WO2000031306A3 - Multiplex amplification of short tandem repeat loci - Google Patents

Multiplex amplification of short tandem repeat loci Download PDF

Info

Publication number
WO2000031306A3
WO2000031306A3 PCT/US1999/027876 US9927876W WO0031306A3 WO 2000031306 A3 WO2000031306 A3 WO 2000031306A3 US 9927876 W US9927876 W US 9927876W WO 0031306 A3 WO0031306 A3 WO 0031306A3
Authority
WO
WIPO (PCT)
Prior art keywords
loci
methods
materials
tandem repeat
short tandem
Prior art date
Application number
PCT/US1999/027876
Other languages
French (fr)
Other versions
WO2000031306A9 (en
WO2000031306A2 (en
Inventor
James W Schumm
Cynthia J Sprecher
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22737974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000031306(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Promega Corp filed Critical Promega Corp
Priority to JP2000584113A priority Critical patent/JP5456950B2/en
Priority to CA002352042A priority patent/CA2352042A1/en
Priority to AU31034/00A priority patent/AU774626B2/en
Priority to EP99965030A priority patent/EP1135530B1/en
Priority to ES99965030T priority patent/ES2394070T3/en
Priority to BR9915597-4A priority patent/BR9915597A/en
Publication of WO2000031306A2 publication Critical patent/WO2000031306A2/en
Publication of WO2000031306A3 publication Critical patent/WO2000031306A3/en
Priority to HK01107340.1A priority patent/HK1036638A1/en
Publication of WO2000031306A9 publication Critical patent/WO2000031306A9/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Abstract

Methods and materials are disclosed for use in simultaneously amplifying at least thirteen loci of genomic DNA in a single multiplex reaction, as are methods and materials for use in the analysis of the products of such reactions. Included in the present invention are materials and methods for the simultaneous amplification of at least thirteen short tandem repeat loci, including specific materials and methods for the analysis of thirteen such loci specifically selected by the United States Federal Bureau of Investigation as core loci for use in the Combined DNA Index System (CODIS) database.
PCT/US1999/027876 1998-11-25 1999-11-24 Multiplex amplification of short tandem repeat loci WO2000031306A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2000584113A JP5456950B2 (en) 1998-11-25 1999-11-24 Multiplex amplification of short tandem repeat loci
CA002352042A CA2352042A1 (en) 1998-11-25 1999-11-24 Multiplex amplification of short tandem repeat loci
AU31034/00A AU774626B2 (en) 1998-11-25 1999-11-24 Multiplex amplification of short tandem repeat loci
EP99965030A EP1135530B1 (en) 1998-11-25 1999-11-24 Multiplex amplification of short tandem repeat loci
ES99965030T ES2394070T3 (en) 1998-11-25 1999-11-24 Multiplex amplification of locus of short repetitions in tandem
BR9915597-4A BR9915597A (en) 1998-11-25 1999-11-24 Multiplex amplification of repeated short tandem loci
HK01107340.1A HK1036638A1 (en) 1998-11-25 2001-10-19 Multiplex amplification of short tandem repeat loci

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/199,542 US6479235B1 (en) 1994-09-30 1998-11-25 Multiplex amplification of short tandem repeat loci
US09/199,542 1998-11-25

Publications (3)

Publication Number Publication Date
WO2000031306A2 WO2000031306A2 (en) 2000-06-02
WO2000031306A3 true WO2000031306A3 (en) 2000-11-09
WO2000031306A9 WO2000031306A9 (en) 2002-08-29

Family

ID=22737974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027876 WO2000031306A2 (en) 1998-11-25 1999-11-24 Multiplex amplification of short tandem repeat loci

Country Status (11)

