WO2000001798A3 - Tip design and random access array for microfluidic transfer - Google Patents

Tip design and random access array for microfluidic transfer Download PDF

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Publication number
WO2000001798A3
WO2000001798A3 PCT/US1999/015214 US9915214W WO0001798A3 WO 2000001798 A3 WO2000001798 A3 WO 2000001798A3 US 9915214 W US9915214 W US 9915214W WO 0001798 A3 WO0001798 A3 WO 0001798A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
tip
target
print head
transfer
Prior art date
Application number
PCT/US1999/015214
Other languages
French (fr)
Other versions
WO2000001798A2 (en
Inventor
Don Rose
Thomas C Tisone
Original Assignee
Cartesian Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cartesian Technologies Inc filed Critical Cartesian Technologies Inc
Priority to AU48610/99A priority Critical patent/AU4861099A/en
Priority to EP99932267A priority patent/EP1129008A4/en
Publication of WO2000001798A2 publication Critical patent/WO2000001798A2/en
Publication of WO2000001798A3 publication Critical patent/WO2000001798A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezo-electric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks

Abstract

The present invention relates to a ceramic tip (200) and a random access print head (230) for the transfer of microfluidic quantities of fluid. The print head (230) can randomly collect and deposit fluid samples to transfer the samples from a source plate (29) to a target (30). The print head (230) can also be programmed to create a direct map of the fluid samples from the source plate (29) on the target (30) or to create any desired pattern or print on the target (30). The tip (200) and print head (230) can be used for a wide variety of applications such as DNA microarraying and compound reformatting. In one preferred embodiment, the tip (200) is used as a capillary or 'gravity' pin to draw or collect source fluid and 'spot' or deposit the fluid onto the target (30) via physical contact (touch-off). In another preferred embodiment, the tip (200) is used in conjunction with an aspirate-dispense system (10) to actively aspirate source fluid and deposit the fluid via a contact or non-contact approach. The tip (200) provides improved, accurate and repeatable microfluidic transfer.
PCT/US1999/015214 1998-07-07 1999-07-07 Tip design and random access array for microfluidic transfer WO2000001798A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU48610/99A AU4861099A (en) 1998-07-07 1999-07-07 Tip design and random access array for microfluidic transfer
EP99932267A EP1129008A4 (en) 1998-07-07 1999-07-07 Tip design and random access array for microfluidic transfer

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US9192898P 1998-07-07 1998-07-07
US60/091,928 1998-07-07
US10671998P 1998-11-02 1998-11-02
US60/106,719 1998-11-02
US11306298P 1998-12-21 1998-12-21
US60/113,062 1998-12-21
US13846499P 1999-06-10 1999-06-10
US60/138,464 1999-06-10
US13902499P 1999-06-14 1999-06-14
US60/139,024 1999-06-14

Publications (2)

Publication Number Publication Date
WO2000001798A2 WO2000001798A2 (en) 2000-01-13
WO2000001798A3 true WO2000001798A3 (en) 2000-02-17

Family

ID=27536617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015214 WO2000001798A2 (en) 1998-07-07 1999-07-07 Tip design and random access array for microfluidic transfer

Country Status (4)

Country Link
EP (1) EP1129008A4 (en)
CN (1) CN1315913A (en)
AU (1) AU4861099A (en)
WO (1) WO2000001798A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906618B2 (en) 2000-02-18 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9428800B2 (en) 2002-12-20 2016-08-30 Life Technologies Corporation Thermal cycling apparatus and method

