WO2000011017A3 - Cardenolide complexes useful as cardioactive agents - Google Patents

Cardenolide complexes useful as cardioactive agents Download PDF

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Publication number
WO2000011017A3
WO2000011017A3 PCT/US1999/019039 US9919039W WO0011017A3 WO 2000011017 A3 WO2000011017 A3 WO 2000011017A3 US 9919039 W US9919039 W US 9919039W WO 0011017 A3 WO0011017 A3 WO 0011017A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardenolide
complexes useful
cardioactive agents
cardioactive
agents
Prior art date
Application number
PCT/US1999/019039
Other languages
French (fr)
Other versions
WO2000011017A2 (en
WO2000011017A9 (en
Inventor
Akira Kawamura
Nina Berova
Koji Nakanishi
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Priority to AU55768/99A priority Critical patent/AU5576899A/en
Publication of WO2000011017A2 publication Critical patent/WO2000011017A2/en
Publication of WO2000011017A9 publication Critical patent/WO2000011017A9/en
Publication of WO2000011017A3 publication Critical patent/WO2000011017A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C07J19/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Abstract

The invention relates to synthetic Na+/K+-ATPase inhibitory factors, compositions and dosage forms comprising them, and methods of their preparation and use. Specific inhibitory factors of the invention include borate and phosphate complexes of ouabain.
PCT/US1999/019039 1998-08-19 1999-08-19 Cardenolide complexes useful as cardioactive agents WO2000011017A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55768/99A AU5576899A (en) 1998-08-19 1999-08-19 Synthetic inhibitory factors and methods for preparing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9732598P 1998-08-19 1998-08-19
US60/097,325 1998-08-19

Publications (3)

Publication Number Publication Date
WO2000011017A2 WO2000011017A2 (en) 2000-03-02
WO2000011017A9 WO2000011017A9 (en) 2000-06-22
WO2000011017A3 true WO2000011017A3 (en) 2003-04-17

Family

ID=22262786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019039 WO2000011017A2 (en) 1998-08-19 1999-08-19 Cardenolide complexes useful as cardioactive agents

Country Status (2)

Country Link
AU (1) AU5576899A (en)
WO (1) WO2000011017A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910484A (en) 1997-05-30 1999-06-08 The General Hospital Corporation Treatment of ischemic cardiac malfunction
US6846646B1 (en) 1998-12-24 2005-01-25 The General Hospital Corporation Methods for screening HIF like ouabain-resistant Na+-K+-ATPase agents
US6317439B1 (en) 1999-06-03 2001-11-13 Fujitsu Network Communications, Inc. Architecture for a SONET line unit including optical transceiver, cross-connect and synchronization subsystem

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593701A1 (en) * 1966-12-27 1970-08-27 Dresden Arzneimittel Process for the preparation and isolation of boron-containing cardenolide and bufadienolide glycosides
GB1283406A (en) * 1969-08-14 1972-07-26 Dresden Arzneimittel Acyl derivatives of cardioactive steroids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593701A1 (en) * 1966-12-27 1970-08-27 Dresden Arzneimittel Process for the preparation and isolation of boron-containing cardenolide and bufadienolide glycosides
GB1283406A (en) * 1969-08-14 1972-07-26 Dresden Arzneimittel Acyl derivatives of cardioactive steroids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAWAMURA, AKIRA ET AL: "On the structure of endogenous ouabain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 96, no. 12, June 1999 (1999-06-01), WASHINGTON US, pages 6654 - 6659, XP002119477 *
N ZHAO ET AL: "NA,K-ATPase INHIBITORS FROM BOVINE HYPOTHALAMUS AND HUMAN PLASMA ARE DIFFERENT FROM OUABAIN: NANOGRAM SCALE CD STRUCTURAL ANALYSIS", BIOCHEMISTRY, vol. 34, no. 31, 1 January 1995 (1995-01-01), pages 9893 - 9896, XP002081420, ISSN: 0006-2960 *
TYMIAK A A ET AL: "PHSICOCHEMICAL CHARACTERIZATION OF A OUABAIN ISOMER ISOLATED FROM BOVINE HYPOTHALAMUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 90, no. 17, 1 September 1993 (1993-09-01), pages 8189 - 8193, XP002074993, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2000011017A2 (en) 2000-03-02
AU5576899A (en) 2000-03-14
WO2000011017A9 (en) 2000-06-22

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