WO2000029847A3 - Device and method for analyzing a biologic sample - Google Patents

Device and method for analyzing a biologic sample Download PDF

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Publication number
WO2000029847A3
WO2000029847A3 PCT/CA1999/001079 CA9901079W WO0029847A3 WO 2000029847 A3 WO2000029847 A3 WO 2000029847A3 CA 9901079 W CA9901079 W CA 9901079W WO 0029847 A3 WO0029847 A3 WO 0029847A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
sample
microspheres
separating
analyte
Prior art date
Application number
PCT/CA1999/001079
Other languages
French (fr)
Other versions
WO2000029847A2 (en
Inventor
Peter Lea
Original Assignee
Biophys Inc
Peter Lea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002254223A external-priority patent/CA2254223A1/en
Application filed by Biophys Inc, Peter Lea filed Critical Biophys Inc
Priority to CA002350789A priority Critical patent/CA2350789A1/en
Priority to EP99972308A priority patent/EP1131632A2/en
Priority to JP2000582799A priority patent/JP4544498B2/en
Priority to AU11440/00A priority patent/AU1144000A/en
Priority to BR9915406-4A priority patent/BR9915406A/en
Priority to AU47126/00A priority patent/AU4712600A/en
Priority to PCT/US2000/013056 priority patent/WO2000078917A1/en
Publication of WO2000029847A2 publication Critical patent/WO2000029847A2/en
Publication of WO2000029847A3 publication Critical patent/WO2000029847A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Ecology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A device for separating fluid from a biologic sample when the sample has a fluid and non-fluid component. The device is a point-of-care device through which data may be electronically collected and electronically transmitted for further evaluation. A method for separating fluid from a biologic sample is provided wherein the method comprises the step of bringing the fluid sample in fluid contact with the microspheres such that the fluid component moves by capillary action between the microspheres along capillary channels formed by the spaces between the spheres and leaving, for example, a cellular fraction behind. In the device of the present invention, the step of separating the fluid may be combined with other assay techniques for detecting and/or measuring one or more analytes which may be present in the fluid sample such as immunoassays and chromatographic assays. These may be further combined with groups of microspheres for use in the analyte detection step as well as the separation step whereby the microspheres act as labels for the analyte or as a source of label for the analyte.
PCT/CA1999/001079 1998-11-16 1999-11-12 Device and method for analyzing a biologic sample WO2000029847A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002350789A CA2350789A1 (en) 1998-11-16 1999-11-12 Device and method for analyzing a biologic sample
EP99972308A EP1131632A2 (en) 1998-11-16 1999-11-12 Device and method for analyzing a biologic sample
JP2000582799A JP4544498B2 (en) 1998-11-16 1999-11-12 Biological sample analysis apparatus and method
AU11440/00A AU1144000A (en) 1998-11-16 1999-11-12 Device and method for analyzing a biologic sample
BR9915406-4A BR9915406A (en) 1998-11-16 1999-11-12 Device and method for the analysis of a biological sample
AU47126/00A AU4712600A (en) 1999-06-18 2000-05-12 Device and method for analyzing a biologic sample
PCT/US2000/013056 WO2000078917A1 (en) 1999-06-18 2000-05-12 Device and method for analyzing a biologic sample

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA002254223A CA2254223A1 (en) 1998-11-16 1998-11-16 Device and method for analyzing a biologic sample
CA2,254,223 1998-11-16
US09/335,732 1999-06-18
US09/335,732 US6403384B1 (en) 1998-11-16 1999-06-18 Device and method for analyzing a biologic sample

Publications (2)

Publication Number Publication Date
WO2000029847A2 WO2000029847A2 (en) 2000-05-25
WO2000029847A3 true WO2000029847A3 (en) 2000-09-08

Family

ID=25680640

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/001079 WO2000029847A2 (en) 1998-11-16 1999-11-12 Device and method for analyzing a biologic sample

Country Status (6)