Country Link
US (1) US6479235B1 (en)
EP (1) EP1135530B1 (en)
JP (2) JP5456950B2 (en)
CN (2) CN100366753C (en)
AU (1) AU774626B2 (en)
BR (1) BR9915597A (en)
CA (1) CA2352042A1 (en)
ES (1) ES2394070T3 (en)
HK (1) HK1036638A1 (en)
PT (1) PT1135530E (en)
WO (1) WO2000031306A2 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2118048C (en) * 1994-09-30 2003-04-08 James W. Schumm Multiplex amplification of short tandem repeat loci
US7008771B1 (en) * 1994-09-30 2006-03-07 Promega Corporation Multiplex amplification of short tandem repeat loci
US6238863B1 (en) * 1998-02-04 2001-05-29 Promega Corporation Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers
US6531282B1 (en) * 2000-05-30 2003-03-11 Oligotrail, Llc Multiplex amplification and analysis of selected STR loci
US6617137B2 (en) * 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
WO2003050269A2 (en) * 2001-12-11 2003-06-19 Arizona Board Of Regents HIGH RESOLUTION TYPING SYSTEM FOR PATHOGENIC $i(E. COLI)
FR2836484B1 (en) * 2002-02-25 2005-02-04 Assist Publ Hopitaux De Paris METHOD OF IN VITRO DETECTION OF CANCERS BY THE EVIDENCE OF ALLELIC IMBALANCES OF INSERT-DELETION MARKERS
US7445893B2 (en) * 2002-04-12 2008-11-04 Primera Biosystems, Inc. Sampling method for amplification reaction analysis
US7081339B2 (en) * 2002-04-12 2006-07-25 Primera Biosystems, Inc. Methods for variation detection
WO2004009837A2 (en) * 2002-07-19 2004-01-29 Arizona Board Of Regents A high resolution typing system for pathogenic mycobacterium tuberculosum
AU2003261215A1 (en) * 2002-07-19 2004-02-09 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Dna fingerprinting for cannabis sativa (marijuana) using short tandem repeat (str) markers
US7955795B2 (en) * 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
CA2510587A1 (en) * 2002-12-20 2004-07-15 Qiagen Gmbh Nucleic acid amplification
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20040219533A1 (en) * 2003-04-29 2004-11-04 Jim Davis Biological bar code
US20050026181A1 (en) * 2003-04-29 2005-02-03 Genvault Corporation Bio bar-code
US20050112591A1 (en) * 2003-11-25 2005-05-26 Applera Corporation Novel method for isolating single stranded product
WO2005102309A2 (en) * 2004-04-26 2005-11-03 Ltb4 Sweden Ab In vivo release of endogenous anti-microbial mediators by leukotriene b4 (ltb4) administration
US20060008823A1 (en) * 2004-05-12 2006-01-12 Kemp Jennifer T DNA profiling and SNP detection utilizing microarrays
CN1327005C (en) * 2004-12-03 2007-07-18 公安部第二研究所 Complex aplification detecting system of fluorescent marker short tandem repetitive sequence gene locus
EP1863908B1 (en) 2005-04-01 2010-11-17 Qiagen GmbH Reverse transcription and amplification of rna with simultaneous degradation of dna
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
EP1762627A1 (en) 2005-09-09 2007-03-14 Qiagen GmbH Method for the activation of a nucleic acid for performing a polymerase reaction
US20080057499A1 (en) * 2006-02-06 2008-03-06 Affymetrix, Inc. Methods for high specificity whole genome amplification and hybridization
US8153372B2 (en) * 2006-12-19 2012-04-10 The Board Of Regents For Oklahoma State University Method for simultaneously determining in a single multiplex reaction gender of donors and quantities of genomic DNA and ratios thereof, presence and extent of DNA degradation, and PCR inhibition within a human DNA sample
CA2984820C (en) 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
US20090004662A1 (en) 2007-06-18 2009-01-01 Applera Corporation Method and compositions for nucleic acid amplification
ES2532632T3 (en) 2008-06-30 2015-03-30 Life Technologies Corporation Direct amplification method from raw nucleic acid samples
CA2731991C (en) 2008-08-04 2021-06-08 Gene Security Network, Inc. Methods for allele calling and ploidy calling
WO2010045252A1 (en) * 2008-10-14 2010-04-22 Casework Genetics System and method for inferring str allelic genotype from snps
JP2012529908A (en) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド Improved method for quantification of forensic DNA
WO2010146339A1 (en) * 2009-06-15 2010-12-23 Bg Research Ltd Nucleic acid detection
EP2290004B1 (en) 2009-07-31 2016-08-31 Ems-Patent Ag Polyamide blend moulding material
CN101691607B (en) * 2009-08-14 2013-07-17 河北医科大学 Method and reagent kit for testing human gene typing by labeling mini-STR (short tandem repeats) with fluorescence
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
ES2378204B1 (en) * 2010-08-19 2013-03-13 Universidad Del Pais Vasco METHOD FOR OBTAINING THE GENETIC PROFILE OF AN INDIVIDUAL.
ES2378203B1 (en) * 2010-08-19 2013-03-04 Universidad Del Pais Vasco METHOD FOR OBTAINING THE GENETIC PROFILE OF AN INDIVIDUAL.
WO2012022821A1 (en) * 2010-08-19 2012-02-23 Universidad Del País Vasco Method for obtaining an individual's genetic profile
JP6328934B2 (en) 2010-12-22 2018-05-23 ナテラ, インコーポレイテッド Noninvasive prenatal testing
AU2011358564B9 (en) 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
WO2012155084A1 (en) 2011-05-12 2012-11-15 Netbio, Inc. Methods and compositions for rapid multiplex amplification of str loci
ES2416836B1 (en) * 2011-12-29 2014-04-07 Universidad Del País Vasco METHOD FOR OBTAINING THE GENETIC PROFILE OF AN INDIVIDUAL
CN102586433B (en) * 2012-02-14 2014-01-29 北京科聆金仪生物技术有限公司 Deafness predisposing gene 12S rRNA (ribosomal ribonucleic acid) 1494C>T fluorescence detection kit and application thereof
CN102605052B (en) * 2012-02-14 2014-01-29 北京科聆金仪生物技术有限公司 Fluorescence detection kit for detecting deafness susceptibility gene GJB2 235delC and application of fluorescence detection kit
KR101890466B1 (en) * 2012-07-24 2018-08-21 내테라, 인코포레이티드 Highly multiplex pcr methods and compositions
WO2015048535A1 (en) 2013-09-27 2015-04-02 Natera, Inc. Prenatal diagnostic resting standards
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
CN113774132A (en) 2014-04-21 2021-12-10 纳特拉公司 Detection of mutations and ploidy in chromosomal segments
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US10253352B2 (en) 2015-11-17 2019-04-09 Omniome, Inc. Methods for determining sequence profiles
US10822647B2 (en) 2016-07-12 2020-11-03 Biodynamics S.R.L. Methods for using long ssDNA polynucleotides as primers (superprimers) in PCR assays
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3049139A1 (en) 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN107012225B (en) * 2017-04-20 2020-10-09 司法鉴定科学研究院 STR locus detection kit and detection method based on high-throughput sequencing
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN110229871B (en) * 2019-04-26 2023-06-23 上海晶准生物医药有限公司 Preparation method of universal short tandem repeat sequence allele ladder
EP3739064A1 (en) * 2019-05-15 2020-11-18 Biotype GmbH Comparative analysis of microsatellites by capillary electrophoresis (ce) dna profiles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039138A1 (en) * 1996-04-15 1997-10-23 Promega Corporation Multiplex amplification of short tandem repeat loci
EP0846775A2 (en) * 1996-12-03 1998-06-10 The Secretary of State for the Home Department Improvements and relating to indentification

