WO2000030610A3 - Microporous drug delivery system - Google Patents

Microporous drug delivery system Download PDF

Info

Publication number
WO2000030610A3
WO2000030610A3 PCT/US1999/026759 US9926759W WO0030610A3 WO 2000030610 A3 WO2000030610 A3 WO 2000030610A3 US 9926759 W US9926759 W US 9926759W WO 0030610 A3 WO0030610 A3 WO 0030610A3
Authority
WO
WIPO (PCT)
Prior art keywords
pores
drug delivery
therapeutic drug
annulus
medical devices
Prior art date
Application number
PCT/US1999/026759
Other languages
French (fr)
Other versions
WO2000030610A2 (en
Inventor
Gregory R Ley
Christopher P Knapp
Original Assignee
Cardiac Pacemakers Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiac Pacemakers Inc filed Critical Cardiac Pacemakers Inc
Priority to AU16188/00A priority Critical patent/AU1618800A/en
Publication of WO2000030610A2 publication Critical patent/WO2000030610A2/en
Publication of WO2000030610A3 publication Critical patent/WO2000030610A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Abstract

A drug delivery device is described comprising a porous biocompatible solid having at least one therapeutic drug within its pores, the therapeutic drug being removable from the pores by immersion in an aqueous solution. This may also be described as a drug delivery device comprising a porous annulus comprising a biocompatible solid having at least one therapeutic drug within its pores, the therapeutic drug being removable from the pores by immersion in an aqueous solution, the annulus having a top outer surface with an outside diameter, an inner surface with an inside diameter, and a side surface, at least one of the side surface and the top outer surface having openings of the pores exposed on that surface. The device may comprise pores having an average size of the greatest dimensions within the pores of between about 10?-6 and 10-1¿ mm. The device may have a medical device or component of a medical device pass through an opening in the annulus. Examples of such medical devices may include, but not be limited to medical devices or components of medical devices selected from the group consisting of catheters, tubes, and electrical leads.
PCT/US1999/026759 1998-11-12 1999-11-12 Microporous drug delivery system WO2000030610A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16188/00A AU1618800A (en) 1998-11-12 1999-11-12 Microporous drug delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/190,902 1998-11-12
US09/190,902 US6361780B1 (en) 1998-11-12 1998-11-12 Microporous drug delivery system

Publications (2)

Publication Number Publication Date
WO2000030610A2 WO2000030610A2 (en) 2000-06-02
WO2000030610A3 true WO2000030610A3 (en) 2002-10-03

Family

ID=22703259

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026759 WO2000030610A2 (en) 1998-11-12 1999-11-12 Microporous drug delivery system

Country Status (3)