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000157272A (en) * 1998-12-01 2000-06-13 Hitachi Software Eng Co Ltd Biochip and its production
WO2000056456A1 (en) 1999-03-19 2000-09-28 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
US6589791B1 (en) 1999-05-20 2003-07-08 Cartesian Technologies, Inc. State-variable control system
GB9916406D0 (en) * 1999-07-13 1999-09-15 Biorobotics Ltd Liquid transfer pin
DE19946525A1 (en) * 1999-09-28 2001-05-03 Fraunhofer Ges Forschung Device for taking up and dispensing the smallest amounts of liquid
CA2399189A1 (en) * 2000-02-22 2001-08-30 Genospectra, Inc. Microarray fabrication techniques and apparatus
CN1404415A (en) * 2000-02-22 2003-03-19 基因谱公司 Microarray fabrication techniques and apparatus
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US6756232B1 (en) * 2000-03-20 2004-06-29 Perkinelmer Las, Inc. Method and apparatus for producing compact microarrays
US6878554B1 (en) * 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
DE10017105A1 (en) * 2000-04-06 2001-10-11 Basf Ag Method and device for producing biopolymer fields
US6943035B1 (en) * 2000-05-19 2005-09-13 Genetix Limited Liquid dispensing apparatus and method
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
EP1333926B1 (en) * 2000-11-17 2004-09-22 Tecan Trading AG Device and system for dispensing or aspirating/dispensing liquid samples
US6613284B2 (en) * 2001-02-01 2003-09-02 V&P Scientific, Inc. Microarrayer
AU2002242148A1 (en) * 2001-02-06 2002-08-19 Parallel Synthesis Technologies Microfabricated spotting apparatus for producing low cost microarrays
CH694754A5 (en) * 2001-03-15 2005-07-15 Tecan Trading Ag Pipette tip, to pipette and dispense fluid samples especially at micro titration plates, is capillary wholly or partially of ceramic material with coating if required
CN1385518A (en) * 2001-04-23 2002-12-18 株式会社百尼尔 Microarrayer for microarrangement for biological test material and microarray pin used in same
US6558907B2 (en) 2001-05-16 2003-05-06 Corning Incorporated Methods and compositions for arraying nucleic acids onto a solid support
US6752182B2 (en) * 2001-06-28 2004-06-22 Genetix Limited Microarraying apparatus, pin head therefor and spotting method
JP2003043041A (en) * 2001-08-01 2003-02-13 Canon Inc Liquid discharge device and apparatus for manufacturing sample carrier
WO2003013718A1 (en) * 2001-08-10 2003-02-20 Oxford Glycosciences (Uk) Ltd Liquid delivery apparatus and method
EP1658894A1 (en) 2002-02-22 2006-05-24 Biodot, Inc. Apparatus for dispersing reagent droplets below a fluid surface using non-contact dispensing
AU2003218727A1 (en) * 2002-03-11 2003-09-22 Axaron Bioscience Ag Method for applying a substance to a substrate
JP2003329680A (en) * 2002-05-10 2003-11-19 Hitachi Software Eng Co Ltd Spot pin, spotting device, and method of spotting biological molecule
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
DE10255595A1 (en) 2002-11-26 2004-06-03 Cybio Ag Multi-channel dosing device with automatic calibration
EP1594951A2 (en) * 2003-01-31 2005-11-16 Apogent Robotics Limited Liquid transfer system
DE10316580A1 (en) * 2003-04-10 2004-11-04 Infineon Technologies Ag Device for the damage-free application of bio-molecules in solution on sensitive substrates
US7488604B2 (en) * 2003-07-11 2009-02-10 Genomic Solutions Inc. Apparatus and methods for liquid sample handling based on capillary action
AU2005222618A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
US7690325B2 (en) 2004-04-30 2010-04-06 Bioforce Nanosciences, Inc. Method and apparatus for depositing material onto a surface
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
WO2008034914A2 (en) 2006-09-22 2008-03-27 Clondiag Gmbh A dispenser device for and a method of dispensing a substance onto a substrate
JP5632316B2 (en) * 2011-03-18 2014-11-26 株式会社日立ハイテクノロジーズ Mass spectrometer and ion source used therefor
CN104759373B (en) * 2012-04-25 2017-08-01 艾博生物医药(杭州)有限公司 A kind of fluid distribution equipment
CN103657548A (en) * 2012-08-31 2014-03-26 艾博生物医药(杭州)有限公司 Method and equipment for automatically adding liquid reagent
US11148164B2 (en) 2014-07-25 2021-10-19 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
CN106604777A (en) * 2014-09-23 2017-04-26 基因细胞生物系统有限公司 Pressure based dispensing
DE102016211496A1 (en) * 2016-06-27 2017-12-28 Robert Bosch Gmbh Dispensing needle and system with such a dispensing needle
EP3502650B1 (en) * 2017-12-22 2023-07-19 Universiteit Maastricht Method of and apparatus for applying liquid to a substrate
TWI816777B (en) * 2018-04-16 2023-10-01 大陸商南京金斯瑞生物科技有限公司 System for extracting biomolecules from a sample and related methods
EP3599021B1 (en) * 2018-07-23 2021-04-21 Scienion AG Apparatus and method for isolating single particles from a particle suspension
US20210311081A1 (en) * 2018-11-02 2021-10-07 Hewlett-Packard Development Company, L.P. Randomized dispensing order
KR20210119455A (en) * 2019-02-01 2021-10-05 엑스티피엘 에스.에이. fluid printing device
DE112019006815T5 (en) * 2019-02-01 2021-10-21 Xtpl S.A. Method of printing a fluid
US20220305494A1 (en) * 2019-08-30 2022-09-29 Beijing Dawei Biotech Ltd. Sample adding needle for preparing microdroplets and microdroplet preparation method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164304A (en) * 1961-05-08 1965-01-05 Standard Thomson Corp Liquid dispensing apparatus for small quantities
US4944922A (en) * 1986-07-04 1990-07-31 Tosoh Corporation Quantitative dispenser for a liquid
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR52270E (en) * 1942-06-04 1943-12-01 Improvements in droppers, bottles, eye drops, pipettes, etc.
GB8612261D0 (en) * 1986-05-20 1986-06-25 Boots Celltech Diagnostics Fluid dispensing apparatus
GB2310006B (en) * 1995-12-01 2000-01-12 Genetix Ltd Pneumatic actuator
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164304A (en) * 1961-05-08 1965-01-05 Standard Thomson Corp Liquid dispensing apparatus for small quantities
US4944922A (en) * 1986-07-04 1990-07-31 Tosoh Corporation Quantitative dispenser for a liquid
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1129008A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906618B2 (en) 2000-02-18 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9518299B2 (en) 2000-02-18 2016-12-13 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9428800B2 (en) 2002-12-20 2016-08-30 Life Technologies Corporation Thermal cycling apparatus and method

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EP1129008A2 (en) 2001-09-05
WO2000001798A2 (en) 2000-01-13
EP1129008A4 (en) 2001-12-05
CN1315913A (en) 2001-10-03
AU4861099A (en) 2000-01-24

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