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8606719D0 (en) 1986-03-19 1986-04-23 Lister Preventive Med Genetic probes
US4963663A (en) 1988-12-23 1990-10-16 University Of Utah Genetic identification employing DNA probes of variable number tandem repeat loci
JPH05501946A (en) 1988-02-18 1993-04-15 ユニバーシティ・オブ・ユタ Genetic identification using DNA probes of variable number tandem repeat loci
US5766847A (en) 1988-10-11 1998-06-16 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for analyzing length polymorphisms in DNA regions
US5582979A (en) 1989-04-21 1996-12-10 Marshfield Clinic Length polymorphisms in (dC-dA)n.(dG-dT)n sequences and method of using the same
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5364759B2 (en) * 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
WO1993018178A1 (en) 1992-03-13 1993-09-16 The Children's Hospital Of Philadelphia DIAGNOSIS OF β-THALASSEMIA USING A MULTIPLEX AMPLIFICATION REFRACTORY MUTATION SYSTEM
WO1993018177A1 (en) 1992-03-13 1993-09-16 The Children's Hospital Of Philadelphia Diagnosis of cystic fibrosis using allele specific multiplex polymerase chain reactions
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
US5599666A (en) 1994-03-28 1997-02-04 Promega Corporation Allelic ladders for short tandem repeat loci
US6013444A (en) * 1997-09-18 2000-01-11 Oligotrail, Llc DNA bracketing locus compatible standards for electrophoresis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039138A1 (en) * 1996-04-15 1997-10-23 Promega Corporation Multiplex amplification of short tandem repeat loci
EP0846775A2 (en) * 1996-12-03 1998-06-10 The Secretary of State for the Home Department Improvements and relating to indentification