Country Link
US (1) US6361780B1 (en)
AU (1) AU1618800A (en)
WO (1) WO2000030610A2 (en)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050171594A1 (en) * 1998-12-31 2005-08-04 Angiotech International Ag Stent grafts with bioactive coatings
US7013182B1 (en) * 2000-05-04 2006-03-14 Cardiac Pacemakers, Inc. Conductive polymer sheath on defibrillator shocking coils
US7369890B2 (en) * 2000-11-02 2008-05-06 Cardiac Pacemakers, Inc. Technique for discriminating between coordinated and uncoordinated cardiac rhythms
US6689117B2 (en) * 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US7209783B2 (en) * 2001-06-15 2007-04-24 Cardiac Pacemakers, Inc. Ablation stent for treating atrial fibrillation
US7493162B2 (en) * 2001-06-15 2009-02-17 Cardiac Pacemakers, Inc. Pulmonary vein stent for treating atrial fibrillation
US6629969B2 (en) * 2001-07-26 2003-10-07 Durect Corporation Catheter for modification of agent formulation
US7340303B2 (en) * 2001-09-25 2008-03-04 Cardiac Pacemakers, Inc. Evoked response sensing for ischemia detection
US6671562B2 (en) 2001-11-09 2003-12-30 Oscor Inc. High impedance drug eluting cardiac lead
US7236821B2 (en) * 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
US7072711B2 (en) * 2002-11-12 2006-07-04 Cardiac Pacemakers, Inc. Implantable device for delivering cardiac drug therapy
US7627373B2 (en) * 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US20040158289A1 (en) * 2002-11-30 2004-08-12 Girouard Steven D. Method and apparatus for cell and electrical therapy of living tissue
US8409618B2 (en) * 2002-12-20 2013-04-02 Kimberly-Clark Worldwide, Inc. Odor-reducing quinone compounds
US7666410B2 (en) * 2002-12-20 2010-02-23 Kimberly-Clark Worldwide, Inc. Delivery system for functional compounds
US20040204735A1 (en) * 2003-04-11 2004-10-14 Shiroff Jason Alan Subcutaneous dissection tool incorporating pharmacological agent delivery
US7566318B2 (en) * 2003-04-11 2009-07-28 Cardiac Pacemakers, Inc. Ultrasonic subcutaneous dissection tool incorporating fluid delivery
US7702399B2 (en) * 2003-04-11 2010-04-20 Cardiac Pacemakers, Inc. Subcutaneous electrode and lead with phoresis based pharmacological agent delivery
US20040230230A1 (en) * 2003-04-11 2004-11-18 Lindstrom Curtis Charles Methods and systems involving subcutaneous electrode positioning relative to a heart
US20040230272A1 (en) * 2003-04-11 2004-11-18 Cates Adam W. Subcutaneous lead with temporary pharmacological agents
US7529592B2 (en) * 2003-04-11 2009-05-05 Cardiac Pacemakers, Inc. Subcutaneous electrode and lead with temporary pharmacological agents
US20030216803A1 (en) * 2003-05-28 2003-11-20 Ledergerber Walter J. Textured and drug eluting stent-grafts
US7041127B2 (en) * 2003-05-28 2006-05-09 Ledergerber Walter J Textured and drug eluting coronary artery stent
US7320675B2 (en) * 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US7488343B2 (en) * 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
US7879350B2 (en) * 2003-10-16 2011-02-01 Kimberly-Clark Worldwide, Inc. Method for reducing odor using colloidal nanoparticles
US7438875B2 (en) * 2003-10-16 2008-10-21 Kimberly-Clark Worldwide, Inc. Method for reducing odor using metal-modified silica particles
US7794737B2 (en) * 2003-10-16 2010-09-14 Kimberly-Clark Worldwide, Inc. Odor absorbing extrudates
US7678367B2 (en) * 2003-10-16 2010-03-16 Kimberly-Clark Worldwide, Inc. Method for reducing odor using metal-modified particles
EP1687043A2 (en) * 2003-11-20 2006-08-09 Angiotech International Ag Electrical devices and anti-scarring agents
US20050137626A1 (en) * 2003-12-19 2005-06-23 Pastore Joseph M. Drug delivery system and method employing external drug delivery device in conjunction with computer network
US7803178B2 (en) 2004-01-30 2010-09-28 Trivascular, Inc. Inflatable porous implants and methods for drug delivery
US8137397B2 (en) * 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US7840263B2 (en) * 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US20050267556A1 (en) * 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US7567841B2 (en) * 2004-08-20 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for delivering combined electrical and drug therapies
US20060129215A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US8818504B2 (en) 2004-12-16 2014-08-26 Cardiac Pacemakers Inc Leadless cardiac stimulation device employing distributed logic
