WO1999022810A1 - Apparatus and method for in vivo delivery of therapeutic agents - Google Patents
Apparatus and method for in vivo delivery of therapeutic agents Download PDFInfo
- Publication number
- WO1999022810A1 WO1999022810A1 PCT/US1998/023649 US9823649W WO9922810A1 WO 1999022810 A1 WO1999022810 A1 WO 1999022810A1 US 9823649 W US9823649 W US 9823649W WO 9922810 A1 WO9922810 A1 WO 9922810A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electrode
- permeable membrane
- membrane
- agent
- casing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/0424—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/042—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0444—Membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Electrotherapy Devices (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU13120/99A AU1312099A (en) | 1997-11-05 | 1998-11-04 | Apparatus and method for (in vivo) delivery of therapeutic agents |
JP2000518738A JP2001521798A (en) | 1997-11-05 | 1998-11-04 | Apparatus and method for in vivo delivery of therapeutic agents |
EP98956643A EP1030714A4 (en) | 1997-11-05 | 1998-11-04 | APPARATUS AND METHOD FOR $i(IN VIVO) DELIVERY OF THERAPEUTIC AGENTS |
US10/274,626 US20030040696A1 (en) | 1997-11-05 | 2002-10-18 | Apparatus and method for in vivo delivery of therapeutic agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/964,872 | 1997-11-05 | ||
US08/964,872 US6775569B2 (en) | 1997-11-05 | 1997-11-05 | Electroporation device for in vivo delivery of therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999022810A1 true WO1999022810A1 (en) | 1999-05-14 |
WO1999022810A9 WO1999022810A9 (en) | 1999-08-19 |
Family
ID=25509107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/023649 WO1999022810A1 (en) | 1997-11-05 | 1998-11-04 | Apparatus and method for in vivo delivery of therapeutic agents |
Country Status (5)
Country | Link |
---|---|
US (4) | US6775569B2 (en) |
EP (1) | EP1030714A4 (en) |
JP (1) | JP2001521798A (en) |
AU (1) | AU1312099A (en) |
WO (1) | WO1999022810A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000047274A1 (en) * | 1999-02-10 | 2000-08-17 | Gmp Drug Delivery, Inc. | Iontophoresis, electroporation and combination patches for local drug delivery |
WO2003061757A1 (en) * | 2002-01-24 | 2003-07-31 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal/transmucosal preparations for electroporation |
EP1457233A1 (en) * | 2003-03-12 | 2004-09-15 | Novosis AG | Transdermal drug delivery system with mesh electrode |
EP1487976A2 (en) * | 2002-03-25 | 2004-12-22 | Genetronics, Inc. | Minimizing metal toxicity during electroporation enhanced delivery of polynucleotides |
FR2903911A1 (en) * | 2006-07-21 | 2008-01-25 | Albert Teboul | Electro-magneto therapy device for e.g. dorsal belt, has source supplying transformer device, and magnets arranged in contact with conductors via surface opposite to another surface that is applied on skin of patient in region to be treated |
WO2008032282A3 (en) * | 2006-09-13 | 2008-05-22 | Compex Medical Sa | Electrode set and stimulating device |
US9717891B2 (en) | 2012-03-23 | 2017-08-01 | Microarray Limited | Skin dressing with electrodes and physiologically active precursor substance |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6775569B2 (en) * | 1997-11-05 | 2004-08-10 | Hisamitsu Pharmaceutical Co., Inc. | Electroporation device for in vivo delivery of therapeutic agents |
US6792306B2 (en) * | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
