007
- 2007-01-31 US US11/669,649 patent/US7727558B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811127A (en) * | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
US5541155A (en) * | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
US9364502B2 (en) | 2006-06-28 | 2016-06-14 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
Also Published As
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JP2002534363A (en) | 2002-10-15 |
ZA200105213B (en) | 2002-07-17 |
EP1146860A2 (en) | 2001-10-24 |
CA2358463A1 (en) | 2000-07-13 |
CN1338924A (en) | 2002-03-06 |
US7727558B2 (en) | 2010-06-01 |
BR0008590A (en) | 2001-10-30 |
WO2000040203A2 (en) | 2000-07-13 |
US20070141022A1 (en) | 2007-06-21 |
IL143962A0 (en) | 2002-04-21 |
NZ512581A (en) | 2002-12-20 |
EP1146860A4 (en) | 2002-07-03 |
US20030232085A1 (en) | 2003-12-18 |
US7208483B2 (en) | 2007-04-24 |
US6627228B1 (en) | 2003-09-30 |
AU3581300A (en) | 2000-07-24 |
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