WO2000019984A3 - Überzogene arzneiformen mit kontrollierter wirkstoffabgabe - Google Patents
Überzogene arzneiformen mit kontrollierter wirkstoffabgabe Download PDFInfo
- Publication number
- WO2000019984A3 WO2000019984A3 PCT/EP1999/007179 EP9907179W WO0019984A3 WO 2000019984 A3 WO2000019984 A3 WO 2000019984A3 EP 9907179 W EP9907179 W EP 9907179W WO 0019984 A3 WO0019984 A3 WO 0019984A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- meth
- optionally
- acrylate copolymers
- active substance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99948881A EP1117387B1 (de) | 1998-10-02 | 1999-09-28 | Überzogene arzneiformen mit kontrollierter wirkstoffabgabe |
JP2000573346A JP4615124B2 (ja) | 1998-10-02 | 1999-09-28 | 制御された作用物質放出性を有する被覆された医薬品形 |
US09/787,438 US6878387B1 (en) | 1998-10-02 | 1999-09-28 | Coated medicament forms with controlled active substance release |
PL99347780A PL193899B1 (pl) | 1998-10-02 | 1999-09-28 | Powlekany preparat farmaceutyczny z kontrolowanymuwalnianiem substancji czynnej |
BRPI9913104-8A BR9913104B1 (pt) | 1998-10-02 | 1999-09-28 | preparações farmacêuticas reservadas com desprendimento controlado de substáncia ativa. |
DE59911452T DE59911452D1 (de) | 1998-10-02 | 1999-09-28 | Überzogene arzneiformen mit kontrollierter wirkstoffabgabe |
AT99948881T ATE286724T1 (de) | 1998-10-02 | 1999-09-28 | Überzogene arzneiformen mit kontrollierter wirkstoffabgabe |
CA002346062A CA2346062C (en) | 1998-10-02 | 1999-09-28 | Coated medicament forms with controlled active substance release |
MXPA01003392A MXPA01003392A (es) | 1998-10-02 | 1999-09-28 | Formas de medicamento recubiertas con una liberacion controlada de sustancia activa. |
AU61974/99A AU6197499A (en) | 1998-10-02 | 1999-09-28 | Coated medicament forms with controlled active substance release |
SK426-2001A SK285295B6 (sk) | 1998-10-02 | 1999-09-28 | Farmaceutický prípravok s riadeným uvoľňovaním účinnej látky skladajúci sa z jadra obsahujúceho účinnú látku a soľ organickej kyseliny a z vonkajšieho obalu |
HK04101002A HK1058152A1 (en) | 1998-10-02 | 2004-02-13 | Coated medicament forms with controlled active substance release. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19845358.2 | 1998-10-02 | ||
DE19845358A DE19845358A1 (de) | 1998-10-02 | 1998-10-02 | Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000019984A2 WO2000019984A2 (de) | 2000-04-13 |
WO2000019984A3 true WO2000019984A3 (de) | 2000-07-20 |
Family
ID=7883150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/007179 WO2000019984A2 (de) | 1998-10-02 | 1999-09-28 | Überzogene arzneiformen mit kontrollierter wirkstoffabgabe |
Country Status (16)
Country | Link |
---|---|
US (1) | US6878387B1 (de) |
EP (1) | EP1117387B1 (de) |
JP (1) | JP4615124B2 (de) |
KR (1) | KR100657779B1 (de) |
CN (1) | CN1182840C (de) |
AT (1) | ATE286724T1 (de) |
AU (1) | AU6197499A (de) |
BR (1) | BR9913104B1 (de) |
CA (1) | CA2346062C (de) |
DE (2) | DE19845358A1 (de) |
ES (1) | ES2234303T3 (de) |
HK (1) | HK1058152A1 (de) |
MX (1) | MXPA01003392A (de) |
PL (1) | PL193899B1 (de) |
SK (1) | SK285295B6 (de) |
