WO2000008032A1

WO2000008032A1 - Catalyst ligands useful for cross-coupling reactions

Info

Publication number: WO2000008032A1
Application number: PCT/US1999/017899
Authority: WO
Inventors: Anil Guram; Xiaohong Bei; Timothy Powers; Bernd Jandeleit; Thomas Crevier
Original assignee: Symyx Technologies, Inc.
Priority date: 1998-08-06
Filing date: 1999-08-05
Publication date: 2000-02-17
Also published as: US6124476A; AU5469599A

Abstract

The present invention discloses new organic compounds (e.g., ligands), their metal complexes and compositions using those compounds. The invention also relates to the field of catalysis. In particular, this invention relates to new compounds which when combined with suitable metals or metal precursor compounds provide useful catalysts for various bond-forming reactions, including Suzuki cross-coupling or aryl amination reactions. The invention also relates to performing Suzuki cross coupling reactions with unreactive aryl-chlorides.

Description

CATALYST LIGANDS USEFUL FOR CROSS-COUPLING REACTIONS

FIELD OF THE INVENTION

The present invention relates to new organic compounds (e.g., ligands), their metal complexes and compositions using those compounds; the invention also relates to the field of catalysis. In particular, this invention relates to new compounds which when combined with suitable metals or metal precursor compounds provide useful catalysts for various bond-forming reactions, including aryl aminations and Suzuki cross-coupling reactions. The invention also relates to a process for preparing polycyclic aromatic compounds by a cross-coupling reaction of suitable aromatic nucleophiles and suitable aromatic electrophiles catalyzed by the novel compositions or metal complexes.

BACKGROUND OF THE INVENTION

Ancillary (or spectator) ligand-metal coordination complexes (e.g., organometallic complexes) and compositions are useful as catalysts, additives, stoichiometric reagents, monomers, solid state precursors, therapeutic reagents and drugs. Ancillary ligand-metal coordination complexes of this type can be prepared by combining an ancillary ligand with a suitable metal compound or metal precursor in a suitable solvent under suitable reaction conditions. The ancillary ligand may contain functional groups that bind to the metal center(s), remain associated with the metal center(s), and therefore provide an opportunity to modify the steric, electronic and chemical properties of the active metal center(s) of the complex.

Certain known ancillary ligand-metal complexes and compositions are catalysts for reactions such as oxidation, reduction, hydrogenation, hydrosilylation, hydrocyanation, hydroformylation, polymerization, carbonylation, isomerization, metathesis, carbon-hydrogen activation, carbon-halogen activation, cross-coupling, hetero cross-coupling, Friedel-Crafts acylation and alkylation, hydration, amination, aryl amination, dimerization, trimerization, oligomerization, Diels- Alder reactions and other transformations.

One example of the use of these types of ancillary ligand-metal complexes and compositions is in the field of cross-coupling reactions. The palladium- catalyzed cross-coupling reactions of aryl-chlorides, bromides, iodides, and triflates with alkyl or aryl-boron compounds provide a general and efficient route to a wide variety of substituted alkylphenyl or biphenyl compounds, and have now been extensively developed. See Suzuki, A. in Metal-Catalyzed Cross-Coupling Reactions; Diederich, F., Stang, P. J., Eds.; Wiley- VCH: Weinheim, Germany, 1998; Chapter 2, pp. 49-97, which is incorporated herein by reference. See also U.S. Patents 5,550,236 and 5,756,804, both of which are incorporated herein by reference.

However, the related palladium-catalyzed reactions of the comparatively inexpensive and readily available aryl chlorides, which represent the most attractive candidates for industrial applications of these reactions, have been underdeveloped. See Old, D. W., Wolfe, J. P., Buchwald, S. L., J. Am. Chem. Soc. 1998, 120, 9722- 9723; and Littke, A. F., Fu, G. C, Angew. Chem. Int. Ed. Eng. 1998, 37, 3387- 3388, which are both incorporated herein by reference. Another example is the palladium-catalyzed cross-coupling reactions of aryl- bromides, iodides, and triflates with primary and secondary amines, which provide a general and efficient route to a wide variety of substituted aryl amines, and have now been extensively developed. See Guram, A. S., Rennels, R. A., Buchwald, S. L. Angew. Chem., Int. Ed. Engl. 1995, 34, 1348-1350; Wolfe, J. P., Wagaw, S., Buchwald, S. L. J. Am. Chem. Soc. 1996, 118, 7215-7216; Louie, J., Hartwig, J. F. Tetrahedron Lett. 1995, 36, 3609-3612; Driver, M. S., Hartwig, J. F. J. Am. Chem. Soc. 1996, 118, 7217-7218; Sadighi, J. P., Singer, R. A., Buchwald, S. L. 7. Am. Chem. Soc. 1998, 120, 4960-4976; Marcoux, J-F., Wagaw, S., Buchwald, S. L. J. Org. Chem. 1997, 62, 1568-1569; Ahman, J., Buchwald, S. L. Tetrahedron Lett. 1997, 38, 6363-6366; Wolfe, J. P., Buchwald, S. L. J. Org. Chem. 1997, 62, 6066-6068; Yamamoto, T., Nishiyama, M., Koie, Y. Tetrahedron Lett. 1998, 39, 2367-2370. For a recent review, see Baranano, D., Mann, G, Hartwig, J. F. Curr. Org. Chem. 1997, 1, 287-305.

However, the related palladium-catalyzed reactions of the comparatively inexpensive and readily available aryl chlorides, which represent the most attractive candidates for industrial applications of these reactions, have been underdeveloped. Previous studies of palladium-catalyzed amination of aryl chlorides have been limited to activated aryl chlorides. See Reddy, N. P., Tanaka, M. Tetrahedron Lett. 1997, 38, 4807-4810 and Beller, ML, Reirmeier, T. H., Reisinger, C, Hermann, W. A. Tetrahedron Lett. 1997, 38, 2073-2074. The nickel-catalyzed amination of aryl chlorides has been previously reported; see Wolfe, J. P., Buchwald, S. L. f. Am. Chem. Soc. 1997, 119, 6054-6058. See also Hamann, B. C, Hartwig, J. F. J. Am. Chem. Soc. 1998, 120, 7369-7370; Ben-David, Y., Portnoy, M., Milstein, D. f. Am. Chem. Soc. 1989, 111, 8742-8744; Ben-David, Y., Portnoy, M., Milstein, D. J. Chem. Soc, Chem. Commun. 1989, 1816-1817; Gouda, K., Hagiwara, E., Hatanaka, Y., Hiyama, T. J. Org. Chem. 1996, 61, 7232-7233. The related nickel- catalyzed cross-coupling reactions have been reproted to be efficient; for example see Saito, S., Oh-tani, S., Miyaura, N. J. Org. Chem. 1997, 62, 8024-8030; Saito, S., Sakai, M., Miyaura, N. Tetrahedron Lett. 1996, 37, 2993-3996; Perec, V., Bae, J. Y., Hill, D. H. J. Org. Chem. 1995, 60, 1060-1065; Indolese, A. F. Tetrahedron Lett. 1997, 38, 3513; and Grushin, V. V., Alper, H. Chem. Rev. 1994, 94, 1047- 1062.

This invention provides a new, general, and efficient catalyst for cross- coupling reactions in general and more specifically for the Suzuki reaction between aryl halides, especially relatively unreactive aryl chlorides, with alkyl and aryl- substituted boronic acid derivatives and aryl-substituted perfluoroalkylsulfonates. Also in particular, the efficient amination of aryl chlorides with acyclic aliphatic secondary amines has not been reported previously. This invention provides a new, general, and efficient catalyst for the amination of aryl chlorides with primary and secondary cyclic and acyclic amines. Compounds prepared according to the invention are suitable for use as precursors for pharmaceuticals, cosmetics, fungicides, herbicides, dyes, detergents, and polymers, including additives for these. Compounds prepared according to the invention are, in particular, valuable precursors for angiotensin II inhibitors. See Drugs of the Future 1993, 18, 428-432.

SUMMARY OF THE INVENTION

Thus, it is an object of this invention to provide novel ligands for use in catalyzing a chemical transformation. These ligands are typically included either in a catalytic composition additionally including a metal precursor or a metal complex. In a first aspect, the invention disclosed herein is a ligand (i.e., an ancillary ligand), which can be characterized by either of the general formulas:

i π wherein each R and R is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl and substituted cycloalkyl.

Each of R³, R⁴ and R⁵ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, metallocene and combinations thereof; and b is 0, 1, 2, 3 or 4; c is 0, 1, 2 or 3 and optionally, R³ and R⁴ are joined together in a ring structure. Each R⁶ and R⁷ is independently selected from the same group as R⁵, but may additionally be a water solubilizing group or a transition metal. Also optionally two or more R or R groups are joined together in a ring structure. In connection with formula II, R will typically be a transition metal containing moiety so that formula II may, for example, be a bis-cyclopentadienyl metallocene.

In a second aspect, the invention disclosed herein is a ligand that can be characterized by the general formula:

wherein R , R , R , R , R , b and c have the definitions given above.

