WO1999055324A1 - Ccr-3 receptor antagonists - Google Patents
Ccr-3 receptor antagonists Download PDFInfo
- Publication number
- WO1999055324A1 WO1999055324A1 PCT/US1999/009182 US9909182W WO9955324A1 WO 1999055324 A1 WO1999055324 A1 WO 1999055324A1 US 9909182 W US9909182 W US 9909182W WO 9955324 A1 WO9955324 A1 WO 9955324A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- propionate
- ethyl
- hydroxyphenyl
- sulfonylamino
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000545523A JP2002512957A (en) | 1998-04-27 | 1999-04-27 | CCR-3 receptor antagonist |
EP99920102A EP1076557A1 (en) | 1998-04-27 | 1999-04-27 | Ccr-3 receptor antagonists |
CA002329777A CA2329777A1 (en) | 1998-04-27 | 1999-04-27 | Ccr-3 receptor antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8322898P | 1998-04-27 | 1998-04-27 | |
US60/083,228 | 1998-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999055324A1 true WO1999055324A1 (en) | 1999-11-04 |
Family
ID=22177004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/009182 WO1999055324A1 (en) | 1998-04-27 | 1999-04-27 | Ccr-3 receptor antagonists |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1076557A1 (en) |
JP (1) | JP2002512957A (en) |
CA (1) | CA2329777A1 (en) |
WO (1) | WO1999055324A1 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000041685A1 (en) * | 1999-01-19 | 2000-07-20 | Smithkline Beecham Corporation | Ccr-3 receptor antagonists |
WO2003022277A1 (en) * | 2001-09-07 | 2003-03-20 | Bayer Healthcare Ag | Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders |
WO2003074478A1 (en) * | 2002-03-05 | 2003-09-12 | Sumitomo Chemical Company, Limited | Process for the preparation of biaryl compounds |
WO2004085384A2 (en) * | 2002-11-18 | 2004-10-07 | Chemocentryx | Bis-aryl sulfonamides |
WO2006028284A1 (en) | 2004-09-08 | 2006-03-16 | Mitsubishi Pharma Corporation | Morpholine compound |
US7101882B2 (en) | 2000-09-29 | 2006-09-05 | Glaxo Group Limited | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
US7115635B2 (en) | 2001-04-27 | 2006-10-03 | Mitsubishi Pharma Corporation | Benzylpiperidine compound |
WO2006129679A1 (en) | 2005-05-31 | 2006-12-07 | Ono Pharmaceutical Co., Ltd. | Spiropiperidine compound and medicinal use thereof |
WO2007049771A1 (en) | 2005-10-28 | 2007-05-03 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
WO2007058322A1 (en) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | Basic group-containing compound and use thereof |
US7227035B2 (en) | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
WO2007105637A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
WO2007132846A1 (en) | 2006-05-16 | 2007-11-22 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
WO2008016006A1 (en) | 2006-07-31 | 2008-02-07 | Ono Pharmaceutical Co., Ltd. | Compound having cyclic group bound thereto through spiro binding and use thereof |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
US7482363B2 (en) | 2002-03-19 | 2009-01-27 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
US7495013B2 (en) | 2003-04-01 | 2009-02-24 | Astrazeneca Ab | Chemical compounds |
US7674797B2 (en) | 2003-03-24 | 2010-03-09 | Axikin Pharmaceuticals, Inc. | 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders |
US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US7999109B2 (en) | 2002-05-24 | 2011-08-16 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
EP2364982A1 (en) | 2003-04-18 | 2011-09-14 | ONO Pharmaceutical Co., Ltd. | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof |
EP2385040A1 (en) | 2003-03-14 | 2011-11-09 | ONO Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
US8314127B2 (en) | 2005-07-21 | 2012-11-20 | Astrazeneca Ab | Piperidine derivatives |
EP2546234A1 (en) | 2004-09-13 | 2013-01-16 | Ono Pharmaceutical Co., Ltd. | Nitrogeneous heterocyclic derivative and medicine containing the same as an active ingredient |
US8741894B2 (en) | 2010-03-17 | 2014-06-03 | Axikin Pharmaceuticals, Inc. | Arylsulfonamide CCR3 antagonists |
US10117931B2 (en) | 2009-04-28 | 2018-11-06 | Kameran Lashkari | Methods for treatment of age-related macular degeneration |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09255572A (en) * | 1996-03-26 | 1997-09-30 | Takeda Chem Ind Ltd | Medicine for antagonizing chemokine receptor |
-
1999
- 1999-04-27 CA CA002329777A patent/CA2329777A1/en not_active Abandoned
- 1999-04-27 WO PCT/US1999/009182 patent/WO1999055324A1/en not_active Application Discontinuation
- 1999-04-27 JP JP2000545523A patent/JP2002512957A/en not_active Withdrawn
- 1999-04-27 EP EP99920102A patent/EP1076557A1/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09255572A (en) * | 1996-03-26 | 1997-09-30 | Takeda Chem Ind Ltd | Medicine for antagonizing chemokine receptor |
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS, vol. 127, no. 25, 1997, Columbus, Ohio, US; abstract no. 351192T, "Chemokine receptor antagonsts" page 977; XP002907196 * |
