WO1999065513A3 - Pharmaceutical compositions for the treatment of helicobacter pylori-associated disorders - Google Patents

Pharmaceutical compositions for the treatment of helicobacter pylori-associated disorders Download PDF

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Publication number
WO1999065513A3
WO1999065513A3 PCT/IL1999/000335 IL9900335W WO9965513A3 WO 1999065513 A3 WO1999065513 A3 WO 1999065513A3 IL 9900335 W IL9900335 W IL 9900335W WO 9965513 A3 WO9965513 A3 WO 9965513A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
pylori
associated disorders
helicobacter pylori
treatment
Prior art date
Application number
PCT/IL1999/000335
Other languages
French (fr)
Other versions
WO1999065513A2 (en
Inventor
Michal Y Chowers
Yehuda Chowers
Original Assignee
Michal Y Chowers
Yehuda Chowers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michal Y Chowers, Yehuda Chowers filed Critical Michal Y Chowers
Priority to EP99926719A priority Critical patent/EP1087783B1/en
Priority to CA002331834A priority patent/CA2331834A1/en
Priority to AU43882/99A priority patent/AU768612B2/en
Priority to JP2000554391A priority patent/JP2003522105A/en
Priority to DE69916273T priority patent/DE69916273T2/en
Priority to AT99926719T priority patent/ATE263572T1/en
Publication of WO1999065513A2 publication Critical patent/WO1999065513A2/en
Publication of WO1999065513A3 publication Critical patent/WO1999065513A3/en
Priority to US09/738,948 priority patent/US6815414B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2207—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
    • A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to pharmaceutical compositions and methods for treating and/or preventing Helicobacter pylori-associated disorders, particularly disorders of the gastrointestinal tract. The pharmaceutical compositions comprise as active ingredient a therapeutically effective amount of a compound which inhibits the growth-enhancing effect of gastrin on H. pylori. The active ingredient may specifically be a compound which is capable of inhibiting gastrin uptake by H. pylori, and/or which is an antagonist of the human or H. pylori gastrin receptor.
PCT/IL1999/000335 1998-06-18 1999-06-17 Pharmaceutical compositions for the treatment of helicobacter pylori-associated disorders WO1999065513A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP99926719A EP1087783B1 (en) 1998-06-18 1999-06-17 Use of gastrin fragments or synthetic analogs of gastrin for the manufacture of a medicament for the treatment of helicobacter pylori-associated disorders
CA002331834A CA2331834A1 (en) 1998-06-18 1999-06-17 Pharmaceutical compositions for the treatment of helicobacter pylori-associated disorders
AU43882/99A AU768612B2 (en) 1998-06-18 1999-06-17 Pharmaceutical compositions for the treatment of (helicobacter pylori)-associated disorders
JP2000554391A JP2003522105A (en) 1998-06-18 1999-06-17 Pharmaceutical composition for treating Helicobacter pylori-related diseases
DE69916273T DE69916273T2 (en) 1998-06-18 1999-06-17 USE OF GASTRIN FRAGMENTS OR SYNTHETIC ANALOGS OF GASTRIN FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING HELICOBACTER PYLORI-ASSOCIATED DISORDER
AT99926719T ATE263572T1 (en) 1998-06-18 1999-06-17 USE OF GASTRIN FRAGMENTS OR SYTHETICAL ANALOGUES OF GASTRIN FOR THE PRODUCTION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF HELICOBACTER PYLORI ASSOCIATED DISORDERS
US09/738,948 US6815414B2 (en) 1998-06-18 2000-12-15 Pharmaceutical compositions for the treatment of helicobacter pylori-associated disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8977098P 1998-06-18 1998-06-18
US60/089,770 1998-06-18
US14719599P 1999-05-20 1999-05-20
US60/147,195 1999-05-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/738,948 Continuation US6815414B2 (en) 1998-06-18 2000-12-15 Pharmaceutical compositions for the treatment of helicobacter pylori-associated disorders

Publications (2)

Publication Number Publication Date
WO1999065513A2 WO1999065513A2 (en) 1999-12-23
WO1999065513A3 true WO1999065513A3 (en) 2000-03-02

Family

ID=26780929

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000335 WO1999065513A2 (en) 1998-06-18 1999-06-17 Pharmaceutical compositions for the treatment of helicobacter pylori-associated disorders

Country Status (8)

