WO2000009666A3 - Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof - Google Patents
Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof Download PDFInfo
- Publication number
- WO2000009666A3 WO2000009666A3 PCT/US1999/018099 US9918099W WO0009666A3 WO 2000009666 A3 WO2000009666 A3 WO 2000009666A3 US 9918099 W US9918099 W US 9918099W WO 0009666 A3 WO0009666 A3 WO 0009666A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- producing cells
- insulin producing
- exendin
- glp
- insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/335—Glucagon; Glucagon-like peptide [GLP]; Exendin
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT99942066T ATE445006T1 (en) | 1998-08-10 | 1999-08-10 | DIFFERENTIATION OF NON-INSULIN INTO INSULIN-PRODUCING CELLS BY GLP-1 AND EXENDIN-4 AND THEIR USE |
US09/762,538 US7056734B1 (en) | 1998-08-10 | 1999-08-10 | Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof |
DE69941510T DE69941510D1 (en) | 1998-08-10 | 1999-08-10 | DIFFERENTIATION OF NON-INSULIN IN INSULIN-PRODUCING CELLS BY GLP-1 AND EXENDIN-4 AND THEIR USE |
CA002339326A CA2339326A1 (en) | 1998-08-10 | 1999-08-10 | Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof |
JP2000565103A JP4624558B2 (en) | 1998-08-10 | 1999-08-10 | Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or Exendin-4 and use thereof |
DK99942066.4T DK1105460T3 (en) | 1998-08-10 | 1999-08-10 | Differentiation of non-insulin producing cells into insulin producing cells with GLP-1 or Exendin-4 and uses thereof |
AU55524/99A AU776514B2 (en) | 1998-08-10 | 1999-08-10 | Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof |
EP99942066A EP1105460B1 (en) | 1998-08-10 | 1999-08-10 | Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof |
US11/400,715 US20070041951A1 (en) | 1998-08-10 | 2006-04-07 | Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9591798P | 1998-08-10 | 1998-08-10 | |
US60/095,917 | 1998-08-10 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/400,715 Continuation US20070041951A1 (en) | 1998-08-10 | 2006-04-07 | Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2000009666A2 WO2000009666A2 (en) | 2000-02-24 |
WO2000009666A9 WO2000009666A9 (en) | 2000-07-13 |
WO2000009666A3 true WO2000009666A3 (en) | 2000-11-23 |
Family
ID=22254191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/018099 WO2000009666A2 (en) | 1998-08-10 | 1999-08-10 | Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof |
Country Status (10)
Country | Link |
---|---|
US (2) | US7056734B1 (en) |
EP (2) | EP2028269B1 (en) |
JP (4) | JP4624558B2 (en) |
AT (1) | ATE445006T1 (en) |
AU (1) | AU776514B2 (en) |
CA (1) | CA2339326A1 (en) |
DE (1) | DE69941510D1 (en) |
DK (1) | DK1105460T3 (en) |
ES (2) | ES2335066T3 (en) |
WO (1) | WO2000009666A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
US8906901B2 (en) | 2005-09-14 | 2014-12-09 | Takeda Pharmaceutical Company Limited | Administration of dipeptidyl peptidase inhibitors |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7138486B2 (en) * | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US6699973B1 (en) * | 1998-11-19 | 2004-03-02 | Elan Corporation, Plc | Antibodies to peptides that target GIT receptors and related methods |
US6242666B1 (en) * | 1998-12-16 | 2001-06-05 | The Scripps Research Institute | Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells |
US6967019B2 (en) * | 1999-04-06 | 2005-11-22 | The Regents Of The University Of California | Production of pancreatic islet cells and delivery of insulin |
US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
US6448045B1 (en) * | 2000-03-10 | 2002-09-10 | The Regents Of The University Of California | Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1 |
EP1346722B1 (en) | 2000-12-01 | 2008-12-10 | Takeda Pharmaceutical Company Limited | Method for producing preparation containing bioactive substance |
EP2022505B1 (en) | 2001-07-31 | 2011-12-14 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | GLP-1, exendin-4, peptide analogs and uses thereof |
US6642003B2 (en) * | 2001-08-02 | 2003-11-04 | Cedars-Sinai Medical Center | Human glucose-dependent insulin-secreting cell line |
US6911324B2 (en) | 2001-10-18 | 2005-06-28 | The Regents Of The University Of California | Induction of beta cell differentiation in human cells |
PL374557A1 (en) * | 2001-11-09 | 2005-10-31 | Artecel Sciences, Inc. | Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof |
ES2545090T3 (en) | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Albumin and GCSF fusion proteins |
US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
AU2003219922B2 (en) * | 2002-02-27 | 2009-09-10 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
EP1507848A4 (en) * | 2002-05-28 | 2005-11-23 | Becton Dickinson Co | Expansion and transdifferentiation of human acinar cells |
EP1569682A2 (en) * | 2002-12-03 | 2005-09-07 | Novo Nordisk A/S | Combination treatment using exendin-4 and thiazolidinediones |
EP1688148A1 (en) * | 2002-12-03 | 2006-08-09 | Novo Nordisk A/S | Combination treatment using exendin-4 and thiazolidinediones |
WO2004069314A1 (en) | 2003-02-04 | 2004-08-19 | Novo Nordisk A/S | Injection device with rotatable dose setting |
WO2004113512A2 (en) * | 2003-06-20 | 2004-12-29 | Vrije Universiteit Brussel | Method of generating islet beta-cells from exocrine pancreatic cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
AU2004252567B2 (en) | 2003-06-27 | 2011-10-06 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
MXPA06007667A (en) | 2004-01-06 | 2006-09-01 | Novo Nordisk As | Heteroaryl-ureas and their use as glucokinase activators. |
ES2642214T3 (en) | 2004-01-21 | 2017-11-15 | Novo Nordisk Health Care Ag | Conjugation of peptides by transglutaminase |
JPWO2005118781A1 (en) * | 2004-06-03 | 2008-04-03 | 国立大学法人京都大学 | Insulin secretory cell induction |
US8148412B2 (en) | 2004-12-03 | 2012-04-03 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
MX2008000255A (en) | 2005-07-14 | 2008-04-02 | Novo Nordisk As | Urea glucokinase activators. |
CN102675221A (en) | 2005-09-16 | 2012-09-19 | 武田药品工业株式会社 | Intermediate in method for preparing pyrimidinedione derivative |
JP5289970B2 (en) | 2005-12-16 | 2013-09-11 | エシコン・インコーポレイテッド | Compositions and methods for inhibiting reverse immune responses in histocompatible incompatible transplants |
JP2009520040A (en) | 2005-12-19 | 2009-05-21 | ファーマイン コーポレーション | Hydrophobic core carrier composition for delivery of therapeutic agents and methods of making and using the same |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
EP1996224B1 (en) | 2006-03-15 | 2012-11-07 | Novo Nordisk A/S | Mixtures of amylin and insulin |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
AU2008204530B2 (en) | 2007-01-11 | 2013-08-01 | Vtv Therapeutics Llc | Urea glucokinase activators |
RU2413528C2 (en) | 2007-01-18 | 2011-03-10 | Открытое Акционерное Общество "Валента Фармацевтика" | Exenatide and dalargin drug for treating diabetes, adminisration and therapy |
EP2170945A1 (en) | 2007-07-16 | 2010-04-07 | Novo Nordisk A/S | Protease stabilized, pegylated insulin analogues |
US7960336B2 (en) * | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
US20090176892A1 (en) | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
EP2259791A2 (en) * | 2008-03-05 | 2010-12-15 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Glp-1 receptor agonists and related active pharmaceutical ingredients for treatment of cancer |
RU2571857C2 (en) | 2008-03-18 | 2015-12-20 | Ново Нордиск А/С | Acylated insulin analogues stabilised with respect to proteases |
JP2011526303A (en) | 2008-06-27 | 2011-10-06 | デューク ユニバーシティ | A therapeutic agent containing an elastin-like peptide |