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000041685A1 (en) * | 1999-01-19 | 2000-07-20 | Smithkline Beecham Corporation | Ccr-3 receptor antagonists |
US7560548B2 (en) | 2000-09-29 | 2009-07-14 | Glaxo Group Limited | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
US7101882B2 (en) | 2000-09-29 | 2006-09-05 | Glaxo Group Limited | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
US7115635B2 (en) | 2001-04-27 | 2006-10-03 | Mitsubishi Pharma Corporation | Benzylpiperidine compound |
WO2003022277A1 (en) * | 2001-09-07 | 2003-03-20 | Bayer Healthcare Ag | Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders |
US7700586B2 (en) | 2001-09-07 | 2010-04-20 | Axikin Pharmaceuticals, Inc. | Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders |
US8242118B2 (en) | 2001-09-07 | 2012-08-14 | Axikin Pharmaceuticals Inc. | Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders |
EP1849469A1 (en) * | 2001-09-07 | 2007-10-31 | Actimis Pharmaceuticals, Inc., | Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders |
US7271280B2 (en) | 2002-03-05 | 2007-09-18 | Sumitomo Chemical Company, Limited | Process for preparing a biaryl compound |
EP1481967A4 (en) * | 2002-03-05 | 2007-01-31 | Sumitomo Chemical Co | Process for the preparation of biaryl compounds |
US7714157B2 (en) | 2002-03-05 | 2010-05-11 | Sumitomo Chemical Company, Limited | Process for preparing a biaryl compound |
WO2003074478A1 (en) * | 2002-03-05 | 2003-09-12 | Sumitomo Chemical Company, Limited | Process for the preparation of biaryl compounds |
EP1481967A1 (en) * | 2002-03-05 | 2004-12-01 | Sumitomo Chemical Company, Limited | Process for the preparation of biaryl compounds |
US7482363B2 (en) | 2002-03-19 | 2009-01-27 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
US8030517B2 (en) | 2002-05-24 | 2011-10-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
US9035096B2 (en) | 2002-05-24 | 2015-05-19 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
US7999109B2 (en) | 2002-05-24 | 2011-08-16 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
US7335653B2 (en) | 2002-11-18 | 2008-02-26 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US9890148B2 (en) | 2002-11-18 | 2018-02-13 | Chemocentryx, Inc. | Aryl sulfonamides |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
WO2004085384A3 (en) * | 2002-11-18 | 2005-02-03 | Chemocentryx | Bis-aryl sulfonamides |
US10364240B2 (en) | 2002-11-18 | 2019-07-30 | ChemoCentryx. Inc. | Aryl sulfonamides |
WO2004085384A2 (en) * | 2002-11-18 | 2004-10-07 | Chemocentryx | Bis-aryl sulfonamides |
US7582661B2 (en) | 2002-11-18 | 2009-09-01 | Chemocentryx, Inc. | Aryl sulfonamides |
US8642808B2 (en) | 2002-11-18 | 2014-02-04 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US7227035B2 (en) | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
EP2385040A1 (en) | 2003-03-14 | 2011-11-09 | ONO Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
US7674797B2 (en) | 2003-03-24 | 2010-03-09 | Axikin Pharmaceuticals, Inc. | 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders |
US9206186B2 (en) | 2003-03-24 | 2015-12-08 | Axikin Pharmaceuticals, Inc. | 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of inflammatory or immunological disorders |
US7495013B2 (en) | 2003-04-01 | 2009-02-24 | Astrazeneca Ab | Chemical compounds |
EP2364982A1 (en) | 2003-04-18 | 2011-09-14 | ONO Pharmaceutical Co., Ltd. | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof |
WO2006028284A1 (en) | 2004-09-08 | 2006-03-16 | Mitsubishi Pharma Corporation | Morpholine compound |
EP2546234A1 (en) | 2004-09-13 | 2013-01-16 | Ono Pharmaceutical Co., Ltd. | Nitrogeneous heterocyclic derivative and medicine containing the same as an active ingredient |
WO2006129679A1 (en) | 2005-05-31 | 2006-12-07 | Ono Pharmaceutical Co., Ltd. | Spiropiperidine compound and medicinal use thereof |
US8314127B2 (en) | 2005-07-21 | 2012-11-20 | Astrazeneca Ab | Piperidine derivatives |
WO2007049771A1 (en) | 2005-10-28 | 2007-05-03 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
EP2657235A1 (en) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
WO2007058322A1 (en) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | Basic group-containing compound and use thereof |
WO2007105637A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
WO2007132846A1 (en) | 2006-05-16 | 2007-11-22 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
WO2008016006A1 (en) | 2006-07-31 | 2008-02-07 | Ono Pharmaceutical Co., Ltd. | Compound having cyclic group bound thereto through spiro binding and use thereof |
US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US10117931B2 (en) | 2009-04-28 | 2018-11-06 | Kameran Lashkari | Methods for treatment of age-related macular degeneration |
US8741894B2 (en) | 2010-03-17 | 2014-06-03 | Axikin Pharmaceuticals, Inc. | Arylsulfonamide CCR3 antagonists |
Also Published As
Publication number | Publication date |
---|---|
EP1076557A1 (en) | 2001-02-21 |
CA2329777A1 (en) | 1999-11-04 |
JP2002512957A (en) | 2002-05-08 |
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