US8060219B2 (en) * 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US7942890B2 (en) * 2005-03-15 2011-05-17 Tyco Healthcare Group Lp Anastomosis composite gasket
KR101207553B1 (en) 2005-06-02 2012-12-03 (주)씨앤팜 Injectable drug carrier comprising layered double hydroxide
CA2613044A1 (en) * 2005-06-20 2007-01-04 Abbeymoor Medical, Inc. Medicament delivery article, accessory & system
US20070051531A1 (en) * 2005-09-08 2007-03-08 Harshad Borgaonkar Drug eluting coatings for a medical lead and method therefor
US7616990B2 (en) 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US20070135847A1 (en) * 2005-12-12 2007-06-14 Kenknight Bruce H Subcutaneous defibrillation system and method using same
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US7881808B2 (en) * 2006-03-29 2011-02-01 Cardiac Pacemakers, Inc. Conductive polymeric coating with optional biobeneficial topcoat for a medical lead
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
CA2655793A1 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
US20080057104A1 (en) * 2006-09-01 2008-03-06 Joseph Walker Matrix metalloproteinase inhibitor delivering devices
CA2662808A1 (en) 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
US8431149B2 (en) * 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8703168B2 (en) 2007-04-25 2014-04-22 Boston Scientific Scimed, Inc. Medical devices for releasing therapeutic agent and methods of making the same
US20090024197A1 (en) * 2007-07-18 2009-01-22 Cardiac Pacemakers, Inc. Elution control via geometric features of an implantable substance matrix
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
EP2185103B1 (en) 2007-08-03 2014-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US7883736B2 (en) 2007-09-06 2011-02-08 Boston Scientific Scimed, Inc. Endoprostheses having porous claddings prepared using metal hydrides
US20090118812A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118821A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US20090118818A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090163887A1 (en) * 2007-12-20 2009-06-25 Arehart Kelly D Odor control cellulose granules with quinone compounds
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
EP2303350A2 (en) * 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2370152B1 (en) * 2008-11-20 2014-04-09 Cardiac Pacemakers, Inc. Overmolded components for implantable medical leads and related methods
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
AU2010203373B2 (en) 2009-01-12 2013-08-01 University Of Massachusetts Lowell Polyisobutylene-based polyurethanes
US8454706B2 (en) * 2009-02-25 2013-06-04 Brian C. de Beaubien Antibiotic delivery system and method for treating an infected synovial joint during re-implantation of an orthopedic prosthesis
US20100274295A1 (en) * 2009-04-24 2010-10-28 Warsaw Orthopedic, Inc. Medical implant configured to deliver a therapeutic substance
US8333791B2 (en) * 2009-04-24 2012-12-18 Warsaw Orthopedic, Inc. Medical implant with tie configured to deliver a therapeutic substance
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
CN102596097B (en) 2009-06-03 2015-05-20 弗赛特实验室有限责任公司 Anterior segment drug delivery
WO2011022583A1 (en) 2009-08-21 2011-02-24 Cardiac Pacemakers, Inc. Crosslinkable polyisobutylene-based polymers and medical devices containing the same
US8644952B2 (en) 2009-09-02 2014-02-04 Cardiac Pacemakers, Inc. Medical devices including polyisobutylene based polymers and derivatives thereof
US8374704B2 (en) 2009-09-02 2013-02-12 Cardiac Pacemakers, Inc. Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same
US8753708B2 (en) * 2009-09-02 2014-06-17 Cardiac Pacemakers, Inc. Solventless method for forming a coating on a medical electrical lead body
JP2013516222A (en) * 2009-12-30 2013-05-13 カーディアック ペースメイカーズ， インコーポレイテッド Tapered drug-eluting color for medical electrical leads
US20120316633A1 (en) * 2011-06-07 2012-12-13 Boston Scientific Scimed, Inc. Durable Stent Drug Eluting Coating
CN106073986B (en) 2011-09-14 2019-01-11 弗赛特影像5股份有限公司 The device for treating the eyes of patient
EP2830847B1 (en) * 2012-03-30 2016-06-08 Cardiac Pacemakers, Inc. Method of manufacturing a steroid eluting collar undermold
US9750636B2 (en) 2012-10-26 2017-09-05 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