The ligands of this invention are added to a metal precursor to provide a catalytic composition or new metal-ligand complexes. And, it is an object of this invention to provide new compositions comprising the new ligand and a metal precursor and new metal complexes. For catalysis, the ligands from the above two aspects can be included in a composition including a suitable metal or metal precursor compound that can be of the form ML_n, where the composition has catalytic properties. Also, the ligands can be coordinated with a metal precursor to form metal-ligand complexes, which may be catalysts. Here, M is a transition metal selected from the group consisting of Groups 5, 6, 7, 8, 9 and 10 of the Periodic Table of Elements, preferably Pd, Ni, Ru, Rh, Pt, Co, Ir and Fe; L is independently each occurrence, a neutral and/or charged ligand; and n is a number 0, 1, 2, 3, 4, and 5, depending on M. Another aspect of this invention is the chemical transformations that the new catalytic compositions or metal complexes enhance, and it is an object of this invention to provide catalysts and methods for such transformations. The compositions and metal complexes are useful as catalysts for various chemical transformations, particularly cross coupling transformations. Specifically, the preparation of polycyclic aromatic compounds by a cross-coupling reaction of a first aromatic compound and second aromatic compound, more specifically with aromatic boron compounds and aromatic halogen compounds or perfluoroalkylsulfonates may be performed, and it is an object of this invention to provide catalysts and methods for such cross coupling reactions. The benefit of using these catalysts in such reactions is generally higher conversions (e.g., turnovers) when using less costly starting materials. Further aspects of this invention will be evident to those of skill in the art upon review of this specification.

DETAILED DESCRIPTION OF THE INVENTION

The invention disclosed herein is new ligands that may be combined with metals or metal precursor compounds to form coordination complexes or compositions of matter, which are useful as catalysts for chemical reactions, as well as processes for making the ligand and using the resultant composition or coordination complex as a catalyst. This invention supplements U.S. patent application no. 09/062,128, incorporated herein by reference. In addition, this invention was made with combinatorial techniques. See Danielson, E., Golden, J. H., McFarland, E. W., Reaves, C. M, Weinberg, W. H., Wu, X. D. Nature 1997, 389, 944-948 and U.S. Patent Application No. 08/898,715, filed July 22, 1997, both of which are incorporated herein by reference. For recent general reviews on combinatorial catalysis, see Weinberg, W. H., Jandeleit, B., Self, K.; Turner, H. Curr. Opin. Solid State Mater. Sci. 1998, 3, 104-110 and Gennari, C, Nestler, H. P., Piarulli, U., Salom, B. Liebigs Ann./Recueil 1997, 637-647, both of which are incorporated herein by reference. As used herein, the phrase "characterized by the formula" is not intended to be limiting and is used in the same way that "comprising" is commonly used. The term "independently selected" is used herein to indicate that the R groups, e.g., R¹, R², R³, R⁴, R⁵ and R⁶ can be identical or different (e.g. R¹, R² and R³ may all be substituted alkyls or R¹ and R² may be a substituted alkyl and R³ may be an aryl, etc.). A named R group will generally have the structure that is recognized in the art as corresponding to R groups having that name. For the purposes of illustration, representative R groups as enumerated above are defined herein. These definitions are intended to supplement and illustrate, not preclude, the definitions known to those of skill in the art. The term "alkyl" is used herein to refer to a branched or unbranched, saturated or unsaturated acyclic hydrocarbon radical. Suitable alkyl radicals include, for example, methyl, ethyl, n-propyl, i-propyl, 2-propenyl (or allyl), vinyl, n-butyl, t-butyl, i-butyl (or 2-methylpropyl), etc. In particular embodiments, alkyls have between 1 and 200 carbon atoms, between 1 and 50 carbon atoms or between 1 and 20 carbon atoms.

"Substituted alkyl" refers to an alkyl as just described in which one or more hydrogen atom to any carbon of the alkyl is replaced by another group such as a halogen, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, and combinations thereof. Suitable substituted alkyls include, for example, benzyl, trifluoromethyl and the like.

The term "heteroalkyl" refers to an alkyl as described above in which one or more hydrogen atoms to any carbon of the alkyl is replaced by a heteroatom selected from the group consisting of N, O, P, B, S, Si, Se and Ge. The bond between the carbon atom and the heteroatom may be saturated or unsaturated. Thus, an alkyl substituted with a heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, boryl, phosphino, amino, silyl, thio, or seleno is within the scope of the term heteroalkyl. Suitable heteroalkyls include cyano, benzoyl, 2-pyridyl, 2-furyl and the like.

The term "cycloalkyl" is used herein to refer to a saturated or unsaturated cyclic non-aromatic hydrocarbon radical having a single ring or multiple condensed rings. Suitable cycloalkyl radicals include, for example, cyclopentyl, cyclohexyl, cyclooctenyl, bicyclooctyl, etc. In particular embodiments, cycloalkyls have between 3 and 200 carbon atoms, between 3 and 50 carbon atoms or between 3 and 20 carbon atoms.

"Substituted cycloalkyl" refers to cycloalkyl as just described including in which one or more hydrogen atom to any carbon of the cycloalkyl is replaced by another group such as a halogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, boryl, phosphino, amino, silyl, thio, seleno and combinations thereof. Suitable substituted cycloalkyl radicals include, for example, 4-dimethylaminocyclohexyl, 4,5-dibromocyclohept-4-enyl, and the like.

The term "heterocycloalkyl" is used herein to refer to a cycloalkyl radical as described, but in which one or more or all carbon atoms of the saturated or unsaturated cyclic radical are replaced by a heteroatom such as nitrogen, phosphorous, oxygen, sulfur, silicon, germanium, selenium, or boron. Suitable heterocycloalkyls include, for example, piperazinyl, morpholinyl, tetrahydropyranyl, tetrahydrofuranyl, piperidinyl, pyrrolidinyl, oxazolinyl, and the like.

"Substituted heterocycloalkyl" refers to heterocycloalkyl as just described including in which one or more hydrogen atom to any atom of the heterocycloalkyl is replaced by another group such as a halogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, boryl, phosphino, amino, silyl, thio, seleno and combinations thereof. Suitable substituted heterocycloalkyl radicals include, for example, N-methylpiperazinyl, 3- dimethylaminomorpholine, and the like.

The term "aryl" is used herein to refer to an aromatic substituent which may be a single aromatic ring or multiple aromatic rings which are fused together, linked covalently, or linked to a common group such as a methylene or ethylene moiety. The common linking group may also be a carbonyl as in benzophenone or oxygen as in diphenylether or nitrogen in diphenylamine. The aromatic ring(s) may include phenyl, naphthyl, biphenyl, diphenylether, diphenylamine and benzophenone among others. In particular embodiments, aryls have between 1 and 200 carbon atoms, between 1 and 50 carbon atoms or between 1 and 20 carbon atoms.

"Substituted aryl" refers to aryl as just described in which one or more hydrogen atom to any carbon is replaced by one or more functional groups such as alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, halogen, alkylhalos (e.g., CF₃), hydroxy, amino, phosphino, alkoxy, amino, thio and both saturated and unsaturated cyclic hydrocarbons which are fused to the aromatic ring(s), linked covalently or linked to a common group such as a methylene or ethylene moiety. The linking group may also be a carbonyl such as in cyclohexyl phenyl ketone.

The term "heteroaryl" as used herein refers to aromatic rings in which one or more carbon atoms of the aromatic ring(s) are replaced by a heteroatom(s) such as nitrogen, oxygen, boron, selenium, phosphorus, silicon or sulfur. Heteroaryl refers to structures that may be a single aromatic ring, multiple aromatic ring(s), or one or more aromatic rings coupled to one or more nonaromatic ring(s). In structures having multiple rings, the rings can be fused together, linked covalently, or linked to a common group such as a methylene or ethylene moiety. The common linking group may also be a carbonyl as in phenyl pyridyl ketone. As used herein, rings such as thiophene, pyridine, isoxazole, phthalimide, pyrazole, indole, furan, etc. or benzo-fused analogues of these rings are defined by the term "heteroaryl."

"Substituted heteroaryl" refers to heteroaryl as just described including in which one or more hydrogen atoms to any atom of the heteroaryl moiety is replaced by another group such as a halogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, boryl, phosphino, amino, silyl, thio, seleno and combinations thereof. Suitable substituted heteroaryl radicals include, for example, 4-N,N-dimethylaminopyridine.

The term "alkoxy" is used herein to refer to the -OZ¹ radical, where Z¹ is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocylcoalkyl, substituted heterocycloalkyl, silyl groups and combinations thereof as described herein. Suitable alkoxy radicals include, for example, methoxy, ethoxy, benzyloxy, t-butoxy, etc. A related term is "aryloxy" where Z¹ is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, and combinations thereof. Examples of suitable aryloxy radicals include phenoxy, substituted phenoxy, 2-pyridinoxy, 8-quinalinoxy and the like.

As used herein the term "silyl" refers to the -SiZ^Z³ radical, where each of Z¹, Z², and Z³ is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, heterocycloalkyl, heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, amino, silyl and combinations thereof.

As used herein the term "boryl" refers to the -BZ'Z² group, where each of

1 9

Z and Z is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, heterocycloalkyl, heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, amino, silyl and combinations thereof. As used herein, the term "phosphino" refers to the group -PZ*Z², where each of Z¹ and Z² is independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, heterocyclic, aryl, heteroaryl, silyl, alkoxy, aryloxy, amino and combinations thereof.

