WO1999055386A3 - Stimulus sensitive gel with radioisotope and methods of making - Google Patents

Stimulus sensitive gel with radioisotope and methods of making Download PDF

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Publication number
WO1999055386A3
WO1999055386A3 PCT/US1999/007662 US9907662W WO9955386A3 WO 1999055386 A3 WO1999055386 A3 WO 1999055386A3 US 9907662 W US9907662 W US 9907662W WO 9955386 A3 WO9955386 A3 WO 9955386A3
Authority
WO
WIPO (PCT)
Prior art keywords
stimulus
gelling
copolymer
sensitive
radioisotope
Prior art date
Application number
PCT/US1999/007662
Other languages
French (fr)
Other versions
WO1999055386A2 (en
Inventor
Richard E Weller
Michael A Lind
Darrell R Fisher
Anna Gutowska
Allison A Campbell
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Priority to AT99938691T priority Critical patent/ATE297224T1/en
Priority to NZ507174A priority patent/NZ507174A/en
Priority to CA002327325A priority patent/CA2327325C/en
Priority to AU53118/99A priority patent/AU752477B2/en
Priority to DE69925722T priority patent/DE69925722T2/en
Priority to JP2000545582A priority patent/JP2002512987A/en
Priority to EP99938691A priority patent/EP1069919B1/en
Publication of WO1999055386A2 publication Critical patent/WO1999055386A2/en
Publication of WO1999055386A3 publication Critical patent/WO1999055386A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213—Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of a [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.
PCT/US1999/007662 1998-04-10 1999-04-06 Stimulus sensitive gel with radioisotope and methods of making WO1999055386A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT99938691T ATE297224T1 (en) 1998-04-10 1999-04-06 STIMULI-RESPONSIVE GEL CONTAINING A RADIOISOTOPE AND METHOD FOR PRODUCING
NZ507174A NZ507174A (en) 1998-04-10 1999-04-06 Stimulus sensitive polymer gel with radioisotape and methods of making
CA002327325A CA2327325C (en) 1998-04-10 1999-04-06 Stimulus sensitive gel with radioisotope and methods of making
AU53118/99A AU752477B2 (en) 1998-04-10 1999-04-06 Stimulus sensitive gel with radioisotope and methods of making
DE69925722T DE69925722T2 (en) 1998-04-10 1999-04-06 STIMULY-RESPONSIBLE GEL CONTAINING A RADIO ISOTOP AND METHOD OF MANUFACTURING THEREOF
JP2000545582A JP2002512987A (en) 1998-04-10 1999-04-06 Stimuli-sensitive gel containing radioisotope and method for producing the same
EP99938691A EP1069919B1 (en) 1998-04-10 1999-04-06 Stimulus sensitive gel comprising a radioisotope and methods of making such gel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/058,712 1998-04-10
US09/058,712 US6296831B1 (en) 1998-04-10 1998-04-10 Stimulus sensitive gel with radioisotope and methods of making

Publications (2)

Publication Number Publication Date
WO1999055386A2 WO1999055386A2 (en) 1999-11-04
WO1999055386A3 true WO1999055386A3 (en) 2000-06-29

Family

ID=22018452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/007662 WO1999055386A2 (en) 1998-04-10 1999-04-06 Stimulus sensitive gel with radioisotope and methods of making

Country Status (9)

Country Link
US (2) US6296831B1 (en)
EP (1) EP1069919B1 (en)
JP (1) JP2002512987A (en)
AT (1) ATE297224T1 (en)
AU (1) AU752477B2 (en)
CA (1) CA2327325C (en)
DE (1) DE69925722T2 (en)
NZ (1) NZ507174A (en)
WO (1) WO1999055386A2 (en)

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Also Published As

Publication number Publication date
AU752477B2 (en) 2002-09-19
DE69925722D1 (en) 2005-07-14
AU5311899A (en) 1999-11-16
US6296831B1 (en) 2001-10-02
WO1999055386A2 (en) 1999-11-04
DE69925722T2 (en) 2005-12-15
EP1069919A2 (en) 2001-01-24
EP1069919B1 (en) 2005-06-08
CA2327325C (en) 2006-01-24
US20010024636A1 (en) 2001-09-27
US6869588B2 (en) 2005-03-22
NZ507174A (en) 2003-11-28
ATE297224T1 (en) 2005-06-15
JP2002512987A (en) 2002-05-08
CA2327325A1 (en) 1999-11-04

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