WO2000009255A3 - Parallel reactor with internal sensing and method of using same - Google Patents

Parallel reactor with internal sensing and method of using same Download PDF

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Publication number
WO2000009255A3
WO2000009255A3 PCT/US1999/018358 US9918358W WO0009255A3 WO 2000009255 A3 WO2000009255 A3 WO 2000009255A3 US 9918358 W US9918358 W US 9918358W WO 0009255 A3 WO0009255 A3 WO 0009255A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction mixtures
monitoring
controlling
disclosed
pressure
Prior art date
Application number
PCT/US1999/018358
Other languages
French (fr)
Other versions
WO2000009255A2 (en
Inventor
Howard Turner
G Cameron Dales
Erden Lynn Van
Beek Johannes A M Van
Damian A Hajduk
Ralph B Nielsen
Paul Mansky
Leonid Matsiev
Pei Wang
Eric Mcfarland
Original Assignee
Symyx Technologies Inc
Howard Turner
G Cameron Dales
Erden Lynn Van
Beek Johannes A M Van
Damian A Hajduk
Ralph B Nielsen
Paul Mansky
Leonid Matsiev
Pei Wang
Eric Mcfarland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27378216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000009255(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/177,170 external-priority patent/US6548026B1/en
Application filed by Symyx Technologies Inc, Howard Turner, G Cameron Dales, Erden Lynn Van, Beek Johannes A M Van, Damian A Hajduk, Ralph B Nielsen, Paul Mansky, Leonid Matsiev, Pei Wang, Eric Mcfarland filed Critical Symyx Technologies Inc
Priority to JP2000564745A priority Critical patent/JP3618295B2/en
Priority to CA002306807A priority patent/CA2306807C/en
Priority to DK99942147T priority patent/DK1069942T3/en
Priority to EP99942147A priority patent/EP1069942B1/en
Priority to DE69908336T priority patent/DE69908336T2/en
Priority to AT99942147T priority patent/ATE241427T1/en
Priority to AU55590/99A priority patent/AU5559099A/en
Publication of WO2000009255A2 publication Critical patent/WO2000009255A2/en
Publication of WO2000009255A3 publication Critical patent/WO2000009255A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
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    • B01L2200/02—Adapting objects or devices to another
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    • C—CHEMISTRY; METALLURGY
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    • C40B40/04—Libraries containing only organic compounds
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    • C40B40/18—Libraries containing only inorganic compounds or inorganic materials
    • G—PHYSICS
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    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/115831—Condition or time responsive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/12—Condition responsive control

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Abstract

Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also for conventional experimental reactors as well. The apparatus generally includes multiple vessels (102, 206, 236, 266, 338, 362, 396, 522, 710, 876, 912, 1286, 1542) for containing reaction mixtures, and systems (180, 230, 260, 270, 272, 500, 1544, 1546, 1548, 1604) for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system (146, 1002) for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers (160, 268, 678, 720, 928, 1500, 1508, 1604), and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
PCT/US1999/018358 1998-08-13 1999-08-12 Parallel reactor with internal sensing and method of using same WO2000009255A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2000564745A JP3618295B2 (en) 1998-08-13 1999-08-12 Parallel processing apparatus and method for introducing fluid
CA002306807A CA2306807C (en) 1998-08-13 1999-08-12 Parallel reactor with internal sensing and method of using same
DK99942147T DK1069942T3 (en) 1998-08-13 1999-08-12 Parallel reactor with internal registration and method of using the same
EP99942147A EP1069942B1 (en) 1998-08-13 1999-08-12 Parallel reactor with internal sensing and method of using same
DE69908336T DE69908336T2 (en) 1998-08-13 1999-08-12 PARALLEL REACTOR WITH INTERNAL FEELING AND METHOD FOR USING IT
AT99942147T ATE241427T1 (en) 1998-08-13 1999-08-12 PARALLEL REACTOR WITH INTERNAL SENSING AND METHOD OF USE THEREOF
AU55590/99A AU5559099A (en) 1998-08-13 1999-08-12 Parallel reactor with internal sensing and method of using same

Applications Claiming Priority (6)

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US9660398P 1998-08-13 1998-08-13
US60/096,603 1998-08-13
US09/177,170 1998-10-22
US09/177,170 US6548026B1 (en) 1998-08-13 1998-10-22 Parallel reactor with internal sensing and method of using same
US09/211,982 1998-12-14
US09/211,982 US6306658B1 (en) 1998-08-13 1998-12-14 Parallel reactor with internal sensing

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WO2000009255A2 WO2000009255A2 (en) 2000-02-24
WO2000009255A3 true WO2000009255A3 (en) 2000-11-23

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EP (1) EP1069942B1 (en)
JP (3) JP3618295B2 (en)
AT (5) ATE279255T1 (en)
AU (1) AU5559099A (en)
CA (1) CA2306807C (en)
DE (5) DE69927720T2 (en)
DK (1) DK1069942T3 (en)
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