WO2000010007A3 - Devices and methods for analysis of non-ionic solutes - Google Patents

Devices and methods for analysis of non-ionic solutes Download PDF

Info

Publication number
WO2000010007A3
WO2000010007A3 PCT/US1999/018615 US9918615W WO0010007A3 WO 2000010007 A3 WO2000010007 A3 WO 2000010007A3 US 9918615 W US9918615 W US 9918615W WO 0010007 A3 WO0010007 A3 WO 0010007A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor composition
target molecule
sensor
electrode
concentration
Prior art date
Application number
PCT/US1999/018615
Other languages
French (fr)
Other versions
WO2000010007A2 (en
WO2000010007A9 (en
Inventor
Frances H Arnold
Alan S Michaels
Weigong Zheng
Original Assignee
California Inst Of Techn
Frances H Arnold
Alan S Michaels
Weigong Zheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Frances H Arnold, Alan S Michaels, Weigong Zheng filed Critical California Inst Of Techn
Priority to AU55652/99A priority Critical patent/AU5565299A/en
Publication of WO2000010007A2 publication Critical patent/WO2000010007A2/en
Publication of WO2000010007A9 publication Critical patent/WO2000010007A9/en
Publication of WO2000010007A3 publication Critical patent/WO2000010007A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood

Abstract

This invention relates to devices and methods for detecting and monitoring the concentration, level or amount of a target molecule in solution. More particularly, the invention is directed to sensors that evaluate changes in conductivity produced by the reaction of a target molecule with a sensor composition. The invention is particularly well suited for determining the concentration of carbohydrate compounds in solution, such as diol compounds, preferably biologically significant cis-diols such as various sugars including glucose. The invention also encompasses sensors for determining the total or relative amount of target molecule in a sample, particularly a biological sample such as blood, urine, or other biological fluids. A laminated sensor of the invention comprises a sensor composition applied to a metal electrode, such as an interdigitated gold electrode on a non-conductive support. The sensor composition and electrode are and preferably encapsulated by a bipolar membrane. In a preferred embodiment, the sensor composition is a blend of a boronic acid polymer and a non-ionogenic hydrogel matrix.
PCT/US1999/018615 1998-08-17 1999-08-16 Devices and methods for analysis of non-ionic solutes WO2000010007A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55652/99A AU5565299A (en) 1998-08-17 1999-08-16 Devices and methods for analysis of non-ionic solutes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9673998P 1998-08-17 1998-08-17
US60/096,739 1998-08-17
US30125299A 1999-04-28 1999-04-28
US09/301,252 1999-04-28

Publications (3)

Publication Number Publication Date
WO2000010007A2 WO2000010007A2 (en) 2000-02-24
WO2000010007A9 WO2000010007A9 (en) 2000-07-06
WO2000010007A3 true WO2000010007A3 (en) 2000-08-17

Family

ID=26792028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018615 WO2000010007A2 (en) 1998-08-17 1999-08-16 Devices and methods for analysis of non-ionic solutes

Country Status (2)

Country Link
AU (1) AU5565299A (en)
WO (1) WO2000010007A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9119530B2 (en) 2005-10-24 2015-09-01 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
US6287870B1 (en) * 1999-08-20 2001-09-11 Robert A. Levine Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
EP1206213B1 (en) 1999-08-26 2005-01-26 Novartis AG Ocular analyte sensor
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US20020142306A1 (en) * 2001-03-28 2002-10-03 3M Innovative Properties Company Method of transferring molecules to a film laminate
IL164685A0 (en) 2002-04-22 2005-12-18 Marcio Marc Aurelio Martins Ab Apparatus and method for measuring biologic parameters
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US9848815B2 (en) 2002-04-22 2017-12-26 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
ME01775B (en) 2003-11-05 2011-02-28 Glycart Biotechnology Ag Cd20 antibodies with increased fc receptor binding affinity and effector function
US10227063B2 (en) 2004-02-26 2019-03-12 Geelux Holdings, Ltd. Method and apparatus for biological evaluation
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
DE102006026668B4 (en) 2006-06-08 2008-07-10 Technische Universität Dresden Sensor and method for measuring the concentration of components in a liquid
RU2009116271A (en) * 2006-09-29 2010-11-10 Конинклейке Филипс Электроникс, Н.В. (Nl) MINIATURE THRESHOLD SENSORS
CN101627073B (en) * 2007-03-05 2014-02-26 Mip技术股份公司 Imprinted polymers
US20090014340A1 (en) * 2007-06-15 2009-01-15 Williams John R Devices, systems, and methods for measuring glucose
US8181531B2 (en) 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
ES2915692T3 (en) 2008-08-13 2022-06-24 California Inst Of Techn Carrier nanoparticles and related compositions, methods and systems
US9011670B2 (en) 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
WO2010077709A2 (en) * 2008-12-30 2010-07-08 Bausch & Lomb Incorporated Biomedical devices
US8706425B2 (en) 2011-07-20 2014-04-22 Veolia Water Solutions & Technologies Support Method for validation of polymer aqueous solutions concentration and activation in water treatment applications and polymer make-up unit therefor
JP6251295B2 (en) * 2013-03-01 2017-12-20 カリフォルニア インスティテュート オブ テクノロジー Nanoparticles stabilized by nitrophenylboronic acid composition
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
CA2980062A1 (en) 2013-10-11 2015-04-16 Marcio Marc Abreu Method and apparatus for biological evaluation
CA2936235A1 (en) 2014-01-10 2015-07-16 Marcio Marc Abreu Devices to monitor and provide treatment at an abreu brain tunnel
JP2017501844A (en) 2014-01-10 2017-01-19 マーシオ マーク アブリュー Device for measuring the infrared output of an Abreu brain thermal tunnel
AU2015209304A1 (en) 2014-01-22 2016-07-21 Marcio Marc Abreu Devices configured to provide treatment at an Abreu brain thermal tunnel
JP5599012B1 (en) * 2014-06-23 2014-10-01 国立大学法人 東京大学 Collection unit and biosensor
KR102255158B1 (en) * 2014-10-21 2021-05-27 엘지전자 주식회사 Sensor for detecting saccharide and manufacturing method thereof and detection method of glycated hemoglobin using the same
WO2016145215A1 (en) 2015-03-10 2016-09-15 Marcio Marc Abreu Devices, apparatuses, systems, and methods for measuring temperature of an abtt terminus
JP2016217929A (en) * 2015-05-22 2016-12-22 セイコーエプソン株式会社 Sensor gel and sensor
ES2882255T3 (en) 2015-07-01 2021-12-01 California Inst Of Techn Delivery systems based on cationic mucic acid polymers
CN108137155A (en) * 2015-08-14 2018-06-08 瑞斯百瑞公司 Electrode and the method for detecting explosive and other volatile materials
WO2020047606A1 (en) * 2018-09-06 2020-03-12 The University Of Sydney Systems, sensors and methods for determining a concentration of an analyte
CN112782251B (en) * 2021-01-07 2022-03-25 安徽大学 Method for quantitatively detecting potassium dichromate