JP2015535538A (en) 2012-11-21 2015-12-14 ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ High strength polyisobutylene polyurethane
WO2015106015A1 (en) 2014-01-10 2015-07-16 Cardiac Pacemakers, Inc. Systems and methods for detecting cardiac arrhythmias
CN106102830B (en) 2014-01-10 2019-07-16 心脏起搏器股份公司 For improving the method and system of the communication between medical device
WO2016033197A2 (en) 2014-08-28 2016-03-03 Cardiac Pacemakers, Inc. Medical device with triggered blanking period
JP6510660B2 (en) 2015-02-06 2019-05-08 カーディアック ペースメイカーズ， インコーポレイテッド System and method for treating cardiac arrhythmias
ES2713231T3 (en) 2015-02-06 2019-05-20 Cardiac Pacemakers Inc Systems for the safe supply of electrical stimulation therapy
US10046167B2 (en) 2015-02-09 2018-08-14 Cardiac Pacemakers, Inc. Implantable medical device with radiopaque ID tag
US11285326B2 (en) 2015-03-04 2022-03-29 Cardiac Pacemakers, Inc. Systems and methods for treating cardiac arrhythmias
US10050700B2 (en) 2015-03-18 2018-08-14 Cardiac Pacemakers, Inc. Communications in a medical device system with temporal optimization
WO2016149262A1 (en) 2015-03-18 2016-09-22 Cardiac Pacemakers, Inc. Communications in a medical device system with link quality assessment
EP3283004A4 (en) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
US10433965B2 (en) 2015-06-17 2019-10-08 Joint Purification Systems Llc Total joint replacement infection control devices and methods
US10357159B2 (en) 2015-08-20 2019-07-23 Cardiac Pacemakers, Inc Systems and methods for communication between medical devices
EP3337558A1 (en) 2015-08-20 2018-06-27 Cardiac Pacemakers, Inc. Systems and methods for communication between medical devices
US9968787B2 (en) 2015-08-27 2018-05-15 Cardiac Pacemakers, Inc. Spatial configuration of a motion sensor in an implantable medical device
US9956414B2 (en) 2015-08-27 2018-05-01 Cardiac Pacemakers, Inc. Temporal configuration of a motion sensor in an implantable medical device
WO2017040115A1 (en) 2015-08-28 2017-03-09 Cardiac Pacemakers, Inc. System for detecting tamponade
US10226631B2 (en) 2015-08-28 2019-03-12 Cardiac Pacemakers, Inc. Systems and methods for infarct detection
CN108136189B (en) 2015-08-28 2021-10-15 心脏起搏器股份公司 System for behavioral response signal detection and therapy delivery
WO2017044389A1 (en) 2015-09-11 2017-03-16 Cardiac Pacemakers, Inc. Arrhythmia detection and confirmation
EP3359251B1 (en) 2015-10-08 2019-08-07 Cardiac Pacemakers, Inc. Adjusting pacing rates in an implantable medical device
CN113069681B (en) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 Method of manufacturing a therapeutic device for sustained drug delivery
EP3389775B1 (en) 2015-12-17 2019-09-25 Cardiac Pacemakers, Inc. Conducted communication in a medical device system
US10905886B2 (en) 2015-12-28 2021-02-02 Cardiac Pacemakers, Inc. Implantable medical device for deployment across the atrioventricular septum
WO2017127548A1 (en) 2016-01-19 2017-07-27 Cardiac Pacemakers, Inc. Devices for wirelessly recharging a rechargeable battery of an implantable medical device
WO2017136548A1 (en) 2016-02-04 2017-08-10 Cardiac Pacemakers, Inc. Delivery system with force sensor for leadless cardiac device
WO2017173275A1 (en) 2016-03-31 2017-10-05 Cardiac Pacemakers, Inc. Implantable medical device with rechargeable battery
US10668294B2 (en) 2016-05-10 2020-06-02 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker configured for over the wire delivery
US10328272B2 (en) 2016-05-10 2019-06-25 Cardiac Pacemakers, Inc. Retrievability for implantable medical devices
US10512784B2 (en) 2016-06-27 2019-12-24 Cardiac Pacemakers, Inc. Cardiac therapy system using subcutaneously sensed P-waves for resynchronization pacing management
WO2018009569A1 (en) 2016-07-06 2018-01-11 Cardiac Pacemakers, Inc. Method and system for determining an atrial contraction timing fiducial in a leadless cardiac pacemaker system
US10426962B2 (en) 2016-07-07 2019-10-01 Cardiac Pacemakers, Inc. Leadless pacemaker using pressure measurements for pacing capture verification
WO2018017226A1 (en) 2016-07-20 2018-01-25 Cardiac Pacemakers, Inc. System for utilizing an atrial contraction timing fiducial in a leadless cardiac pacemaker system
WO2018035343A1 (en) 2016-08-19 2018-02-22 Cardiac Pacemakers, Inc. Trans septal implantable medical device