WO (1) | WO2000019984A2 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10220470A1 (de) * | 2002-04-30 | 2003-11-20 | Roehm Gmbh | ph-sensitives Polymer |
US6162466A (en) * | 1999-04-15 | 2000-12-19 | Taro Pharmaceutical Industries Ltd. | Sustained release formulation of carbamazepine |
DE19961334A1 (de) * | 1999-12-17 | 2001-06-21 | Roehm Gmbh | Spritzgußverfahren für neutrale und säuregruppenhaltige (Meth)acrylat-Copolymere |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
DE10013029A1 (de) * | 2000-03-17 | 2001-09-20 | Roehm Gmbh | Mehrschichtige Arzneiform für die Colonfreigabe |
US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
ES2314087T3 (es) * | 2001-03-08 | 2009-03-16 | The Trustees Of The University Of Pennsylvania | Polimeros facialmente anfifilicos como agentes antiinfecciosos. |
DE10127134A1 (de) * | 2001-06-05 | 2002-12-12 | Roehm Gmbh | verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß |
TWI252111B (en) * | 2001-12-14 | 2006-04-01 | Solvay Pharm Gmbh | Matrix film tablet with controlled release of a natural mixture of conjugated estrogens |
DE10208335A1 (de) * | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
ATE398445T1 (de) * | 2002-03-28 | 2008-07-15 | Alcon Inc | Co-perlchen von dha und rosmarin und verwendungsverfahren |
DE10250543A1 (de) * | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
MXPA04010956A (es) | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
EP2471527A3 (de) * | 2003-03-17 | 2012-12-12 | The Trustees Of The University Of Pennsylvania | Fazial-amphiphile Polymere und Oligomere sowie Verwendungen davon |
EP1633358A1 (de) * | 2003-05-20 | 2006-03-15 | Pfizer Products Inc. | Pharmazeutische zusammensetzungen enthaltend varenicline |
DE10332160A1 (de) * | 2003-07-15 | 2005-02-03 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
WO2005009364A2 (en) | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
US8313775B2 (en) | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
US8313776B2 (en) | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
EP1653925A1 (de) | 2003-08-11 | 2006-05-10 | Advancis Pharmaceutical Corporation | Robustes pellet |
CA2535398C (en) | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
JP5686494B2 (ja) | 2003-08-29 | 2015-03-18 | シオノギ インコーポレイテッド | 抗生物質製剤、その使用法及び作成方法 |
JP2007513869A (ja) | 2003-09-15 | 2007-05-31 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
DE10353186A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz |
DE10353196A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix |
EP1711455A4 (de) | 2004-01-23 | 2007-11-07 | Univ Pennsylvania | Fazial amphiphile polyaryl- und polyarylalkinylpolymere und -oligomere und deren anwendungen |
US8715727B2 (en) | 2004-07-02 | 2014-05-06 | Shionogi Inc. | Tablet for pulsed delivery |
AU2005332637B2 (en) * | 2004-07-23 | 2011-04-07 | The Trustees Of The University Of Pennsylvania | Antimicrobial copolymers and uses thereof |
EP2433627A1 (de) * | 2005-02-25 | 2012-03-28 | The Trustees Of The University Of Pennsylvania | Facial amphiphile Polymere und Oligomere, Zusammensetzungen damit und ihre Verwendung bei Krebsbehandlungsverfahren. |
WO2006102965A1 (en) * | 2005-03-29 | 2006-10-05 | Evonik Röhm Gmbh | Multiparticulate pharmaceutical form comprising pellets with a matrix which influences the delivery of a modulatory substance |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
CN101484147B (zh) * | 2006-08-18 | 2015-07-08 | 赢创罗姆有限责任公司 | 对于具有水中良好溶解性的活性成分具有受控的活性成分释放性的药物组合物 |
US9011907B2 (en) * | 2008-01-10 | 2015-04-21 | Evonik Röhm Gmbh | Coated pharmaceutical or nutraceutical preparation with enhanced pulsed active substance release |
SI2230932T1 (sl) * | 2008-01-10 | 2017-07-31 | Evonik Roehm Gmbh | Oplaščeni farmacevtski ali nutracevtski pripravek s povečanim sproščanjem aktivne učinkovine v črevesu |
KR101647869B1 (ko) | 2009-07-30 | 2016-08-11 | 에보니크 룀 게엠베하 | 공중합체, 디카르복실산 및 지방 모노카르복실산을 포함하는 분말 또는 과립 조성물 |
CN105419206B (zh) * | 2009-07-30 | 2017-12-15 | 赢创罗姆有限公司 | 包含共聚物、二羧酸和脂肪单羧酸的粉末状或粒状组合物 |
CA2936740C (en) | 2014-10-31 | 2017-10-10 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
CA3093077A1 (en) * | 2018-03-09 | 2019-09-12 | Evonik Operations Gmbh | Polymer mixture with resistance against the influence of ethanol |
CN110105487B (zh) * | 2018-03-09 | 2021-07-30 | 广州茂丰药业有限公司 | 含季铵基(甲基)丙烯酸酯共聚物的溶液聚合制备方法 |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0068191A2 (de) * | 1981-06-19 | 1983-01-05 | Dr. Karl Thomae GmbH | Orale Dipyridamolformen |
EP0148811A1 (de) * | 1984-01-10 | 1985-07-17 | Lejus Medical Aktiebolag | Pharmazeutische Komposition |
EP0225085A1 (de) * | 1985-11-13 | 1987-06-10 | ELAN CORPORATION, Plc | Arzneiformulierung mit gesteuerter Absorption |
EP0436370A1 (de) * | 1989-12-28 | 1991-07-10 | Tanabe Seiyaku Co., Ltd. | Pharmazeutische Zubereitung mit verzögerter Freisetzung und seine Herstellung |
EP0640341A1 (de) * | 1993-08-27 | 1995-03-01 | Mitsui Toatsu Chemicals, Incorporated | Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2470599A1 (fr) * | 1979-12-07 | 1981-06-12 | Panoz Donald | Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus |
IE55745B1 (en) * | 1983-04-06 | 1991-01-02 | Elan Corp Plc | Sustained absorption pharmaceutical composition |
PH18946A (en) * | 1983-04-21 | 1985-11-14 | Elan Corp Plc | Controlled absorption pharmaceutical composition |
US5292522A (en) * | 1989-06-20 | 1994-03-08 | Rohm Gmbh | Aqueous film coating agent for solid medicaments |
JP2558396B2 (ja) * | 1990-06-28 | 1996-11-27 | 田辺製薬株式会社 | 放出制御型製剤 |
EP0621032B1 (de) * | 1993-04-23 | 2000-08-09 | Novartis AG | Wirkstoffabgabevorrichtung mit gesteuerter Freigabe |
AUPN969796A0 (en) * | 1996-05-07 | 1996-05-30 | F.H. Faulding & Co. Limited | Taste masked liquid suspensions |
DE19626045C2 (de) * | 1996-06-28 | 1998-12-03 | Klinge Co Chem Pharm Fab | Stabile Arzneiform zur oralen Verabreichung, welche Omeprazol als aktiven Wirkstoff enthält, sowie Verfahren zur Herstellung derselben |
US5948440A (en) * | 1997-12-17 | 1999-09-07 | Ranbaxy Laboratories Limited | Modified release matrix formulation of cefaclor and cephalexin |