Country Link
US (1) US6815414B2 (en)
EP (1) EP1087783B1 (en)
JP (1) JP2003522105A (en)
AT (1) ATE263572T1 (en)
AU (1) AU768612B2 (en)
CA (1) CA2331834A1 (en)
DE (1) DE69916273T2 (en)
WO (1) WO1999065513A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040001842A1 (en) * 1997-05-12 2004-01-01 Dov Michaeli Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
CA2328501A1 (en) * 1998-05-15 1999-11-25 Aphton Corporation Prevention and treatment of hypergastrinemia
EP1229925A2 (en) * 1999-11-19 2002-08-14 Axxima Pharmaceuticals Aktiengesellschaft Inhibitors of helicobacter pylori induced gastrointestinal diseases
US6849409B2 (en) 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
AU2002252456A1 (en) 2001-03-23 2002-10-08 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
US20030021786A1 (en) * 2001-07-09 2003-01-30 Gevas Philip C. Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
US6810583B2 (en) * 2001-08-07 2004-11-02 International Business Machines Corporation Coupling of conductive vias to complex power-signal substructures
IL152289A0 (en) * 2002-10-14 2003-05-29 Vectabiotics Ltd Method and composition for inhibiting h.pylori infection in a mammalian tissue
US7235376B2 (en) * 2003-03-28 2007-06-26 Receptor Biologix, Inc. Gastrin hormone immunoassays
EP1794586B1 (en) * 2004-09-22 2013-01-30 Cancer Advances, Inc., Monoclonal antibodies to progastrin
US20060121031A1 (en) * 2004-12-07 2006-06-08 Mckenzie Brent S Relay vaccine
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
JP5474541B2 (en) 2006-07-25 2014-04-16 ベクタ・リミテッド Compositions and methods for inhibiting gastric acid secretion using PPI in combination with small dicarboxylic acid derivatives
WO2012174102A2 (en) 2011-06-14 2012-12-20 Medical Defense Technologies, Llc. Methods and apparatus for guiding medical care based on detected gastric function
US9700514B1 (en) 2014-08-20 2017-07-11 Darren Rubin Single solid oral dosage forms for treating Helicobacter pylori infection and duodenal ulcer disease
WO2018232230A1 (en) 2017-06-15 2018-12-20 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
US11263510B2 (en) * 2020-07-15 2022-03-01 GM Global Technology Operations LLC Method for performing measurements of dendritic structures for all magnifications and camera resolutions of microscopes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09183764A (en) * 1995-12-28 1997-07-15 Roussel Morishita Kk N-benzoylproline ester derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1204430B (en) * 1986-01-10 1989-03-01 Alfio Bertolini PHARMACEUTICAL COMPOSITIONS INCLUDING PEPTIDES OF THE COLECISTOKININA-CERULINA GROUP FOR THE THERAPEUTIC TREATMENT OF SHOCK STATES AND RESPIRATORY AND CARDIOCIRCULATORY INSUFFICIENCY
DK0380230T3 (en) * 1989-01-24 1995-01-16 Aphton Corp Immunogenic compositions against gastrin peptides
US4997950A (en) * 1989-04-20 1991-03-05 Richard Finbar Murphy Novel C-terminal gastrin antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09183764A (en) * 1995-12-28 1997-07-15 Roussel Morishita Kk N-benzoylproline ester derivative

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199738, Derwent World Patents Index; Class B03, AN 1997-410809, XP002126333 *
K. YAMASHITA ET AL.: "INHIBITORY EFFECT OF SOMATOSTATIN ON HELICOBACTER PYLORI PROLIFERATION IN VITRO.", GASTROENTEROLOGY, vol. 115, no. 5, November 1998 (1998-11-01), NEW YORK, US, pages 1123 - 1130, XP000857858 *

Also Published As

Publication number Publication date
US20010020005A1 (en) 2001-09-06
AU768612B2 (en) 2003-12-18
WO1999065513A2 (en) 1999-12-23
US6815414B2 (en) 2004-11-09
JP2003522105A (en) 2003-07-22
AU4388299A (en) 2000-01-05
CA2331834A1 (en) 1999-12-23
EP1087783B1 (en) 2004-04-07
DE69916273D1 (en) 2004-05-13
DE69916273T2 (en) 2005-05-19
ATE263572T1 (en) 2004-04-15
EP1087783A2 (en) 2001-04-04

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