CN109640809B (en) 2016-08-24 2021-08-17 心脏起搏器股份公司 Integrated multi-device cardiac resynchronization therapy using P-wave to pacing timing
EP3503970B1 (en) 2016-08-24 2023-01-04 Cardiac Pacemakers, Inc. Cardiac resynchronization using fusion promotion for timing management
US10905889B2 (en) 2016-09-21 2021-02-02 Cardiac Pacemakers, Inc. Leadless stimulation device with a housing that houses internal components of the leadless stimulation device and functions as the battery case and a terminal of an internal battery
US10758737B2 (en) 2016-09-21 2020-09-01 Cardiac Pacemakers, Inc. Using sensor data from an intracardially implanted medical device to influence operation of an extracardially implantable cardioverter
WO2018057626A1 (en) 2016-09-21 2018-03-29 Cardiac Pacemakers, Inc. Implantable cardiac monitor
WO2018081237A1 (en) 2016-10-27 2018-05-03 Cardiac Pacemakers, Inc. Use of a separate device in managing the pace pulse energy of a cardiac pacemaker
US10463305B2 (en) 2016-10-27 2019-11-05 Cardiac Pacemakers, Inc. Multi-device cardiac resynchronization therapy with timing enhancements
US10561330B2 (en) 2016-10-27 2020-02-18 Cardiac Pacemakers, Inc. Implantable medical device having a sense channel with performance adjustment
EP3532159B1 (en) 2016-10-27 2021-12-22 Cardiac Pacemakers, Inc. Implantable medical device delivery system with integrated sensor
US10765871B2 (en) 2016-10-27 2020-09-08 Cardiac Pacemakers, Inc. Implantable medical device with pressure sensor
US10413733B2 (en) 2016-10-27 2019-09-17 Cardiac Pacemakers, Inc. Implantable medical device with gyroscope
CN109890456B (en) 2016-10-31 2023-06-13 心脏起搏器股份公司 System for activity level pacing
JP6843235B2 (en) 2016-10-31 2021-03-17 カーディアック ペースメイカーズ， インコーポレイテッド Systems and methods for activity level pacing
WO2018089311A1 (en) 2016-11-08 2018-05-17 Cardiac Pacemakers, Inc Implantable medical device for atrial deployment
US10632313B2 (en) 2016-11-09 2020-04-28 Cardiac Pacemakers, Inc. Systems, devices, and methods for setting cardiac pacing pulse parameters for a cardiac pacing device
US10881863B2 (en) 2016-11-21 2021-01-05 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker with multimode communication
US10894163B2 (en) 2016-11-21 2021-01-19 Cardiac Pacemakers, Inc. LCP based predictive timing for cardiac resynchronization
US10881869B2 (en) 2016-11-21 2021-01-05 Cardiac Pacemakers, Inc. Wireless re-charge of an implantable medical device
US10639486B2 (en) 2016-11-21 2020-05-05 Cardiac Pacemakers, Inc. Implantable medical device with recharge coil
CN109996585B (en) 2016-11-21 2023-06-13 心脏起搏器股份公司 Implantable medical device with magnetically permeable housing and induction coil disposed around the housing
FR3059553B1 (en) * 2016-12-07 2021-04-23 Univ Grenoble Alpes IMPLANTABLE DEVICE
US11207532B2 (en) 2017-01-04 2021-12-28 Cardiac Pacemakers, Inc. Dynamic sensing updates using postural input in a multiple device cardiac rhythm management system
EP3573708B1 (en) 2017-01-26 2021-03-10 Cardiac Pacemakers, Inc. Leadless implantable device with detachable fixation
JP7000438B2 (en) 2017-01-26 2022-01-19 カーディアック ペースメイカーズ， インコーポレイテッド Human device communication with redundant message transmission
CN110234392B (en) 2017-01-26 2023-08-11 心脏起搏器股份公司 Leadless device with overmolded component
CA3050442A1 (en) * 2017-01-31 2018-08-09 Medallion Therapeutics, Inc. Ambulatory infusion devices and filter assemblies for use with same
EP3592786B1 (en) 2017-03-07 2023-05-10 Cardiac Pacemakers, Inc. Hydroboration/oxidation of allyl-terminated polyisobutylene
US10905872B2 (en) 2017-04-03 2021-02-02 Cardiac Pacemakers, Inc. Implantable medical device with a movable electrode biased toward an extended position
AU2018248361B2 (en) 2017-04-03 2020-08-27 Cardiac Pacemakers, Inc. Cardiac pacemaker with pacing pulse energy adjustment based on sensed heart rate
CN110997746B (en) 2017-08-17 2021-12-28 心脏起搏器股份公司 Photocrosslinked polymers for enhanced durability
US10918875B2 (en) 2017-08-18 2021-02-16 Cardiac Pacemakers, Inc. Implantable medical device with a flux concentrator and a receiving coil disposed about the flux concentrator
US11065459B2 (en) 2017-08-18 2021-07-20 Cardiac Pacemakers, Inc. Implantable medical device with pressure sensor
CN111107899B (en) 2017-09-20 2024-04-02 心脏起搏器股份公司 Implantable medical device with multiple modes of operation
US11185703B2 (en) 2017-11-07 2021-11-30 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker for bundle of his pacing
EP3717059A1 (en) 2017-12-01 2020-10-07 Cardiac Pacemakers, Inc. Methods and systems for detecting atrial contraction timing fiducials within a search window from a ventricularly implanted leadless cardiac pacemaker
CN111417433A (en) 2017-12-01 2020-07-14 心脏起搏器股份公司 Method and system for detecting atrial contraction timing reference during ventricular filling from a ventricular implanted leadless cardiac pacemaker
WO2019108830A1 (en) 2017-12-01 2019-06-06 Cardiac Pacemakers, Inc. Leadless cardiac pacemaker with reversionary behavior
WO2019108482A1 (en) 2017-12-01 2019-06-06 Cardiac Pacemakers, Inc. Methods and systems for detecting atrial contraction timing fiducials and determining a cardiac interval from a ventricularly implanted leadless cardiac pacemaker
US11529523B2 (en) 2018-01-04 2022-12-20 Cardiac Pacemakers, Inc. Handheld bridge device for providing a communication bridge between an implanted medical device and a smartphone
US10874861B2 (en) 2018-01-04 2020-12-29 Cardiac Pacemakers, Inc. Dual chamber pacing without beat-to-beat communication
EP3740253B1 (en) 2018-01-17 2023-08-16 Cardiac Pacemakers, Inc. End-capped polyisobutylene polyurethane
CN111902187A (en) 2018-03-23 2020-11-06 美敦力公司 VFA cardiac resynchronization therapy
CN111886046A (en) 2018-03-23 2020-11-03 美敦力公司 AV-synchronized VFA cardiac therapy
US11058880B2 (en) 2018-03-23 2021-07-13 Medtronic, Inc. VFA cardiac therapy for tachycardia
CN112770807A (en) 2018-09-26 2021-05-07 美敦力公司 Capture in atrial-to-ventricular cardiac therapy
US11679265B2 (en) 2019-02-14 2023-06-20 Medtronic, Inc. Lead-in-lead systems and methods for cardiac therapy
US11697025B2 (en) 2019-03-29 2023-07-11 Medtronic, Inc. Cardiac conduction system capture
US11213676B2 (en) 2019-04-01 2022-01-04 Medtronic, Inc. Delivery systems for VfA cardiac therapy
US11712188B2 (en) 2019-05-07 2023-08-01 Medtronic, Inc. Posterior left bundle branch engagement
US11305127B2 (en) 2019-08-26 2022-04-19 Medtronic Inc. VfA delivery and implant region detection
US11813466B2 (en) 2020-01-27 2023-11-14 Medtronic, Inc. Atrioventricular nodal stimulation
US11911168B2 (en) 2020-04-03 2024-02-27 Medtronic, Inc. Cardiac conduction system therapy benefit determination
US11813464B2 (en) 2020-07-31 2023-11-14 Medtronic, Inc. Cardiac conduction system evaluation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220153A (en) * 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4601893A (en) * 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
US5232444A (en) * 1988-06-25 1993-08-03 Just Hansjoerg Dilatation catheter
WO1995003083A1 (en) * 1993-07-23 1995-02-02 Boston Scientific Corporation Drug delivery
WO1996008286A1 (en) * 1994-09-13 1996-03-21 Localmed, Inc. Catheter sleeve and method of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545439A (en) * 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
US3857934A (en) 1971-02-02 1974-12-31 Herculite Protective Fab Activated polymer materials and process for making same
US4018220A (en) * 1974-07-19 1977-04-19 Lionel C. R. Emmett Method of insertion for intrauterine device of C or omega form with tubular inserter
US4191741A (en) 1978-09-22 1980-03-04 Eli Lilly And Company Removable drug implant
US4961931A (en) * 1982-07-29 1990-10-09 Alza Corporation Method for the management of hyperplasia
US4581028A (en) 1984-04-30 1986-04-08 The Trustees Of Columbia University In The City Of New York Infection-resistant materials and method of making same through use of sulfonamides
EP0180264A1 (en) * 1984-10-12 1986-05-07 Akzo N.V. Release system for two or more active substances
US4846844A (en) 1987-08-31 1989-07-11 Eli Lilly And Company Antimicrobial coated implants
US4819662A (en) 1987-10-26 1989-04-11 Cardiac Pacemakers, Inc. Cardiac electrode with drug delivery capabilities
US5269770A (en) * 1990-01-10 1993-12-14 Rochester Medical Corporation Microcidal agent releasing catheter with balloon
US5844017A (en) * 1995-03-06 1998-12-01 Ethicon, Inc. Prepolymers of absorbable polyoxaesters containing amines and/or amido groups
TW358031B (en) * 1997-04-11 1999-05-11 Akze Nobel N V Drug delivery system for 2 or more active substances

