WO1999039765A3 - Soft x-ray emitting medical devices - Google Patents

Soft x-ray emitting medical devices Download PDF

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Publication number
WO1999039765A3
WO1999039765A3 PCT/US1999/002788 US9902788W WO9939765A3 WO 1999039765 A3 WO1999039765 A3 WO 1999039765A3 US 9902788 W US9902788 W US 9902788W WO 9939765 A3 WO9939765 A3 WO 9939765A3
Authority
WO
WIPO (PCT)
Prior art keywords
medical devices
neutron activation
soft
implantable medical
medical device
Prior art date
Application number
PCT/US1999/002788
Other languages
French (fr)
Other versions
WO1999039765A2 (en
Inventor
Anthony J Armini
Original Assignee
Implant Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Implant Sciences Corp filed Critical Implant Sciences Corp
Priority to AU28674/99A priority Critical patent/AU2867499A/en
Priority to BR9907800-7A priority patent/BR9907800A/en
Priority to JP2000530258A priority patent/JP2002502638A/en
Priority to EP99909482A priority patent/EP1054695A2/en
Priority to CA002319029A priority patent/CA2319029A1/en
Publication of WO1999039765A2 publication Critical patent/WO1999039765A2/en
Publication of WO1999039765A3 publication Critical patent/WO1999039765A3/en

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0095—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof radioactive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy

Abstract

An implantable medical device according to the present invention comprises a body, such as a stent or a wire, and an isotope having a high neutron activation cross section, such as ?168Yb or 124¿Xe, ion-implanted onto the surface of the body. The use of isotopes having high neutron activation cross sections allows a wider choice of substrates to be employed, including stainless steel, nickel, titanium, and alloys including these metals, because the time required for neutron activation of the device is reduced. A coating of high-density material may be incorporated to serve several useful purposes, including containment of undesirable beta particles from long-lived radioactive species, creation of a biologically inert surface, and enhancement of x-ray radiopacity to improve the visibility of an implanted medical device. The implantable medical devices of the present invention also comprise radioactive medical devices which include radioisotopes such as ?169Yb and 125¿I.
PCT/US1999/002788 1998-02-10 1999-02-09 Soft x-ray emitting medical devices WO1999039765A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU28674/99A AU2867499A (en) 1998-02-10 1999-02-09 Soft x-ray emitting medical devices
BR9907800-7A BR9907800A (en) 1998-02-10 1999-02-09 Flexible medical devices emitting x-ray
JP2000530258A JP2002502638A (en) 1998-02-10 1999-02-09 Medical devices that emit soft X-rays
EP99909482A EP1054695A2 (en) 1998-02-10 1999-02-09 Soft x-ray emitting medical devices
CA002319029A CA2319029A1 (en) 1998-02-10 1999-02-09 Soft x-ray emitting medical devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7418198P 1998-02-10 1998-02-10
US60/074,181 1998-02-10

Publications (2)

Publication Number Publication Date
WO1999039765A2 WO1999039765A2 (en) 1999-08-12
WO1999039765A3 true WO1999039765A3 (en) 1999-09-30

Family

ID=22118169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002788 WO1999039765A2 (en) 1998-02-10 1999-02-09 Soft x-ray emitting medical devices

Country Status (7)

Country Link
US (1) US6183409B1 (en)
EP (1) EP1054695A2 (en)
JP (1) JP2002502638A (en)
AU (1) AU2867499A (en)
BR (1) BR9907800A (en)
CA (1) CA2319029A1 (en)
WO (1) WO1999039765A2 (en)

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US6527693B2 (en) * 2001-01-30 2003-03-04 Implant Sciences Corporation Methods and implants for providing radiation to a patient
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DE20104145U1 (en) * 2001-03-09 2002-10-31 Mri Devices Daum Gmbh Cardiovascular stent
US6537195B2 (en) 2001-05-07 2003-03-25 Xoft, Microtube, Inc. Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia
US7041046B2 (en) * 2001-05-07 2006-05-09 Xoft, Inc. Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia
WO2002100480A2 (en) * 2001-06-13 2002-12-19 Apple Marc G Brachytherapy device and method
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EP1946797A3 (en) * 2001-12-12 2009-03-11 The Univ. of Alberta, The Univ. of British Columbia, Carleton Univ., Simon Fraser Univ. and The Univ. of Victoria Radioactive ion
EP1463533B1 (en) * 2001-12-12 2008-05-14 The Univ. of Alberta, The Univ. of British Columbia, Carleton Univ., Simon Fraser Univ. and The Univ. of Victoria Radioactive ion
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Also Published As

Publication number Publication date
WO1999039765A2 (en) 1999-08-12
EP1054695A2 (en) 2000-11-29
JP2002502638A (en) 2002-01-29
BR9907800A (en) 2001-01-09
US6183409B1 (en) 2001-02-06
CA2319029A1 (en) 1999-08-12
AU2867499A (en) 1999-08-23

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