US6159504A (en) * | 1999-01-11 | 2000-12-12 | Kitii Corporation, Ltd. | Core substance-containing calcium microparticles and methods for producing the same |
JP2001139471A (ja) * | 2000-11-20 | 2001-05-22 | Kyoto Pharmaceutical Industries Ltd | 矯味経口用医薬組成物 |
-
1998
- 1998-10-02 DE DE19845358A patent/DE19845358A1/de not_active Withdrawn
-
1999
- 1999-09-28 CN CNB998106801A patent/CN1182840C/zh not_active Expired - Fee Related
- 1999-09-28 KR KR1020017004111A patent/KR100657779B1/ko not_active IP Right Cessation
- 1999-09-28 WO PCT/EP1999/007179 patent/WO2000019984A2/de active IP Right Grant
- 1999-09-28 ES ES99948881T patent/ES2234303T3/es not_active Expired - Lifetime
- 1999-09-28 EP EP99948881A patent/EP1117387B1/de not_active Expired - Lifetime
- 1999-09-28 AU AU61974/99A patent/AU6197499A/en not_active Abandoned
- 1999-09-28 DE DE59911452T patent/DE59911452D1/de not_active Expired - Lifetime
- 1999-09-28 PL PL99347780A patent/PL193899B1/pl unknown
- 1999-09-28 JP JP2000573346A patent/JP4615124B2/ja not_active Expired - Fee Related
- 1999-09-28 SK SK426-2001A patent/SK285295B6/sk not_active IP Right Cessation
- 1999-09-28 CA CA002346062A patent/CA2346062C/en not_active Expired - Fee Related
- 1999-09-28 US US09/787,438 patent/US6878387B1/en not_active Expired - Lifetime
- 1999-09-28 AT AT99948881T patent/ATE286724T1/de active
- 1999-09-28 BR BRPI9913104-8A patent/BR9913104B1/pt not_active IP Right Cessation
- 1999-09-28 MX MXPA01003392A patent/MXPA01003392A/es active IP Right Grant
-
2004
- 2004-02-13 HK HK04101002A patent/HK1058152A1/xx not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0068191A2 (de) * | 1981-06-19 | 1983-01-05 | Dr. Karl Thomae GmbH | Orale Dipyridamolformen |
EP0148811A1 (de) * | 1984-01-10 | 1985-07-17 | Lejus Medical Aktiebolag | Pharmazeutische Komposition |
EP0225085A1 (de) * | 1985-11-13 | 1987-06-10 | ELAN CORPORATION, Plc | Arzneiformulierung mit gesteuerter Absorption |
EP0436370A1 (de) * | 1989-12-28 | 1991-07-10 | Tanabe Seiyaku Co., Ltd. | Pharmazeutische Zubereitung mit verzögerter Freisetzung und seine Herstellung |
EP0640341A1 (de) * | 1993-08-27 | 1995-03-01 | Mitsui Toatsu Chemicals, Incorporated | Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren |
Also Published As
Publication number | Publication date |
---|---|
BR9913104B1 (pt) | 2010-11-30 |
BR9913104A (pt) | 2001-05-08 |
ATE286724T1 (de) | 2005-01-15 |
KR100657779B1 (ko) | 2006-12-21 |
HK1058152A1 (en) | 2004-05-07 |
EP1117387B1 (de) | 2005-01-12 |
CN1182840C (zh) | 2005-01-05 |
US6878387B1 (en) | 2005-04-12 |
PL347780A1 (en) | 2002-04-22 |
CA2346062C (en) | 2008-09-16 |
WO2000019984A2 (de) | 2000-04-13 |
SK285295B6 (sk) | 2006-10-05 |
PL193899B1 (pl) | 2007-03-30 |
DE59911452D1 (de) | 2005-02-17 |
KR20010075502A (ko) | 2001-08-09 |
ES2234303T3 (es) | 2005-06-16 |
JP2002526401A (ja) | 2002-08-20 |
CA2346062A1 (en) | 2000-04-13 |
CN1446083A (zh) | 2003-10-01 |
AU6197499A (en) | 2000-04-26 |
EP1117387A2 (de) | 2001-07-25 |
DE19845358A1 (de) | 2000-04-06 |
JP4615124B2 (ja) | 2011-01-19 |
MXPA01003392A (es) | 2003-07-21 |
SK4262001A3 (en) | 2002-10-08 |
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