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Publication numberWO2000028952 A1
Publication typeApplication
Application numberPCT/GB1999/003779
Publication date25 May 2000
Filing date12 Nov 1999
Priority date12 Nov 1998
Also published asCA2350450A1, CN1333674A, EP1128800A1, US6169118
Publication numberPCT/1999/3779, PCT/GB/1999/003779, PCT/GB/1999/03779, PCT/GB/99/003779, PCT/GB/99/03779, PCT/GB1999/003779, PCT/GB1999/03779, PCT/GB1999003779, PCT/GB199903779, PCT/GB99/003779, PCT/GB99/03779, PCT/GB99003779, PCT/GB9903779, WO 0028952 A1, WO 0028952A1, WO 2000/028952 A1, WO 2000028952 A1, WO 2000028952A1, WO-A1-0028952, WO-A1-2000028952, WO0028952 A1, WO0028952A1, WO2000/028952A1, WO2000028952 A1, WO2000028952A1
InventorsEssat Bilali
ApplicantBlock Drug Company, Inc., Whalley, Kevin
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Flavour blend for masking unpleasant taste of zinc compounds
WO 2000028952 A1
Abstract
A synergistic flavouring combination of at least a flavouring oil and lauryl alcohol for use in an orally administered formulation which contains an ionisable zinc compound having an undesirable taste. The flavouring combination is unexpectedly effective in masking the unpleasant taste or aftertaste of zinc.
Claims  (OCR text may contain errors)
CLAIMS:
1. An orally administered formulation that releases zinc ions to the oral and oral pharyngeal mucous membranes of a human comprising a suitable carrier and uniformly contained in said formulation: about 0.1 to 25 wt. % of an ionisable zinc compound having an undesirable taste; a synergistic flavouring combination of at least a flavouring oil and lauryl alcohol in an amount effective to mask the undesirable taste of said ionisable zinc compound.
2. The orally administered formulation of claim 1, wherein the lauryl alcohol is present in an amount of about 0.5-20 wt. % of the synergistic flavouring combination.
3. The orally administered formulation of claim 1 or claim 2, wherein said at least a flavouring oil is selected from the group consisting of: peppermint oil, spearmint oil, carvone, anethole and mixtures thereof.
4. The orally administered formulation of any one of claims 1 to 3, wherein said ionisable zinc compound is selected from the group consisting of: zinc oxide, zinc citrate, zinc chloride, zinc acetate, zinc hydroxide, zinc fluorosilicate, zinc fluorozirconate , zinc acetate, zinc gluconate and mixtures thereof.
5. The orally administered formulation of claim 4, wherein said ionisable zinc compound is zinc citrate.
6. The orally administered formulation of any one of claims 1 to 5, in the form of a dentifrice.
7. The orally administered formulation of any one of claims 1 to 5, in the form of a lozenge.
8. The orally administered formulation of any one of claims 1 to 5, in the form of a mouth rinse.
9. The orally administered formulation of any one of claims 1 to 5, in the form of a chewable tablet.
10. The orally administered formulation of any one of claims 1 to 5, in the form of a syrup.
11. The orally administered formulation of any one of claims 1 to 5, selected from the group consisting of foods, pharmaceuticals, and mixtures thereof.
12. A method for improving the taste of an orally administered formulation, which formulation includes about 0.1 to 25 wt. % of an ionisable zinc compound having an undesirable taste, said method comprising mixing a synergistic flavouring combination of at least a flavouring oil and lauryl alcohol in an amount effective to mask the undesirable taste of said ionisable zinc.
13. The method of claim 12, wherein the lauryl alcohol is present in an amount of about 0.5-20 wt. % of the synergistic flavouring combination.
14. The method of claim 12 or claim 13, wherein said flavouring oil is selected from the group consisting of: peppermint oil, spearmint oil, carvone, anethole and mixtures thereof.
15. The method of any one of claims 12 to 14, wherein said ionisable zinc compound is selected from the group consisting of: zinc oxide, zinc citrate, zinc chloride, zinc acetate, zinc hydroxide, zinc fluorosilicate, zinc fluorozirconate, zinc acetate, zinc gluconate and mixtures thereof.
16. The method of any one of claims 12 to 15, wherein said orally administered formulation is selected from the group consisting of foods, pharmaceuticals, and mixtures thereof.
17. A preformulation consisting essentially of about 80 - 99.5 wt. % of at least a flavouring oil and about 0.5 to 20 wt. % lauryl alcohol, wherein said preformulation when uniformly mixed in an orally administered formulation containing about 0.1 to 25 wt. % of an ionisable zinc compound with undesirable taste, masks the undesirable taste of said ionisable zinc compound.
18. The preformulation of claim 17, wherein said flavouring oil is selected from the group consisting of: peppermint oil, spearmint oil, carvone, anethole and mixtures thereof.
19. The preformulation of claim 17 or claim 18, wherein said orally administered formulation is selected from the group consisting of foods, pharmaceuticals, and mixtures thereof.
20. The preformulation of any one of claims 17 to 19, wherein said ionisable zinc compound is selected from the group consisting of: zinc oxide, zinc citrate, zinc chloride, zinc acetate, zinc hydroxide, zinc fluorosilicate, zinc fluorozirconate , zinc acetate, zinc gluconate and mixtures thereof.
Description  (OCR text may contain errors)

