WO1999036104A2 - Preparation of a lipid blend and a phospholipid suspension containing the lipid blend, and contrast agents based on these - Google Patents
Preparation of a lipid blend and a phospholipid suspension containing the lipid blend, and contrast agents based on these Download PDFInfo
- Publication number
- WO1999036104A2 WO1999036104A2 PCT/US1999/000747 US9900747W WO9936104A2 WO 1999036104 A2 WO1999036104 A2 WO 1999036104A2 US 9900747 W US9900747 W US 9900747W WO 9936104 A2 WO9936104 A2 WO 9936104A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- process according
- suspension
- lipid
- lipid blend
- aqueous solvent
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title claims abstract description 180
- 239000000203 mixture Substances 0.000 title claims abstract description 151
- 239000000725 suspension Substances 0.000 title claims abstract description 85
- 150000003904 phospholipids Chemical class 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000002872 contrast media Substances 0.000 title description 3
- 238000000034 method Methods 0.000 claims abstract description 80
- 230000008569 process Effects 0.000 claims abstract description 66
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 84
- 239000003125 aqueous solvent Substances 0.000 claims description 58
- 239000000243 solution Substances 0.000 claims description 58
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 48
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 42
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
- 239000011780 sodium chloride Substances 0.000 claims description 29
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 28
- 239000007864 aqueous solution Substances 0.000 claims description 28
- 238000001914 filtration Methods 0.000 claims description 27
- 239000007787 solid Substances 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 24
- 235000011187 glycerol Nutrition 0.000 claims description 24
- 230000001954 sterilising effect Effects 0.000 claims description 22
- 230000007704 transition Effects 0.000 claims description 17
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 15
- 238000004090 dissolution Methods 0.000 claims description 15
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical group COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 8
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 8
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims description 7
- 229960004065 perflutren Drugs 0.000 claims description 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 6
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims description 6
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 4
- 229940068886 polyethylene glycol 300 Drugs 0.000 claims description 4
- 239000002961 echo contrast media Substances 0.000 abstract description 3
- 239000002245 particle Substances 0.000 description 15
- 238000009472 formulation Methods 0.000 description 14
- 239000012071 phase Substances 0.000 description 14
- 238000013329 compounding Methods 0.000 description 10
- 238000002156 mixing Methods 0.000 description 9
- 239000000706 filtrate Substances 0.000 description 7
- 239000008364 bulk solution Substances 0.000 description 6
- -1 DPPA Chemical class 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- TXLHNFOLHRXMAU-UHFFFAOYSA-N 2-(4-benzylphenoxy)-n,n-diethylethanamine;hydron;chloride Chemical compound Cl.C1=CC(OCCN(CC)CC)=CC=C1CC1=CC=CC=C1 TXLHNFOLHRXMAU-UHFFFAOYSA-N 0.000 description 4
- 239000012736 aqueous medium Substances 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 238000012792 lyophilization process Methods 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 238000011146 sterile filtration Methods 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 238000003828 vacuum filtration Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000004973 liquid crystal related substance Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000013020 final formulation Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000002390 rotary evaporation Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000013190 lipid storage Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012569 microbial contaminant Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 238000011085 pressure filtration Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020007007716A KR100711663B1 (en) | 1998-01-14 | 1999-01-14 | Preparation of a Lipid Blend and a Phospholipid Suspension containing the Lipid Blend |
AU21155/99A AU746067C (en) | 1998-01-14 | 1999-01-14 | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
SK1031-2000A SK285333B6 (en) | 1998-01-14 | 1999-01-14 | Method for the preparation of phospholipid suspension |
EEP200000422A EE04900B1 (en) | 1998-01-14 | 1999-01-14 | Preparation of lipid blend and lipol blend phospholipid suspension and contrast agents based thereon |
PL99342473A PL193672B1 (en) | 1998-01-14 | 1999-01-14 | Method of obtaining a mixture of lipides and suspension of phopholipides containing such mixture |
JP2000539875A JP5160702B2 (en) | 1998-01-14 | 1999-01-14 | Preparation of phospholipid suspensions containing lipid blends |
EA200000765A EA002978B1 (en) | 1998-01-14 | 1999-01-14 | Process for preparation phospholipid suspension and process for preparation phospholipid mixture |
BR9907066-9A BR9907066A (en) | 1998-01-14 | 1999-01-14 | Process for preparing a suspension of phospholipids, process for preparing a mixture of lipids and suspension of phospholipids |
IL13701899A IL137018A0 (en) | 1998-01-14 | 1999-01-14 | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
NZ505082A NZ505082A (en) | 1998-01-14 | 1999-01-14 | A phospholipid suspension containing a lipid blend useful as an ultrasound contrast agent |