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"The ninth international symposium on human identification october 8-10, 1998", PROFILES IN DNA, vol. 2, no. 3, January 1999 (1999-01-01), XP002142668, Retrieved from the Internet <URL:http://www.promega.com/profiles/203/203_13/> [retrieved on 20000712] *
AMIOTT ET AL.: "Incorporating high quality markers into forensically useful multiplexes", HUMAN IDENTIFICATION SYMPOSIUM PROCEEDINGS: THE NINTH INTERNATIONAL SYMPOSIUM ON HUMAN IDENTIFICATION, 8 October 1998 (1998-10-08) - 10 October 1998 (1998-10-10), pages 2 - 6, XP002142665, Retrieved from the Internet <URL:http://www.promega.com/geneticidproc/ussymp9proc/content/02.pdf> [retrieved on 20000712] *
KIMPTON P ET AL: "AUTOMATED DNA PROFILING EMPLOYING MULTIPLEX AMPLIFICATION OF SHORT TANDEM REPEAT LOCI", PCR METHODS AND APPLICATIONS,US,COLD SPRING HARBOR, NY, vol. 3, no. 1, 1 August 1993 (1993-08-01), pages 13 - 22, XP000565542, ISSN: 1054-9803 *
LIN Z ET AL: "Multiplex genotype determination at a large number of gene loci.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1996 MAR 19) 93 (6) 2582-7., XP002142667 *
LINS A M ET AL: "Development and population study of an eight-locus short tandem repeat ( STR ) multiplex system.", JOURNAL OF FORENSIC SCIENCES, (1998 NOV) 43 (6) 1168-80., XP000915485 *
MCKEOWN B J ET AL: "Increasing the size of PCR products without redesigning primer binding sequences.", NUCLEIC ACIDS RESEARCH, (1995 JUN 25) 23 (12) 2337-8., XP002142666 *
SCHUMM ET AL: "Pentanucleotide repeats: Highly polymorphic genetic markers displayining minimal stutter artifact", HUMAN IDENTIFICATION SYMPOSIUM PROCEEDINGS: THE NINTH INTERNATIONAL SYMPOSIUM ON HUMAN IDENTIFICATION, 8 October 1998 (1998-10-08) - 10 October 1998 (1998-10-10), pages 24 - 37, XP002142664, Retrieved from the Internet <URL:http://www.promega.com/geneticidproc/ussymp9proc/content/08.pdf> [retrieved on 20000712] *
SPARKES R ET AL: "The validation of a 7-locus multiplex STR test for us in forensic casework. (II), Artefacts, casework studies and success rates", INTERNATIONAL JOURNAL OF LEGAL MEDICINE, (1996) 109 (4) 195-204., XP000915489 *