The term "amino" is used herein to refer to the group -NZ^², where each of Z¹ and Z² is independently selected from the group consisting of hydrogen; alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl and combinations thereof.

The term "thio" is used herein to refer to the group — SZ¹, where Z¹ is selected from the group consisting of hydrogen; alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl and combinations thereof.

The term "seleno" is used herein to refer to the group -SeZ¹, where Z¹ is selected from the group consisting of hydrogen; alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl and combinations thereof.

The term "saturated" refers to lack of double and triple bonds between atoms of a radical group such as ethyl, cyclohexyl, pyrrolidinyl, and the like. The term "unsaturated" refers to the presence one or more double and triple bonds between atoms of a radical group such as vinyl, acetylenyl, oxazolinyl, cyclohexenyl, acetyl and the like.

The ancillary ligands of this invention can be characterized by either of the general formulas:

i π wherein each R¹ and R² is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl and substituted cycloalkyl; and each of R³, R⁴ and R⁵ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and optionally, R³ and R⁴ are joined together in a ring structure; also optionally two or more R groups are joined together in a ring structure; each R⁶ and R⁷ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, water solubilizing groups, transition metals and combinations thereof; b is 0, 1, 2, 3 or 4; and c is 0, 1, 2 or 3. Also optionally two or more R⁶ or R⁷ groups are joined together in a ring structure. In more specific embodiments, each R³, R⁴ and R⁵ is independently selected from a group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl and silyl. Specific examples of R³, R⁴ and R⁵ are methyl, ethyl, propyl, butyl, cyclopentyl, cylcohexyl, cyclooctyl, phenyl, naphthyl, benzyl, trimethylsilyl, and the like.

More specifically, of R⁶ may be chosen from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, silyl, amino, alkoxy, aryloxy, phosphino, boryl, transition metals, halogens and combinations thereof. Specific examples of R⁶ include methyl, ethyl, propyl, t- butyl, phenyl, methoxy, alkoxy, thioalkyl, cyano, acetyl, benzoyl, nitro, dimethylamino, diethylamino, methylphenylamino, benzylmethylamino, trimethylsilyl, dimethylboryl, diphenylboryl, methylphenylboryl, dimethoxyboryl, chromium tricarbonyl, ruthenium tricarbonyl, and cyclopentadienyl iron. R⁶ can also be a water-solubilizing group, such as SO₃G, where G is Na, K and the like. R⁶ may also be a transition metal that is eta bonded to the benzene ring in the backbone of the ligand. Optionally, two or more R⁶ groups combine to form a fused ring structure with the aromatic group that forms a part of the ligand backbone. The additional fused ring may or may not contain a heteroatom. Examples of the aromatic group that is part of the backbone as combined with two or more R⁶ groups that have formed a fused ring are nathphalene, quinoline, indole and the like.

More specific embodiments of R⁷ are those where a mono-cyclopentadienyl or bis-cyclopentadienyl metallocene is formed as part of the ligand. Thus, R⁷ may be a moiety having a metal atom selected from the group consisting of metals from the Periodic Table of Elements, such as Fe, Rh, Mo, Ru, Cr, Zr, Ti, Hf, Co. Specific examples of R⁷ include FeCp, CrCp and ZrCpR , where Cp is a substituted or unsubstituted cyclopentadienyl and R is selected from the same group as R⁵. Throughout this specification, it is intended that the bond between the Cp ring in the ligand and R⁷ is an • ⁵ bond. Thus, formula LI may appear to have the structure:

π Within this first aspect, particularly preferred ligands are

In a second aspect, the ligands of this invention may be characterized by the general formulas:

m IV where R¹, R², R⁵, R⁶ R⁷, b and c have the definitions given above. A particularly preferred ligand within this second aspect is:

The ligands of this invention may be on a support or not. For example, the support could be any one of the R groups in the formulas I, II, III or IV (i.e., R , R , R³, R⁴, R⁵, R⁶ or R⁷). In that embodiment, the support may be a polymer or functionalized polymer, such as polystyrene. In the case of heterogeneous reactions, the ligands may be supported, with or without the metal coordinated (discussed below), on an organic or inorganic support. Suitable supports include silicas, aluminas, zeolites, polyethyleneglycols, polystyrenes, polyesters, polyamides, peptides and the like.

The desired ligand is typically combined with a metal atom, ion, compound or other metal precursor compound. In many applications, the ligands of this invention will be combined with such a metal compound or precursor and the product of such combination is not determined, if a product forms. For example, the ligand may be added to a reaction vessel at the same time as the metal or metal precursor compound along with the reactants. The metal precursor compounds may be characterized by the general formula M(L)_n (also referred to as ML_n or M-L- where M is a metal selected from the group consisting of Groups 5, 6, 7, 8, 9 and 10 of the Periodic Table of Elements. In more specific embodiments, M is selected from the group consisting of Ni, Pd, Fe, Pt, Ru, Rh, Co and Ir. L is a ligand chosen from the group consisting of halide, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, hydroxy, boryl, silyl, hydrido, thio, seleno, phosphino, amino, and combinations thereof. When L is a charged ligand, L is selected from the group consisting of hydrogen, halogens, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof . When L is a neutral ligand, L is selected from the group consisting of carbon monoxide, isocyanide, nitrous oxide, PA₃, NA₃, OA₂, SA₂, SeA₂, and combinations thereof, wherein each A is independently selected from a group consisting of alkyl, substituted alkyl, heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, and amino. Specific examples of suitable metal precursor compounds include Pd(dba) (dba = dibenzylydieneacteone), Pd₂(dba)₃, Pd(OAc)₂ (Ac = acetate), PdCl₂, Pd(TFA)₂, (TFA = trifluoroacetate), (CH₃CN)₂PdCl₂, and the like. In this context, the ligand to metal precursor compound ratio is in the range of about 0.01 : 1 to about 100: 1 , more preferably in the range of about 0.5: 1 to about 20: 1. The metal atom, ion or metal precursor may be supported or not. Supports may be organic or inorganic. Similar to the ligands, the support may be an L. In other embodiments, the support will not form part of the metal precursor and suitable supports include silicas, aluminas, zeolites, polyethyleneglycols, polystyrenes, polyesters, polyamides, peptides and the like. Specific examples of Pd supported metals include Pd/C,

Pd/SiO₂, Pd/CaCO₃, Pd/BaCO₃, Pd/aluminate, Pd/aluminum oxide, Pd/polystyrene, although any of the metals listed above could replace Pd in this list, e.g., Ni/C, etc.

In other applications, the ligand will be mixed with a suitable metal precursor compound prior to or simultaneous with allowing the mixture to be contacted to the reactants. When the ligand is mixed with the metal precursor compound, a metal-ligand complex may be formed, which may be a catalyst. Looking at the first ligand aspect of this application, the metal complexes of this invention may be characterized by either of the formulas:

V VI

vπ vm where R¹, R², R³, R⁴, R⁵, R⁶, M, L, b, c and n have the definitions given above and additionally m is a number that is 1, 2 or 3. The single crystal X-ray crystallographic characterization of one such complex by combining one of the above preferred ligands with metal precursor Pd(dba)₂ and para-t- butylbromobenzene resulted in a complex having the following structure:

Looking at the second ligand aspect of this invention, the metal complexes of this invention may take the form:

LX X

Generally, the ligands of the first aspect of this invention may be prepared by the following schemes. For the ligands within the first aspect, a general scheme is

Scheme 1

where each of the variables has the above definition and J is selected from the group consisting of H, Br, I, Cl, F, tosylates, triflates and nonaflates. In scheme 1, step 1 is a standard acetal/ketal formation reaction that is acid-catalyzed in the presence of a suitable alcohol. In scheme 1, step 2 changes depending on J. When J is H or Br, step 2 comprises the addition of a butyl lithium reagent (e.g., n-BuLi or s-BuLi or t-BuLi) followed by addition of C1PR^!R² or BrPR'R². When J is F, step

1

2 comprises addition of a reagent that is characterized by M"PR R where M" is either Li, Mg, Zn or K. Finally, when J is Br, I, Cl, a tosylate, a triflate or a nonaflate, step 2 in scheme 1 comprises a metal catalyzed cross-coupling reaction with M"'PR¹R² where M'" is H, SiR₃ (with R = alkyl, aryl or cycloalkyl) or M". The catalyst for this step 2 is a suitable metal, such as Pd or Ni, optionally with a ligand. Such step 2 cross coupling reactions are known to those skilled in the art. A more specific description within scheme 1 for making the ligands is where one starts with 2-bromobenzaldehyde taken up in 100 ml dry benzene in a 250 ml round-bottom flask equipped with a reflux condensor and Dean-Stark apparatus upon which p-toluenesulfonic acid monohydrate and alcohol are added (except that where the alcohol is methanol, methanol was as a reagent and trimethylformate was used as the solvent at 65°C for 8 hours). The mixture is then heated to reflux with stirring. After cooling to room temperature, the benzene is removed. To the resulting residue is added 200 ml of a saturated aqueous solution of NaHCO₃ and extracted with Et₂O. The organic extracts are combined and washed with brine, dried over MgSO , filtered, and concentrated on a rotary evaporator to give the desired acetal which is used in the next step without further purification. The o-dialkoxy-bromobenzene derivatives are dissolved in anhydrous diethyl ether (30 mL) and the solution is cooled to - 78 °C. t-Butyllithium is added dropwise with stirring. The reaction is stirred for 1 hour. A secondary chlorophoshine is added dropwise via a syringe at -78 °C with stirring. The reaction mixture is allowed to warm up to room temperature over an additional 18 hours. To the mixture, deoxygenated water is added slowly. The organic phase is separated under argon and the aqueous phase is washed with diethyl ether. The combined organic phase is dried under vacuum at 40°C. The crude product is washed with methanol and dried under vacuum, affording the desired ligands. For the ligands of the second aspect, a synthesis procedure is as follows:

Scheme 2 In scheme 2, the variables are as defined above. As can be seen the ligands of the second aspect can be prepared from the same starting material and following step 3 or by starting with the ligands of the first aspect and following step 4. Step 3 in scheme 2 changes depending on J. When J is H or Br, step 3 comprises the addition of a butyl lithium reagent (e.g., n-BuLi or s-BuLi or t-BuLi) followed by addition of CIPR'R² or BrPR'R². When J is F, step 3 comprises addition of a reagent that is characterized by M'TR^² where M" is either Li, Mg, Zn or K. Finally, when J is Br, I, Cl, a tosylate, a triflate or a nonaflate, step 3 in scheme 2 comprises a metal catalyzed cross-coupling reaction with M'"PR¹R² where M'" is H, SiR₃ (with R = alkyl, aryl or cycloalkyl) or M". The catalyst for.this step 3 is a suitable metal, such as Pd or Ni, optionally with a ligand. Such step 3 cross coupling reactions are known to those skilled in the art. When step 4 is being followed, a standard acetal/ketal hydrolysis, acid-catalyzed reaction is run in the presence of water.

The catalyst compositions and metal complexes of this invention catalyze reactions that include activation of and/or formation of H-Si, H-H, H-N, H-O, H-P, H-S, C-H, C-C, C=C, C≡C, C-halogen, C-N, C-O, C-S, C-P, and C-Si bonds. Specifically, such reactions include carbonylation, hydroformylation, hydroxycarbonylation, hydrocarbonylation, hydroesterification, hydrogenation, transfer hydrogenation, hydrosilylation, hydroboration, hydroamination, epoxidation, aziridation, reductive amination, C-H activation, insertion, C-H activation-insertion, C-H activation-substitution, C-halogen activation, C-halogen activation-substitution, C-halogen activation-insertion, cyclopropanation, alkene metathesis, alkene oligomerization, alkene polymerization, alkyne oligomerization, alkyne polymerization, co-polymerization, CO-alkene co-oligomerization, CO- alkene co-polymerization, CO-alkyne co-oligomerization and CO-alkyne co- polymerization. These reactions may occur at previously known conditions (or possibly novel conditions). Moreover, these reactions may be homogeneous or heterogeneous.

More specifically, the catalyst compositions and metal complexes of this invention are useful for many metal-catalyzed reactions, particularly for Suzuki cross-coupling reactions with aryl chlorides. In general, this invention may be effectively employed for metal-catalyzed coupling of organometallic reagents with organic electrophiles; metal-catalyzed coupling of organometallic reagents with organic halides; metal-catalyzed coupling of organometallic reagents with aryl halides and vinyl halides; and metal-catalyzed coupling of organometallic reagents with aryl chlorides. In particular, the following reactions can be effectively performed with this invention: aryl-aryl or biaryl coupling reactions, including coupling of aryl boron reagents (aryl boronic acid and esters) with aryl halides including aryl chlorides, aryl triflates, aryl tosylates, aryl mesylates (Suzuki coupling); coupling of aryl zinc reagents with the compounds as above; coupling of aryl magnesium reagents with the compounds as above; coupling of aryl tin reagents with the compounds as above; and coupling of aryl metal reagents with the compounds as above. Those of skill in the art will recognize that this list can be repeated by simply substituting heteroaryl for aryl without departing from the scope of this invention. Additional reactions that can be effectively performed with this invention include vinyl-aryl coupling reactions such as the coupling of vinyl metal reagents with the compounds as above, coupling of vinyl aluminate reagents with the compounds as above, coupling of vinyl cuprate reagents with the compounds as above, coupling of vinyl zirconium reagents with the compounds as above; and the coupling of vinyl boron reagents with the compounds as above. Still further, reactions that can be effectively performed with this invention include reactions which involve oxidative addition, transmetallation and reductive elimination sequence or oxidative addition, insertion or beta-hydride elimnation sequence in the catalytic cycle, including Heck reactions that involve metal-catalyzed olefination of aryl halides including chloride, aryl mesylates, tosylates, aryl triflates. Other reaction examples, include Sonogashira, cyanation, aryl amination, Stille coupling, Castro-Stephens, and hydrogenations.

To carry out the process of this invention for one type of reaction, a first aromatic compound, a second aromatic compound, a base, a catalytic amount of metal precursor and a catalytic amount of the ligand are added to an inert solvent or inert solvent mixture. In a batch methodology, this mixture is stirred at a temperature of from 0°C to 200°C, preferably at from 30°C to 170°C, particularly preferably at from 50°C to 150°C, most particularly preferably at from 60°C to 120°C, for a period of from 5 minutes to 100 hours, preferably from 15 minutes to 70 hours, particularly preferably from 1/2 hour to 50 hours, most particularly preferably from 1 hour to 30 hours. After the reaction is complete, the catalyst may be obtained as solid and separated off by filtration. The crude product is freed of the solvent or the solvents and is subsequently purified by methods known to those skilled in the art and matched to the respective product, e.g. by recrystallization, distillation, sublimation, zone melting, melt crystallization or chromatography.

Solvents suitable for the process of the invention are, for example, ethers (e.g., diethyl ether, dimethoxymethane, diethylene glycol, dimethyl ether, tetrahydrofuran, dioxane, diisopropyl ether, tert-butyl methyl ether), hydrocarbons (e.g., hexane, iso-hexane, heptane, cyclohexane, benzene, toluene, xylene), alcohols (e.g., methanol, ethanol, 1-propanol, 2-propanol, ethylene glycol, 1-butanol, 2- butanol, tert-butanol), ketones (e.g., acetone, ethyl methyl ketone, iso-butyl methyl ketone), amides (e.g., dimethylformamide, dimethylacetamide, N- methylpyrrolidone), nitriles (e.g., acetonitrile, propionitrile, butyronitrile), water and mixtures thereof. Particularly preferred solvents are ethers (e.g., dimethoxyethane, tetrahydrofuran), hydrocarbons (e.g., cyclohexane, benzene, toluene, xylene), alcohols (e.g., ethanol, 1-propanol, 2-propanol), water and combinations thereof. Most particularly preferred are dimethoxyethane, benzene, toluene, xylene, dioxane, ethanol, water and combinations thereof. Bases which are useful in the process of the invention are alkali metal and alkaline earth metal hydroxides, alkali metal and alkaline earth metal carbonates, alkali metal hydrogen carbonates, alkali metal and alkaline earth metal acetates, alkali metal and alkaline earth metal alkoxides, alkali metal and alkaline earth metal phosphates, primary, secondary and tertiary amines, alkali metal and alkaline earth fluorides, and ammonium fluorides. Particularly preferred are alkali metal and alkaline earth metal phosphates, alkali metal and alkaline earth metal carbonates, alkali metal hydrogen carbonates, alkali metal and alkaline earth fluorides, and ammonium fluorides. Most particularly preferred are alkali metal phosphates, such as potassium phosphate. The base is preferably used in the process of the invention in an amount of from about 1 to about 1000 mol %, particularly preferably from about 50 to about 500 mol %, very particularly preferably from about 100 to about 400 mol %, in particular from about 150 to about 300 mol %, based on the aromatic boronic acid.

The metal precursor used is as described above and may be added to the process along with the reactants. The metal portion of the catalyst (metal precursor or metal complex) is used in the process of this invention in a proportion of from about 0.0001 to about 10 mol %, preferably from about 0.1 to about 5 mol %, particularly preferably from about 0.5 to about 3 mol %, most particularly preferably from about 1.0 to about 1.5 mol %, based on the second aromatic compound. The ancillary ligand is used in the process in a proportion of from about 0.0001 to about 20 mol %, preferably from about 0.2 to about 15 mol %, particularly preferably from about 0.5 to about 10 mol %, most particularly preferably from about 1 to about 6 mol %, based on the second aromatic compound. These amounts may be combined to give metal precursor to ligand ratios useful in the process. It is also possible, if desired, to use mixtures of two or more different ligands.