CA2747794C (en) | 2008-12-19 | 2018-10-30 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of lung and pulmonary diseases and disorders |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
BRPI1013409A2 (en) | 2009-03-26 | 2018-01-16 | Advanced Tech And Regenerative Medicine Llc | human umbilical cord tissue cells as therapy for alzheimer's disease |
CN101991580B (en) * | 2009-08-28 | 2013-03-20 | 杏辉天力(杭州)药业有限公司 | Application of lanostane and poria cocos extracts in diabetes treatment |
CA2782056C (en) | 2009-11-25 | 2021-03-09 | Arisgen Sa | Mucosal delivery of peptides |
SG184988A1 (en) | 2010-04-27 | 2012-11-29 | Zealand Pharma As | Peptide conjugates of glp-1 receptor agonists and gastrin and their use |
JP5866106B2 (en) | 2010-05-12 | 2016-02-17 | コロンビア ユニヴァーシティ | Method for producing enteroendocrine cells that produce and secrete insulin |
BR112014010780A2 (en) | 2011-11-03 | 2017-04-25 | Zealand Pharma As | glp-1-gastrin receptor agonist peptide conjugates |
JP6301263B2 (en) | 2011-12-23 | 2018-03-28 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | Detection of human umbilical cord tissue-derived cells |
NZ704043A (en) | 2012-07-23 | 2017-07-28 | Zealand Pharma As | Glucagon analogues |
TWI608013B (en) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | Glucagon analogues |
UA116217C2 (en) | 2012-10-09 | 2018-02-26 | Санофі | Exendin-4 derivatives as dual glp1/glucagon agonists |
AU2013366691A1 (en) | 2012-12-21 | 2015-07-09 | Sanofi | Exendin-4 derivatives |
PL3057984T3 (en) | 2013-10-17 | 2018-12-31 | Zealand Pharma A/S | Acylated glucagon analogues |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
MX369770B (en) | 2013-11-06 | 2019-11-21 | Zealand Pharma As | Glucagon-glp-1-gip triple agonist compounds. |
EP3065767B1 (en) | 2013-11-06 | 2020-12-30 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
TW201609799A (en) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | Dual GLP-1/GIP receptor agonists |
EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
TW201609796A (en) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | Non-acylated EXENDIN-4 peptide analogues |
TW201609797A (en) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | Dual GLP-1/glucagon receptor agonists |
TW201625670A (en) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4 |
TW201625669A (en) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4 |
TW201625668A (en) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists |
JP2017513875A (en) * | 2014-04-22 | 2017-06-01 | ティーエックスピー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Peptide analogs with branched amino acid probes |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
US10487314B2 (en) | 2014-06-26 | 2019-11-26 | The Trustees Of Columbia University In The City Of New York | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells |
RU2573933C1 (en) | 2014-08-21 | 2016-01-27 | Дафот Энтерпрайсис Лимитед | Peptide for medical treatment of pancreatic diabetes of 2nd type and its complications |
CA2965732A1 (en) | 2014-10-29 | 2016-05-06 | Zealand Pharma A/S | Gip agonist compounds and methods |
JP6989385B2 (en) | 2015-04-16 | 2022-01-05 | ジーランド ファーマ アクティーゼルスカブ | Acylated glucagon analog |
AR105319A1 (en) | 2015-06-05 | 2017-09-27 | Sanofi Sa | PROPHARMS THAT INCLUDE A DUAL AGONIST GLU-1 / GLUCAGON CONJUGATE HIALURONIC ACID CONNECTOR |
TW201706291A (en) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | New EXENDIN-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists |
JP6563614B1 (en) | 2016-12-09 | 2019-08-21 | ジーランド・ファーマ・ア/エス | Acylated GLP-1 / GLP-2 dual agonist |
CN109679964A (en) * | 2019-01-12 | 2019-04-26 | 青岛华义宏博生物科技有限公司 | A kind of Recombinant Lactococcus lactis for expressing human insulin gene |
EP3938037A1 (en) | 2019-03-15 | 2022-01-19 | Diet4Life ApS | Combination of dietary peptides |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5424286A (en) * | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
WO1995031214A1 (en) * | 1994-05-12 | 1995-11-23 | London Health Association | Treatment of diabetes |
WO1999043705A1 (en) * | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
AU4114493A (en) * | 1992-04-24 | 1993-11-29 | Polymer Technology Group, Inc., The | Method of culturing viable cells and method of regulating the level of a compound in a body fluid |
JP2575298B2 (en) | 1992-06-15 | 1997-01-22 | フアイザー・インコーポレイテツド | Glucagon-like peptide and insulinotropin derivatives |
HU225496B1 (en) | 1993-04-07 | 2007-01-29 | Scios Inc | Pharmaceutical compositions of prolonged delivery, containing peptides |
CA2137206A1 (en) | 1993-12-09 | 1995-06-10 | John A. Galloway | Glucagon-like insulinotropic peptides, compositions and methods |
CA2262647C (en) * | 1996-08-08 | 2007-12-04 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
EP1932535A3 (en) | 1998-07-31 | 2008-10-29 | Novo Nordisk A/S | Stimulation of beta cell profileration |
-
1999
- 1999-08-10 CA CA002339326A patent/CA2339326A1/en not_active Abandoned
- 1999-08-10 DK DK99942066.4T patent/DK1105460T3/en active
- 1999-08-10 AU AU55524/99A patent/AU776514B2/en not_active Ceased
- 1999-08-10 JP JP2000565103A patent/JP4624558B2/en not_active Expired - Fee Related
- 1999-08-10 ES ES99942066T patent/ES2335066T3/en not_active Expired - Lifetime
- 1999-08-10 ES ES08019260.2T patent/ES2553108T3/en not_active Expired - Lifetime
- 1999-08-10 EP EP08019260.2A patent/EP2028269B1/en not_active Expired - Lifetime
- 1999-08-10 EP EP99942066A patent/EP1105460B1/en not_active Expired - Lifetime
- 1999-08-10 DE DE69941510T patent/DE69941510D1/en not_active Expired - Lifetime
- 1999-08-10 US US09/762,538 patent/US7056734B1/en not_active Expired - Fee Related
- 1999-08-10 AT AT99942066T patent/ATE445006T1/en active
- 1999-08-10 WO PCT/US1999/018099 patent/WO2000009666A2/en active IP Right Grant
-
2006
- 2006-04-07 US US11/400,715 patent/US20070041951A1/en not_active Abandoned
-
2007
- 2007-04-24 JP JP2007114374A patent/JP4755133B2/en not_active Expired - Fee Related
-
2009
- 2009-08-07 JP JP2009184807A patent/JP2009291206A/en active Pending
-
2011
- 2011-04-05 JP JP2011083828A patent/JP2011177181A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5424286A (en) * | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
WO1995031214A1 (en) * | 1994-05-12 | 1995-11-23 | London Health Association | Treatment of diabetes |
WO1999043705A1 (en) * | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
Non-Patent Citations (3)
Title |
---|
GEFEL ET AL: "GLUCAGON-LIKE PEPTIDE-I ANALOGS: EFFECTS ON INSULIN SECRETION AND ADENOSINE 3',5'-MONOPHOSPHATE FORMATION", ENDOCRINOLOGY, vol. 126, no. 4, 1990, pages 2164 - 2168, XP000574862, ISSN: 0013-7227 * |
MASHIMA ET AL: "FORMATION OF INSULIN-PRODUCING CELLS FROM PANCREATIC ACINAR AR42J CELLS BY HEPATOCYTE GROWTH FACTOR", ENDOCRINOLOGY, vol. 137, no. 9, 1996, pages 3969 - 3976, XP000670297, ISSN: 0013-7227 * |
THORENS B ET AL: "CLONING AND FUNCTIONAL EXPRESSION OF THE HUMAN ISLET GLP-1 RECEPTORÖDEMONSTRATION THAT EXENDIN-4 IS AN AGONIST AND EXENDIN-(9-39) AN ANTAGONIST OF THE RECEPTOR", DIABETES, vol. 42, no. 11, 1 November 1993 (1993-11-01), pages 1678 - 1682, XP000571435, ISSN: 0012-1797 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8906901B2 (en) | 2005-09-14 | 2014-12-09 | Takeda Pharmaceutical Company Limited | Administration of dipeptidyl peptidase inhibitors |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
ATE445006T1 (en) | 2009-10-15 |
AU5552499A (en) | 2000-03-06 |
DE69941510D1 (en) | 2009-11-19 |
US20070041951A1 (en) | 2007-02-22 |
US7056734B1 (en) | 2006-06-06 |
WO2000009666A2 (en) | 2000-02-24 |
EP1105460A2 (en) | 2001-06-13 |
CA2339326A1 (en) | 2000-02-24 |
DK1105460T3 (en) | 2010-02-08 |
EP2028269B1 (en) | 2015-10-21 |
