WO1999033431A3 - Preparation and selection of pharmaceutically useful compounds from a diverse universal library - Google Patents

Preparation and selection of pharmaceutically useful compounds from a diverse universal library Download PDF

Info

Publication number
WO1999033431A3
WO1999033431A3 PCT/US1998/027695 US9827695W WO9933431A3 WO 1999033431 A3 WO1999033431 A3 WO 1999033431A3 US 9827695 W US9827695 W US 9827695W WO 9933431 A3 WO9933431 A3 WO 9933431A3
Authority
WO
WIPO (PCT)
Prior art keywords
selection
preparation
pharmaceutically useful
useful compounds
universal library
Prior art date
Application number
PCT/US1998/027695
Other languages
French (fr)
Other versions
WO1999033431A2 (en
Inventor
Michael R Pavia
Harold V Meyers
Guy Milot
Mark E Hediger
Original Assignee
Michael R Pavia
Harold V Meyers
Guy Milot
Mark E Hediger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael R Pavia, Harold V Meyers, Guy Milot, Mark E Hediger filed Critical Michael R Pavia
Priority to AU20175/99A priority Critical patent/AU2017599A/en
Publication of WO1999033431A2 publication Critical patent/WO1999033431A2/en
Publication of WO1999033431A3 publication Critical patent/WO1999033431A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Abstract

This invention relates to novel combinatorial libraries of bridged biaromatic and triaromatic ring compounds, methods for preparing such libraries, and an apparatus for storing such libraries and for use as a component of assay systems for identifying compounds for drug development.
PCT/US1998/027695 1997-12-30 1998-12-29 Preparation and selection of pharmaceutically useful compounds from a diverse universal library WO1999033431A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20175/99A AU2017599A (en) 1997-12-30 1998-12-29 Methods for preparing and selecting pharmaceutically useful bridged biaromatic and triaromatic ring compounds from structurally diverse universal library

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7002197P 1997-12-30 1997-12-30
US60/070,021 1997-12-30

Publications (2)

Publication Number Publication Date
WO1999033431A2 WO1999033431A2 (en) 1999-07-08
WO1999033431A3 true WO1999033431A3 (en) 1999-09-16

Family

ID=22092628

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027695 WO1999033431A2 (en) 1997-12-30 1998-12-29 Preparation and selection of pharmaceutically useful compounds from a diverse universal library

Country Status (2)

Country Link
AU (1) AU2017599A (en)
WO (1) WO1999033431A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003932A (en) * 1972-03-07 1977-01-18 Gist-Brocades N.V. Aminoalkylethers
EP0331073A2 (en) * 1988-02-29 1989-09-06 Chugai Seiyaku Kabushiki Kaisha Benzhydrylamine derivatives
US4964893A (en) * 1986-04-17 1990-10-23 Monsanto Company Benzhydryl compounds as herbicide antidotes
US5324483A (en) * 1992-10-08 1994-06-28 Warner-Lambert Company Apparatus for multiple simultaneous synthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003932A (en) * 1972-03-07 1977-01-18 Gist-Brocades N.V. Aminoalkylethers
US4964893A (en) * 1986-04-17 1990-10-23 Monsanto Company Benzhydryl compounds as herbicide antidotes
EP0331073A2 (en) * 1988-02-29 1989-09-06 Chugai Seiyaku Kabushiki Kaisha Benzhydrylamine derivatives
US5324483A (en) * 1992-10-08 1994-06-28 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GORDON E. M., ET AL.: "APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY. Ö2. COMBINATORIAL ORGANIC SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE DIRECTIONS1.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37., no. 10., 13 May 1994 (1994-05-13), US, pages 1385 - 1401., XP000605162, ISSN: 0022-2623, DOI: 10.1021/jm00036a001 *
JANDA K. D.: "TAGGED VERSUS UNTAGGED LIBRARIES: METHODS FOR THE GENERATION AND SCREENING OF COMBINATORIAL CHEMICAL LIBRARIES.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 91., 1 November 1994 (1994-11-01), US, pages 10779 - 10785., XP002912829, ISSN: 0027-8424, DOI: 10.1073/pnas.91.23.10779 *

Also Published As

Publication number Publication date
WO1999033431A2 (en) 1999-07-08
AU2017599A (en) 1999-07-19

Similar Documents

Publication Publication Date Title
AU5110096A (en) Process for the production of combinatorial compound libraries
AU2021099A (en) Software for the display of chromatographic separation data
AU3974899A (en) Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
AU5663698A (en) New aqueous medicament preparations for the production of propellent gas-free aerosols
AU4081297A (en) Rapid process for arraying and synthesizing bead-based combinatorial libraries
AU7707898A (en) Device for isolating a component of a physiological sample
CA2187969A1 (en) A template for solution phase synthesis of combinatorial libraries
AU6202998A (en) Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof
AU3272295A (en) Soluble combinatorial libraries
AU9383198A (en) Amine compounds and combinatorial libraries comprising same
AU5426398A (en) Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
AU1875195A (en) Solid phase assay for detection of ligands
AU4066097A (en) Methods for removing unreacted electrophiles from a reaction mixture
FI962371A0 (en) Process for preparation of combinatorial compound libraries
AU7522596A (en) Synthesis of substituted n-heteroaromatic compounds by combinatorial chemistry
IL132096A0 (en) Solvent system for enhanced penetration of pharmaceutical compounds
AU6015098A (en) Method of screening agents as candidates for drugs or sources of drugs
AU2889097A (en) Identification of members of combinatorial libraries by mass spectrometry
AU4860297A (en) Reaction chamber system for chemical synthesis or related applications
WO1999033431A3 (en) Preparation and selection of pharmaceutically useful compounds from a diverse universal library
AU6618098A (en) Method for obtaining hexamethylene diamine from mixtures containing hexamethylene diamine
WO1997008190A3 (en) Compounds
AUPO938897A0 (en) A potential effector for the grb7 family of signalling proteins
AU5320099A (en) Synthesis of combinatorial libraries of compounds reminiscent of natural products
AU7058498A (en) Method for the preparation of a chemical library

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase