WO1999030643A1 - Expandable stent having radiopaque marker and method - Google Patents
Expandable stent having radiopaque marker and method Download PDFInfo
- Publication number
- WO1999030643A1 WO1999030643A1 PCT/US1998/026748 US9826748W WO9930643A1 WO 1999030643 A1 WO1999030643 A1 WO 1999030643A1 US 9826748 W US9826748 W US 9826748W WO 9930643 A1 WO9930643 A1 WO 9930643A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- wall
- stent
- eyelet
- insert
- framework
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91508—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a difference in amplitude along the band
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
Definitions
- This invention relates to an expandable stent having a radiopaque marker and a method for fabricating the radiopaque marker.
- Stents herebefore have been provided typically are formed of stainless steel and other metals, which in and of themselves are not readily visible in fluoroscopic imaging systems. It has been found that it is important to be able to visualize the stents during the time that they are being deployed and also to be able to visualize the stents after they have been deployed, at periodic time intervals. Attempts have been made to make such stents more radiopaque by brazing gold or platinum onto the stents. However, even though the desired radiopacity may be achieved, such approaches have not been found to be particularly satisfactory in that the brazing process may cause local annealing of the stent, and may change its mechanical properties. There is therefore a need for a new and improved radiopaque marker for use on stents.
- Another object of the invention is to provide an expandable stent with a radiopaque marker in which the radiopaque marker does not experience stresses or strains during expansion of the stent.
- Another object of the invention is to provide an expandable stent having a radiopaque marker in which the radiopaque marker is isolated from the stent pattern so that it does not interfere with the expansion of the stent.
- Another object of the invention is to provide an expandable stent with a radiopaque marker of the above character in which the radiopaque marker does not protrude from the exterior surface or the interior surface of the stent.
- Another object of the invention is to provide a radiopaque marker which can be readily and economically fabricated.
- Figure 1 is a side elevational view of a stent having a radiopaque marker incorporating the present invention.
- Figure 1A is an enlarged view taken from Figure 1 of a radiopaque marker shown in Figure 1.
- Figure 2 is a cross-sectional view taken along the line 2-2 of Figure 1.
- Figures 3A, 3B and 3C illustrate various placements of radiopaque markers on stents and incorporating the present invention in stents.
- Figure 4 is an enlarged isometric view of the framework provided in the radiopaque marker of the present invention and showing an eyelet provided by the framework.
- Figure 5 is an isometric view of an insert as provided to fit within the eyelet shown in Figure 3.
- Figure 6 is a cross-sectional illustration showing the manner in which an insert is placed in an eyelet by use of a mandrel in a stent.
- Figure 7 is a cross-sectional view of the radiopaque marker after the insert has been forged into the eyelet in accordance with the method of the present invention.
- the stent having a radiopaque marker therein is comprised of a cylindrical member having a wall defining a central bore extending along a longitudinal axis and having an outside diameter and an inside diameter and a length.
- the wall has a pattern formed therein with openings therein.
- At least one radiopaque marker is carried by the wall and is disposed in an opening.
- the radiopaque marker is comprised of a framework formed in the wall and lying within the inner and outer confines of the wall and is carried by the wall and is disposed in an opening in the pattern so that it is isolated from the pattern so that it does not interfere with the expansion of the stent.
- the framework has an eyelet therein and an insert formed of a radiopaque material is secured in the stent and lies within the confines of the inner wall and the outer wall.
- the method for forming a radiopaque marker for use with a cylindrical stent having a wall defining a bore extending therethrough and having an outside diameter and inside diameter and a longitudinal axis with the wall of the stent having a pattern with openings therein comprises forming an eyelet in the wall of the stent so that it is disposed in at least one of the openings in the wall.
- An insert is provided which has a volume which corresponds to the volume of the eyelet and is mounted in the eyelet so that it is retained in the eyelet and lies within the confines of the inner and outer diameter of the wall.
- a stent 11 utilized in conjunction with the radiopaque marker of the present invention is shown in Figure 1 and consists of at least one segment 12 and generally a plurality of segments 12.