Flavour Blend For Masking Unpleasant Taste Of Zinc Compounds

BACKGROUND OF THE INVENTION

1. Field of Invention. This invention relates to a flavouring method and flavour composition for masking flavour and taste of compositions for oral absorption and administration by humans which contain zinc compounds.

2. General background. The value of the element zinc is well-established. Zinc has a vital role in a number of pharmaceutical formulations. Zinc deficiency is an important feature of many cases of sickle cell anaemia characterised by growth retardation and hypogonadism, and zinc appears to have an antisickling effect. Zinc has also been shown to be beneficial in the relief of acute inflammatory conditions associated with rheumatoid arthritis. Use of zinc gluconate and zinc acetate has been described as a method for reducing duration of common cold symptoms. Zinc oxides are used in a number of dental products such as dentifrices, denture adhesives, dental fillings, dental cements, and dental impression materials. Zinc salts are generally reported to enhance activity of triclosan and cationic anti-microbials in dentifrices and mouthwashes. Zinc chloride has been recognised as possessing anti-odour properties in oral health care products. Zinc citrates are useful in reducing dental calculus formation.

In recent years, formulations for oral administration and /or absorption such as tablets, powders, lozenges, syrups, sprays, dentifrices, mouthwashes, etc. have been formulated containing a zinc component. One of the major drawbacks of the incorporation of zinc compounds into various orally absorbed or administered products has been the characteristic bitterness of zinc that is experienced as soon as the zinc compound is released and proceeds to break down in the mouth. A variety of formulations and methods have been prepared and attempted to lessen or mask entirely the bitter taste and aftertaste of zinc compounds.

US Pat. Nos. 4,684,528 and 4,758,439 disclose the formulation of zinc compounds with glycine and certain other amino acids to reduce the unpalatable and undesirable aftertaste of prior zinc formulations. US Patent No. 5,095,035 teaches masking compositions which contain zinc acetate with the addition of extramolar citric acid. US Patent No. 5,002,970 discloses that ionisable zinc compounds can be masked with anethole to eliminate or reduce the taste and after taste of zinc. US Patent No. 5,766,622 teaches the use of phosphorylated amino acid in oral compositions to inhibit bitter and/or metallic taste from a pharmaceutical active component. US Patent No. 5,817,295 discloses a tripartite blend of peppermint oils that provides for a pleasant tasting mouthwash and masking the bitter taste of essential oils used for antimicrobial efficacy in the mouthwash.

There is still a need for a new way to eliminate the objectionable taste and after taste of zinc compounds using new technologies.

SUMMARY OF THE INVENTION

The present invention relates to an orally administered formulation comprising about 0.1 to 25 wt. % of an ionisable zinc compound having an undesirable taste, and a synergistic flavouring combination of at least a flavouring oil and lauryl alcohol in an amount effective to mask the undesirable taste of said ionisable zinc compound.

The invention also provides a method for improving the taste of an orally administered formulation containing about 0.1 to 25 wt. % of an ionisable zinc compound with undesirable taste, by mixing into said formulation a synergistic flavouring combination of at least a flavouring oil and lauryl alcohol in an amount effective to mask the undesirable taste of said ionisable zinc.

