WO2000023061A3 - Irrigation solution and method for inhibition of pain and inflammation - Google Patents

Irrigation solution and method for inhibition of pain and inflammation Download PDF

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Publication number
WO2000023061A3
WO2000023061A3 PCT/US1999/024557 US9924557W WO0023061A3 WO 2000023061 A3 WO2000023061 A3 WO 2000023061A3 US 9924557 W US9924557 W US 9924557W WO 0023061 A3 WO0023061 A3 WO 0023061A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonist
pain
solution
inflammation
inhibitor
Prior art date
Application number
PCT/US1999/024557
Other languages
French (fr)
Other versions
WO2000023061A2 (en
Inventor
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Original Assignee
Omeros Med Sys Inc
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Med Sys Inc, Gregory A Demopulos, Pamela P Palmer, Jeffrey M Herz filed Critical Omeros Med Sys Inc
Priority to AU12148/00A priority Critical patent/AU1214800A/en
Publication of WO2000023061A2 publication Critical patent/WO2000023061A2/en
Publication of WO2000023061A3 publication Critical patent/WO2000023061A3/en
Priority to US09/839,633 priority patent/US7091181B2/en
Priority to US09/839,633 priority patent/US20020028798A1/en
Priority to US11/410,407 priority patent/US20060205658A1/en
Priority to US11/410,406 priority patent/US20060205657A1/en
Priority to US11/409,919 priority patent/US20060229588A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one COX-2 inhibitor and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a COX-2 inhibitor, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a ν-opioid agonist.
PCT/US1999/024557 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation WO2000023061A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU12148/00A AU1214800A (en) 1998-10-21 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 US7091181B2 (en) 1994-12-12 2001-04-20 Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US09/839,633 US20020028798A1 (en) 1995-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10516698P 1998-10-21 1998-10-21
US60/105,166 1998-10-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/072,913 Continuation-In-Part US6261279B1 (en) 1994-12-12 1998-05-04 Surgical irrigation solution and method for inhibition of pain and inflammation

Related Child Applications (5)

Application Number Title Priority Date Filing Date
PCT/US1999/024558 Continuation-In-Part WO2000023062A2 (en) 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 Continuation-In-Part US20020028798A1 (en) 1994-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 Continuation-In-Part US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 Continuation-In-Part US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 Continuation-In-Part US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Publications (2)

Publication Number Publication Date
WO2000023061A2 WO2000023061A2 (en) 2000-04-27
WO2000023061A3 true WO2000023061A3 (en) 2000-11-16

Family

ID=22304411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024557 WO2000023061A2 (en) 1994-12-12 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation

Country Status (2)

Country Link
AU (1) AU1214800A (en)
WO (1) WO2000023061A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2407469A1 (en) * 2000-05-15 2001-11-22 Merck Frosst Canada & Co. Combination therapy using cox-2 selective inhibitor and thromboxane inhibitor and compositions therefor
PT1534313E (en) 2002-07-30 2013-01-25 Omeros Corp Ophthalmologic irrigation solutions and method
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI809304B (en) 2014-12-01 2023-07-21 奥默羅斯公司 Anti-inflammatory and mydriatic intracameral solutions for inhibition of postoperative ocular inflammatory conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5373022A (en) * 1991-03-04 1994-12-13 The Warner-Lambert Company Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5373022A (en) * 1991-03-04 1994-12-13 The Warner-Lambert Company Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BURITOVA JAROSLAVA; CHAPMAN VICTORIA; HONORE PRISCA; BESSON JEAN-MARIE: "Selective cyclooxygenase-2 inhibition reduces carrageenan oedema and associated spinal c-Fos expression in the rat.", BRAIN RESEARCH, vol. 715, no. 1-2, 1996, pages 217 - 220, XP000905607 *
ENGELHARDT G: "Pharmacology of meloxicam, a new non-steroidal anti-inflammatory drug with an improved safety profile through preferential inhibition of COX-2.", BRITISH JOURNAL OF RHEUMATOLOGY, vol. 35, no. suppl. 1, 1996, pages 4 - 12, XP000905630 *
HAY CATRIONA; DE BELLEROCHE JACQUELINE: "Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord.", NEUROREPORT, vol. 8, no. 5, 1997, pages 1249 - 1251, XP000905625 *
JOSHI G.P.: "Postoperative pain management.", INTERNATIONAL ANESTHESIOLOGY CLINICS, (1994) 32/3 (113-126)., XP000905593 *
MEHLISCH D R; HUBBARD R C; ISAKSON P; KARIM A; WEAVER M; MILLS S: "Analgesic efficacy and plasma levels of a highly selective inhibitor of COX-2 (SC-58635;SC) in patients with post-surgical dental pain.", CLINICAL PHARMACOLOGY & THERAPEUTICS, vol. 61, no. 2, 1997, pages 195, XP000905616 *
OSIPOVA N A: "[Antinociceptive components of general anesthesia and postoperative analgesia]. Antinotsitseptivnye komponenty obschchei anestezii i posleoperatsionnoi analgezii.", ANESTEZIOLOGIIA I REANIMATOLOGIIA, (1998 SEP-OCT) (5) 11-5. REF: 21, XP000905655 *
REYNOLDS J.: "Martindale - The Extra Pharmacopoeia Edition 31", 1996, ROYAL PHARMACEUTICAL SOCIETY, LONDON GB, XP002137139, 224540 *
SCHWEIZER A; BROM R; WIESENBERG-BOETTCHER I: "INHIBITION OF INTERLEUKIN-1 IL-1 ENHANCED PAIN REFLEXES IN THE RABBIT BY CGP-28238", AGENTS AND ACTIONS, vol. 32, no. 1-2, 1991, pages 67 - 69, XP000905639 *
SEIBERT KAREN; ZHANG YAN; LEAHY KATHLEEN; HAUSER SCOTT; MASFERRER JAIME; PERKINS WILLIAM; LEE LEN; ISAKSON PETER: "Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 91, no. 25, 1994, pages 12013 - 12017, XP000604765 *
SOUTER A J ET AL: "CONTROVERSIES IN THE PERIOPERATIVE USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS", ANESTHESIA AND ANALGESIA, (DEC 1994) VOL. 79, NO. 6, PP. 1178-1190. ISSN: 0003-2999., UNIV TEXAS, SW MED CTR, DEPT ANESTHESIOL & PAIN MANAGEMENT, 5323 HARRY HINES BLVD, DALLAS, TX, 75235 (Reprint);UNIV TEXAS, SW MED CTR, DEPT ANESTHESIOL & PAIN MANAGEMENT, DALLAS, TX, 75235, XP000905591 *

Also Published As

Publication number Publication date
WO2000023061A2 (en) 2000-04-27
AU1214800A (en) 2000-05-08

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