US7083580B2 (en) * | 2001-04-06 | 2006-08-01 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US7520875B2 (en) * | 2001-04-06 | 2009-04-21 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US7010343B2 (en) | 2001-04-06 | 2006-03-07 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US7496401B2 (en) * | 2001-04-06 | 2009-02-24 | Mattioli Engineering Ltd | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US6932894B2 (en) * | 2001-05-15 | 2005-08-23 | Therasense, Inc. | Biosensor membranes composed of polymers containing heterocyclic nitrogens |
AT411150B (en) * | 2001-05-25 | 2003-10-27 | Nova Technical Res Gmbh | DEVICE FOR INTRODUCING SUBSTANCES |
JP4033382B2 (en) * | 2002-04-08 | 2008-01-16 | 久光製薬株式会社 | Insulin administration device |
US6772535B2 (en) | 2002-06-10 | 2004-08-10 | Koslow Technologies Corporation | Humidity generating system and method and use in wood drying kiln |
EP1594477A4 (en) * | 2003-01-29 | 2009-07-15 | Pill Pharma Ltd E | Active drug delivery in the gastrointestinal tract |
US20050058701A1 (en) * | 2003-01-29 | 2005-03-17 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
WO2005010161A2 (en) * | 2003-07-16 | 2005-02-03 | University Of South Florida | Device and method to facilitate directed delivery and electroporation |
US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
IL159273A0 (en) | 2003-12-09 | 2004-06-01 | Transpharma Medical Ltd | Transdermal delivery system for sustained release of polypeptides |
US8165651B2 (en) * | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
US7840263B2 (en) | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
US7729761B2 (en) * | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
JP4728631B2 (en) * | 2004-11-30 | 2011-07-20 | Tti・エルビュー株式会社 | Iontophoresis device |
US7590444B2 (en) | 2004-12-09 | 2009-09-15 | Tti Ellebeau, Inc. | Iontophoresis device |
JP2008522778A (en) * | 2004-12-14 | 2008-07-03 | イー−ピル ファーマ リミティド | Local transport of drugs or substances using increased electrical permeability |
JP4731931B2 (en) * | 2005-02-03 | 2011-07-27 | Tti・エルビュー株式会社 | Iontophoresis device |
US20070027426A1 (en) * | 2005-06-24 | 2007-02-01 | Transcutaneous Technologies Inc. | Iontophoresis device to deliver active agents to biological interfaces |
US9211332B2 (en) | 2005-07-21 | 2015-12-15 | The Invention Science Fund I, Llc | Selective resonance of bodily agents |
US8364407B2 (en) * | 2005-07-21 | 2013-01-29 | The Invention Science Fund I, Llc | Selective resonance of chemical structures |
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US9427465B2 (en) | 2005-07-21 | 2016-08-30 | Deep Science, Llc | Selective resonance of chemical structures |
US8364412B2 (en) | 2005-07-21 | 2013-01-29 | The Invention Science Fund I, Llc | Selective resonance of chemical structures |
US8346484B2 (en) | 2005-07-21 | 2013-01-01 | The Invention Science Fund I, Llc | Selective resonance of chemical structures |
US8195403B2 (en) | 2005-07-21 | 2012-06-05 | The Invention Science Fund I, Llc | Selective resonance of bodily agents |
JP2007037868A (en) * | 2005-08-05 | 2007-02-15 | Transcutaneous Technologies Inc | Transdermal administration device and its controlling method |
US8386030B2 (en) | 2005-08-08 | 2013-02-26 | Tti Ellebeau, Inc. | Iontophoresis device |
US8295922B2 (en) * | 2005-08-08 | 2012-10-23 | Tti Ellebeau, Inc. | Iontophoresis device |
US20070060860A1 (en) * | 2005-08-18 | 2007-03-15 | Transcutaneous Technologies Inc. | Iontophoresis device |
US20070071807A1 (en) * | 2005-09-28 | 2007-03-29 | Hidero Akiyama | Capsule-type drug-releasing device and capsule-type drug-releasing device system |
WO2007038028A1 (en) * | 2005-09-28 | 2007-04-05 | Tti Ellebeau, Inc. | Iontophoresis apparatus and method to deliver active agents to biological interfaces |
US20070078375A1 (en) * | 2005-09-30 | 2007-04-05 | Transcutaneous Technologies Inc. | Iontophoretic delivery of active agents conjugated to nanoparticles |
US20070078445A1 (en) * | 2005-09-30 | 2007-04-05 | Curt Malloy | Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces |
JP2009509659A (en) * | 2005-09-30 | 2009-03-12 | Tti・エルビュー株式会社 | Iontophoresis device and method for delivery of active agents to biological interfaces |
US7848801B2 (en) | 2005-12-30 | 2010-12-07 | Tti Ellebeau, Inc. | Iontophoretic systems, devices, and methods of delivery of active agents to biological interface |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
WO2007117651A2 (en) * | 2006-04-07 | 2007-10-18 | University Of South Florida | Passive electric field focus system for in vivo and in vitro applications |
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US8260411B1 (en) | 2006-09-06 | 2012-09-04 | Twin Star Medical, Inc. | Conductive injection and aspiration device and method |
BRPI0719353A2 (en) | 2006-12-01 | 2014-01-07 | Titi Ellebeau Inc | SYSTEMS, DEVICES AND METHODS FOR ENERGIZATION AND / OR CONTROL DEVICES, FOR EXAMPLE, TRANSDERMIC DISTRIBUTION DEVICES |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
EP2196212A4 (en) * | 2007-10-04 | 2012-01-25 | Josai University Corp | Preparation and method of administering vaccine and iontophoresis device using the preparation |
WO2009047774A2 (en) * | 2007-10-09 | 2009-04-16 | Transpharma Ltd. | Magnetic patch coupling |
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US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
WO2009093230A2 (en) | 2008-01-24 | 2009-07-30 | Syneron Medical Ltd. | A device, apparatus, and method of adipose tissue treatment |
US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
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US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
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US8992517B2 (en) | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
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US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
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US20090299266A1 (en) * | 2008-06-02 | 2009-12-03 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
WO2010032235A1 (en) | 2008-09-21 | 2010-03-25 | Syneron Medical Ltd. | A method and apparatus for personal skin treatment |
KR101674904B1 (en) | 2009-02-26 | 2016-11-10 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | Interventional drug delivery system and associated methods |
US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
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US20100286587A1 (en) * | 2009-05-07 | 2010-11-11 | Yossi Gross | Sublingual electrical drug delivery |
US20100286628A1 (en) * | 2009-05-07 | 2010-11-11 | Rainbow Medical Ltd | Gastric anchor |
US20110066175A1 (en) * | 2009-05-07 | 2011-03-17 | Rainbow Medical Ltd. | Gastric anchor |
US8414559B2 (en) * | 2009-05-07 | 2013-04-09 | Rainbow Medical Ltd. | Gastroretentive duodenal pill |
SG175341A1 (en) * | 2009-05-08 | 2011-11-28 | Isis Biopolymer Inc | Iontophoretic device with improved counterelectrode |
US20110092881A1 (en) * | 2009-05-08 | 2011-04-21 | Isis Biopolymer Inc. | Iontophoretic device with contact sensor |
US8903488B2 (en) | 2009-05-28 | 2014-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
US9014799B2 (en) * | 2009-10-08 | 2015-04-21 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including electrically-actuated permeation enhancement |
US9017310B2 (en) * | 2009-10-08 | 2015-04-28 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including microneedles |
US8882748B2 (en) | 2009-10-08 | 2014-11-11 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including chemical permeation enhancers |