DESCRIPTION OF THE INVENTION The present invention provides an orally administered formulation containing an ionisable zinc compound with undesirable taste, but without the unpleasant metallic taste of zinc. The formulation can be in the form of foods, pharmaceuticals, toiletries, etc. The formulation contains an ionisable zinc compound and a carrier medium making up the balance.

Zinc Compounds. The orally administered formulations may contain one or more ionisable zinc compounds depending on the application. Zinc compounds include both inorganic and organic zinc salts and, in particular, salts such as the halides, nitrates, sulfates, chromates, silicates, and compounds comprising complexes of these materials constituting the inorganic salts contemplated herein. Organic salts of zinc include but not limited zinc gluconate, zinc formate, zinc succinate, zinc aspartate and the like. Particular zinc halides include zinc chloride, zinc bromide, zinc fluoride, and mixtures.

In terms of specific applications, typical zinc compounds used in dental formulations include such materials as zinc oxide for use in inhibiting bacterial attack in dentifrices. Zinc oxide is also used as a binding materials in denture adhesives. Zinc chloride and zinc citrate are used as anti-odour ingredients in dental formulations. Zinc acetate and hydroxide is used for their anti-plaque properties. Zinc citrate, polyphosphates such as disodium ethane- 1- hydroxy-1, 1-diphosphonate (EHDP), pyrophosphate, tetrametaphosphate, metaphosphate and orthophosphate salts of zinc for tartar removal effects in dentifrices. Zinc glycerophosphate, zinc phenolsulfonate, zinc fluorosilicate, zinc fluorozirconate are known for their astringent and deodorant capabilities. Zinc citrate is preferred for dental formulations. Zinc acetate and zinc gluconate are favoured in compositions for treating common colds.

In general, the concentration of zinc compounds in orally administered formulations varies from about 0.1 to 15 wt. %. The concentration can range up to as much as 25% depending on the particular formulation in which the zinc compound is incorporated. A more preferred amount is about 0.2 to 2 wt. %. A most preferred amount is from about 0.5 to 2 wt. %.

Flavouring / masking components: The taste masking / flavouring combination of the present invention is made up of a mixture of flavouring oils and lauryl alcohol.

For the purpose of this invention, flavouring oils used herein refer to both entire essential oils and the aroma chemicals making up the essential oils. Essential oils are predominately volatile materials from botanical sources. The most widely used process for the isolation of essential oils is steam distillation of plant matter, although dry distillation and solvent extraction are also used. Essential oils are generally recognised as safe compositions that can be included in ingested materials. Aroma chemicals refer to chemicals which may be synthetic or natural, derived from essential oils, i.e., derived from plants by distillation, expression, or extraction, and which usually carry the flavour of the plant from which they are derived.

Although the invention is not limited to the specific essential oils listed individually in this specification, a number of important essential oils include spearmint oil; peppermint oil; wintergreen oil; lavender oil; sassafras oil; ginger oil; clove oil; sage oil; basil oil; eucalyptus oil; laurel oil; mayonara oil; cinnamon oil; camomile oil; thyme oil; citrus oils such as lemon oil, orange oil, grapefruit oil, tangerine oil; oil of anise; camphor oil; and the like.

Aroma chemicals include but not limited to anethole, carvone, cintronellal, camphor, linalool, menthol, menthone, thymol, and the like.

It has been found that in an orally administered formulation of the claimed invention, the additional presence of lauryl alcohol in combination with a mixture of flavouring oils as a flavouring composition, enhances the organoleptic properties, imparts freshness in the mouth and masks the unpleasant taste and aftertaste of the zinc compound in the formulation. The flavouring oils appear to be operating in synergistic combination, perhaps with the lauryl alcohol or perhaps because of the ability of various components of the flavouring oils themselves to inhibit different biological pathways associated with bioavailability.

The individual flavouring oils can be mixed and matched as desired to provide the intended flavour in the orally administered composition. The concentrations of the individual components can therefore vary quite widely. It is preferred, nevertheless, that the flavouring oils in total will be about 80 - 99.5 wt. % of the synergistic taste masking / flavouring combination, and most preferred about 95 - 99%. The lauryl alcohol makes up the rest of the masking / flavouring combination.

In general, the synergistic taste masking / flavouring combination is present in an amount of about 0.1 to 5 wt. % of the orally administered formulation. A preferred amount is about 0.1-3% wt. %. A most preferred amount is from about 0.1 to 2 wt. %.