- Each segment 12 is comprised of a cylindrical member 13 which has a wall 14 formed of a suitable metal such as stainless steel which defines a bore 16 extending along a longitudinal axis 17.
- the wall 14 has a thickness so that there is provided an inside surface 18 and an outside surface 19.
- a pattern 21 is provided in the wall and has a plurality of openings 22 extending through the wall.
- the stent 11 hereinbefore described is merely one stent on which the radiopaque marker 26 of the present invention can be used.
- the characteristics of the particular stent 11 shown in Figure 1 are described in detail in co-pending application Serial Number filed (A-65468) and the more detailed features thereof are incorporated herein by reference.
- At least one radiopaque marker 26 is provided in the stent 11.
- Different patterns for use of the radiopaque markers are shown in Figures 3A, 3B and 3C.
- a radiopaque marker 26 is provided in opposite ends of the stent 11.
- radiopaque markers 26 are provided at opposite ends of the stent 11 and also at an intermediate point of the stent with radiopaque markers 26 also being disposed in each location at diametrically opposite points so that the amount of radial expansion of the stents can be ascertained by observing the locations of the radiopaque markers.
- a plurality of radiopaque markers 26 are provided which are spaced apart equi-distant along the length of the stent to make possible observation of the elongation or shortening of the stent during expansion.
- Each of the radiopaque markers 26 consists of a framework 27 which is provided with an eyelet 28 therein (see Figures 1A and 4) .
- the framework 27 with the eyelet 28 therein typically is formed in the wall 14 during the same time that the pattern 21 is formed and is connected by a link 29 to the pattern.
- a pattern can be formed by laser cutting or etching. It is important that the framework 27 have the same wall thickness as the wall 14 itself and therefore it is preferable that it be formed of the wall 14 and in the wall 14 so that the framework 27 is disposed in one of the openings 22 in the pattern 21 so that it is not subjected to stresses and strains during expansion of the stent and also so that it does not interfere with the expansion of the stent.
- the framework 27 is provided with a plurality of circumferentially spaced-apart substantially conical protrusions or projections 31 which are cone shaped as shown in Figures 3 and 4 and lie within the confines of the inner and outer surfaces 18 and 19 of the wall 14.
- a plurality of such projections 31 are provided in accordance with the present invention and it is desirable to have at least three of such inwardly and radially extending projections and preferably four as shown, but as many as eight.
- the radiopaque marker 26 also includes an insert 36 which is formed of a suitable radiopaque material such as gold or platinum or alloys thereof.
- an insert 36 which is formed of a suitable radiopaque material such as gold or platinum or alloys thereof.
- the volume of the eyelet 28 between the inner and outer surfaces 18 and 19 of the wall, taking into account the volume occupied by the protrusions or projections 31 is precisely calculated.
- such projections can be provided with the eyelet having a diameter of 0.015 inches and having an inner diameter of 0.010 inches extending between two opposite protrusions or projections 31 with each of the projections extending inwardly by a distance of 0.0025 inches with the wall being of a suitable thickness as for example 0.003 inches.
- a sheet of the desired radiopaque material is selected as for example of platinum or gold, having a suitable thickness as for example 0.008 is. Since the plug 37 must be of a suitable diameter to as for example 0.010 inches when it is disposed between the projections or spikes 31, the additional volume required is obtained by providing the additional volume in the thickness of the plug which can be obtained by providing a sheet (not shown) of radiopaque material and then rolling it down to the desired thickness to achieve the desired volume for the plug 47 when it is punched up from the sheet. A cylindrical plug 37 (see Figure 5) of the desired diameter is punched therefrom.
- the plug 37 is then taken and placed in the eyelet 28 of the framework 27 carried by the stent with a cylindrical tight fitting mandrel 38 being disposed within the stent as shown in Figure 6.