The first aromatic compounds for the process may be characterized by either of the general formulas:

Xffl XIV where R⁸ is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; a is 0, 1, 2, 3, 4 or 5 and optionally two or more R⁸ groups are joined together in a ring structure; X' is selected from the group consisting of BR ₂, B(OR¹⁰)₂, MgQ , ZnQ¹, CuQ¹, SiR¹⁰ ₃ SnR¹⁰ ₃ or Li, wherein each R¹⁰ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and Q¹ is selected from the group consisting of Cl, Br, I or F. See also U.S. Patent No. 5,756,804, incorporated herein by reference for other, similar formulas. Specific boronic acids that fit this definition of first aromatic compounds are listed in Table 1, below. The second aromatic compounds for the process of the invention those of the formula:

where X is Br, Cl, F, I, tosylates, triflates, or N₂ ⁺ and R⁹ is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and a is 0, 1, 2, 3, 4 or 5. Optionally two or more R⁹ groups are joined together in a ring structure. Preferable, R⁹ is selected from the group consisting of methyl, ethyl, methoxy, — CN and — CF₃. See also U.S. Patent No. 5,756,804, incorporated herein by reference for other, similar formulas. Specific compounds that meet fit within the scope of the second aromatic compounds are listed in Table 1.

Products of the process of the invention are polycyclic aromatic compounds having a aryl-aryl bond, having the general structure:

The products are also suitable as precursors for pharmaceuticals, cosmetics, fungicides, herbicides, insecticides, dyes, detergents and polymers, including additives for the same.

For the aryl-aminations, refer to Scheme 3 as follows: Scheme 3.

catalyst : P ( ba) ₂ /Ligand 1

Ligand 1 where R¹¹ and R¹² are defined as R¹⁰ is defined above and there can be 0, 1, 2, 3, 4 or 5 R¹⁰'s. Moreover, R¹¹ and R¹² can be joined in a ring structure, with the ring optionally containing a heteroatom, such as O, N or S. A representative experimental procedure is as follows: A mixture of 5-chloro-m-xylene (0.14 mL, 1.04 mmol), N-heptylmethylamine (0.19 mL, 1.13 mmol), NaO'Bu ( 125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) was heated to 105 °C for 1 hour and analyzed by GCMS. The reaction was cooled to room temperature, taken up in diethyl ether (125 mL), washed with water (30 mL) and brine (30 mL), dried over MgSO₄, filtered and concentrated in vacuo. The crude product was purified by column chromatography on silica gel using hexanes as the eluent to afford compound 5-N-heptymethylamino-m-xylene (entry 9, Table 1, which follows), after drying under vacuum, as a colorless oil (yield: 230 mg, 95 %). 1H NMR (CDC1₃): • 6.33 (br. s, 3H, ArH), 3.25 (t, J = 7.6 Hz, 2H, - NCH₂-), 2.89 (s, 3H, -N-CH₃), 2.27 (s, 6H, Ar(CH₃)₂), 1.54 (br., 2H, -NCH₂CH₂-), 1.30 (br., 8Η, -(CH₂)₄CH₃), 0.89 (br. t, J = 6.6 Hz, 3H, -CH₃). ¹³C NMR (CDC1₃): • 149.6, 138.6, 117.9, 110.1, 52.8, 38.3, 31.9, 29.2, 27.1, 26.7, 22.6, 21.8, 14.1. Anal, for C₁₆H₂₇N; Calcd: C, 82.34; H, 11.66; N, 6.00; Found: C, 82.02; H, 11.92; N. 6.21.

Table 1. Pd(dba)₂/Ligand 1 - Catalyzed Amination of Aryl Chlorides.³ entry starting materials product yield' *->

9 X = Cl 95 10 X = Br 93 ll^β X = I 91 Notes from Table 1 are: ^a Unless otherwise noted, all reactions were performed at 105 °C for 1 hour using 1.0 equiv. of aryl halide, 1.1 - 1.2 equiv. of amine, 1.2 - 1.3 equiv. of NaOtBu, 2 mol% Pd(dba)2/ 6 mol% Ligand as catalyst, and toluene as the reaction solvent; ^b Yields reported correspond to isolated material of > 95 % purity; ^c 2 hour reaction time; ^d 3 hour reaction time; and ^e 15 min reaction time.

The Pd(dba)₂/Ligand 1 catalyst is generally efficient in catalyzing the amination of a wide variety of aryl chlorides (Scheme 3 and Table 1, above). Aryl chlorides containing both electron-deficient and electron-rich substituents reacted efficiently with a wide variety of secondary cyclic and acyclic aliphatic amines to afford the desired aryl amines in very high selectivity and isolated yields (entries 1- 4, and 9, Table 1). These reactions were essentially complete in 1 hour and formed undetectable to only trace (less than 1 %) amounts of the undesired hydrodehalogenated product. Such high rates and selectivities for the amination of aryl chlorides with acyclic aliphatic secondary amines are unprecedented and particularly notable. Aryl chlorides containing ortho substituents also reacted efficiently with primary aromatic and aliphatic amines to afford the desired aryl amines in high selectivity and isolated yields (entries 5-8, Table 1). The amination of aryl chlorides with primary aliphatic amines is not limited to ørt o-substituted aryl chlorides. Thus, the reaction of 5-chloro-met -xylene with octylamine under the conditions described proceeds to completion in 2 hours and affords the desired aryl amine. The formation of the undesired hydrodehalogenated product was undetectable. However, the diarylated product was detected (ca. 15 - 20 % by GCMS). These reactions also proceeded rapidly and were complete in 3 hours. Products resulting from diarylation were not detected in these reactions. The Pd(dba) /Ligand 1 catalyst system was also found to be equally efficient in catalyzing the aminations of aryl bromides and iodides with secondary amines in high selectivities and isolated yields (entries 10-11, Table 1), although our studies were limited to the illustrated substrates. The reaction of the aryl iodide substrate proceeded smoothly and rapidly in toluene and was complete within 15 minutes.

EXAMPLES General. All reactions were performed under an argon atmosphere in oven- dried glass Schlenk tubes using standard Schlenk techniques. All aryl halides, all amines, sodium t-butoxide, bis(dibenzylideneacetone)palladium, benzene, ethanol, diethyl ether, methylene chloride, toluene, and 1 ,4-dioxane were purchased from commercial sources and used as such. All solvents were of the anhydrous, sure-seal grade. Column chromatography was performed using commercially available Silica Gel 60 (particle size: 0.063 - 0.100 mm), hexanes, and ethyl acetate. GCMS analyses were conducted on a Hewlett-Packard 6890 instrument. 1H, ¹³C, and ³¹P NMR spectra were obtained using a Bruker 300 MHz FT-NMR spectrometer using standard frequencies for the different nuclei. Chemical shifts in 1H and ¹³C NMR spectra were calibrated with reference to the chemical shift of residual protiated solvent. Chemical shifts in ³¹P NMR spectra were calibrated with reference to 85% H₃PO₄; a negative value of chemical shift denotes resonance upfield from H₃PO₄. Coupling constants are reported in Hz. Elemental analyses were performed by E & R Microanalytical Laboratory, Inc., NJ. The Pd(dba)₂/Ligand 1-catalyzed aryl amination procedure described for the synthesis 5-(N-heptylmethylamino)-m- xylene was generally used in synthesis of all other aryl amines.

Example 1: 2-(2'-Dicyclohexylphosphinophenyl)-2-methyl-l,3- dioxolane (Ligand 1): 2-(2'-bromophenyl)-2-methyl-l,3-dioxolane (2.02 g, 8.31 mmol) was dissolved in anhydrous diethyl ether (30 mL) and the solution was cooled to - 78 °C. n-Butyllithium (5.7 mL, 1.6 M solution in hexane, 9.13 mmol) was added dropwise with stirring. The reaction was stirred for 2 hours. Chlorodicyclohexylphosphine (2.32 g, 9.96 mmol) was added dropwise via a syringe at -78 °C with stirring. The reaction mixture was allowed to warm up to room temperature and stirred for an additional 18 hours. To the reaction mixture was added argon purged water (25 mL) slowly. The organic phase was separated under argon and the aqueous phase was washed with diethyl ether (20 mL). The combined organic phase was concentrated under vacuum to afford a colorless oil, which was crystallized from methanol to afford ligand 1 as a white crystalline solid having the structure shown below (yield: 2.13 g, 71 % un-optimized yield). ³¹P{1H} NMR (CDC1₃): δ -8.2. 1H NMR (CDC1₃): δ 7.67 (br 1H, ArH), 7.59 (br, 1H, ArH), 7.29 (br, 2H, ArH), 4.02 (m, 2H, -OCH₂CH₂O-), 3.73 (m, 2H, - OCH₂CH₂O-), 1.97 - 1.15 (br. m, 25H, CyH and CH₃). ¹³C NMR (CDC1₃): δ 149.3 (d, J_PC = 23), 134.8 (d, J_PC = 28), 134.0, 128.0, 127.1, 125.4 (d, J_PC= 6), 109.6 (-OCO-), 64.0 (-OCH2-), 36.3 (d, J_PC = 15), 30.8 (d, J_PC = 18), 30.0 (d, J_PC = 11), 29.4 (d, JP_C = 14), 27.4 (d, J_PC = 9), 27.2 (d, J_PC = 12), 26.4. Anal, for C22H33O2P; Calcd: C, 73.30; H, 9.23; P, 8.59; Found: C, 73.50; H, 9.46; P, 8.36.

