WO2000019984A3 - Überzogene arzneiformen mit kontrollierter wirkstoffabgabe - Google Patents

Überzogene arzneiformen mit kontrollierter wirkstoffabgabe Download PDF

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Publication number
WO2000019984A3
WO2000019984A3 PCT/EP1999/007179 EP9907179W WO0019984A3 WO 2000019984 A3 WO2000019984 A3 WO 2000019984A3 EP 9907179 W EP9907179 W EP 9907179W WO 0019984 A3 WO0019984 A3 WO 0019984A3
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WO
WIPO (PCT)
Prior art keywords
weight
meth
optionally
acrylate copolymers
active substance
Prior art date
Application number
PCT/EP1999/007179
Other languages
English (en)
French (fr)
Other versions
WO2000019984A2 (de
Inventor
Hans-Ulrich Petereit
Thomas Beckert
Eva Lynenskjold
Original Assignee
Roehm Gmbh
Petereit Hans Ulrich
Thomas Beckert
Eva Lynenskjold
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SK426-2001A priority Critical patent/SK285295B6/sk
Priority to AU61974/99A priority patent/AU6197499A/en
Priority to CA002346062A priority patent/CA2346062C/en
Priority to PL99347780A priority patent/PL193899B1/pl
Priority to DE59911452T priority patent/DE59911452D1/de
Priority to JP2000573346A priority patent/JP4615124B2/ja
Priority to US09/787,438 priority patent/US6878387B1/en
Priority to MXPA01003392A priority patent/MXPA01003392A/es
Application filed by Roehm Gmbh, Petereit Hans Ulrich, Thomas Beckert, Eva Lynenskjold filed Critical Roehm Gmbh
Priority to AT99948881T priority patent/ATE286724T1/de
Priority to EP99948881A priority patent/EP1117387B1/de
Priority to BRPI9913104-8A priority patent/BR9913104B1/pt
Publication of WO2000019984A2 publication Critical patent/WO2000019984A2/de
Publication of WO2000019984A3 publication Critical patent/WO2000019984A3/de
Priority to HK04101002A priority patent/HK1058152A1/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

Die Erfindung betrifft eine pharmazeutische Zubereitung bestehend aus (a) einem Kern, enthaltend einen Wirkstoff, gegebenenfalls einen Träger und übliche pharmazeutische Zusatzstoffe, sowie das Salz einer organischen Säure, dessen Anteil am Kerngewicht 2,5 bis 97,5 Gew.-% ausmacht und (b) einem äußeren Überzugsfilm, der aus einem oder mehreren (Meth)acrylat-Copolymeren sowie gegebenenfalls aus üblichen pharmazeutischen Hilfsstoffen besteht, wobei 40 bis 100 Gew.-% der (Meth)acrylat-Copolymeren zu 93 bis 98 Gew.-% aus radikalisch polymerisierten C1- bis C4-Alkylestern der Acryl- oder der Methacrylsäure und 7 bis 2 Gew.-% (Meth)acrylat-Monomeren mit einer quaternären Ammoniumgruppe im Alkylrest bestehen und gegebenenfalls in einer Mischung vorliegen können mit 1 bis 60 Gew.-% einem oder mehreren weiteren, vom erstgenannten (Meth)acrylat-Copolymeren verschiedenen (Meth)acrylat-Copolymeren, die sich zu 85 bis 100 Gew.- % aus radikalisch polymerisierten C1- bis C4-Alkylestern der Acryl- oder der Methacrylsäure und gegebenenfalls bis zu 15 Gew.-% weiterer (Meth)acrylat-Monomere mit basischen Gruppen oder Säuregruppe im Alkylrest zusammensetzen.
PCT/EP1999/007179 1998-10-02 1999-09-28 Überzogene arzneiformen mit kontrollierter wirkstoffabgabe WO2000019984A2 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US09/787,438 US6878387B1 (en) 1998-10-02 1999-09-28 Coated medicament forms with controlled active substance release
CA002346062A CA2346062C (en) 1998-10-02 1999-09-28 Coated medicament forms with controlled active substance release
PL99347780A PL193899B1 (pl) 1998-10-02 1999-09-28 Powlekany preparat farmaceutyczny z kontrolowanymuwalnianiem substancji czynnej
DE59911452T DE59911452D1 (de) 1998-10-02 1999-09-28 Überzogene arzneiformen mit kontrollierter wirkstoffabgabe
JP2000573346A JP4615124B2 (ja) 1998-10-02 1999-09-28 制御された作用物質放出性を有する被覆された医薬品形
SK426-2001A SK285295B6 (sk) 1998-10-02 1999-09-28 Farmaceutický prípravok s riadeným uvoľňovaním účinnej látky skladajúci sa z jadra obsahujúceho účinnú látku a soľ organickej kyseliny a z vonkajšieho obalu
MXPA01003392A MXPA01003392A (es) 1998-10-02 1999-09-28 Formas de medicamento recubiertas con una liberacion controlada de sustancia activa.
AU61974/99A AU6197499A (en) 1998-10-02 1999-09-28 Coated medicament forms with controlled active substance release
AT99948881T ATE286724T1 (de) 1998-10-02 1999-09-28 Überzogene arzneiformen mit kontrollierter wirkstoffabgabe
EP99948881A EP1117387B1 (de) 1998-10-02 1999-09-28 Überzogene arzneiformen mit kontrollierter wirkstoffabgabe
BRPI9913104-8A BR9913104B1 (pt) 1998-10-02 1999-09-28 preparações farmacêuticas reservadas com desprendimento controlado de substáncia ativa.
HK04101002A HK1058152A1 (en) 1998-10-02 2004-02-13 Coated medicament forms with controlled active substance release.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845358.2 1998-10-02
DE19845358A DE19845358A1 (de) 1998-10-02 1998-10-02 Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe

Publications (2)

Publication Number Publication Date
WO2000019984A2 WO2000019984A2 (de) 2000-04-13
WO2000019984A3 true WO2000019984A3 (de) 2000-07-20

Family

ID=7883150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/007179 WO2000019984A2 (de) 1998-10-02 1999-09-28 Überzogene arzneiformen mit kontrollierter wirkstoffabgabe

Country Status (16)

Country Link
US (1) US6878387B1 (de)
EP (1) EP1117387B1 (de)
JP (1) JP4615124B2 (de)
KR (1) KR100657779B1 (de)
CN (1) CN1182840C (de)
AT (1) ATE286724T1 (de)
AU (1) AU6197499A (de)
BR (1) BR9913104B1 (de)
CA (1) CA2346062C (de)
DE (2) DE19845358A1 (de)
ES (1) ES2234303T3 (de)
HK (1) HK1058152A1 (de)
MX (1) MXPA01003392A (de)
PL (1) PL193899B1 (de)
SK (1) SK285295B6 (de)
WO (1) WO2000019984A2 (de)

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US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
DE10013029A1 (de) * 2000-03-17 2001-09-20 Roehm Gmbh Mehrschichtige Arzneiform für die Colonfreigabe
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US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
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DE10127134A1 (de) * 2001-06-05 2002-12-12 Roehm Gmbh verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß
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EP0068191A2 (de) * 1981-06-19 1983-01-05 Dr. Karl Thomae GmbH Orale Dipyridamolformen
EP0148811A1 (de) * 1984-01-10 1985-07-17 Lejus Medical Aktiebolag Pharmazeutische Komposition
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Also Published As

Publication number Publication date
EP1117387B1 (de) 2005-01-12
US6878387B1 (en) 2005-04-12
ATE286724T1 (de) 2005-01-15
MXPA01003392A (es) 2003-07-21
CA2346062C (en) 2008-09-16
PL193899B1 (pl) 2007-03-30
CN1446083A (zh) 2003-10-01
EP1117387A2 (de) 2001-07-25
WO2000019984A2 (de) 2000-04-13
BR9913104B1 (pt) 2010-11-30
PL347780A1 (en) 2002-04-22
SK285295B6 (sk) 2006-10-05
AU6197499A (en) 2000-04-26
JP2002526401A (ja) 2002-08-20
JP4615124B2 (ja) 2011-01-19
DE19845358A1 (de) 2000-04-06
DE59911452D1 (de) 2005-02-17
KR20010075502A (ko) 2001-08-09
SK4262001A3 (en) 2002-10-08
CA2346062A1 (en) 2000-04-13
BR9913104A (pt) 2001-05-08
HK1058152A1 (en) 2004-05-07
ES2234303T3 (es) 2005-06-16
CN1182840C (zh) 2005-01-05
KR100657779B1 (ko) 2006-12-21

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