WO1999033447A3 - Tissue regeneration at internal wound sites - Google Patents

Tissue regeneration at internal wound sites Download PDF

Info

Publication number
WO1999033447A3
WO1999033447A3 PCT/US1998/027596 US9827596W WO9933447A3 WO 1999033447 A3 WO1999033447 A3 WO 1999033447A3 US 9827596 W US9827596 W US 9827596W WO 9933447 A3 WO9933447 A3 WO 9933447A3
Authority
WO
WIPO (PCT)
Prior art keywords
implant
wound site
tissue regeneration
disclosed
porous biodegradable
Prior art date
Application number
PCT/US1998/027596
Other languages
French (fr)
Other versions
WO1999033447A2 (en
Inventor
Ioannis V Yannas
Original Assignee
Massachusetts Inst Technology
Ioannis V Yannas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Ioannis V Yannas filed Critical Massachusetts Inst Technology
Priority to AU20951/99A priority Critical patent/AU2095199A/en
Publication of WO1999033447A2 publication Critical patent/WO1999033447A2/en
Publication of WO1999033447A3 publication Critical patent/WO1999033447A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Abstract

Disclosed is a method of promoting tissue regeneration at a wound site on an internal organ in a subject. The method comprises applying a porous biodegradable implant to said wound site after injury. The implant has the following characteristics: a) the pores of said implant have an average diameter of between about 1 νm and about 300 νm; b) the implant has a minimum water content of at least about 80 %; and a minimum specific surface area of at least about 10?3 mm2 per cm3¿; c) between about 20 % to about 80 % by weight of the implant is biodegraded at the wound site during the time period required for a wound of about the same severity, size and tissue type to complete about one half of the contraction which normally takes place in the absence of the implant; d) the implant comprises: i) a three-dimensional network of polymers which is substantially insoluble under physiological conditions; and ii) one or more specific cell-binding fragments. Also disclosed is a porous biodegradable implant having the characteristics described above, wherein the implant is a microparticle having an average diameter from about 10 νm to about 1000 νm. Also disclosed is a method of promoting tissue regeneration at an internal wound site in a subject. The method comprises applying the porous biodegradable microparticles to the wound site after injury.
PCT/US1998/027596 1997-12-30 1998-12-24 Tissue regeneration at internal wound sites WO1999033447A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20951/99A AU2095199A (en) 1997-12-30 1998-12-24 Tissue regeneration at internal wound sites

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63897A 1997-12-30 1997-12-30
US09/000,638 1997-12-30

Publications (2)

Publication Number Publication Date
WO1999033447A2 WO1999033447A2 (en) 1999-07-08
WO1999033447A3 true WO1999033447A3 (en) 1999-08-19

Family

ID=21692379

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027596 WO1999033447A2 (en) 1997-12-30 1998-12-24 Tissue regeneration at internal wound sites

Country Status (2)

Country Link
AU (1) AU2095199A (en)
WO (1) WO1999033447A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082773A2 (en) * 2000-04-28 2001-11-08 The Regents Of The University Of California Structures useful for bone engineering and methods
WO2009042514A1 (en) * 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522753A (en) * 1980-07-17 1985-06-11 Massachusetts Institute Of Technology Method for preserving porosity in porous materials
US4787900A (en) * 1982-04-19 1988-11-29 Massachusetts Institute Of Technology Process for forming multilayer bioreplaceable blood vessel prosthesis
WO1989010728A1 (en) * 1988-05-09 1989-11-16 Massachusetts Institute Of Technology Prosthesis for promotion of nerve regeneration
US4947840A (en) * 1987-08-21 1990-08-14 Massachusetts Institute Of Technology Biodegradable templates for the regeneration of tissues
WO1995003011A1 (en) * 1993-07-23 1995-02-02 Rice University Bone regeneration templates

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522753A (en) * 1980-07-17 1985-06-11 Massachusetts Institute Of Technology Method for preserving porosity in porous materials
US4787900A (en) * 1982-04-19 1988-11-29 Massachusetts Institute Of Technology Process for forming multilayer bioreplaceable blood vessel prosthesis
US4947840A (en) * 1987-08-21 1990-08-14 Massachusetts Institute Of Technology Biodegradable templates for the regeneration of tissues
WO1989010728A1 (en) * 1988-05-09 1989-11-16 Massachusetts Institute Of Technology Prosthesis for promotion of nerve regeneration
US4955893A (en) * 1988-05-09 1990-09-11 Massachusetts Institute Of Technologh Prosthesis for promotion of nerve regeneration
WO1995003011A1 (en) * 1993-07-23 1995-02-02 Rice University Bone regeneration templates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ELLIS D L ET AL: "Recent advances in tissue synthesis in vivo by use of collagen -glycosaminoglycan copolymers", BIOMATERIALS, vol. 17, no. 3, 1 February 1996 (1996-02-01), pages 291-299, XP004032795 *

Also Published As

Publication number Publication date
AU2095199A (en) 1999-07-19
WO1999033447A2 (en) 1999-07-08

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