WO1999025322A3 - Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids - Google Patents

Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids Download PDF

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Publication number
WO1999025322A3
WO1999025322A3 PCT/EP1998/007311 EP9807311W WO9925322A3 WO 1999025322 A3 WO1999025322 A3 WO 1999025322A3 EP 9807311 W EP9807311 W EP 9807311W WO 9925322 A3 WO9925322 A3 WO 9925322A3
Authority
WO
WIPO (PCT)
Prior art keywords
cross
pharmaceutical compositions
drugs
powders
linked polymers
Prior art date
Application number
PCT/EP1998/007311
Other languages
French (fr)
Other versions
WO1999025322A2 (en
Inventor
Fabio Carli
Italo Colombo
Paolo Alessi
Ireneo Kikic
Angelo Cortesi
Original Assignee
Vectorpharma S P A
Fabio Carli
Italo Colombo
Paolo Alessi
Ireneo Kikic
Angelo Cortesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vectorpharma S P A, Fabio Carli, Italo Colombo, Paolo Alessi, Ireneo Kikic, Angelo Cortesi filed Critical Vectorpharma S P A
Priority to AU21531/99A priority Critical patent/AU738748B2/en
Priority to EP98965674A priority patent/EP1033977A2/en
Priority to KR1020007005454A priority patent/KR20010032251A/en
Priority to NZ505290A priority patent/NZ505290A/en
Priority to CA002310423A priority patent/CA2310423A1/en
Priority to JP2000520756A priority patent/JP2001522873A/en
Priority to BR9814656-4A priority patent/BR9814656A/en
Publication of WO1999025322A2 publication Critical patent/WO1999025322A2/en
Publication of WO1999025322A3 publication Critical patent/WO1999025322A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

Pharmaceutical compositions in powder form are prepared by loading drugs solubilized in supercritical fluids on cross-linked polymers. The loading process is carried out by means of two steps. In the first step the supercritical fluid is saturated with the drug in suitable temperature and pressure conditions. In the second step the supercritical fluid containing the drug is contacted with the cross-linked polymer. Owing to its particular properties the supercritical fluid penetrates into the polymer and allows the drug to impregnate the polymer itself. After the removal of the fluid the drug remains in the polymer itself.
PCT/EP1998/007311 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids WO1999025322A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU21531/99A AU738748B2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
EP98965674A EP1033977A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
KR1020007005454A KR20010032251A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
NZ505290A NZ505290A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions comprising cross-linked polymers loaded with drugs prepared by using supercritical fluids to solubilize and load the drugs on to the polymers
CA002310423A CA2310423A1 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids
JP2000520756A JP2001522873A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having crosslinked polymers in powder form bearing pharmaceuticals and related supercritical fluid preparation methods
BR9814656-4A BR9814656A (en) 1997-11-19 1998-11-16 Pharmaceutical compositions in the form of powders, and process for the preparation of pharmaceutical compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI002571A IT1296464B1 (en) 1997-11-19 1997-11-19 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF DRUG-LOADED CROSS-LINKED POLYMER POWDERS AND RELATED PREPARATION PROCESS BY MEANS
ITMI97A002571 1997-11-19

Publications (2)

Publication Number Publication Date
WO1999025322A2 WO1999025322A2 (en) 1999-05-27
WO1999025322A3 true WO1999025322A3 (en) 1999-08-19

Family

ID=11378230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/007311 WO1999025322A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids

Country Status (9)