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
JPH04124145A (en) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd Sugar-responsive polymeric complex material
EP0539625A1 (en) * 1991-10-28 1993-05-05 Dräger Medical Electronics B.V. Electrochemical sensor for measuring the glucose content of glucose containing fluids
JPH05262779A (en) * 1992-03-18 1993-10-12 Nippon Oil & Fats Co Ltd Boric acid group-containing monomer and its polymer
EP0596700A1 (en) * 1992-11-03 1994-05-11 Hewlett-Packard Company Cis-diol detection method and solid supports
DE4437274A1 (en) * 1994-10-18 1996-04-25 Inst Chemo Biosensorik Analyte selective sensor
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
WO1997033177A1 (en) * 1996-03-04 1997-09-12 California Institute Of Technology Sensors for sugars and other metal binding analytes

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
JPH04124145A (en) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd Sugar-responsive polymeric complex material
EP0539625A1 (en) * 1991-10-28 1993-05-05 Dräger Medical Electronics B.V. Electrochemical sensor for measuring the glucose content of glucose containing fluids
JPH05262779A (en) * 1992-03-18 1993-10-12 Nippon Oil & Fats Co Ltd Boric acid group-containing monomer and its polymer
EP0596700A1 (en) * 1992-11-03 1994-05-11 Hewlett-Packard Company Cis-diol detection method and solid supports
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
DE4437274A1 (en) * 1994-10-18 1996-04-25 Inst Chemo Biosensorik Analyte selective sensor
WO1997033177A1 (en) * 1996-03-04 1997-09-12 California Institute Of Technology Sensors for sugars and other metal binding analytes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 016, no. 383 (C - 0974) 17 August 1992 (1992-08-17) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 032 (C - 1154) 18 January 1994 (1994-01-18) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9119530B2 (en) 2005-10-24 2015-09-01 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters

Also Published As

Publication number Publication date
WO2000010007A2 (en) 2000-02-24
AU5565299A (en) 2000-03-06
WO2000010007A9 (en) 2000-07-06

Similar Documents

Publication Publication Date Title
WO2000010007A3 (en) Devices and methods for analysis of non-ionic solutes
Ye et al. Recent advances in electrochemical biosensors for antioxidant analysis in foodstuff
CN1313822C (en) Hemoglobin sensor
EP1021720B1 (en) Electrochemical determination of fructosamine
Moser et al. Biosensor arrays for simultaneous measurement of glucose, lactate, glutamate, and glutamine
Guilbault et al. Non-invasive biosensors in clinical analysis
Soldatkin et al. Creatinine sensitive biosensor based on ISFETs and creatinine deiminase immobilised in BSA membrane
CN1284652A (en) Electrochemical analysis for determinating initial time of sample detection
DE69809391T2 (en) SMALL VOLUME SENSOR FOR IN-VITRO DETERMINATION
US20080177166A1 (en) Ultrasensitive amperometric saliva glucose sensor strip
WO2000059373A1 (en) Assay device for measuring characteristics of a fluid on a continual basis
DE69902265D1 (en) REDOX REVERSIBLE IMIDAZOLE OSMIUM COMPLEX CONJUGATES
EP2909606B1 (en) Device and methods of using device for detection of aminoacidopathies
Ching et al. A mediated glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
Kudo et al. Electrochemical Biosensor for Simplified Determination of Salivary Uric Acid.
Rhemrev-Boom et al. On-line continuous monitoring of glucose or lactate by ultraslow microdialysis combined with a flow-through nanoliter biosensor based on poly (m-phenylenediamine) ultra-thin polymer membrane as enzyme electrode
Ikariyama et al. Surface control of platinized platinum as a transducer matrix for micro-enzyme electrodes
CN1404575A (en) Enzymatic-electrochemical measuring device
EP1511999A1 (en) Electrochemical biosensor
Dempsey et al. In vitro optimisation of a microdialysis system with potential for on-line monitoring of lactate and glucose in biological samples
AU2018311346A1 (en) Detection of creatine levels using enzyme compositions
CN214622434U (en) Electrochemical biosensor
Campanella et al. Enzyme-entrapping membranes for enzyme sensors
CN102565162A (en) Biological nanometer material sensor electrode and manufacturing method and using method thereof
Pfeiffer Commercial biosensors for medical application

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/14-14/14, DRAWINGS, REPLACED BY NEW PAGES 1/21-21/21; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase