WO2000009110A3 - N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders - Google Patents

N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders Download PDF

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Publication number
WO2000009110A3
WO2000009110A3 PCT/US1999/018243 US9918243W WO0009110A3 WO 2000009110 A3 WO2000009110 A3 WO 2000009110A3 US 9918243 W US9918243 W US 9918243W WO 0009110 A3 WO0009110 A3 WO 0009110A3
Authority
WO
WIPO (PCT)
Prior art keywords
vision
carbamate
memory disorders
linked urea
heterocyclic thioesters
Prior art date
Application number
PCT/US1999/018243
Other languages
French (fr)
Other versions
WO2000009110A2 (en
Inventor
Douglas T Ross
Hansjorg Sauer
Gregory S Hamilton
Joseph P Steiner
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Priority to AU55558/99A priority Critical patent/AU5555899A/en
Priority to JP2000564613A priority patent/JP2002522486A/en
Priority to EP99942110A priority patent/EP1104299A2/en
Priority to CA002336080A priority patent/CA2336080A1/en
Publication of WO2000009110A2 publication Critical patent/WO2000009110A2/en
Publication of WO2000009110A3 publication Critical patent/WO2000009110A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked urea or carbamate of heterocyclic thioesters derivatives.
PCT/US1999/018243 1998-08-14 1999-08-12 N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders WO2000009110A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU55558/99A AU5555899A (en) 1998-08-14 1999-08-12 N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
JP2000564613A JP2002522486A (en) 1998-08-14 1999-08-12 N-linked ureas or carbamates of heterocyclic thioesters for visual and memory disorders
EP99942110A EP1104299A2 (en) 1998-08-14 1999-08-12 N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
CA002336080A CA2336080A1 (en) 1998-08-14 1999-08-12 N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/134,416 1998-08-14
US09/134,416 US6506788B1 (en) 1998-08-14 1998-08-14 N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders

Publications (2)

Publication Number Publication Date
WO2000009110A2 WO2000009110A2 (en) 2000-02-24
WO2000009110A3 true WO2000009110A3 (en) 2000-05-11

Family

ID=22463295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018243 WO2000009110A2 (en) 1998-08-14 1999-08-12 N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders

Country Status (6)

Country Link
US (1) US6506788B1 (en)
EP (1) EP1104299A2 (en)
JP (1) JP2002522486A (en)
AU (1) AU5555899A (en)
CA (1) CA2336080A1 (en)
WO (1) WO2000009110A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008960B1 (en) 1999-03-02 2006-03-07 Vitreo-Retinal Technologies, Inc. Agents for intravitreal administration to treat or prevent disorders of the eye
US20030199574A1 (en) * 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
US7977385B2 (en) * 2000-03-02 2011-07-12 Numoda Biotechnologies, Inc. Agents for corneal or intrastromal administration to treat or prevent disorders of the eye
US20050137124A1 (en) * 2002-08-09 2005-06-23 Vitreo-Retinal Technologies, Inc. A California Corporation Agents for intravitreal administration to treat or prevent disorders of the eye
US20040087576A1 (en) * 2002-11-05 2004-05-06 Haracz John L. Antimnemonic therapy for hypermemory syndromes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013343A1 (en) * 1996-09-25 1998-04-02 Guilford Pharmaceuticals Inc. Heterocyclic thioesters and ketones
WO1998029116A1 (en) * 1996-12-31 1998-07-09 Guilford Pharmaceuticals Inc. N-linked sulfonamides of heterocyclic thioesters
WO1998029117A1 (en) * 1996-12-31 1998-07-09 Guilford Pharmaceuticals Inc. N-linked ureas and carbamates of heterocyclic thioesters

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WO1998029116A1 (en) * 1996-12-31 1998-07-09 Guilford Pharmaceuticals Inc. N-linked sulfonamides of heterocyclic thioesters
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Title
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Also Published As

Publication number Publication date
CA2336080A1 (en) 2000-02-24
US6506788B1 (en) 2003-01-14
JP2002522486A (en) 2002-07-23
EP1104299A2 (en) 2001-06-06
AU5555899A (en) 2000-03-06
WO2000009110A2 (en) 2000-02-24

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