WO1999062510A3 - Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases - Google Patents

Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases Download PDF

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Publication number
WO1999062510A3
WO1999062510A3 PCT/CA1999/000464 CA9900464W WO9962510A3 WO 1999062510 A3 WO1999062510 A3 WO 1999062510A3 CA 9900464 W CA9900464 W CA 9900464W WO 9962510 A3 WO9962510 A3 WO 9962510A3
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WO
WIPO (PCT)
Prior art keywords
compositions
treating
inflammatory diseases
preventing inflammatory
microtubule agents
Prior art date
Application number
PCT/CA1999/000464
Other languages
French (fr)
Other versions
WO1999062510A2 (en
Inventor
William L Hunter
Original Assignee
Angiotech Pharm Inc
William L Hunter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiotech Pharm Inc, William L Hunter filed Critical Angiotech Pharm Inc
Priority to AU40255/99A priority Critical patent/AU4025599A/en
Publication of WO1999062510A2 publication Critical patent/WO1999062510A2/en
Publication of WO1999062510A3 publication Critical patent/WO1999062510A3/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Methods and compositions for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis are provided, comprising the step of delivering to the site of inflammation an anti-microtubule agent, or analogue or derivative thereof.
PCT/CA1999/000464 1998-06-01 1999-06-01 Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases WO1999062510A2 (en)

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US09/088,546 1998-06-01
US09/088,546 US6495579B1 (en) 1996-12-02 1998-06-01 Method for treating multiple sclerosis

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