Also Published As

Publication number Publication date
AU3103400A (en) 2000-06-13
JP2010081944A (en) 2010-04-15
CN101230394A (en) 2008-07-30
JP5711887B2 (en) 2015-05-07
JP5456950B2 (en) 2014-04-02
US6479235B1 (en) 2002-11-12
CA2352042A1 (en) 2000-06-02
WO2000031306A9 (en) 2002-08-29
PT1135530E (en) 2012-12-18
WO2000031306A2 (en) 2000-06-02
CN1332805A (en) 2002-01-23
EP1135530B1 (en) 2012-09-19
EP1135530A2 (en) 2001-09-26
AU774626B2 (en) 2004-07-01
ES2394070T3 (en) 2013-01-16
BR9915597A (en) 2001-10-23
HK1036638A1 (en) 2002-01-11
JP2002530121A (en) 2002-09-17
CN100366753C (en) 2008-02-06

Similar Documents

Publication Publication Date Title
WO2000031306A3 (en) Multiplex amplification of short tandem repeat loci
EP0587298A3 (en) Nucleic acid sequence amplification method
AU3376897A (en) Microfluidic method for nucleic acid amplification
WO2003064691A3 (en) Methods and means for amplifying nucleic acid
WO1999055857A3 (en) Nucleoside triphosphates and their incorporation into ribozymes
WO2006076017A3 (en) Methods and kits for identifying target nucleotides in mixed populations
IL130477A0 (en) Processes for amplifying nucleic acid
EP0875584A3 (en) Nucleic acid assays
WO2004033649A3 (en) High throughput multiplex dna sequence amplifications
AU3365095A (en) High throughput screening method for sequences or genetic alterations in nucleic acids
AU4774196A (en) Method for suppressing dna fragment amplification during pcr
AU5579699A (en) Rapid amperometric verification of pcr amplification of dna
WO1996010648A3 (en) Multiplex amplification of short tandem repeat loci
AU6152301A (en) Detection of nucleic acid hybridization by fluorescence polarization
AU2001259290A1 (en) Apparatus, method, and computer program product for quantitative analysis of a nucleic acid amplification reaction
AU3595493A (en) Method for nucleic acid hybridization using single-stranded DNA binding protein
ATE210192T1 (en) METHOD FOR DIRECT SEQUENCING DURING BTEMPLATES AMPLIFICATION
HUP9602289A2 (en) Method for amplifying nucleic acid
WO1999067619A3 (en) Compounds and methods for detecting biomolecules
AU3890795A (en) Improved method for nucleotide sequence amplification
WO2000053804A3 (en) Genetic screening
WO1999038962A3 (en) Compositions and methods for using a lysing matrix for isolating dna
CA2295306A1 (en) Dna polymerase-related factors
FI953990A (en) A method of rendering a nucleic acid amplification reaction product incapable of further amplification, a diagnostic assay method using this method, and a test kit and container suitable for performing the method or assay.
WO2002037944A3 (en) Multiplexed cell analysis system

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99813729.4

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 31034/00

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2352042

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2352042

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2000 584113

Country of ref document: JP

Kind code of ref document: A

REEP Request for entry into the european phase

Ref document number: 1999965030

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1999965030

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999965030

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

AK Designated states

Kind code of ref document: C2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/12-12/12, DRAWINGS, REPLACED BY NEW PAGES 1/12-12/12; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

WWG Wipo information: grant in national office

Ref document number: 31034/00

Country of ref document: AU