- a suitable force is then applied as for example by an arbor press as indicated by the "F" arrows 39 to press and forge the plug 37 into the eyelet 28 so that it completely fills the volume of the eyelet 28 and so that it overlies and underlies the protrusions 31 within the confines of the inner and outer surfaces 18 and 19, so that it does not protrude from the wall but is substantially flush with both surfaces thereof.
- the material of the plug 37 is forced to flow over the eyelets 28 and thereby be cold forged into the eyelet 28.
- this formation of a radiopaque marker or markers in the stent 11 can be accomplished without interfering with the mechanical properties of the stent itself.
- the method then makes it possible to securely mount the insert within the eyelet to ensure that it will not accidentally pop out.
- the method provided has made it possible to capture the radiopaque material so that a robust mechanically reliable construction is provided which provides the desired radiopacity needed to observe the stent as hereinbefore described.
- it can be seen that it is possible to provide a plurality of radiopaque markers in a stent.
- radiopaque markers can be incorporated into the stent one by one by longitudinal movement or rotation of the stent in the arbor during insertion of the inserts into the eyelets of the radiopaque markers.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU19200/99A AU1920099A (en) | 1997-12-16 | 1998-12-15 | Expandable stent having radiopaque marker and method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/991,378 US6022374A (en) | 1997-12-16 | 1997-12-16 | Expandable stent having radiopaque marker and method |
US08/991,378 | 1997-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999030643A1 true WO1999030643A1 (en) | 1999-06-24 |
Family
ID=25537154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/026748 WO1999030643A1 (en) | 1997-12-16 | 1998-12-15 | Expandable stent having radiopaque marker and method |
Country Status (3)
Country | Link |
---|---|
US (1) | US6022374A (en) |
AU (1) | AU1920099A (en) |
WO (1) | WO1999030643A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2002078762A1 (en) * | 2001-03-29 | 2002-10-10 | Cordis Corporation | Radiopaque intraluminal medical device |
US6814746B2 (en) | 2002-11-01 | 2004-11-09 | Ev3 Peripheral, Inc. | Implant delivery system with marker interlock |
WO2005028014A1 (en) * | 2003-09-16 | 2005-03-31 | Campus Gmbh & Co.Kg | Device for being introduced into body organs and having a marker element for controlling the position thereof |
DE102004054084A1 (en) * | 2004-11-09 | 2006-05-11 | Admedes Schuessler Gmbh | Stent, comprising marker visible under use of x-rays and designed as string accommodated in groove |
DE19937638B4 (en) * | 1999-08-12 | 2006-11-02 | Alveolus Inc. | Tracheal Stent |
EP1849435A2 (en) * | 2003-06-16 | 2007-10-31 | Endotex Interventional Systems, Inc. | Stent with attached sleeve marker |
US8197535B2 (en) | 2001-06-19 | 2012-06-12 | Cordis Corporation | Low profile improved radiopacity intraluminal medical device |
US10052185B2 (en) | 2016-02-12 | 2018-08-21 | Covidien Lp | Vascular device marker attachment |
US10265089B2 (en) | 2016-02-12 | 2019-04-23 | Covidien Lp | Vascular device visibility |
US11376140B1 (en) | 2021-03-26 | 2022-07-05 | Vesper Medical, Inc. | Medical implants with structural members having barbs for retaining radiopaque markers |
CN114985907A (en) * | 2022-05-19 | 2022-09-02 | 深圳泰德激光技术股份有限公司 | Blood vessel stent and manufacturing method thereof |
US11819430B2 (en) | 2017-11-03 | 2023-11-21 | Ceroflo Limited | Expandable stent and a method for promoting a natural intracranial angiogenesis process, and use of the expandable stent in the method for promoting a natural intracranial angiogenesis process |
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US20040186551A1 (en) | 2003-01-17 | 2004-09-23 | Xtent, Inc. | Multiple independent nested stent structures and methods for their preparation and deployment |
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DE10201151B4 (en) * | 2002-01-15 | 2007-10-04 | Qualimed Innovative Medizinprodukte Gmbh | Stent with marker |
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