EP99901466A EP1027035A2 (en) | 1998-01-14 | 1999-01-14 | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend, and contrast agents based on these |
CA2317921A CA2317921C (en) | 1998-01-14 | 1999-01-14 | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
UA2000063850A UA75023C2 (en) | 1998-01-14 | 1999-01-14 | A process for the preparation of lipid blend and phospholipid suspension containing lipid blend |
HU0100206A HUP0100206A3 (en) | 1998-01-14 | 1999-01-14 | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
IL137018A IL137018A (en) | 1998-01-14 | 2000-06-26 | Process for preparing a lipid suspension, a lipid suspension obtained by the process and a composition comprising a lipid suspension |
NO20003471A NO321866B1 (en) | 1998-01-14 | 2000-07-05 | Process for preparing a phospholipid suspension. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7133298P | 1998-01-14 | 1998-01-14 | |
US60/071,332 | 1998-01-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999036104A2 true WO1999036104A2 (en) | 1999-07-22 |
WO1999036104A3 WO1999036104A3 (en) | 2000-01-13 |
Family
ID=22100659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/000747 WO1999036104A2 (en) | 1998-01-14 | 1999-01-14 | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend, and contrast agents based on these |
Country Status (31)
Country | Link |
---|---|
US (8) | US20010003580A1 (en) |
EP (2) | EP1419789B1 (en) |
JP (2) | JP5160702B2 (en) |
KR (1) | KR100711663B1 (en) |
CN (1) | CN1191822C (en) |
AR (1) | AR016444A1 (en) |
AT (1) | ATE447976T1 (en) |
AU (1) | AU746067C (en) |
BR (1) | BR9907066A (en) |
CA (1) | CA2317921C (en) |
DE (1) | DE69941634D1 (en) |
DK (1) | DK1419789T3 (en) |
EA (1) | EA002978B1 (en) |
EE (1) | EE04900B1 (en) |
ES (1) | ES2336669T3 (en) |
HK (1) | HK1064301A1 (en) |
HR (1) | HRP990012A2 (en) |
HU (1) | HUP0100206A3 (en) |
IL (2) | IL137018A0 (en) |
MY (1) | MY137255A (en) |
NO (1) | NO321866B1 (en) |
NZ (1) | NZ505082A (en) |
PH (1) | PH12012000094A1 (en) |
PL (1) | PL193672B1 (en) |
PT (1) | PT1419789E (en) |
SI (1) | SI1419789T1 (en) |
SK (1) | SK285333B6 (en) |
TW (1) | TWI242448B (en) |
UA (1) | UA75023C2 (en) |
WO (1) | WO1999036104A2 (en) |
ZA (1) | ZA99247B (en) |
Cited By (11)
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---|---|---|---|---|
WO2002082462A2 (en) * | 2001-04-03 | 2002-10-17 | Bristol-Myers Squibb Pharma Company | Stabilization and terminal sterilization of phospholipid formulations |
WO2004069284A3 (en) * | 2003-02-04 | 2004-11-25 | Bracco Research Sa | Ultrasound contrast agents and process for the preparation thereof |
US8084056B2 (en) | 1998-01-14 | 2011-12-27 | Lantheus Medical Imaging, Inc. | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US8541399B2 (en) | 2002-02-19 | 2013-09-24 | Resolution Chemicals Limited | Solvent-based sterilisation of pharmaceuticals |
US8951450B2 (en) | 2009-09-02 | 2015-02-10 | Biomedcore, Inc. | Apparatus and method for production of liposomes |
US9248204B2 (en) | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
WO2016109400A2 (en) | 2014-12-31 | 2016-07-07 | Lantheus Medical Imaging, Inc. | Lipid-encapsulated gas microsphere compositions and related methods |
US9750821B2 (en) | 2003-12-22 | 2017-09-05 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
US10588988B2 (en) | 2016-05-04 | 2020-03-17 | Lantheus Medical Imaging, Inc. | Methods and devices for preparation of ultrasound contrast agents |
US10888631B2 (en) | 2014-06-26 | 2021-01-12 | Ge Healthcare As | Lipid sterilization method |
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AU2006200015B8 (en) * | 1998-01-14 | 2008-02-21 | Dupont Pharmaceuticals Company | Preparation of a lipid blend and a phospholipid suspension containing a lipid blend, and contrast agents based on these |
US6975924B2 (en) * | 1999-12-03 | 2005-12-13 | Baxter International Inc. | Method and apparatus for controlling the strategy of compounding pharmaceutical admixtures |
CN1321697C (en) * | 2003-12-23 | 2007-06-20 | 中国人民解放军军事医学科学院毒物药物研究所 | Ultrasound contrast medium composition with phospholipid as membrane material and its preparation method |
US7858115B2 (en) * | 2004-06-24 | 2010-12-28 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
US7854943B2 (en) | 2004-06-24 | 2010-12-21 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
US7618651B2 (en) | 2004-06-24 | 2009-11-17 | Idexx Laboratories | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
US8017159B2 (en) * | 2005-11-16 | 2011-09-13 | Idexx Laboratories, Inc. | Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same |
CN102137713A (en) * | 2008-12-24 | 2011-07-27 | 生物制药开发股份有限公司 | Method for producing liposome and method for dissolving cholesterol |
JP2012086166A (en) * | 2010-10-20 | 2012-05-10 | Biomedcore Inc | Apparatus for producing liposome |
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EP0349429A2 (en) * | 1988-06-30 | 1990-01-03 | Centre National De La Recherche Scientifique (Cnrs) | Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of submicronic liposomes |
WO1995015118A1 (en) * | 1993-11-30 | 1995-06-08 | Imarx Pharmaceutical Corp. | Gas microspheres for topical and subcutaneous application |
WO1995032006A1 (en) * | 1994-05-23 | 1995-11-30 | Imarx, Pharmaceutical Corp. | Gas filled microspheres as computed tomography contrast agents |
WO1996008234A1 (en) * | 1994-09-16 | 1996-03-21 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
WO1996031196A1 (en) * | 1995-04-05 | 1996-10-10 | Imarx Pharmaceutical Corp. | Novel compositions of lipids and stabilizing materials |
WO1996040285A1 (en) * | 1995-06-07 | 1996-12-19 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
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