WO1999022720A3 - Selective cyclooxygenase-2 inhibitors against premature labor - Google Patents

Selective cyclooxygenase-2 inhibitors against premature labor Download PDF

Info

Publication number
WO1999022720A3
WO1999022720A3 PCT/US1998/022246 US9822246W WO9922720A3 WO 1999022720 A3 WO1999022720 A3 WO 1999022720A3 US 9822246 W US9822246 W US 9822246W WO 9922720 A3 WO9922720 A3 WO 9922720A3
Authority
WO
WIPO (PCT)
Prior art keywords
selective cyclooxygenase
premature labor
inhibitors against
against premature
subject
Prior art date
Application number
PCT/US1998/022246
Other languages
French (fr)
Other versions
WO1999022720A2 (en
Inventor
Philip Needleman
Jaime Masferrer
Original Assignee
Searle & Co
Philip Needleman
Jaime Masferrer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Philip Needleman, Jaime Masferrer filed Critical Searle & Co
Priority to EP98955026A priority Critical patent/EP1027048A2/en
Priority to BR9813164-8A priority patent/BR9813164A/en
Priority to CA002308639A priority patent/CA2308639A1/en
Priority to AU11926/99A priority patent/AU758566B2/en
Priority to JP2000518654A priority patent/JP2001521889A/en
Publication of WO1999022720A2 publication Critical patent/WO1999022720A2/en
Publication of WO1999022720A3 publication Critical patent/WO1999022720A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

This invention relates to the use of selective cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating preterm labor. In particular, the invention describes the method of maintaining the fetal ductus arteriosus during prevention and treatment preterm labor in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula (I).
PCT/US1998/022246 1997-10-31 1998-10-27 Selective cyclooxygenase-2 inhibitors against premature labor WO1999022720A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP98955026A EP1027048A2 (en) 1997-10-31 1998-10-27 Selective cyclooxygenase-2 inhibitors against premature labor
BR9813164-8A BR9813164A (en) 1997-10-31 1998-10-27 Method of using cyclooxygenase-2 inhibitors to maintain the fetal arterial duct during treatment and prevent premature labor pains
CA002308639A CA2308639A1 (en) 1997-10-31 1998-10-27 Method of using cyclooxygenase-2 inhibitors in maintaining the fetal ductus ateriosus during treatment and prevention of preterm labor
AU11926/99A AU758566B2 (en) 1997-10-31 1998-10-27 Method of using cyclooxygenase-2 inhibitors in maintaining the fetal ductus ateriosus during treatment and prevention of preterm labor
JP2000518654A JP2001521889A (en) 1997-10-31 1998-10-27 Use of cyclooxygenase-2 inhibitors to maintain fetal arterial tract during treatment and prevention of preterm labor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6388997P 1997-10-31 1997-10-31
US60/063,889 1997-10-31

Publications (2)

Publication Number Publication Date
WO1999022720A2 WO1999022720A2 (en) 1999-05-14
WO1999022720A3 true WO1999022720A3 (en) 1999-08-26

Family

ID=22052179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/022246 WO1999022720A2 (en) 1997-10-31 1998-10-27 Selective cyclooxygenase-2 inhibitors against premature labor

Country Status (9)

Country Link
EP (1) EP1027048A2 (en)
JP (1) JP2001521889A (en)
AR (1) AR014000A1 (en)
AU (1) AU758566B2 (en)
BR (1) BR9813164A (en)
CA (1) CA2308639A1 (en)
TW (2) TW577739B (en)
WO (1) WO1999022720A2 (en)
ZA (1) ZA989876B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152792A0 (en) * 2000-06-08 2003-06-24 Univ Texas Heterocycle derivatives and methods of use
ES2275218T3 (en) 2003-05-07 2007-06-01 Osteologix A/S HYDROSOLUBLE STRONTIUM SALTS FOR THE TREATMENT OF CARTILAGOS AND / OR BONE AFFECTIONS.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521207A (en) * 1993-11-30 1996-05-28 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
US5677318A (en) * 1996-07-11 1997-10-14 Merck Frosst Canada, Inc. Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026731A1 (en) * 1993-05-13 1994-11-24 Merck Frosst Canada Inc. 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
EP0889724A1 (en) * 1996-02-27 1999-01-13 Rpms Technology Limited Cox-2 selective inhibitors for managing labour and uterine contractions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521207A (en) * 1993-11-30 1996-05-28 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
US5677318A (en) * 1996-07-11 1997-10-14 Merck Frosst Canada, Inc. Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BOTTING: "COX-2 : selective inhibitors in clinical trials", DRUG NEWS AND PERSPECTIVES, vol. 9, no. 2, 1996, pages 123 - 128, XP002104738 *
DATABASE EMBASE ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; XP002104739 *
KATORI ET AL.: "Multiple roles of inducible cyclooxygenase-2 and its selective inhibitors", FOLIA PHARMACOLOGICA JAPONICA, vol. 109, no. 6, 1 June 1997 (1997-06-01), pages 247 - 258 *
SMITH: "The pharmacology of the ductus arteriosus", PHARMACOL. REVIEWS, vol. 50, no. 1, 1 March 1998 (1998-03-01), pages 35 - 50, XP002104737 *
VANE ET AL.: "Cyclooxygenases 1 and 2", ANN. REV. PHARMOCOL. TOXICOL., vol. 38, 1 January 1998 (1998-01-01), pages 97 - 120, XP002074177 *
VANE ET AL.: "Mechanism of action of antiinflammatory drugs", INT. J. TISSUE REACT., vol. 20, no. 1, January 1998 (1998-01-01), pages 3 - 15, XP002104736 *
VANE ET AL.: "Mechanism of action of aspirin-like drugs", SEMIN. ARTHRITIS RHEUM., vol. 26, no. 6sup1, June 1997 (1997-06-01), pages 2 - 10, XP002104735 *

Also Published As

Publication number Publication date
EP1027048A2 (en) 2000-08-16
AR014000A1 (en) 2001-01-31
AU1192699A (en) 1999-05-24
AU758566B2 (en) 2003-03-27
JP2001521889A (en) 2001-11-13
CA2308639A1 (en) 1999-05-14
WO1999022720A2 (en) 1999-05-14
ZA989876B (en) 1999-10-29
BR9813164A (en) 2000-08-22
TW577739B (en) 2004-03-01
TW200404535A (en) 2004-04-01

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