Ligand

Examples 2-8: General Procedure for Pd(dba)₂/Ligand 1 -catalyzed reaction of aryl chlorides with boronic acid derivatives listed in Table 1: A mixture of aryl chloride (1.0 mmol), aryl boronic acid (1.5 mmol), CsF (3.0 mmol) or K₃PO₄ (2.0 mmol), Pd(dba)₂ (0.005-0.02 mmol), ligand 1 (0.015-0.06 mmol) in 1,4-dioxane (4 ml) was heated to 80 °C or 100 °C. The reaction was monitored by GC/MS. The details of the reaction conditions and results are summarized in Table 1.

Table 2. Examples of Suzuki Reactions

Example Aryl Chloride Boronic acid Temp % Pd Product Yield %

°C

^F^-\_f- ^Cl - B(OH)₂ 80 0.5 F,C- \\ t- // 92

Example 9: l-(2'-Dicyclohexylphosphinophenyl)-l,l- dimethoxymethane (Ligand 2): o-Dimethoxymethyl-bromobenzene (4.13 g, 17.9 mmol) was dissolved in anhydrous diethyl ether (60 mL) and the solution was cooled to - 78 °C. t-Butyllithium (21.2 mL, 1.7 M solution in hexane, 36 mmol) was added dropwise with stirring. The reaction was stirred for 1 hour. Chlorodicyclohexylphosphine (5.0 g, 21.5 mmol) was added dropwise via a syringe at -78 °C with stirring. The reaction mixture was allowed to warm up to room temperature over an additional 18 hours. To the mixture was added deoxygenated water (40 mL) slowly. The organic phase was separated under argon and the aqueous phase was washed with diethyl ether (20 mL). The combined organic phase was dried under vacuum at 40 °C. The crude product was washed with methanol (3 x 10 mL) and dried under vacuum, affording ligand 2 as a white solid product, having the structure shown below (Yield: 5.66 g, 90.7%). ³¹P{1H} (CDCI3): δ-18.5. *H NMR (CDC1₃): δ 7.62 (br, 1H, ArH), 7.40 (br, 1H, ArH), 7.25 (m, 2H, ArH), 6.17 (d, J_PH = 6.5, 1H CH(OCH₃)₂), 3.35 (s, 6H, -OCH₃), 2.0 - 0.9 (m, 22H, CyH). "CfK} NMR (CDC1₃): δ 144.8 (d, J_PC = 22), 134.3 (d, J_PC = 25), 132.3, 128.5, 127.5, 126.2 (d, J_PC = 5), 101.8 (d, J_PC = 29), 53.8, 34.2 (d, J_PC = 12), 30.3 (d, J_PC = 17), 29.3 (d, J_PC = 9), 27.0 (m, 2C), 26.2. Anal. For C₂₁H₃₃O₂P; Calcd: C, 72.38; H, 9.55; P, 8.89; Found: C, 72.46; H, 9.90; P, 9.03.

i _Q Ligand 2

Example 10: 7.65 mg of Pd₂(dba)₃ (8.35 • mol) and 11.60 mg of Ligand 2 (33.33* mol) were combined in 5 ml of solvent (dioxane, toluene, or 2-propanone) and stirred at room temperature for 2 hours to form a catalyst solution that was used

15 in this example and other examples. CsF (2.28 g, 15.0 mmol), 2-chlorobenzonitrile (0.689 g, 5.00 mmol), and p-tolueneboronic acid (0.748 g, 5.50 mmol) were taken up in 14 ml of dry dioxane under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in dioxane) was added. The mixture was then heated to 80 °C for 12 hours. The mixture was then cooled to room temperature, diluted with Et₂O, and

20 extracted with a saturated NH C1 solution (3 x 20 ml). The Et₂O layer was dried over MgSO₄, filtered and concentrated to give a viscous oil which was purified by flash chromatography to give 844 mg of 2-cyano-4'-methylbiphenyl in 87 % isolated yield.

25 Example 11: NaF (0.126 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g,

1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of <1 % based on the disappearance of 2-chlorobenzonitrile.

Example 12: K₃PO₄ (0.638 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g,

1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 43 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.03 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4'-dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 65 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.46 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl.

Example 13: K₂CO₃ (0.415 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g, 1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 52 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.26 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 73 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.45 % for the desired product 2-cyano-4' -methylbiphenyl over 4,4' -dimethylbiphenyl.

Example 14: Na₂CO₃ (0.318 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g, 1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 9 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >98.88 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4'-dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 16 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >96.76 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl.

Example 15: NaF (0.126 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g, 1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added followed by the addition of 1 ml distilled H₂O. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 11 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >96.55 % for the desired product 2-cyano- 4'-methylbiphenyl over 4,4' -dimethylbiphenyl.

Example 16: K₃PO₄ (0.638 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g,

1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added followed by the addition of 1 ml distilled H₂O. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 19 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >98.56 % for the desired product 2-cyano- 4'-methylbiphenyl over 4,4'-dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 20 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >98.87 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4'-dimethylbiphenyl.

Example 17: K₂CO₃ (0.415 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g, 1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added followed by the addition of 1 ml distilled H₂O. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 24 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >98.60 % for the desired product 2-cyano- 4'-methylbiphenyl over 4,4'-dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 26 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.26 % for the desired product 2-cyano-4'-methylbiphenyl over 4 ,4 ' -dimethylbiphenyl .

Example 18: Na₂CO₃ (0.318 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g, 1.00 mmol), and -tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry toluene under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in toluene) from Example 10 was added followed by the addition of 1 ml distilled H₂O. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 27 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.28 % for the desired product 2-cyano- 4'-methylbiphenyl over 4,4' -dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 31 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.11 % for the desired product 2-cyano-4'-methylbiphenyl over 4, 4 '-dimethylbiphenyl.

Example 19: NaF (0.126 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g, 1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry 2-butanone under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in 2-butanone) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 2 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.50 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 46 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.20 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4'-dimethylbiphenyl.

Example 20: K₃PO₄ (0.638 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g,

1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry 2-butanone under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in 2-butanone) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 63 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.53 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of >99 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.28 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl.

Example 21: K₂CO₃ (0.415 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g, 1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry 2-butanone under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in 2-butanone) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 38 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.15 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4'-dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of >99 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.29 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl.

Example 22: Na₂CO₃ (0.318 g, 3.00 mmol), 2-chlorobenzonitrile (0.138 g,

1.00 mmol), and p-tolueneboronic acid (0.143 g, 1.05 mmol) were taken up in 2 ml of dry 2-butanone under nitrogen and a 0.1 mol % aliquot from the catalyst solution (in 2-butanone) from Example 10 was added. The mixture was then heated to 80 °C and monitored by GC/MS. After 1 hour, GC/MS analysis showed a conversion of 25 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.18 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl. After 12 hours, GC/MS analysis showed a conversion of 56 % based on the disappearance of 2-chlorobenzonitrile and a selectivity of >99.06 % for the desired product 2-cyano-4'-methylbiphenyl over 4,4' -dimethylbiphenyl.

Example 23: This is a synthesis of Ligand 3, whose structure is shown below. Dicyclohexylphosphine (0.25 ml, 1.26 mmol) was added to a mixture of 2'- bromobenzophenone (261 mg, 1 mmol), NaO'Bu (115 mg, 1.2 mmol), Pd(dba)₂ (12 mg, 0.02 mmol) in o-xylene (4 mL). The mixture was heated from 85 °C to 140 °C within 30 min. GC-MS analysis indicated complete consumption of the 2- bromobenzophenone starting material. The reaction mixture was passed through a short silica column (Aldrich 2g SiO₂ column) and the column was washed with toluene, yellow solution was obtained. The solution was concentrated under vacuum and MeOH (0.3 ml) was added resulting in the formation of a pale yellow precipitate. After filtration, the solid was further washed with MeOH (4 x 0.3 ml) and dried under vacuum, yielding the desired ligand 3 as a pale yellow solid (150 mg, 40 %). The yield was not optimized. ³¹P{^XH} NMR (CDC1₃): • -8.6.

Example 24: This is a synthesis of Ligand 4, shown below. Ligand 4 was prepared from 2-bromoacetophenone by using the experimental procedure described above in Example 23. ³¹P{^XH} NMR (CDC1₃): • - 6.2.

Example 25: This is a synthesis of Ligand 5, shown below. A reaction mixture of l-(2'-Dicyclohexylphosphinophenyl)-l,l-dimethoxymethane (ligand 2, 1.0 g, 2.9 mmol), deoxygenated water (5 mL), and p-toluenesulfonic acid monohydrate (55 mg, 0.29 mmol) in THF (10 mL) was stirred at 50 - 55 °C for 20 hours. The reaction was cooled to ambient temperature and extracted with diethyl ether (2 x 5 mL). The organic phase was concentrated under vacuum, affording a yellow oil. The crude product was purified by column chromatography on silica gel using hexanes:ethyl acetate (8: 1) as the eluent to afford o- dicyclohexylphosphinobenzaldehyde (ligand 5) as a yellow oil (Yield: 740 mg, 85 %). ³¹P{1H} NMR (CDC1₃): • -20.5.

