WO2000039280A8 - Leukocyte-derived interferon preparations - Google Patents

Leukocyte-derived interferon preparations

Info

Publication number
WO2000039280A8
WO2000039280A8 PCT/US1999/031198 US9931198W WO0039280A8 WO 2000039280 A8 WO2000039280 A8 WO 2000039280A8 US 9931198 W US9931198 W US 9931198W WO 0039280 A8 WO0039280 A8 WO 0039280A8
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
leukocyte
omega
natural type
interferon preparations
Prior art date
Application number
PCT/US1999/031198
Other languages
French (fr)
Other versions
WO2000039280A3 (en
WO2000039280A9 (en
WO2000039280A2 (en
Inventor
Joseph P Morris
Duy Nguyen
James Kappelman
Mead M Mccabe
Michael D Potter
M Reza Ziai
Stephen Feldman
Hipolito Hartman
Original Assignee
Viragen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/224,895 external-priority patent/US6350589B1/en
Priority claimed from US09/229,039 external-priority patent/US6433144B1/en
Application filed by Viragen Inc filed Critical Viragen Inc
Priority to EP99967753A priority Critical patent/EP1140144A4/en
Publication of WO2000039280A2 publication Critical patent/WO2000039280A2/en
Publication of WO2000039280A8 publication Critical patent/WO2000039280A8/en
Publication of WO2000039280A3 publication Critical patent/WO2000039280A3/en
Publication of WO2000039280A9 publication Critical patent/WO2000039280A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention relates to methods for isolating highly-purified mixtures of natural type I interferons from white blood cells. The invention also relates to highly-purified mixtures of natural type I interferons which resemble natural type interferon in that it includes 9 subtypes, i.e., alpha-1, alpha-2, alpha-5, alpha-7, alpha-8, alpha-10, alpha-14, alpha-21 and omega, giving rise to possibly 20 molecular species, including alpha-1a, alpha-1new, alpha-2a, alpha-2b, alpha-2c, alpha-5, alpha-5LG, alpha-7, alpha-8a, alpha-8c, alpha-10a, alpha-14a, alpha14-b, alpha 14-c, alpha-14LG, alpha-21a, alpha-21b, alpha-21c, omega and omega LG.
PCT/US1999/031198 1998-12-31 1999-12-29 Leukocyte-derived interferon preparations WO2000039280A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP99967753A EP1140144A4 (en) 1998-12-31 1999-12-29 Composition of highly purified natural mixtures of type i interferon derived from leukocytes and methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/224,895 1998-12-31
US09/224,895 US6350589B1 (en) 1998-12-31 1998-12-31 Compositions of highly-purified natural mixtures of type I interferon derived from leukocytes and methods
US09/229,039 US6433144B1 (en) 1999-01-12 1999-01-12 Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods
US09/229,039 1999-01-12

Publications (4)

Publication Number Publication Date
WO2000039280A2 WO2000039280A2 (en) 2000-07-06
WO2000039280A8 true WO2000039280A8 (en) 2000-10-19
WO2000039280A3 WO2000039280A3 (en) 2001-07-19
WO2000039280A9 WO2000039280A9 (en) 2001-08-23

Family

ID=26919102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/031198 WO2000039280A2 (en) 1998-12-31 1999-12-29 Leukocyte-derived interferon preparations

Country Status (2)

Country Link
EP (1) EP1140144A4 (en)
WO (1) WO2000039280A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002225870B2 (en) 2000-11-03 2006-09-21 Intarcia Therapeutics, Inc. Method for short-term and long-term drug dosimetry
FR2822845B1 (en) 2001-03-30 2003-12-12 Genodyssee NOVEL POLYNUCLEOTIDES COMPRISING FUNCTIONAL SNP-LIKE POLYMORPHISMS IN THE NUCLEOTIDE SEQUENCE OF THE IFN-ALPHA-21 GENE AS WELL AS NEW POLYPEPTIDES ENCODED BY THESE POLYNUCLEOTIDES AND THEIR THERAPEUTIC USES
FR2823764B1 (en) * 2001-04-24 2003-12-12 Genodyssee NOVEL POLYNUCLEOTIDES AND POLYPEPTIDES OF THE IFN ALPHA-17 GENE
FR2825716B1 (en) * 2001-06-11 2004-09-24 Genodyssee NOVEL POLYNUCLEOTIDES AND POLYPEPTIDES FROM IFN ALPHA 7
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
AU2006212012B2 (en) 2005-02-12 2011-10-13 Swedish Orphan Biovitrum International Ab Methods and uses of antibodies in the purification of interferon
KR101200728B1 (en) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 Osmotic delivery system and piston assemblies
AU2008244523B2 (en) 2007-04-23 2012-02-16 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
SI2462246T1 (en) 2009-09-28 2018-01-31 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
RU2482871C2 (en) * 2010-06-07 2013-05-27 Общество с ограниченной ответственностью "Центр Инновационных Технологий "БиоФарм" (ООО "ЦИТ "БиоФарм") Composition for treating viral diseases in animals
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
KR20240042548A (en) 2015-06-03 2024-04-02 인타르시아 세라퓨틱스 인코포레이티드 Implant placement and removal systems
MA53353A (en) 2016-05-16 2021-06-09 Intarcia Therapeutics Inc GLUCAGON RECEPTOR SELECTIVE POLYPEPTIDES AND METHODS FOR THEIR USE
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
EP3565580B1 (en) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732683A (en) * 1986-12-02 1988-03-22 Biospectrum, Inc. Purification method for alpha interferon
EP0625991B1 (en) * 1992-02-10 1999-04-28 Interferon Sciences, Inc. Improved alpha interferon composition and method for its production from human peripheral blood leukocytes
US5676942A (en) * 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof
EP0626448A3 (en) * 1993-05-26 1998-01-14 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Process for preparing and purifying alpha-interferon
EP1104809A1 (en) * 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Process for producing alpha-interferon

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

Also Published As

Publication number Publication date
EP1140144A2 (en) 2001-10-10
WO2000039280A3 (en) 2001-07-19
EP1140144A4 (en) 2002-10-30
WO2000039280A2 (en) 2000-07-06

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