Country Link
EP (1) EP1131632A2 (en)
JP (1) JP4544498B2 (en)
AU (1) AU1144000A (en)
BR (1) BR9915406A (en)
TW (1) TW468046B (en)
WO (1) WO2000029847A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8928877B2 (en) 2011-07-06 2015-01-06 Optiscan Biomedical Corporation Sample cell for fluid analysis system
US8936755B2 (en) 2005-03-02 2015-01-20 Optiscan Biomedical Corporation Bodily fluid composition analyzer with disposable cassette
US8992443B2 (en) 2005-02-14 2015-03-31 Optiscan Biomedical Corporation Fluid handling cassette
US9404852B2 (en) 2001-11-08 2016-08-02 Optiscan Biomedical Corporation Analyte monitoring systems and methods
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU780825B2 (en) 1999-09-27 2005-04-21 Clifford L. Librach Detection of HLA-G
DE10354806A1 (en) * 2003-11-21 2005-06-02 Boehringer Ingelheim Microparts Gmbh sample carrier
US20050266398A1 (en) * 2004-06-01 2005-12-01 Peter Lea Method and device for rapid detection and quantitation of macro and micro matrices
WO2011011462A1 (en) 2009-07-20 2011-01-27 Optiscan Biomedical Corporation Adjustable connector and dead space reduction
EP3156796A1 (en) 2010-06-09 2017-04-19 Optiscan Biomedical Corporation Measuring analytes in a fluid sample drawn from a patient
US9523682B2 (en) 2011-11-16 2016-12-20 Becton, Dickinson And Company Methods and systems for detecting an analyte in a sample
BR112015010695B1 (en) 2013-01-11 2023-03-07 Becton, Dickinson And Company MICROFLUID DEVICE AND METHOD FOR PERFORMING A LIQUID SAMPLE TEST, METHOD FOR FORMING A MICROFLUID DEVICE, SYSTEM AND KIT
CN113477149B (en) 2013-11-06 2023-09-12 贝克顿·迪金森公司 Microfluidic devices and methods of making and using the same
US10018640B2 (en) 2013-11-13 2018-07-10 Becton, Dickinson And Company Optical imaging system and methods for using the same
ES2962033T3 (en) 2014-10-14 2024-03-14 Becton Dickinson Co Blood sample management using open cell foam
US9693723B2 (en) 2014-10-14 2017-07-04 Becton, Dickinson And Company Blood sample management using open cell foam
AU2016229837B2 (en) 2015-03-10 2018-05-24 Becton, Dickinson And Company Biological fluid micro-sample management device
US10578606B2 (en) 2015-09-01 2020-03-03 Becton, Dickinson And Company Depth filtration device for separating specimen phases
JP7170042B2 (en) * 2017-11-30 2022-11-11 ヤンタイ・アウスビオ・ラボラトリーズ・カンパニー・リミテッド Methods, systems and filtration units for isolating particles from biological samples
KR102074150B1 (en) * 2018-04-11 2020-02-06 바디텍메드(주) System and method for changing reaction characteristic information of plurality of diagnosis cartridge set

Citations (6)

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US4088448A (en) * 1975-09-29 1978-05-09 Lilja Jan Evert Apparatus for sampling, mixing the sample with a reagent and making particularly optical analyses
US4381921A (en) * 1978-12-27 1983-05-03 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4430436A (en) * 1980-12-17 1984-02-07 Konishiroku Photo Industry Co., Ltd. Analytical element and method of use
JPH0768785A (en) * 1993-09-07 1995-03-14 Fuji Xerox Co Ltd Ink supply device
WO1996014933A1 (en) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Mesoscale devices for analysis of motile cells
WO1996019739A2 (en) * 1994-12-22 1996-06-27 Karo Bio Ab Assay apparatus

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US4790640A (en) * 1985-10-11 1988-12-13 Nason Frederic L Laboratory slide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088448A (en) * 1975-09-29 1978-05-09 Lilja Jan Evert Apparatus for sampling, mixing the sample with a reagent and making particularly optical analyses
US4381921A (en) * 1978-12-27 1983-05-03 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4430436A (en) * 1980-12-17 1984-02-07 Konishiroku Photo Industry Co., Ltd. Analytical element and method of use
JPH0768785A (en) * 1993-09-07 1995-03-14 Fuji Xerox Co Ltd Ink supply device
WO1996014933A1 (en) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Mesoscale devices for analysis of motile cells
WO1996019739A2 (en) * 1994-12-22 1996-06-27 Karo Bio Ab Assay apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 06 31 July 1995 (1995-07-31) *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9404852B2 (en) 2001-11-08 2016-08-02 Optiscan Biomedical Corporation Analyte monitoring systems and methods
US8992443B2 (en) 2005-02-14 2015-03-31 Optiscan Biomedical Corporation Fluid handling cassette
US8936755B2 (en) 2005-03-02 2015-01-20 Optiscan Biomedical Corporation Bodily fluid composition analyzer with disposable cassette
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
US8928877B2 (en) 2011-07-06 2015-01-06 Optiscan Biomedical Corporation Sample cell for fluid analysis system

Also Published As

Publication number Publication date
TW468046B (en) 2001-12-11
EP1131632A2 (en) 2001-09-12
BR9915406A (en) 2001-07-24
AU1144000A (en) 2000-06-05
JP4544498B2 (en) 2010-09-15
JP2002530648A (en) 2002-09-17
WO2000029847A2 (en) 2000-05-25

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