EP2563460B1 (en) | 2010-04-28 | 2017-07-19 | Inovio Pharmaceuticals, Inc. | Oral mucosal electroporation device and use thereof |
WO2012009080A2 (en) * | 2010-07-12 | 2012-01-19 | University Of Miami | Device for radiation-activated localized delivery of treatment agents |
WO2012051433A2 (en) | 2010-10-13 | 2012-04-19 | Angiodynamics, Inc. | System and method for electrically ablating tissue of a patient |
WO2012088149A2 (en) | 2010-12-20 | 2012-06-28 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
US9999720B2 (en) | 2012-09-27 | 2018-06-19 | Palo Alto Research Center Incorporated | Drug reconstitution and delivery device and methods |
US9005108B2 (en) * | 2012-09-27 | 2015-04-14 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
US9744341B2 (en) | 2013-01-15 | 2017-08-29 | Palo Alto Research Center Incorporated | Devices and methods for intraluminal retention and drug delivery |
US9297083B2 (en) | 2013-12-16 | 2016-03-29 | Palo Alto Research Center Incorporated | Electrolytic gas generating devices, actuators, and methods |
WO2015102745A1 (en) | 2013-12-31 | 2015-07-09 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
GB2524777A (en) * | 2014-04-02 | 2015-10-07 | Microarray Ltd | Dressing comprising electrodes |
CN112807074A (en) | 2014-05-12 | 2021-05-18 | 弗吉尼亚暨州立大学知识产权公司 | Electroporation system |
US10278675B2 (en) | 2014-07-31 | 2019-05-07 | Palo Alto Research Center Incorporated | Implantable estrus detection devices, systems, and methods |
US9801660B2 (en) | 2014-07-31 | 2017-10-31 | Palo Alto Research Center Incorporated | Implantable fluid delivery devices, systems, and methods |
US10694972B2 (en) | 2014-12-15 | 2020-06-30 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
EP3322451B1 (en) | 2015-07-14 | 2021-03-24 | Washington State University | Electrochemical reduction or prevention of infections |
CN114209420A (en) | 2015-10-07 | 2022-03-22 | 梅约医学教育与研究基金会 | Electroporation for the treatment of obesity or diabetes |
US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
CA2975932A1 (en) * | 2017-08-10 | 2019-02-10 | Innovative Potential Inc. | Electrolytic reactor |
US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
JP6964235B2 (en) * | 2018-01-17 | 2021-11-10 | パナソニックIpマネジメント株式会社 | Drug infiltration device |
US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
CN109528504B (en) * | 2019-01-07 | 2021-06-01 | 东华大学 | Micro-current freckle-removing mask with sound wave response characteristic and preparation method thereof |
US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
CN112614698B (en) * | 2020-12-08 | 2022-06-14 | 成都理工大学 | Pb/PbCl2Solid nonpolarizing electrode |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5697896A (en) * | 1994-12-08 | 1997-12-16 | Alza Corporation | Electrotransport delivery device |
US5843014A (en) * | 1995-03-24 | 1998-12-01 | Alza Corporation | Display for an electrotransport delivery device |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4211222A (en) * | 1976-08-25 | 1980-07-08 | Robert Tapper | Iontophoretic burn-protection method |
US4820263A (en) | 1981-03-06 | 1989-04-11 | Medtronic, Inc. | Apparatus and method for iontophoretic drug delivery |
JPS5810066A (en) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | Plaster structure for ion tofuorese |
US5224928A (en) * | 1983-08-18 | 1993-07-06 | Drug Delivery Systems Inc. | Mounting system for transdermal drug applicator |
US5651768A (en) | 1983-08-18 | 1997-07-29 | Drug Delivery Systems, Inc. | Transdermal drug applicator and electrodes therefor |
CA1262564A (en) * | 1983-09-01 | 1989-10-31 | Minoru Sasaki | Iontophoresis device |
US5135477A (en) | 1984-10-29 | 1992-08-04 | Medtronic, Inc. | Iontophoretic drug delivery |