Country Link
EP (1) EP1033977A2 (en)
JP (1) JP2001522873A (en)
KR (1) KR20010032251A (en)
AU (1) AU738748B2 (en)
BR (1) BR9814656A (en)
CA (1) CA2310423A1 (en)
IT (1) IT1296464B1 (en)
NZ (1) NZ505290A (en)
WO (1) WO1999025322A2 (en)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
EP1250189B1 (en) * 2000-01-17 2005-06-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for modifying the surfaces of fine-porous adsorbents
IT1318404B1 (en) * 2000-03-17 2003-08-25 Eurand Int PROCESS FOR THE PREPARATION OF FORMULATIONS WITH ACCELERATED RELEASE WITH THE USE OF COMPRESSED FLUIDS.
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
DE10296849T5 (en) * 2001-05-30 2004-04-29 Csir Corporate Building Scientia Process for encapsulating an active substance
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
DE10132366A1 (en) * 2001-07-04 2003-01-30 Degussa Process for the physical treatment of starch (derivatives)
FR2830760B1 (en) 2001-10-12 2004-06-04 Pf Medicament PROCESS FOR THE PREPARATION OF AN INTERACTION COMPOUND OF ACTIVE SUBSTANCES WITH A POROUS SUPPORT BY SUPERCRITICAL FLUID
GB0127786D0 (en) * 2001-11-20 2002-01-09 Univ Nottingham Impregnation of antimicrobial substances
EP1515699B1 (en) * 2002-03-07 2009-02-04 Eurand Pharmaceuticals Ltd. Process for loading and thermodynamically activating drugs on polymers by means of supercritical fluids
KR100508518B1 (en) * 2002-11-13 2005-08-17 한미약품 주식회사 Method for the preparation of paclitaxel solid dispersion by using the supercritical fluid process and paclitaxel solid dispersion prepared thereby
FR2854079B1 (en) 2003-04-25 2007-11-30 Pf Medicament PROCESS FOR THE PREPARATION OF MOLECULAR COMPLEXES
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1611877A1 (en) 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
CN101384250A (en) * 2005-11-09 2009-03-11 诺瓦提斯公司 Process for making pharmaceutical compositions with a transient plasticizer
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (en) * 2009-05-15 2012-10-05 Pf Medicament SUPERCRITICAL CO2 IMPREGNATION PROCESS
CN105687141A (en) * 2016-03-04 2016-06-22 中国药科大学 Technical study for preparing Nim-PLLA (nimesulide-poly-l-lactic acid) composite microsphere with supercritical anti-solvent method
CN112812355B (en) * 2020-12-31 2022-09-23 厦门天生爱科技有限公司 Functional polymer foaming material with slow-release volatile Chinese herbal medicine effective components, preparation method and application
CN113425895A (en) * 2021-07-12 2021-09-24 大连大学 Drug-loaded bone repair internal fixation material and preparation method thereof

Citations (6)

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Publication number Priority date Publication date Assignee Title
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
US5039372A (en) * 1988-08-05 1991-08-13 Compagnie Generale Des Etablissements Michelin - Michelin Et Cie Component elements of an apparatus for the manufacture of a tire reinforcement
US5128142A (en) * 1986-02-03 1992-07-07 Elan Corporation, Plc Sustained release drug delivery system
WO1993012797A1 (en) * 1991-12-31 1993-07-08 Istituto Gentili S.P.A. Pharmaceutical compositions containing natural progesterone having a high biological availability
DE4202320A1 (en) * 1992-01-29 1993-08-05 Dierk Dr Knittel Impregnating substrate by contact with supercritical fluid contg. impregnant - followed by conversion of fluid to subcritical state
WO1994018264A1 (en) * 1993-02-11 1994-08-18 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128142A (en) * 1986-02-03 1992-07-07 Elan Corporation, Plc Sustained release drug delivery system
US5039372A (en) * 1988-08-05 1991-08-13 Compagnie Generale Des Etablissements Michelin - Michelin Et Cie Component elements of an apparatus for the manufacture of a tire reinforcement
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
WO1993012797A1 (en) * 1991-12-31 1993-07-08 Istituto Gentili S.P.A. Pharmaceutical compositions containing natural progesterone having a high biological availability
DE4202320A1 (en) * 1992-01-29 1993-08-05 Dierk Dr Knittel Impregnating substrate by contact with supercritical fluid contg. impregnant - followed by conversion of fluid to subcritical state
WO1994018264A1 (en) * 1993-02-11 1994-08-18 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Non-Patent Citations (2)

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Title
SUBRANANIAM B ET AL: "PHARMACEUTICAL PROCESSING WITH SUPERCRITICAL CARBON DIOXIDE", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 86, no. 8, 1 August 1997 (1997-08-01), pages 885 - 890, XP000693966 *
ZIA, HOSSEIN ET AL: "Comparison of nasal insulin powders prepared by supercritical fluid and freeze-drying techniques", PART. SCI. TECHNOL. (1997), 15(3), 217-244 CODEN: PTCHDS;ISSN: 0272-6351, XP002103767 *

Also Published As

Publication number Publication date
NZ505290A (en) 2002-08-28
AU2153199A (en) 1999-06-07
KR20010032251A (en) 2001-04-16
AU738748B2 (en) 2001-09-27
IT1296464B1 (en) 1999-06-25
EP1033977A2 (en) 2000-09-13
BR9814656A (en) 2000-10-03
JP2001522873A (en) 2001-11-20
WO1999025322A2 (en) 1999-05-27
ITMI972571A1 (en) 1999-05-19
CA2310423A1 (en) 1999-05-27

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