Ligand 3 Ligand 4 Ligand 5

Examples 26-32: General procedure for Pd(dba)₂/ligand 3 & 5 - catalyzed Suzuki reaction of p-toluylboronic acid with 2-chlornbenzonitrile: Solvent(s) were added to a solid mixture of 2-chlorobenzonitrile (230-305 mg, 1.7- 2.2 mmol), p-toluylboronic acid (329 mg), Pd(dba)₂ (lmg), base (1.8 - 3 equiv.) and ligand (5 - 7 mg) under argon. Toluene (3 ml) was added to the solid mixture first and H₂O (distilled, 1 ml) was added afterwards in cases where toluene and H O were used as solvents (see Table 3). The reaction mixture was heated at 85-90 °C unless indicated otherwise (Table 3). The reactions were analyzed by GC-MS.

Details are provided in Table 3. Selectivity to the desired product are > 98 % in all examples. Conversions are based on relative intensities of the starting material 2- chlorobenzonitrile and product 2-cyano-4'-methylbiphenyl signals and for the disappearance of 2-chlorobenzonitrile. It should be noted that the response factors for the product and starting material are different and the conversion numbers in Table 3 are not corrected for those differences. In Table 3, below, the following abbreviations apply: C or Cat = catalyst; Ar = 2-chlorobenzonitrile; Conv. = conversion; L3 = Ligand 3; and L5 = Ligand 5. For all examples other than example 29, the reactions were analyzed by GC-MS at the two times listed under the reaction time giving the two conversion numbers.

Table 3:

Example Cat [C]/[Ar] Base [Base]/[Ar] Solvent Reaction Conv. Ratio Ratio Time

26 Pd/L3 0.001 CsF 1.8 Toluene l h 79

2 h 50 min 100

27 Pd/L3 0.001 CsF 1.8 1 ,4-dioxane l h 79

2 h 50 min >95

28 Pd/L3 0.001 Na₂CO₃ 3 Tol/H₂O (3:l) l h 41 2 h 73 Pd/L3 0.001 K₃PO₄ 2 Tol/H₂O (3: l) l h 73 Pd/L3 0.0001 CsF 1.8 1 ,4-dioxane 0.5 h 0

13.5 h 33 Pd/L5 0.001 Na₂CO₃ 3 Tol/H₂O (3:l) l h 0

4 h 83 Pd/L5 0.001 CsF 3 1 ,4-dioxane 2 h 90

2.5 h 100

Example 33:

The following are examples for aryl-aminations, with the general procedure being presented in part A.

Part A: 5-(N-heptylmethylamino)- -xylene: A mixture of 5-chloro-m- xylene (0.14 mL, 1.04 mmol), N-heptylmethylamine (0.19 mL, 1.13 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) was heated to 105 °C for 1 hour and analyzed by GCMS. The reaction was cooled to room temperature, taken up in diethyl ether (125 mL), washed with water (30 mL) and brine (30 mL), dried over MgSO , filtered and concentrated in vacuo. The crude product was purified by column chromatography on silica gel using hexanes as the eluent to afford compound 5-(N- heptylmethylamino)-m-xylene, after drying under vacuum, as an colorless oil (yield: 230 mg, 95 %). Analogous reactions of 5-bromo-m-xylene (1 hour) and 5- iodo-m-xylene (15 minute) also afford the desired 5-(N-heptylmethylamino)-m- xylene in 93 % and 91 % isolated yields, respectively. 1H NMR (CDC1₃): • 6.33 (br. s, 3H, ArH), 3.25 (t, J = 7.6 Hz, 2H, -NCH₂-), 2.89 (s, 3H, -N-CH₃), 2.27 (s, 6H, Ar(CH₃)₂), 1.54 (br., 2H, -NCH₂CH₂-), 1.30 (br., 8Η, -(CH₂)₄CH₃), 0.89 (br. t, J = 6.6 Hz, 3H, -CH₃). ¹³C NMR (CDC1₃): • 149.6, 138.6, 117.9, 110.1, 52.8, 38.3, 31.9, 29.2, 27.1, 26.7, 22.6, 21.8, 14.1. Anal, for C₁₆H₂₇N; Calcd: C, 82.34; H, 11.66; N, 6.00; Found: C, 82.02; H, 11.92; N, 6.21.

Part B: 5-(morpholino)-m -xylene: The title compound (181 mg, 92 % yield) was obtained as a yellow oil from the reaction of 5-chloro-m-xylene (0.14 mL, 1.03 mmol), morpholine (0.10 mL, 1.04 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 1 hour. 1H NMR (CDC1₃): • 6.60 (s, 3 H, ArH), 3.88 (t, J = 4.8 Hz, 2H, -O-CH₂-), 3.17 (t, J = 4.8 Hz, 2H, -O-CH₂-), 2.34 (s, 3H, CH₃). ¹³C NMR (CDC1₃): • 151.3, 138.5, 121.8, 113.6, 66.8, 49.4, 21.5. Anal, for d₂Hι₇NO; Calcd: C, 75.35; H, 8.96; N, 7.32; Found: C, 75.48; H, 9.23; N, 7.33.

Part C: 4-(N-benzylmethylamino)benzophenone: The title compound (289 mg, 96 % yield) was obtained as a yellow oil from the reaction of 4- chlorobenzophenone (217 mg, 1.00 mmol), N-benzylmethylamine (0.14 mL, 1.08 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 1 hour. 1H NMR (CDC1₃): • 7.83 (d, J = 9.0 Hz, 2H, ArH), 7.75 (d, J = 6.8 Hz, 2H, ArH), 7.58 - 7.22 (m, 8H, ArH), 6.77 (d, J = 8.9 Hz, 2H, ArH), 4.69 (s, 2H, -N-CH₂Ph), 3.19 (s, 3H, -NCH₃). ¹³C NMR (CDC1₃): • 195.0, 152.7, 139.2, 137.5, 132.8, 131.1, 129.4, 128.8, 127.9, 127.2, 126.4, 125.3, 110.8, 56.0, 38.8.

Part D: 4-(N-phenylpiperazinyl)benzonitrile: The title compound (238 mg, 90 % yield) was obtained as a colorless cotton-like solid from the reaction of 4- chlorobenzonitrile (138 mg, 1.00 mmol), N-phenylpiperazine (0.17 mL, 1.11 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 1 hour. Isolated compound contained trace amounts of solvents. 1H NMR (CDC1₃): • 7.50 (d, J = 8.8 Hz, 2H, ArH), 7.28 (m, 3H, ArH), 6.95 (d, J = 8.3 Hz, 2H, ArH), 6.89 (d, J = 8.0 Hz, 2H, ArH), 3.48 (br., 4H, -NCH₂'s), 3.31 (br., 4H, -NCH₂'s). ¹³C NMR (CDC1₃): • 153.2, 150.7, 133.5, 129.3, 120.4, 119.9, 116.4, 114.3, 100.6, 49.0, 47.2.

Part E: 4-(dihexylamino)benzotrifluoride: The title compound (311 mg, 97 % yield) was obtained as a colorless oil from the reaction of 4- chlorobenzotrifluoride (0.13 mL, 0.97 mmol), dihexylamine (0.25 mL, 1.07 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 1 hour. 1H NMR (CDC1₃): • 7.39 (d, J = 8.8 Hz, 2H, ArH), 6.59 (d, J = 8.8 Hz, 2H, ArH), 3.27 (t, J = 7.6 Hz, 4H, -NCH₂'s), 1.55 (br., 4H, -{CH₂CH₂'s), 1.31 (br., 12H), 0.90 (t, J = 6.4 Hz, -CH₃'s). ¹³C NMR (CDC1₃): • 150.1, 126.5, 110.5, 51.0, 31.7, 27.0, 26.8, 22.7, 14.0 (due to coupling to fluorine atoms, the two carbon atoms • and • to fluorine atoms could not be conclusively identified from the baseline).

Part F: 2-(2'-2- -butylanilinophenyl)-2-methyl-l,3-dioxolane: The title compound (277 mg, 89 % yield) was obtained as a colorless crystalline solid from the reaction of 2-(2'-chlorophenyl)-2-methyl-l,3-dioxolane (198 mg, 1.00 mmol), 2-t-butylaniline (0.17 mL, 1.10 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 2 hours. *H NMR (CDC1₃): • 7.47 (br., 2H, ArH), 7.27 (br., 2H, ArH), 7.18 - 7.06 (m, 3H, ArH), 6.90 (d, J = 8.1 Hz, IH, ArH), 6.79 (t, J = 8.0 Hz, IH, ArH), 4.12 (br., 2H, -OCH₂-), 3.95 (br., 2H, -OCH₂-), 1.82 (s, 3H, CH₃), 1.47 (s, 9H, 3 CH₃'s). ¹³C NMR (CDCI₃): • 143.5, 142.9, 141.1, 128.9, 127.7, 127.1, 126.7, 126.4, 125.5, 123.2, 118.2, 115.8, 109.5, 64.1, 34.1, 30.2, 24.9.

Part G: 2-(2,4,6-trimethylanilino)-p-xylene: The title compound (222 mg, 96 % yield) was obtained as a off-white solid from the reaction of 2-chloro-p- xylene (0.13 mL, 0.97 mmol), 2,4,6-trimethylaniline (0.14 mL, 0.99 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 1 hour. *H NMR (CDC1₃): • 7.02 (d, J = 7.4 Hz, IH, ArH), 6.97 (s, 2H, ArH), 6.52 (d, J = 7.4 Hz, IH, ArH), 5.98 (s, IH, ArH), 4.84 (br., IH, -NH), 2.34 (s, 3H, -CH₃), 2.29 (s, 3H, -CH₃), 2.17 (br. s, 9H, 3 CH₃'s). ¹³C NMR (CDC1₃): • 144.2, 136.6, 136.0, 135.5, 134.9, 130.0, 129.2, 119.1, 118.4, 112.1, 21.3, 20.9, 18.2, 17.2.

