WO2000025725A3 - Functional antagonists of hedgehog activity - Google Patents

Functional antagonists of hedgehog activity Download PDF

Info

Publication number
WO2000025725A3
WO2000025725A3 PCT/US1999/025700 US9925700W WO0025725A3 WO 2000025725 A3 WO2000025725 A3 WO 2000025725A3 US 9925700 W US9925700 W US 9925700W WO 0025725 A3 WO0025725 A3 WO 0025725A3
Authority
WO
WIPO (PCT)
Prior art keywords
hedgehog
functional antagonists
antagonists
variants
ability
Prior art date
Application number
PCT/US1999/025700
Other languages
French (fr)
Other versions
WO2000025725A2 (en
Inventor
Kevin Williams
Paul Rayhorn
Ellen A Garber
Blake R Pepinsky
Original Assignee
Biogen Inc
Kevin Williams
Paul Rayhorn
Ellen A Garber
Blake R Pepinsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc, Kevin Williams, Paul Rayhorn, Ellen A Garber, Blake R Pepinsky filed Critical Biogen Inc
Priority to EP99965744A priority Critical patent/EP1133519B1/en
Priority to CA2348773A priority patent/CA2348773C/en
Priority to IL14290599A priority patent/IL142905A0/en
Priority to JP2000579170A priority patent/JP4574012B2/en
Priority to AU21445/00A priority patent/AU765485B2/en
Priority to DE69939327T priority patent/DE69939327D1/en
Publication of WO2000025725A2 publication Critical patent/WO2000025725A2/en
Publication of WO2000025725A3 publication Critical patent/WO2000025725A3/en
Priority to IL142905A priority patent/IL142905A/en
Priority to US10/164,282 priority patent/US8410061B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking the ability to elicit a hedgehog-dependent response in C3H 10T1/2 cells but having the ability to bind to the hedgehog receptor, patched-1. Methods for producing such functional antagonists and methods of using the funtional antagonists are also described.
PCT/US1999/025700 1998-11-02 1999-11-02 Functional antagonists of hedgehog activity WO2000025725A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP99965744A EP1133519B1 (en) 1998-11-02 1999-11-02 Functional antagonists of hedgehog activity
CA2348773A CA2348773C (en) 1998-11-02 1999-11-02 Functional antagonists of hedgehog activity
IL14290599A IL142905A0 (en) 1998-11-02 1999-11-02 Functional antagonists of hedgehog activity
JP2000579170A JP4574012B2 (en) 1998-11-02 1999-11-02 Functional antagonist of hedgehog activity
AU21445/00A AU765485B2 (en) 1998-11-02 1999-11-02 Functional antagonists of hedgehog activity
DE69939327T DE69939327D1 (en) 1998-11-02 1999-11-02 FUNCTIONAL ANTAGONISTS OF HEDGEHOG ACTIVITY
IL142905A IL142905A (en) 1998-11-02 2001-05-01 Functional antagonists of hedgehog activity
US10/164,282 US8410061B2 (en) 1998-11-02 2002-06-05 Functional antagonists of hedgehog activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10670398P 1998-11-02 1998-11-02
US60/106,703 1998-11-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09890975 A-371-Of-International 1999-11-02
US10/164,282 Continuation US8410061B2 (en) 1998-11-02 2002-06-05 Functional antagonists of hedgehog activity

Publications (2)

Publication Number Publication Date
WO2000025725A2 WO2000025725A2 (en) 2000-05-11
WO2000025725A3 true WO2000025725A3 (en) 2000-11-30

Family

ID=22312815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025700 WO2000025725A2 (en) 1998-11-02 1999-11-02 Functional antagonists of hedgehog activity

Country Status (9)

Country Link
US (1) US8410061B2 (en)
EP (1) EP1133519B1 (en)
JP (1) JP4574012B2 (en)
AT (1) ATE404583T1 (en)
AU (1) AU765485B2 (en)
CA (1) CA2348773C (en)
DE (1) DE69939327D1 (en)
IL (2) IL142905A0 (en)
WO (1) WO2000025725A2 (en)

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US6713065B2 (en) 1997-02-10 2004-03-30 President And Fellows Of Harvard College Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth
CA2312009A1 (en) * 1997-11-28 1999-06-10 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
IL146842A0 (en) * 1999-06-01 2002-07-25 Biogen Inc Polymer conjugates of hedgehog proteins and uses
JP2003501395A (en) * 1999-06-08 2003-01-14 ローランティス・リミテッド Therapeutic use
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
JP2003513660A (en) * 1999-11-05 2003-04-15 バイオジェン インコーポレイテッド Hedgehog fusion proteins and uses
US8168178B2 (en) 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US20030022819A1 (en) * 2000-06-16 2003-01-30 Ling Leona E. Angiogenesis-modulating compositions and uses
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
WO2002011752A1 (en) * 2000-08-04 2002-02-14 Takeda Chemical Industries, Ltd. Use of gli1 gene
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
CA2425356C (en) * 2000-10-13 2015-10-06 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
DK1730280T3 (en) 2004-03-26 2019-02-04 Curis Inc RNA interference modulators for hedgehog signaling and applications thereof
AU2006308870B2 (en) 2005-10-31 2012-08-16 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
WO2007053648A2 (en) 2005-10-31 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US8026354B2 (en) 2005-11-23 2011-09-27 Institut Pasteur Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
NZ592338A (en) 2008-09-26 2012-11-30 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
PT2470173E (en) 2009-08-25 2016-06-15 Abraxis Bioscience Llc Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening
NZ602700A (en) 2010-04-01 2014-10-31 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
JP2015536933A (en) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Methods of treating neuroendocrine tumors using Wnt pathway binding agents
JP2016510411A (en) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Methods and monitoring of treatment with WNT pathway inhibitors
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759811A (en) * 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene

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US6610656B1 (en) * 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6261786B1 (en) * 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US6165747A (en) * 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6884775B1 (en) * 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US6384192B1 (en) * 1993-12-30 2002-05-07 President & Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins
WO1995023223A1 (en) 1994-02-25 1995-08-31 The Trustees Of Columbia University In The City Of New York Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof
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IL146842A0 (en) * 1999-06-01 2002-07-25 Biogen Inc Polymer conjugates of hedgehog proteins and uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759811A (en) * 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KATSUURA M ET AL: "THE NH2-TERMINAL REGION OF THE ACTIVE DOMAIN OF SONIC HEDGEHOG IS NECESSARY FOR ITS SIGNAL TRANSDUCTION", FEBS LETTERS, vol. 447, 26 March 1999 (1999-03-26), pages 325 - 328, XP000919493, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
IL142905A (en) 2009-12-24
JP4574012B2 (en) 2010-11-04
CA2348773C (en) 2010-04-13
US8410061B2 (en) 2013-04-02
IL142905A0 (en) 2002-04-21
CA2348773A1 (en) 2000-05-11
AU2144500A (en) 2000-05-22
ATE404583T1 (en) 2008-08-15
AU765485B2 (en) 2003-09-18
EP1133519B1 (en) 2008-08-13
JP2002534060A (en) 2002-10-15
DE69939327D1 (en) 2008-09-25
EP1133519A2 (en) 2001-09-19
US20030166543A1 (en) 2003-09-04
WO2000025725A2 (en) 2000-05-11

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