Carriers & Other Ingredients: The carriers vary according to the applications. In toothpastes it is desirable to employ thickening agents such as hydroxyethylcellulose and water-soluble salts of cellulose ethers, including sodium carboxymethyl cellulose and sodium carboxymethylhydroxyethyl cellulose; or natural gums, including gum karaya, gum arabic, and gum tragacanth. Also, colloidal magnesium aluminium silicate or finely divided silica can be used as part of the thickening agent to improve the texture of the product. Thickening agents are used at levels of from 0.1 % to 5.0%> of the toothpaste composition. It is also desirable to include a humectant material in toothpastes. Suitable materials for this purpose include glycerine, sorbitol, and other edible polyhydric alcohols or mixtures thereof. These materials can comprise from about 1%> to about 50% of the toothpaste composition. Dentifrices normally also contain sweetening agents. Suitable sweetening agents for use in dentifrices include for example saccharin, dextrose and levulose. The sweetening agents are used at levels of from about 0.05% to about 2%. In addition to the aforementioned typical components of a toothpaste, water usually comprises the balance of the toothpaste, and is usually present at levels up to about 50%.

Mouthwashes generally comprise a water/ethyl alcohol solution and optionally other ingredients such as sweeteners, and humectants such as those mentioned above for dentifrices. The alcohols provide an antibacterial effect and help the solubility of the flavouring oils. Optionally, mouthwashes also contain sudsing agents. Humectants such as glycerine and sorbitol give a moist and sweet feel in the mouth and are desirably also present. While these materials are not always essential, they are useful to help solubilise and enhance the flavouring oils, and aid in making the product sweet, smoother and imparting body. Antibacterial agents are sometimes incorporated into mouthwashes or dentifrices at levels from about 0.01% to about 2.0%. Generally, mouthwashes suitable for use as carriers herein contain: 5% to 40% ethyl alcohol; 0% to 20%, preferably 5% to 20%, glycerine or other humectant; 0% to 12%, preferably 0.1% to 12%, sudsing agent, 0% to 0.5%, preferably 0.05% to 0.5%), sweetening agent such as saccharin; and 0%> to 0.3%, preferably 0.05%> to 2% of the flavouring / masking components of the present invention; and the balance, water with colorants or dyes if desired.

Chewing gum suitable for use as a carrier herein comprises a gum base and flavouring materials such as those mentioned above for dentifrices. The flavouring materials are present at a level of 0.01 % to about 2.0% of the final chewing gum composition. The gum base is a chewable plastic gum material such as natural rubber, chicle, polyvinyl acetate, ester gum, coumarone resin, and paraffin wax. The gum base is typically made from a mixture of two or more plastic gum materials to achieve a preferred degree of plasticity for chewing. Optionally, corn syrup is added as a softener and binder for the chewing gum and sugar is optionally added as a sweetener and adding nuance to the flavour. A typical chewing gum suitable as a carrier herein comprises 15%> to 30% gum base, 15% to 20% corn syrup, 50% to 65% sugar, 1% of zinc gluconate trihydrate, and 0.05%) to 1.5% of the flavouring / masking composition of the invention.

Lozenges suitable as carriers herein comprise a hard sugar candy base and one or more flavouring oils. Optionally, lozenges can contain various other materials. A typical lozenge suitable as a carrier in this invention is a hard candy comprised of a hard candy base containing 0.05% to 1.5 wt. % of the flavouring / masking components and about 1 wt. % of zinc acetate dihydrate. The hard candy base is a solidified solution of amorphous sugar which is generally formed from a sugar solution which has been cooked at high temperature so as to remove nearly all of the moisture. The taste masking / flavouring materials are added before the moisture is removed.

The orally administered compositions of the present invention can also optionally contain additional therapeutic materials including for example, water-soluble fluoride such as sodium fluoride and stannous fluoride.

Preparations: The orally administered compositions of the present invention without the metallic zinc taste can be prepared by any convenient method. The individual components of the synergistic masking / flavouring composition can be added separately as separate components to the orally administered compositions, but it is generally preferred to prepare the masking / flavouring composition separately and thereafter combine it with the orally administered compositions.

The orally administered compositions of the present invention can be in solid forms such as tablets, lozenges and powders; chewable forms such as chewing gums and soft candies; paste and gel forms such as dentifrices; liquids such as syrups, mouthwashes, and sprays. Flavoured lozenges with zinc compounds can be prepared by mixing the masking components of the present invention with the carriers and other ingredients, then by direct compression of the ingredients.

When the compositions are applied to or in contact with oral and oral pharyngeal membranes of a human, they are palatable and without undesirable taste or unpleasant metallic taste of zinc compounds. The flavours produced are truer, smoother, and better in taste than formulations without the masking/flavouring components of the present invention. In order to further illustrate the present invention, examples are set forth below. All parts and percentages are by weight and all temperatures in degrees in centigrade unless otherwise indicated.

Various flavouring compositions were prepared by mixing the components (in wt. %) set forth in Table 1 that follows: TABLE 1

The flavour compositions were combined into a dentifrice composition containing the following components, shown in Table 2 below: TABLE 2

In blind taste tests, it is found that the dentifrice compositions containing the masking / flavouring compositions in the Examples exhibit "good tasting" properties and without any trace of the unpleasant metallic taste of zinc compounds.

Various changes and modifications can be made in the products of the present invention without departing from the spirit and scope thereof. The various embodiments which were disclosed herein were for the purpose of further illustrating the invention but were not intended to limit it.

Patent Citations
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EP0049671A1 *7 Oct 198114 Apr 1982BioSystems Research, Inc.New metal oxyalkylates, pharmaceutical compositions containing the same and process for preparing the same
GB1055854A * Title not available
JPS6366115A * Title not available
JPS59101418A * Title not available
US4758439 *3 Aug 198719 Jul 1988Godfrey Science & Design, Inc.Flavor of zinc supplements for oral use
US5002970 *18 Apr 198826 Mar 1991Eby Iii George AFlavor masked ionizable zinc compositions for oral absorption
Non-Patent Citations
Reference
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2 *PATENT ABSTRACTS OF JAPAN vol. 012, no. 297 (C - 519) 12 August 1988 (1988-08-12)
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
WO2012112141A1 *15 Feb 201123 Aug 2012Colgate-Palmolive CompanyTaste -masked oral care compositions
CN103354758A *15 Feb 201116 Oct 2013高露洁-棕榄公司Taste -masked oral care compositions
CN103354758B *15 Feb 201120 Apr 2016高露洁-棕榄公司掩味的口腔护理组合物
US877831120 Mar 200715 Jul 2014The Procter & Gamble CompanyOral zinc compositions
US937131726 Mar 201521 Jun 2016Senomyx, Inc.Sweet flavor modifier
US938219615 Oct 20135 Jul 2016Senomyx, Inc.Processes and intermediates for making sweet taste enhancers
US94208144 Sep 201523 Aug 2016Senomyx, Inc.Sweet flavor modifier
US947580319 Feb 201425 Oct 2016Senomyx, Inc.Sweet flavor modifier
US96038488 Jun 200728 Mar 2017Senomyx, Inc.Modulation of chemosensory receptors and ligands associated therewith
US968701529 Jul 201627 Jun 2017Senomyx, Inc.Sweet flavor modifier
US969516211 Oct 20164 Jul 2017Senomyx, Inc.Sweet flavor modifier
US973205216 Jun 201615 Aug 2017Senomyx, Inc.Processes and intermediates for making sweet taste enhancers
US974529315 Mar 201729 Aug 2017Senomyx, Inc.Sweet flavor modifier
US977579219 Dec 20123 Oct 2017Colgate-Palmolive CompanyOral care products comprising a tetrabasic zinc-amino acid-halide complex
Classifications
International ClassificationA61Q11/02, A61K8/25, A61K8/40, A61K8/92, A61K8/20, A61K36/534, A61K8/24, A61K8/21, A61K8/36, A61K8/97, A61K9/10, A61K47/46, A61K47/10, A61K47/12, A61K9/20, A23G3/34, A61Q11/00, A23L1/09, A61K8/27, A23L1/22, A61K8/34, A61K8/73, A61K8/19, A61K8/00
Cooperative ClassificationA61K8/342, A61K8/21, Y10S514/849, A61K8/27, A61K2800/59, A61K8/922, A61Q11/00
European ClassificationA61K8/21, A61K8/34C, A61K8/27, A61Q11/00, A61K8/92C
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