US4810263A (en) * | 1986-04-11 | 1989-03-07 | Exxon Research And Engineering Company | Fuel composition |
US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US5128257A (en) * | 1987-08-31 | 1992-07-07 | Baer Bradford W | Electroporation apparatus and process |
US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
DE68925030T2 (en) | 1988-01-21 | 1996-07-25 | Massachusetts Inst Technology | MOLECULE TRANSPORT THROUGH FABRICS WITH THE USE OF ELECTROPORATION. |
IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
CA2001444C (en) * | 1988-10-28 | 2000-07-25 | Darrel F. Untereker | Iontophoresis electrode |
US5006108A (en) * | 1988-11-16 | 1991-04-09 | Noven Pharmaceuticals, Inc. | Apparatus for iontophoretic drug delivery |
US5374241A (en) * | 1989-07-21 | 1994-12-20 | Iomed, Inc. | Electrodes for iontophoresis |
EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
AU652494B2 (en) * | 1991-11-15 | 1994-08-25 | Minnesota Mining And Manufacturing Company | Solid state conductive polymer compositions, biomedical electrodes containing such compositions, and method of preparing same |
US5310404A (en) * | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
US5507724A (en) * | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
US5304120A (en) * | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
US5464386A (en) | 1992-08-17 | 1995-11-07 | Genetronics, Inc. | Transdermal drug delivery by electroincorporation of vesicles |
US6009345A (en) | 1992-08-17 | 1999-12-28 | Genetronics, Inc. | Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes |
US5688233A (en) | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
US5318514A (en) | 1992-08-17 | 1994-06-07 | Btx, Inc. | Applicator for the electroporation of drugs and genes into surface cells |
JP2542792B2 (en) * | 1992-11-05 | 1996-10-09 | ベクトン・ディッキンソン・アンド・カンパニー | User-operated iontophoretic device |
US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
CA2126487C (en) * | 1993-06-23 | 2001-05-29 | Keiichiro Okabe | Iontophoresis device |
US5533971A (en) | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
FR2709670B1 (en) * | 1993-09-10 | 1995-10-20 | Asulab Sa | Device in three modules for transdermal administration of drugs by electrophoresis or iontophoresis. |
US5387189A (en) * | 1993-12-02 | 1995-02-07 | Alza Corporation | Electrotransport delivery device and method of making same |
US5843015A (en) * | 1993-12-28 | 1998-12-01 | Becton Dickinson And Company | Molecules for iontophoretic delivery |
ATE197396T1 (en) * | 1994-07-13 | 2000-11-11 | Alza Corp | COMPOSITION AND METHOD FOR PROMOTING TRANSDERMAL ELECTRICAL TRANSPORT DOSAGE |
US5700481A (en) * | 1995-03-17 | 1997-12-23 | Takeda Chemical Industries, Ltd. | Transdermal drug delivery process |
US5624415A (en) * | 1995-04-24 | 1997-04-29 | Alza Corporation | Reduction of skin irritation and resistance during electrotransport |
US5678545A (en) * | 1995-05-04 | 1997-10-21 | Stratbucker; Robert A. | Anisotropic adhesive multiple electrode system, and method of use |
US5983131A (en) * | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
US5601618A (en) * | 1996-02-26 | 1997-02-11 | James; Brian C. | Stimulation and heating device |
US5676648A (en) | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
US5704908A (en) * | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
US6775569B2 (en) * | 1997-11-05 | 2004-08-10 | Hisamitsu Pharmaceutical Co., Inc. | Electroporation device for in vivo delivery of therapeutic agents |
US6295469B1 (en) * | 1997-11-14 | 2001-09-25 | Alza Corporation | Formulation for electrically assisted delivery of lidocaine and epinephrine |