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220153A (en) * 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4601893A (en) * 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
US5232444A (en) * 1988-06-25 1993-08-03 Just Hansjoerg Dilatation catheter
WO1995003083A1 (en) * 1993-07-23 1995-02-02 Boston Scientific Corporation Drug delivery
WO1996008286A1 (en) * 1994-09-13 1996-03-21 Localmed, Inc. Catheter sleeve and method of use

Also Published As

Publication number Publication date
AU1618800A (en) 2000-06-13
US6361780B1 (en) 2002-03-26
WO2000030610A2 (en) 2000-06-02

Similar Documents

Publication Publication Date Title
WO2000030610A3 (en) Microporous drug delivery system
ATE238821T1 (en) EQUIPMENT INCLUDING AN IMPLANTABLE DEVICE
CA2226718A1 (en) Transcorneal drug-release system
TW224428B (en)
CA2366361A1 (en) Orthopaedic implant device
WO1997048438A3 (en) Medical tube for insertion and detection within the body of a patient
MXPA02011599A (en) Infusion of liquids into the human or animal body.
EP0604546A4 (en) Controlled porosity implantable primary lumen device.
ES267885U (en) Medical tubing having exterior hydrophilic coating for microbiocide absorption therein and method for using same
EE04216B1 (en) Liquid polymeric composition and its use as a medicament for the controlled release of a hydrophobic bioactive substance in an animal
CA2194555A1 (en) Implanted device containing tumor cells for the treatment of cancer
EP1961429A3 (en) A method for sterilising a medical device having a hydrophilic coating
EP1844769A3 (en) Methods for treating neuropsychiatric disorders
WO2001017581A3 (en) Guidable intravascular blood pump and related methods
NO874873L (en) DEVICE FOR AUTO-ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBSTANCES, WITHOUT OVERDOSAGE PREVENTION.
CA2206762A1 (en) A stent assembly
WO2002038052A3 (en) Steerable loop structure
FR2651683B3 (en) CATHETER, PARTICULARLY FOR ANGIOGRAPHIC EXAMINATION, COMPRISING AN IMPROVED HOLDING DEVICE.
CZ20022079A3 (en) Fungicidal combinations of active substances, method of fighting fungi and use of such combinations of the active substances
NZ334392A (en) Device with polymeric coating containing a nitrosyl-containing organometallic compound which releases nitric oxide and inhibits platelet aggregation
CA2367209A1 (en) Stent security balloon/balloon cathether
WO2000018331A3 (en) Drug delivery systems
GB2210884B (en) Granules based on hydrophilic polymers on which an aqueous formulation, containing one or more active principles, is absorbed
EP0853883A4 (en) Agricultural chemical composition with improved raindrop resistance
EP1177811A4 (en) Living body insertion electrode lead, and living body insertion medical instrument using the same

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref country code: AU

Ref document number: 2000 16188

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
CR1 Correction of entry in section i

Free format text: PAT. BUL. 16/2002 UNDER (81) DELETE ALL DESIGNATED STATES EXCEPT US AND UNDER (84) DELETE ALL DESIGNATED STATES EXCEPT EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

122 Ep: pct application non-entry in european phase