JP4624558B2 (en) | 2011-02-02 |
JP4755133B2 (en) | 2011-08-24 |
JP2002522068A (en) | 2002-07-23 |
ES2335066T3 (en) | 2010-03-18 |
AU776514B2 (en) | 2004-09-09 |
EP2028269A1 (en) | 2009-02-25 |
WO2000009666A9 (en) | 2000-07-13 |
JP2009291206A (en) | 2009-12-17 |
EP1105460B1 (en) | 2009-10-07 |
JP2007209348A (en) | 2007-08-23 |
ES2553108T3 (en) | 2015-12-04 |
JP2011177181A (en) | 2011-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2000009666A3 (en) | Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof | |
YU59392A (en) | A-B-C PROINSULIN, OBTAINING PROCESS AND INTERMEDIARIES IN INSULIN PRODUCTION | |
DK2210947T3 (en) | Process for the production of secreted proteins | |
AU5027299A (en) | Use of glp-1 and analogues for preventing type ii diabetes | |
WO2003014318A3 (en) | Methods for treating diabetes and other blood sugar disorders | |
MY119174A (en) | Process for the production of chemically prestressed glass, and the use thereof | |
ATE203769T1 (en) | DNA ENCODING ASPARTOCINASE III MUTANTS AND THEIR USE FOR PRODUCING L-THREONINE BY FERMENTATION | |
DE69133342D1 (en) | Recombinant DNA sequences coding for enzymes free from feedback inhibition, plasmids containing these sequences, transformed microorganisms useful for the production of aromatic amino acids and their processes for the production by fermentation | |
DE59915077D1 (en) | Process for the fermentative production of D-pantothenic acid by amplification of the panD gene in microorganisms | |
WO2002044362A1 (en) | Method of screening remedy for diabetes | |
WO2001003680A3 (en) | Compounds for inhibiting diseases and preparing cells for transplantation | |
ATE403008T1 (en) | METHOD FOR PRODUCING L-AMINO ACIDS USING STRAINS FROM THE ENTEROBACTERIACEA FAMILY WHICH CONTAIN AN ATTENUATE DGSA GENE | |
DE502004000547D1 (en) | Process for the fermentative production of L-methionine | |
EP0158892A3 (en) | 59 valine insulin-like growth factor i and process for production thereof | |
HU896613D0 (en) | Process for the preparation of tgf-betal/beta2 chimer | |
AU2099301A (en) | Method for obtaining proteins having improved functional characteristics | |
DE69803805T2 (en) | NEW MATERIAL AND METHOD FOR THE PRODUCTION THEREOF | |
CA2341610A1 (en) | Method for making a supported catalyst | |
DE59807382D1 (en) | Mutants of formate dehydrogenase from Candida biodinii, gene sequences encoding them and use of these formate dehydrogenases | |
CA2011378A1 (en) | Achromobacter protease i gene and gene product thereof | |
WO2003080666A3 (en) | An adipocyte insulin and a method of treating diabetes | |
EP0850970A3 (en) | Process for preparing the polycarbonate of 2,2,4,4-tetramethyl-1,3-cyclobutanediol | |
AU545665B2 (en) | Microbiological production of the amino acid sequences of proinsulin from primates | |
DE10146589A1 (en) | New mutants of formate dehydrogenase from Candida boidinii | |
WO1997035993A3 (en) | PSA positive regulating (PSAR) sequences and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: C2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: C2 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
COP | Corrected version of pamphlet |
Free format text: PAGES 1/30-30/30, DRAWINGS, REPLACED BY NEW PAGES 1/26-26/26; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
ENP | Entry into the national phase |
Ref document number: 2339326 Country of ref document: CA Kind code of ref document: A Ref document number: 2339326 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1999942066 Country of ref document: EP Ref document number: 55524/99 Country of ref document: AU |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1999942066 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09762538 Country of ref document: US |
|
WWG | Wipo information: grant in national office |
Ref document number: 55524/99 Country of ref document: AU |