US5938658A (en) | 1997-12-02 | 1999-08-17 | Tu; Hosheng | Device and methods for treating canker sores by RF ablation |
US6104952A (en) | 1998-01-07 | 2000-08-15 | Tu; Lily Chen | Devices for treating canker sores, tissues and methods thereof |
US5968005A (en) | 1998-01-07 | 1999-10-19 | Tu; Hosheng | Devices and means for treating canker sores |
US6192270B1 (en) * | 1998-08-14 | 2001-02-20 | Genetronics, Inc. | Apparatus and method for the delivery of drugs and genes into tissue |
-
1997
- 1997-11-05 US US08/964,872 patent/US6775569B2/en not_active Expired - Fee Related
-
1998
- 1998-11-04 EP EP98956643A patent/EP1030714A4/en not_active Withdrawn
- 1998-11-04 US US09/186,564 patent/US6490482B2/en not_active Expired - Fee Related
- 1998-11-04 AU AU13120/99A patent/AU1312099A/en not_active Abandoned
- 1998-11-04 WO PCT/US1998/023649 patent/WO1999022810A1/en not_active Application Discontinuation
- 1998-11-04 JP JP2000518738A patent/JP2001521798A/en active Pending
-
2002
- 2002-10-18 US US10/274,626 patent/US20030040696A1/en not_active Abandoned
- 2002-12-30 US US10/335,641 patent/US6978172B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5697896A (en) * | 1994-12-08 | 1997-12-16 | Alza Corporation | Electrotransport delivery device |
US5843014A (en) * | 1995-03-24 | 1998-12-01 | Alza Corporation | Display for an electrotransport delivery device |
Non-Patent Citations (1)
Title |
---|
See also references of EP1030714A4 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2000047274A1 (en) * | 1999-02-10 | 2000-08-17 | Gmp Drug Delivery, Inc. | Iontophoresis, electroporation and combination patches for local drug delivery |
US6662044B2 (en) | 1999-02-10 | 2003-12-09 | Gmp Drug Delivery, Inc. | Iontophoresis, electroporation and combination patches for local drug delivery to body tissues |
WO2003061757A1 (en) * | 2002-01-24 | 2003-07-31 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal/transmucosal preparations for electroporation |
EP1487976A2 (en) * | 2002-03-25 | 2004-12-22 | Genetronics, Inc. | Minimizing metal toxicity during electroporation enhanced delivery of polynucleotides |
EP1487976A4 (en) * | 2002-03-25 | 2005-03-30 | Genetronics Inc | Minimizing metal toxicity during electroporation enhanced delivery of polynucleotides |
EP1457233A1 (en) * | 2003-03-12 | 2004-09-15 | Novosis AG | Transdermal drug delivery system with mesh electrode |
FR2903911A1 (en) * | 2006-07-21 | 2008-01-25 | Albert Teboul | Electro-magneto therapy device for e.g. dorsal belt, has source supplying transformer device, and magnets arranged in contact with conductors via surface opposite to another surface that is applied on skin of patient in region to be treated |
WO2008032282A3 (en) * | 2006-09-13 | 2008-05-22 | Compex Medical Sa | Electrode set and stimulating device |
US9452282B2 (en) | 2006-09-13 | 2016-09-27 | DJO Global Switzerland Sarl | Electrode set and stimulating device |
US9981120B2 (en) | 2006-09-13 | 2018-05-29 | Djo Global Switzerland Sàrl | Electrode set and stimulating device |
US9717891B2 (en) | 2012-03-23 | 2017-08-01 | Microarray Limited | Skin dressing with electrodes and physiologically active precursor substance |
Also Published As
Publication number | Publication date |
---|---|
US6978172B2 (en) | 2005-12-20 |
US20010039393A1 (en) | 2001-11-08 |
AU1312099A (en) | 1999-05-24 |
EP1030714A4 (en) | 2004-12-08 |
US20030097090A1 (en) | 2003-05-22 |
US20030040696A1 (en) | 2003-02-27 |
JP2001521798A (en) | 2001-11-13 |
WO1999022810A9 (en) | 1999-08-19 |
US6490482B2 (en) | 2002-12-03 |
US6775569B2 (en) | 2004-08-10 |
US20020055703A1 (en) | 2002-05-09 |
EP1030714A1 (en) | 2000-08-30 |
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