WO2000009085A3 - Oral formulation containing cyclosporin - Google Patents

Oral formulation containing cyclosporin Download PDF

Info

Publication number
WO2000009085A3
WO2000009085A3 PCT/GB1999/002639 GB9902639W WO0009085A3 WO 2000009085 A3 WO2000009085 A3 WO 2000009085A3 GB 9902639 W GB9902639 W GB 9902639W WO 0009085 A3 WO0009085 A3 WO 0009085A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulation containing
oral formulation
containing cyclosporin
immunosuppressant
cyclosporin
Prior art date
Application number
PCT/GB1999/002639
Other languages
French (fr)
Other versions
WO2000009085A2 (en
Inventor
Stanley Stewart Davis
Peter James Watts
Yu-Hui Cheng
Original Assignee
West Pharm Serv Drug Res Ltd
Stanley Stewart Davis
Peter James Watts
Cheng Yu Hui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharm Serv Drug Res Ltd, Stanley Stewart Davis, Peter James Watts, Cheng Yu Hui filed Critical West Pharm Serv Drug Res Ltd
Priority to AU53785/99A priority Critical patent/AU5378599A/en
Publication of WO2000009085A2 publication Critical patent/WO2000009085A2/en
Publication of WO2000009085A3 publication Critical patent/WO2000009085A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Abstract

The present invention provides a composition comprising (i) an immunosuppressant, (ii) at least one compound selected from tocopherol, tocotrienol and the derivatives thereof, (iii) a short chain phospholipid and (iv) a non-ionic surfactant. The immunosuppressant is preferably cyclosporin.
PCT/GB1999/002639 1998-08-14 1999-08-10 Oral formulation containing cyclosporin WO2000009085A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53785/99A AU5378599A (en) 1998-08-14 1999-08-10 Oral formulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9817650.6A GB9817650D0 (en) 1998-08-14 1998-08-14 Oral formulation
GB9817650.6 1998-08-14

Publications (2)

Publication Number Publication Date
WO2000009085A2 WO2000009085A2 (en) 2000-02-24
WO2000009085A3 true WO2000009085A3 (en) 2000-09-28

Family

ID=10837203

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002639 WO2000009085A2 (en) 1998-08-14 1999-08-10 Oral formulation containing cyclosporin

Country Status (3)

Country Link
AU (1) AU5378599A (en)
GB (1) GB9817650D0 (en)
WO (1) WO2000009085A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961588B2 (en) 2002-03-27 2015-02-24 Advanced Cardiovascular Systems, Inc. Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin
USRE45744E1 (en) 2003-12-01 2015-10-13 Abbott Cardiovascular Systems Inc. Temperature controlled crimping

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596306B1 (en) * 2000-07-07 2003-07-22 David Ho Sue San Ho Drug delivery system:formulation for fat-soluble drugs
AUPR510001A0 (en) * 2001-05-18 2001-06-14 Jupitar Pty Ltd Formulation and method
GB0425255D0 (en) * 2004-11-16 2004-12-15 Novartis Ag Pharmaceutical composition
KR101245022B1 (en) * 2005-01-21 2013-03-19 카무러스 에이비 Pharmaceutical lipid compositions
WO2017047618A1 (en) * 2015-09-18 2017-03-23 日本化薬株式会社 Medicinal composition comprising rapamycin or derivative thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391369A2 (en) * 1989-04-05 1990-10-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
WO1995011039A1 (en) * 1993-10-22 1995-04-27 Hexal Pharma Gmbh PHARMACEUTICAL COMPOSITION CONTAINING CYCLOSPORINE A AND α-TOCOPHEROL
EP0760237A1 (en) * 1995-08-30 1997-03-05 Cipla Limited Oil-in-water microemulsions
WO1997022358A1 (en) * 1995-12-15 1997-06-26 Bernard Charles Sherman Microemulsion preconcentrates comprising cyclosporins
WO1997036610A1 (en) * 1996-07-26 1997-10-09 Chong Kun Dang Corp. Cyclosporin-containing pharmaceutical composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391369A2 (en) * 1989-04-05 1990-10-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
WO1995011039A1 (en) * 1993-10-22 1995-04-27 Hexal Pharma Gmbh PHARMACEUTICAL COMPOSITION CONTAINING CYCLOSPORINE A AND α-TOCOPHEROL
EP0760237A1 (en) * 1995-08-30 1997-03-05 Cipla Limited Oil-in-water microemulsions
WO1997022358A1 (en) * 1995-12-15 1997-06-26 Bernard Charles Sherman Microemulsion preconcentrates comprising cyclosporins
WO1997036610A1 (en) * 1996-07-26 1997-10-09 Chong Kun Dang Corp. Cyclosporin-containing pharmaceutical composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961588B2 (en) 2002-03-27 2015-02-24 Advanced Cardiovascular Systems, Inc. Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin
USRE45744E1 (en) 2003-12-01 2015-10-13 Abbott Cardiovascular Systems Inc. Temperature controlled crimping

Also Published As

Publication number Publication date
AU5378599A (en) 2000-03-06
GB9817650D0 (en) 1998-10-07
WO2000009085A2 (en) 2000-02-24

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