Part H: 2-(octylamino)-/;-xylene: The title compound (209 mg, 92 % yield) was obtained as a yellow oil from the reaction of 2-chloro-p-xylene (0.13 mL, 0.97 mmol), octylamine (0.18 mL, 1.08 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 3 hours. 1H NMR (CDC1₃): • 6.97 (d, J = 7.3 Hz, IH, ArH), 6.50 (d, J = 7.3 Hz, IH, ArH), 6.48 (s, IH, ArH), 3.44 (br., IH, -NH), 3.18 (t, J = 7.2 Hz, 2H, -NCH₂-), 2.35 (s, H, ArCH₃), 2.13 (s, 3H, ArCH₃), 1.69 (m, 2H, -NCH₂CH₂-), 0.94 (br., 3Η, CH₃). ¹³C NMR (CDC1₃): • 146.0, 136.6, 129.8, 118.6, 117.2, 110.5, 43.9, 31.8, 29.6, 29.4, 29.3, 27.2, 22.6, 21.5, 16.9, 14.1.

Part I: 2-(octylamino)anisole: The title compound (183 mg, 83 % yield) was obtained as a yellow oil from the reaction of 2-chloro-anisole (0.12 mL, 0.94 mmol), octylamine (0.19 mL, 1.14 mmol), NaO'Bu (125 mg, 1.30 mmol), Pd(dba)₂ (12 mg, 0.02 mmol), ligand 1 (22 mg, 0.06 mmol) in toluene (4 mL) at 105 °C for 3 hours. 1H NMR (CDC1₃): • 6.92 (t, J = 7.6 Hz, IH, ArH), 6.81 (d, J = 7.6 Hz, IH, ArH), 6.71 (d, J = 7.6 Hz, IH, ArH), 6.67 (t, J = 7.6 Hz, IH, ArH), 4.22 (br., 1H,- NH), 3.86 (s, 3H, -OCH₃), 3.16 (t, J = 7.2 Hz, 2H, -NCH₂-), 1.69 (pentet, 2H, - NCH₂CH₂CH_2-), 1.35 (br., 10H, 5 -CH₂-'s), 0.95 (br., 3H, CH₃). ¹³C NMR (CDC1₃): • 146.7, 138.5, 121.3, 115.9, 109.7, 109.3, 55.3, 43.7, 31.8, 29.5, 29.4, 29.2, 27.2, 22.6, 14.0.

It is to be understood that the above description is intended to be illustrative and not restrictive. Many embodiments will be apparent to those of skill in the art upon reading the above description. The scope of the invention should, therefore, be determined not with reference to the above description, but should instead be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled. The disclosures of all articles and references, including patent applications and publications, are incorporated herein by reference for all purposes.

Claims

What is claimed is:

1. A ligand characterized by one of the general formulas:

i π

1 9 wherein each R and R is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl and substituted cycloalkyl; each R³, R⁴ and R⁵ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and optionally, R³ and R⁴ are joined together in a ring structure; each

is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, water solubilizing groups, transition metals and combinations thereof; b is 0, 1, 2, 3 or 4; c is 0, 1, 2 or 3; and optionally two or more R⁶ or R⁷ groups are joined together in a ring structure.

2. The ligand of claim 1, wherein each R¹ and R² is independently selected from the group consisting of alkyl, substituted alkyl and cycloalkyl.

3. The ligand of claim 2, wherein each R¹ and R² is cyclohexyl.

4. The ligand of claim 1, wherein each R³ and R⁴ is independently selected from the group alkyl, substituted alkyl, cycloalkyl and substituted cycloalkyl.

5. The ligand of claim 1, wherein each of R and R is methyl.

6. The ligand of claim 1 , wherein R³ and R⁴ are joined together in a ring structure with both oxygen atoms and the carbon atom in the backbone of the ligand so that there are between 5 and 20 atoms in said ring.

7. The ligand of claim 6, wherein there are five atoms in said ring and each of R³ and R⁴ is a methylene.

8. A ligand characterized by one of the general formulas:

wherein each R¹ and R² is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl and substituted cycloalkyl; R⁵ is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and optionally, R³ and R⁴ are joined together in a ring structure; each R⁶ and R⁷ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, water solubilizing groups, transition metals and combinations thereof; b is 0, 1, 2, 3 or 4; c is 0, 1, 2 or 3; and optionally two or more R or R groups are joined together in a ring structure.

9. The ligand of claim 8, wherein each R¹ and R² is independently selected from the group consisting of alkyl, substituted alkyl and cycloalkyl.

10. The ligand of claim 9, wherein each R¹ and R² is cyclohexyl.

11. The ligand of claim 9, wherein R⁵ is selected from the group hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl and substituted aryl.

12. The ligand of claim 11, wherein R⁵ is hydrogen.

13. The ligand of claim 11, wherein R⁵ is aryl or substituted aryl.

14. The ligand of claim 13, wherein R⁵ is phenyl.

15. A composition of matter comprising the ligand of claim 1 and a metal precursor characterized by the general formula M(L)_n, where M is a transition metal selected from the group consisting of Pd, Ni, Fe, Co, Ru, Ir and Pt; L is independently each occurrence, a ligand; and n is a number 0, 1, 2, 3, 4, and 5.

16. A composition of matter comprising the ligand of claim 9 and a metal precursor characterized by the general formula M(L)_n, where M is a transition metal selected from the group consisting of Pd, Ni, Fe, Co, Ru, Ir and Pt; L is independently each occurrence, a ligand; and n is a number 0, 1, 2, 3, 4, and 5.

17. A transition metal-catalyzed reaction employing the compound in claim

1.

18. The reaction of claim 17, wherein the reaction involves C-H, C-C, C-N, C-O, C-S, C-P, C-B and C-Si bond formation.

19. The reaction of claim 18, wherein the reaction is a Suzuki cross- coupling reaction or an aryl-amination reaction.

20. A transition metal-catalyzed reaction employing the compound in claim

8.

21. The reaction of claim 20, wherein the reaction involves C-H, C-C, C-N,

C-O, C-S, C-P, C-B and C-Si bond formation.

22. The reaction of claim 21, wherein the reaction is a Suzuki cross- coupling reaction or an aryl amination reaction.

23. A process for preparing polycyclic aromatic compounds by cross- coupling of a first aromatic compound with a second aromatic compounds in the presence of a base, a solvent, a metal precursor and a ligand that is characterized by any of the following formulas:

π

m IN wherein each R¹ and R² is independently selected from the group consisting of alkyl, substituted alkyl, cycloalkyl and substituted cycloalkyl; each R³, R⁴ and R⁵ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and optionally, R³ and R⁴ are joined together in a ring structure;

( 7 each R and R is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, water solubilizing groups, transition metals and combinations thereof; b is 0, 1, 2, 3 or 4; c is 0, 1, 2 or 3; and optionally two or more R⁶ or R⁷ groups are joined together in a ring structure.

24. The process of claim 23, wherein each R¹ and R² is independently selected from the group consisting of alkyl, substituted alkyl and cycloalkyl.

25. The process of claim 24, wherein each R¹ and R² is cyclohexyl.

26. The process of claim 23, wherein said base is selected from the group consisting of alkali metal and alkaline earth metal hydroxides, alkali metal and alkaline earth metal carbonates, alkali metal hydrogen carbonates, alkali metal and alkaline earth metal acetates, alkali metal and alkaline earth metal alkoxides, alkali metal and alkaline earth metal phosphates, alkali metal and alkaline earth fluorides, ammonium fluorides and primary, secondary and tertiary amines.

27. The process of claim 23, wherein said solvent is selected from the group consisting of ethers, hydrocarbons, alcohols, ketones, amides, nitriles, water and mixtures thereof.

28. The process of claim 23, wherein said first aromatic compound is a compound that is characterized by either of the general formulas:

xm xrv

where R is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; a is 0, 1, 2, 3, 4 or 5 and optionally two or more R⁸ groups are joined together in a ring structure; X' is selected from the group consisting of BR¹⁰ ₂, B(OR¹⁰)₂, MgQ¹, ZnQ¹, CuQ¹, SiR¹⁰ ₃ SnR¹⁰ ₃ or Li, wherein each R¹⁰ is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and Q¹ is selected from the group consisting of Cl, Br, I or F.

29. The process of claim 23, wherein said second aromatic compound is selected from the group consisting of compounds that are characterized by the general formula:

where X is Br, Cl, F, I, tosylates, triflates, or N₂ ⁺ and each R⁹ is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, silyl, boryl, phosphino, amino, thio, seleno, and combinations thereof; and a is 0, 1, 2, 3, 4 or 5; and optionally two or more R⁹ groups are joined together in a ring structure.

30. The process of claim 23, wherein the aromatic boronic compound is p- tolueneboronic acid and the aromatic halogen compound is o-chlorobenzonitrile.